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ONTOLOGY REPORT - ANNOTATIONS

Term:general transcription initiation factor activity
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Accession:GO:0140223 term browser browse the term
Definition:A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
Comment:Usage guidance: The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors are the constitutive machinery required for transcription initiation.
Synonyms:exact_synonym: GTF activity;   basal transcription factor activity;   general transcription factor activity
 never_in_taxon: NCBITaxon:2 ! Bacteria


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general transcription initiation factor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dr1 down-regulator of transcription 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638 		JBrowse link
G Tbp TATA box binding protein enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016 		JBrowse link
G Tbpl1 TATA-box binding protein like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:22,777,892...22,803,305
Ensembl chr 1:22,778,459...22,803,122
Ensembl chr 1:22,778,459...22,803,122 		JBrowse link
RNA polymerase I general transcription initiation factor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor enables ISO
IBA		 (PMID:11250903)
GO_REF:0000033		 RGD
GO_Central		 PMID:11250903 GO_REF:0000033 NCBI chr10:2,129,949...2,165,381
Ensembl chr10:2,129,978...2,165,663 		JBrowse link
G Taf1 TATA-box binding protein associated factor 1 enables ISO (PMID:12498690) RGD PMID:12498690 NCBI chr  X:66,640,915...66,716,543
Ensembl chr  X:66,640,982...66,716,543 		JBrowse link
G Taf1c TATA-box binding protein associated factor, RNA polymerase 1 subunit C enables ISO (PMID:12498690) RGD PMID:12498690 NCBI chr19:47,652,451...47,658,971
Ensembl chr19:47,652,452...47,658,971 		JBrowse link
G Ubtf upstream binding transcription factor enables ISO
IBA		 (PMID:12498690)
GO_REF:0000033		 RGD
GO_Central		 PMID:12498690 GO_REF:0000033 NCBI chr10:87,258,217...87,274,291
Ensembl chr10:87,258,217...87,272,969 		JBrowse link
RNA polymerase II general transcription initiation factor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brf2 BRF2 general transcription factor 3B subunit enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:64,928,334...64,933,057
Ensembl chr16:64,928,300...64,933,059 		JBrowse link
G Ccnh cyclin H contributes_to
enables		 ISO
IEA		 (PMID:7533895)
GO_REF:0000107		 RGD
Ensembl		 PMID:7533895 GO_REF:0000107 NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819 		JBrowse link
G Dr1 down-regulator of transcription 1 enables ISO
IBA		 (PMID:8670811)
GO_REF:0000033		 RGD
GO_Central		 PMID:8670811 GO_REF:0000033 NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638 		JBrowse link
G Drap1 Dr1 associated protein 1 enables ISO
IBA		 (PMID:8670811)
GO_REF:0000033		 RGD
GO_Central		 PMID:8670811 GO_REF:0000033 NCBI chr 1:202,731,775...202,734,468
Ensembl chr 1:202,731,788...202,734,425 		JBrowse link
G Gtf2a1 general transcription factor 2A subunit 1 enables ISO (PMID:27193682) RGD PMID:27193682 NCBI chr 6:110,488,891...110,521,502
Ensembl chr 6:110,488,931...110,521,511 		JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 enables ISO
IBA		 (PMID:27193682), (PMID:7958899)
GO_REF:0000033		 RGD
GO_Central		 PMID:7958899 PMID:27193682 GO_REF:0000033 NCBI chr 8:70,662,447...70,675,576
Ensembl chr 8:70,662,428...70,675,569 		JBrowse link
G Gtf2b general transcription factor IIB enables IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:27193682)		 Ensembl
GO_Central
RGD		 PMID:27193682 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651 		JBrowse link
G Gtf2e1 general transcription factor IIE subunit 1 enables ISO (PMID:27193682) RGD PMID:27193682 NCBI chr11:63,182,073...63,215,349
Ensembl chr11:63,182,349...63,213,942 		JBrowse link
G Gtf2e2 general transcription factor IIE subunit 2 enables ISO (PMID:27193682) RGD PMID:27193682 NCBI chr16:58,399,307...58,449,467
Ensembl chr16:58,399,107...58,449,371 		JBrowse link
