ONTOLOGY REPORT - ANNOTATIONS
Term: cellular response to ionizing radiation
Accession: GO:0071479
browse the term
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
Synonyms: exact_synonym: cellular response to ionising radiation; cellular response to ionizing radiation stimulus
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ATM
ATM serine/threonine kinase
ISO
RGD
PMID:28007901
RGD:12879399
NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552
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BABAM2
BRISC and BRCA1 A complex member 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:110,897,250...111,328,414
Ensembl chr 3:110,897,256...111,328,385
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BARD1
BRCA1 associated RING domain 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:117,049,483...117,135,889
Ensembl chr15:117,047,845...117,175,851
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BBC3
BCL2 binding component 3
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16286009)
Ensembl MGI
PMID:16286009
GO_REF:0000107
NCBI chr 6:53,037,103...53,046,902
Ensembl chr 6:53,037,104...53,045,685
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BLM
BLM RecQ like helicase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:53,317,515...53,412,649
Ensembl chr 7:53,317,540...53,412,645
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BRCA1
BRCA1 DNA repair associated
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,854,668
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BRCA2
BRCA2 DNA repair associated
involved_in
ISO
(PMID:14636569)
ComplexPortal
PMID:14636569
NCBI chr11:8,805,950...8,858,128
Ensembl chr11:8,805,913...8,857,793
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BRCC3
BRCA1/BRCA2-containing complex subunit 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr X:125,383,392...125,439,082
Ensembl chr X:125,383,414...125,439,082
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CDKN1A
cyclin dependent kinase inhibitor 1A
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761
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CLOCK
clock circadian regulator
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:54,793,323...54,910,192
Ensembl chr 8:54,793,342...54,877,777
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ECT2
epithelial cell transforming 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr13:111,248,215...111,310,746
Ensembl chr13:111,248,131...111,314,828
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EEF1D
eukaryotic translation elongation factor 1 delta
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:969,532...982,250
Ensembl chr 4:969,527...983,270
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FBXO4
F-box protein 4
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:21911473)
Ensembl MGI
PMID:21911473
GO_REF:0000107
NCBI chr16:26,707,470...26,751,134
Ensembl chr16:26,707,470...26,752,024
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FIGNL1
fidgetin like 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:136,484,217...136,488,262
Ensembl chr 9:136,484,216...136,488,250
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GADD45A
growth arrest and DNA damage inducible alpha
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 6:144,940,702...144,944,089
Ensembl chr 6:144,940,697...144,944,089
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GRB2
growth factor receptor bound protein 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:5,940,723...6,009,095
Ensembl chr12:5,940,647...6,010,835
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HUS1
HUS1 checkpoint clamp component
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr18:48,522,914...48,539,267
Ensembl chr18:48,522,998...48,534,682
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INO80
INO80 complex ATPase subunit
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:130,201,705...130,341,627
Ensembl chr 1:130,201,718...130,342,838
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INTS7
integrator complex subunit 7
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:131,275,530...131,364,490
Ensembl chr 9:131,275,626...131,354,592
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ITGB1
integrin subunit beta 1
ISO
RGD
PMID:19714308
RGD:2312872
NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,396...56,173,326
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ITGB6
integrin subunit beta 6
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:17916808)
Ensembl MGI
PMID:17916808
GO_REF:0000107
NCBI chr15:67,041,516...67,175,409
Ensembl chr15:67,041,522...67,175,234
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LIG4
DNA ligase 4
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr11:75,537,027...75,547,711
Ensembl chr11:75,537,036...75,547,716
