Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:cGAS/STING signaling pathway
go back to main search page
Accession:GO:0140896 term browser browse the term
Definition:The series of molecular signals initiated by the binding of a double-stranded DNA or RNA from another organism to cytosolic cyclic GMP-AMP (cGAMP) synthase (cGAS) that activates innate immune responses through production of the second messenger cGAMP, which activates the adaptor STING.

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:1,697,446...1,723,626
Ensembl chr17:1,697,775...1,723,472 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:42,153,576...42,160,903
Ensembl chr23:42,153,026...42,160,907 		JBrowse link
negative regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 involved_in ISO (PMID:26440888) UniProt PMID:26440888 NCBI chr24:82,704,087...82,730,711
Ensembl chr24:82,704,068...82,727,698 		JBrowse link
G AURKB aurora kinase B involved_in ISO (PMID:33542149) UniProt PMID:33542149 NCBI chr16:7,571,255...7,583,034
Ensembl chr16:7,570,538...7,582,959 		JBrowse link
G BANF1 barrier to autointegration nuclear assembly factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:8,254,186...8,255,571
Ensembl chr 1:8,253,884...8,255,572 		JBrowse link
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:1,697,446...1,723,626
Ensembl chr17:1,697,775...1,723,472 		JBrowse link
G IRGM immunity related GTPase M involved_in ISO (PMID:32715615) UniProt PMID:32715615 NCBI chr23:53,449,576...53,451,373 JBrowse link
G LOC119622651 barrier-to-autointegration factor involved_in IEA Ensembl GO_REF:0000107
G LYPLAL1 lysophospholipase like 1 involved_in ISO (PMID:37802025) UniProt PMID:37802025 NCBI chr25:10,370,715...10,408,807
Ensembl chr25:10,370,814...10,408,767 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in ISO (PMID:35460603) UniProt PMID:35460603 NCBI chr25:3,350,798...3,405,040 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr25:3,350,821...3,388,826 JBrowse link
G PCBP2 poly(rC) binding protein 2 involved_in ISO (PMID:35322803) UniProt PMID:35322803 NCBI chr11:49,548,615...49,580,962 JBrowse link
G PPP6C protein phosphatase 6 catalytic subunit involved_in ISO (PMID:32474700) UniProt PMID:32474700 NCBI chr12:12,964,706...13,007,339
Ensembl chr12:12,964,842...13,007,351 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:43,915,226...44,119,547
Ensembl chr 8:43,914,636...44,119,541 		JBrowse link
G SMPDL3A sphingomyelin phosphodiesterase acid like 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:50,996,472...51,017,056
Ensembl chr13:50,996,674...51,016,108 		JBrowse link
G SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:1,685,741...1,691,542
Ensembl chr 5:1,686,095...1,691,489 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in ISO (PMID:33476576) UniProt PMID:33476576 NCBI chr22:9,869,502...9,871,659 JBrowse link
G ZDHHC18 zinc finger DHHC-type palmitoyltransferase 18 involved_in ISO (PMID:35438208) UniProt PMID:35438208 NCBI chr20:105,907,293...105,941,233 JBrowse link
G ZDHHC18 zinc finger DHHC-type palmitoyltransferase 18 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr20:105,909,557...105,940,971 JBrowse link
positive regulation of cGAS/STING signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO (PMID:37832545) UniProt PMID:37832545 NCBI chr13:15,284,927...15,360,539
Ensembl chr13:15,284,923...15,360,832 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:89,188,171...89,232,081
Ensembl chr 2:89,188,733...89,209,281 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 involved_in ISO (PMID:37832545) UniProt PMID:37832545 NCBI chr19:21,971,362...22,004,289 JBrowse link
G ZDHHC9 zinc finger DHHC-type palmitoyltransferase 9 involved_in ISO (PMID:37802025) UniProt PMID:37802025 NCBI chr  X:105,082,531...105,120,802 JBrowse link
G ZDHHC9 zinc finger DHHC-type palmitoyltransferase 9 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr  X:105,090,824...105,120,787 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17093
    cellular process 16013
      signal transduction 5578
        intracellular signal transduction 2958
          intracellular receptor signaling pathway 393
            cytoplasmic pattern recognition receptor signaling pathway 185
              cGAS/STING signaling pathway 23
                negative regulation of cGAS/STING signaling pathway 17
                positive regulation of cGAS/STING signaling pathway 5
Path 2
Term Annotations click to browse term
  biological_process 17093
    response to stimulus 8707
      response to biotic stimulus 1639
        response to external biotic stimulus 1591
          response to other organism 1588
            defense response to other organism 1130
              defense response to symbiont 1016
                innate immune response 833
                  regulation of innate immune response 446
                    positive regulation of innate immune response 374
                      activation of innate immune response 300
                        innate immune response-activating signaling pathway 278
                          pattern recognition receptor signaling pathway 272
                            cytoplasmic pattern recognition receptor signaling pathway 185
                              cGAS/STING signaling pathway 23
                                negative regulation of cGAS/STING signaling pathway 17
                                positive regulation of cGAS/STING signaling pathway 5
paths to the root