G Gtf2f1 general transcription factor IIF subunit 1 enables ISO
IBA		 (PMID:27193682), (PMID:7929273)
GO_REF:0000033		 RGD
GO_Central		 PMID:7929273 PMID:27193682 GO_REF:0000033 NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423 		JBrowse link
G Gtf2f2 general transcription factor IIF subunit 2 enables IDA PMID:7929273 RGD
ARUK-UCL		 PMID:1429731 PMID:7929273 RGD:632949, RGD:9681417 NCBI chr15:51,206,027...51,327,166
Ensembl chr15:51,206,031...51,327,253 		JBrowse link
G Gtf2h2 general transcription factor IIH subunit 2 enables ISO (PMID:10924514), (PMID:27193682) RGD PMID:10924514 PMID:27193682 NCBI chr 2:31,623,752...31,652,697
Ensembl chr 2:31,624,678...31,652,592 		JBrowse link
G Gtf2h3 general transcription factor IIH subunit 3 enables ISO
IEA		 (PMID:27193682)
GO_REF:0000107		 RGD
Ensembl		 PMID:27193682 GO_REF:0000107 NCBI chr12:32,009,010...32,025,484
Ensembl chr12:32,009,014...32,025,497 		JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 enables ISO (PMID:27193682) RGD PMID:27193682 NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984 		JBrowse link
G Prrx1 paired related homeobox 1 enables ISO (PMID:32188878) RGD PMID:32188878 NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866 		JBrowse link
G Prrx2 paired related homeobox 2 enables ISO (PMID:32188878) RGD PMID:32188878 NCBI chr 3:14,132,574...14,168,533
Ensembl chr 3:14,094,004...14,168,535 		JBrowse link
G Snapc2 small nuclear RNA activating complex, polypeptide 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:2,605,794...2,608,997
Ensembl chr12:2,605,810...2,608,999 		JBrowse link
G Snapc4 small nuclear RNA activating complex, polypeptide 4 enables ISO (PMID:9418884) RGD PMID:9418884 NCBI chr 3:9,182,061...9,200,819
Ensembl chr 3:9,182,067...9,199,518 		JBrowse link
G Snapc5 small nuclear RNA activating complex, polypeptide 5 enables ISO (PMID:9732265) RGD PMID:9732265 NCBI chr 8:64,677,204...64,680,769
Ensembl chr 8:64,677,205...64,681,964 		JBrowse link
G Taf1 TATA-box binding protein associated factor 1 enables ISO UniProtKB:Q15545 (PMID:17996705), (PMID:25412659) RGD PMID:17996705 PMID:25412659 NCBI chr  X:66,640,915...66,716,543
Ensembl chr  X:66,640,982...66,716,543 		JBrowse link
G Taf10 TATA-box binding protein associated factor 10 contributes_to
enables		 ISO
IBA		 (PMID:9603525)
GO_REF:0000033
(PMID:11564863)		 RGD
GO_Central		 PMID:9603525 PMID:11564863 GO_REF:0000033 NCBI chr 1:160,095,108...160,096,401
Ensembl chr 1:160,095,108...160,096,376 		JBrowse link
G Taf11 TATA-box binding protein associated factor 11 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:5,955,774...5,963,593
Ensembl chr20:5,955,777...5,961,905 		JBrowse link
G Taf12 TATA-box binding protein associated factor 12 contributes_to ISO (PMID:9603525) RGD PMID:9603525 NCBI chr 5:144,472,816...144,490,299
Ensembl chr 5:144,472,841...144,488,849 		JBrowse link
G Taf2 TATA-box binding protein associated factor 2 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:86,422,613...86,479,616
Ensembl chr 7:86,422,613...86,479,616 		JBrowse link
G Taf4 TATA-box binding protein associated factor 4 contributes_to ISO
IBA		 (PMID:9603525)
GO_REF:0000033		 RGD
GO_Central		 PMID:9603525 GO_REF:0000033 NCBI chr 3:167,017,992...167,083,413
Ensembl chr 3:167,017,993...167,083,356 		JBrowse link
G Taf4b TATA-box binding protein associated factor 4b contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:5,952,737...6,086,408
Ensembl chr18:5,952,769...6,068,307 		JBrowse link
G Taf5 TATA-box binding protein associated factor 5 contributes_to
enables		 ISO
IBA		 (PMID:9603525)
GO_REF:0000033
(PMID:9045704)		 RGD
GO_Central		 PMID:9045704 PMID:9603525 GO_REF:0000033 NCBI chr 1:245,958,428...245,973,914
Ensembl chr 1:245,958,428...245,973,914 		JBrowse link
G Taf6 TATA-box binding protein associated factor 6 contributes_to
enables		 ISO
IBA
IEA		 (PMID:9603525)
GO_REF:0000033
GO_REF:0000107
(PMID:15328371)		 RGD
GO_Central
Ensembl		 PMID:9603525 PMID:15328371 GO_REF:0000033 GO_REF:0000107 NCBI chr12:17,055,864...17,064,244
Ensembl chr12:17,055,873...17,064,247 		JBrowse link