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LOC100625088
182 kDa tankyrase-1-binding protein
involved_in
ISO
(PMID:25749521)
BHF-UCL
PMID:25749521
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LOC100627380
lysine-specific demethylase 4D-like
acts_upstream_of_or_within
ISO
(PMID:24550317)
MGI
PMID:24550317
NCBI chr 9:27,083,348...27,085,693
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MAPK14
mitogen-activated protein kinase 14
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031
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MFN2
mitofusin 2
ISO
RGD
PMID:26415228
RGD:13204741
NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438
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MGMT
O-6-methylguanine-DNA methyltransferase
ISO
RGD
PMID:9780001
RGD:2316946
NCBI chr14:138,502,005...138,771,543
Ensembl chr14:138,499,309...138,771,540
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MIR21
microRNA mir-21
involved_in
ISO
(PMID:22836756)
BHF-UCL
PMID:22836756
NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358
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NAMPT
nicotinamide phosphoribosyltransferase
ISO
RGD
PMID:27681750
RGD:13781886
NCBI chr 9:106,119,896...106,162,126
Ensembl chr 9:106,119,899...106,294,586
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NAPRT
nicotinate phosphoribosyltransferase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:983,428...986,750
Ensembl chr 4:983,423...986,748
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NET1
neuroepithelial cell transforming 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr10:65,428,013...65,438,346
Ensembl chr10:65,425,011...65,459,754
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RAD1
RAD1 checkpoint DNA exonuclease
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:20,491,851...20,512,198
Ensembl chr16:20,466,889...20,512,135
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RAD51
RAD51 recombinase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,665...130,640,136
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RAD51AP1
RAD51 associated protein 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:65,872,277...65,897,210
Ensembl chr 5:65,872,539...65,897,212
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RAD9A
RAD9 checkpoint clamp component A
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:5,123,142...5,129,740
Ensembl chr 2:5,123,134...5,129,703
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RAD9B
RAD9 checkpoint clamp component B
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr14:31,869,570...31,903,485
Ensembl chr14:31,869,684...31,903,823
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RHNO1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
involved_in
IEA
InterPro Ensembl
GO_REF:0000002 GO_REF:0000107
NCBI chr 5:67,239,907...67,246,150
Ensembl chr 5:67,239,202...67,246,124
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RHOB
ras homolog family member B
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:117,773,400...117,777,569
Ensembl chr 3:117,773,405...117,777,574
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RPL26
ribosomal protein L26
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:53,548,313...53,553,453
Ensembl chr12:53,548,321...53,553,455
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SIRT1
sirtuin 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297
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SNAI2
snail family transcriptional repressor 2
acts_upstream_of_or_within
ISO
(PMID:16286009)
MGI
PMID:16286009
NCBI chr 4:79,264,880...79,268,475
Ensembl chr 4:79,264,880...79,268,475
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SPIDR
scaffold protein involved in DNA repair
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:79,874,937...80,190,744
Ensembl chr 4:79,874,831...80,190,655
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SWI5
SWI5 homologous recombination repair protein
involved_in
ISO
(PMID:23754376)
UniProt
PMID:23754376
NCBI chr 1:268,720,232...268,726,527
Ensembl chr 1:268,720,355...268,726,521
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TANK
TRAF family member associated NFKB activator
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:67,970,972...68,048,681
Ensembl chr15:67,952,173...68,048,963
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TGFB1
transforming growth factor beta 1
involved_in acts_upstream_of_or_within
ISO IEA
(PMID:17916808)
RGD Ensembl MGI
PMID:17916808 PMID:25600523
GO_REF:0000107 RGD:11073671
NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
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TNF
tumor necrosis factor
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415
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TP53
tumor protein p53
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:16286009)