G Taf6l TATA-box binding protein associated factor 6 like enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:205,672,147...205,684,721
Ensembl chr 1:205,672,149...205,684,655 		JBrowse link
G Taf7 TATA-box binding protein associated factor 7 contributes_to
enables		 ISO
IBA		 (PMID:9603525)
GO_REF:0000033
(PMID:25412659), (PMID:7824954)		 RGD
GO_Central		 PMID:7824954 PMID:9603525 PMID:25412659 GO_REF:0000033 NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134 		JBrowse link
G Taf7l TATA-box binding protein associated factor 7-like contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:97,660,222...97,675,241
Ensembl chr  X:97,660,222...97,675,023 		JBrowse link
G Taf7l-ps1 TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, pseudogene 1 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:51,763,259...51,764,401
Ensembl chr 7:51,763,259...51,764,401 		JBrowse link
G Taf9 TATA-box binding protein associated factor 9 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:31,794,316...31,798,324
Ensembl chr 2:31,794,142...31,798,769 		JBrowse link
G Taf9b TATA-box binding protein associated factor 9b contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:71,289,290...71,300,142
Ensembl chr  X:71,289,290...71,300,604 		JBrowse link
G Tbp TATA box binding protein contributes_to
enables		 IDA
ISO		 (PMID:27193682), (PMID:9841876) RGD PMID:9841876 PMID:27193682 PMID:7980586 RGD:2306552 NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016 		JBrowse link
G Tbpl1 TATA-box binding protein like 1 enables ISO (PMID:10220372), (PMID:15767669) RGD PMID:10220372 PMID:15767669 NCBI chr 1:22,777,892...22,803,305
Ensembl chr 1:22,778,459...22,803,122
Ensembl chr 1:22,778,459...22,803,122 		JBrowse link
G Tbpl2 TATA box binding protein-like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:6,771,825...6,793,281
Ensembl chr 3:6,772,419...6,793,231 		JBrowse link
RNA polymerase III general transcription initiation factor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brf1 BRF1 general transcription factor IIIB subunit enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:132,034,378...132,081,313
Ensembl chr 6:132,037,272...132,081,278 		JBrowse link
G Gtf3a general transcription factor III A IDA RGD PMID:11814676 RGD:632850 NCBI chr12:8,136,746...8,144,690
Ensembl chr12:8,136,747...8,144,690 		JBrowse link
G Gtf3c1 general transcription factor IIIC subunit 1 enables ISO
IEA		 (PMID:17409385)
GO_REF:0000107		 RGD
Ensembl		 PMID:17409385 GO_REF:0000107 NCBI chr 1:180,203,995...180,270,201
Ensembl chr 1:180,203,995...180,270,201 		JBrowse link
G Gtf3c2 general transcription factor IIIC subunit 2 enables ISO (PMID:17409385) RGD PMID:17409385 NCBI chr 6:25,196,439...25,221,338
Ensembl chr 6:25,197,268...25,220,490 		JBrowse link
G Gtf3c3 general transcription factor IIIC subunit 3 enables ISO (PMID:17409385) RGD PMID:17409385 NCBI chr 9:55,882,252...55,943,037
Ensembl chr 9:55,883,721...55,942,967 		JBrowse link
G Gtf3c4 general transcription factor IIIC subunit 4 enables ISO (PMID:17409385) RGD PMID:17409385 NCBI chr 3:12,154,803...12,172,795
Ensembl chr 3:12,154,805...12,172,725 		JBrowse link
G Gtf3c5 general transcription factor IIIC subunit 5 enables ISO (PMID:17409385) RGD PMID:17409385 NCBI chr 3:11,893,867...11,914,187
Ensembl chr 3:11,893,875...11,914,180 		JBrowse link
G Gtf3c6 general transcription factor 3C subunit 6 enables ISO (PMID:17409385) RGD PMID:17409385 NCBI chr20:43,656,400...43,668,382
Ensembl chr20:43,655,875...43,667,873 		JBrowse link
G Snapc4 small nuclear RNA activating complex, polypeptide 4 enables ISO (PMID:9418884) RGD PMID:9418884 NCBI chr 3:9,182,061...9,200,819
Ensembl chr 3:9,182,067...9,199,518 		JBrowse link
G Snapc5 small nuclear RNA activating complex, polypeptide 5 enables ISO (PMID:9732265) RGD PMID:9732265 NCBI chr 8:64,677,204...64,680,769
Ensembl chr 8:64,677,205...64,681,964 		JBrowse link
G Tbp TATA box binding protein enables ISO (PMID:26638071) RGD PMID:26638071 NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016 		JBrowse link
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