Ensembl MGI
PMID:16286009
GO_REF:0000107
NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
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ATM
ATM serine/threonine kinase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552
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ATR
ATR serine/threonine kinase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr13:83,175,515...83,289,986
Ensembl chr13:83,174,824...83,289,989
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BCL2L1
BCL2 like 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:15231831)
Ensembl MGI
PMID:15231831
GO_REF:0000107
NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694
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CDKN1A
cyclin dependent kinase inhibitor 1A
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:10710310)
Ensembl MGI
PMID:10710310
GO_REF:0000107
NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761
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CFP
complement factor properdin
ISO
RGD
PMID:17949253
RGD:7488908
NCBI chr X:42,157,980...42,174,964
Ensembl chr X:42,157,988...42,174,951
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CHEK2
checkpoint kinase 2
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:10710310)
Ensembl MGI
PMID:10710310
GO_REF:0000107
NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290
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CRYAB
crystallin alpha B
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:23542032)
MGI Ensembl
PMID:23542032
GO_REF:0000107
NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,506...39,643,530
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CYBA
cytochrome b-245 alpha chain
ISO
RGD
PMID:18640264
RGD:2317861
NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,162...1,021,420
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DDIAS
DNA damage induced apoptosis suppressor
acts_upstream_of_or_within
ISO
(PMID:17515607)
MGI
PMID:17515607
NCBI chr 9:17,077,884...17,097,597
Ensembl chr 9:17,077,884...17,097,588
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EGR1
early growth response 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
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GTF2H5
general transcription factor IIH subunit 5
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:23637614)
Ensembl MGI
PMID:23637614
GO_REF:0000107
NCBI chr 1:8,928,280...8,935,030
Ensembl chr 1:8,917,240...8,934,983
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H2AX
H2A.X variant histone
ISO
RGD
PMID:17552875
RGD:8693710
NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084
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HRAS
HRas proto-oncogene, GTPase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501
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HSF1
heat shock transcription factor 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:463,531...486,483
Ensembl chr 4:463,393...486,473
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HSPA5
heat shock protein family A (Hsp70) member 5
ISO
RGD
PMID:20470193
RGD:11354917
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
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KDM1A
lysine demethylase 1A
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:24217620)
MGI Ensembl
PMID:24217620
GO_REF:0000107
NCBI chr 6:80,903,407...80,971,875
Ensembl chr 6:80,903,424...80,971,873
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MAP3K20
mitogen-activated protein kinase kinase kinase 20
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:79,174,444...79,378,520
Ensembl chr15:79,173,033...79,380,993
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MDM2
MDM2 proto-oncogene
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:33,105,717...33,137,602
Ensembl chr 5:33,105,759...33,137,739
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MIR21
microRNA mir-21
involved_in
ISO
(PMID:19826040)
BHF-UCL
PMID:19826040
NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358
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NOX4
NADPH oxidase 4
ISO
RGD
PMID:18640264
RGD:2317861
NCBI chr 9:22,622,105...22,776,691
Ensembl chr 9:22,624,212...22,776,534
G
RAD51
RAD51 recombinase
ISO
RGD
PMID:9885240
RGD:9831175
NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,665...130,640,136
G
RNF4
ring finger protein 4
ISO
RGD
PMID:22661230
RGD:9480235
NCBI chr 8:1,353,532...1,380,637
Ensembl chr 8:1,353,658...1,380,634
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RPL13A
ribosomal protein L13a
ISO
RGD
PMID:10483362
RGD:11036101
NCBI chr 6:54,551,772...54,568,752
Ensembl chr 6:54,551,533...54,561,489
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RPL26
ribosomal protein L26
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:53,548,313...53,553,453
Ensembl chr12:53,548,321...53,553,455
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TLK2
tousled like kinase 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr12:16,129,249...16,256,642
Ensembl chr12:16,129,256...16,256,359
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TMEM109
transmembrane protein 109
acts_upstream_of_or_within involved_in
ISO IBA IEA
(PMID:23542032)
MGI GO_Central InterPro Ensembl
PMID:23542032
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 2:10,828,644...10,837,124
Ensembl chr 2:10,828,652...10,837,062
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TMEM169
transmembrane protein 169
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:118,335,915...118,352,713
Ensembl chr15:118,346,943...118,352,707
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TP53
tumor protein p53
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:10710310)
Ensembl MGI
PMID:10710310
GO_REF:0000107
NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
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TREX1
three prime repair exonuclease 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:18045533)
Ensembl MGI
PMID:18045533
GO_REF:0000107
NCBI chr13:31,177,604...31,180,764
Ensembl chr13:31,179,291...31,180,747
G
TSPYL5
TSPY like 5
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 4:39,362,945...39,367,405
Ensembl chr 4:39,362,947...39,367,402
G
WRN
WRN RecQ like helicase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:53,966,968...54,094,855
Ensembl chr15:53,966,986...54,094,587
G
XRCC5
X-ray repair cross complementing 5
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr15:118,354,943...118,451,974
Ensembl chr15:118,354,796...118,451,960
G
XRCC6
X-ray repair cross complementing 6
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 5:6,903,496...6,929,162
Ensembl chr 5:6,903,495...6,929,052
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YAP1
Yes1 associated transcriptional regulator
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:32,811,629...32,924,926
Ensembl chr 9:32,811,226...32,925,606
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ZMPSTE24
zinc metallopeptidase STE24
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:15980864)
Ensembl MGI
PMID:15980864
GO_REF:0000107
NCBI chr 6:96,008,307...96,057,131
Ensembl chr 6:96,008,455...96,062,951
G
ATM
ATM serine/threonine kinase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552
G
CCND2
cyclin D2
acts_upstream_of_or_within involved_in
ISO IEA
(PMID:23714078)
MGI Ensembl
PMID:23714078
GO_REF:0000107
NCBI chr 5:66,092,483...66,114,575
Ensembl chr 5:66,087,379...66,114,571
G
DBN1
drebrin 1
ISO
RGD
PMID:23578130
RGD:10398817
NCBI chr 2:80,480,603...80,495,797
Ensembl chr 2:80,479,460...80,495,796
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DNM2
dynamin 2
ISO
RGD
PMID:15994918
RGD:9685147
NCBI chr 2:69,474,011...69,574,427
Ensembl chr 2:69,474,031...69,574,424
G
HAMP
hepcidin antimicrobial peptide
ISO
RGD
PMID:17090718
RGD:11041722
NCBI chr 6:44,785,863...44,787,303
Ensembl chr 6:44,784,160...44,787,305
G
KAT5
lysine acetyltransferase 5
ISO
RGD
PMID:15985650
RGD:2316135
NCBI chr 2:6,560,544...6,572,461
Ensembl chr 2:6,560,513...6,572,466
G
LCN2
lipocalin 2
ISO
RGD
PMID:23331620
RGD:126790570
NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644
G
NIPBL
NIPBL cohesin loading factor
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr16:22,152,455...22,364,373
Ensembl chr16:22,152,469...22,363,821
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NUCKS1
nuclear casein kinase and cyclin dependent kinase substrate 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 9:66,398,845...66,435,548
Ensembl chr 9:66,398,227...66,435,517
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PRAP1
proline rich acidic protein 1
involved_in
ISO
(PMID:32629119)
UniProt
PMID:32629119
NCBI chr14:141,325,965...141,329,955
G
SFRP1
secreted frizzled related protein 1
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748
G
SFRP2
secreted frizzled related protein 2
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 8:75,337,311...75,345,926
Ensembl chr 8:75,337,144...75,345,921
G
TP53BP1
tumor protein p53 binding protein 1
ISO
RGD
PMID:21915754
RGD:9586753
NCBI chr 1:127,958,500...128,032,370
Ensembl chr 1:127,959,213...128,028,712
G
XRCC5
X-ray repair cross complementing 5
ISO
RGD
PMID:11966321
RGD:727219
NCBI chr15:118,354,943...118,451,974
Ensembl chr15:118,354,796...118,451,960
G
XRCC6
X-ray repair cross complementing 6
ISO
RGD
PMID:11175667
RGD:2317102
NCBI chr 5:6,903,496...6,929,162
Ensembl chr 5:6,903,495...6,929,052
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GATA3
GATA binding protein 3
involved_in
ISS IEA
UniProt Ensembl
GO_REF:0000024 GO_REF:0000107
NCBI chr10:63,367,684...63,397,977
Ensembl chr10:63,367,663...63,388,859
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