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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular pH reduction
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Accession:GO:0051452 term browser browse the term
Definition:Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.
Synonyms:exact_synonym: cell pH reduction;   cellular acidification;   reduction of cellular pH;   reduction of pH in cell
 related_synonym: intracellular acidification


show annotations for term's descendants           Sort by:
intracellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100154179 Golgi pH regulator involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:99,654,852...99,712,244 JBrowse link
G SLC12A5 solute carrier family 12 member 5 ISO RGD PMID:16420452 RGD:2303953 NCBI chr17:48,192,072...48,230,674
Ensembl chr17:48,192,075...48,230,661 		JBrowse link
G TCIRG1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23908015) Ensembl
MGI		 PMID:23908015 GO_REF:0000107 NCBI chr 2:4,844,627...4,860,562
Ensembl chr 2:4,844,637...4,860,498 		JBrowse link
G TPCN2 two pore segment channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:4,069,267...4,105,065
Ensembl chr 2:4,069,280...4,105,042 		JBrowse link
G TTPA alpha tocopherol transfer protein ISO RGD PMID:22147702 RGD:7247589 NCBI chr 4:70,960,580...70,980,883
Ensembl chr 4:70,961,465...70,980,876 		JBrowse link
endosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP11 aquaporin 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16107722) Ensembl
MGI		 PMID:16107722 GO_REF:0000107 NCBI chr 9:12,065,550...12,076,339
Ensembl chr 9:12,065,546...12,078,401 		JBrowse link
G FASLG Fas ligand ISO RGD PMID:18045865 RGD:2315735 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464 		JBrowse link
G RNASEK ribonuclease K involved_in ISO (PMID:26212330) UniProt PMID:26212330 NCBI chr12:52,416,903...52,418,876
Ensembl chr12:52,417,135...52,418,873 		JBrowse link
G TMEM9 transmembrane protein 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:23,586,487...23,600,042
Ensembl chr10:23,586,491...23,607,530 		JBrowse link
lysosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP6AP2 ATPase H+ transporting accessory protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:36,271,154...36,300,240
Ensembl chr  X:36,271,223...36,300,240 		JBrowse link
G CCDC115 coiled-coil domain containing 115 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:31,974,715...31,979,062
Ensembl chr15:31,974,724...31,979,059 		JBrowse link
G CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISS
IBA
IEA		 UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:18,433,564...18,450,296
Ensembl chr 3:18,433,836...18,450,290 		JBrowse link
G CLN5 CLN5 intracellular trafficking protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:49,105,822...49,128,425
Ensembl chr11:49,105,878...49,129,886 		JBrowse link
G CLN6 CLN6 transmembrane ER protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:166,107,895...166,126,054
Ensembl chr 1:166,107,228...166,126,808 		JBrowse link
G CREG1 cellular repressor of E1A stimulated genes 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:33966596) Ensembl
MGI		 PMID:33966596 GO_REF:0000107 NCBI chr 4:83,458,358...83,469,931
Ensembl chr 4:83,458,242...83,469,930 		JBrowse link
G GRN granulin precursor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:18,893,772...18,900,444
Ensembl chr12:18,893,770...18,900,446 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:78,600,818...78,617,587
Ensembl chr11:78,600,645...78,617,616 		JBrowse link
G LAMP2 lysosomal associated membrane protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:98,586,718...98,623,939
Ensembl chr  X:98,581,992...98,623,940 		JBrowse link
G PPT1 palmitoyl-protein thioesterase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:95,840,906...95,860,858
Ensembl chr 6:95,840,908...95,860,858 		JBrowse link
G SNAPIN SNAP associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20920792) Ensembl
MGI		 PMID:20920792 GO_REF:0000107 NCBI chr 4:95,987,524...95,989,527
Ensembl chr 4:95,984,358...95,989,474 		JBrowse link
G TMEM106B transmembrane protein 106B acts_upstream_of_or_within ISO (PMID:28728022) MGI PMID:28728022 NCBI chr 9:81,837,654...81,864,215
Ensembl chr 9:81,837,667...81,864,210 		JBrowse link
G TMEM199 transmembrane protein 199 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:44,636,379...44,641,536
Ensembl chr12:44,636,379...44,641,527 		JBrowse link
G TMEM9 transmembrane protein 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:23,586,487...23,600,042
Ensembl chr10:23,586,491...23,607,530 		JBrowse link
negative regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
phagosome acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAB20 RAB20, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:77,167,052...77,188,893
Ensembl chr11:77,167,059...77,188,898 		JBrowse link
G RAB38 RAB38, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:21,577,083...21,640,637
Ensembl chr 9:21,577,033...21,640,115 		JBrowse link
G RAB39A RAB39A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:36,341,339...36,403,690
Ensembl chr 9:36,341,339...36,403,654 		JBrowse link
G RAB7A RAB7A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:71,777,422...71,886,758
Ensembl chr13:71,777,424...71,852,694 		JBrowse link
G SLAMF8 SLAM family member 8 acts_upstream_of_or_within ISO (PMID:22593622) MGI PMID:22593622 NCBI chr 4:90,661,984...90,673,044
Ensembl chr 4:90,661,985...90,672,572 		JBrowse link
G SLC4A7 solute carrier family 4 member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:13,933,552...14,043,108
Ensembl chr13:13,933,711...14,043,058 		JBrowse link
G TCIRG1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19549681) Ensembl
MGI		 PMID:19549681 GO_REF:0000107 NCBI chr 2:4,844,627...4,860,562
Ensembl chr 2:4,844,637...4,860,498 		JBrowse link
positive regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP vasopressin ISO RGD PMID:17762181 RGD:2300343 NCBI chr17:32,581,234...32,583,145
Ensembl chr17:32,581,234...32,583,185 		JBrowse link
G AVPR1A vasopressin receptor 1A ISO RGD PMID:17762181 RGD:2300343 NCBI chr 5:27,824,991...27,832,794
Ensembl chr 5:27,824,992...27,832,703 		JBrowse link
G AVPR1B vasopressin receptor 1B ISO RGD PMID:17762181 RGD:2300343 NCBI chr 9:66,769,472...66,776,916
Ensembl chr 9:66,772,591...66,776,931 		JBrowse link
G CA2 carbonic anhydrase 2 acts_upstream_of_or_within ISO (PMID:23881097) RGD
MGI		 PMID:9665810 PMID:23881097 RGD:1342423 NCBI chr 4:51,194,686...51,211,436
Ensembl chr 4:51,193,756...51,211,259 		JBrowse link
G CA7 carbonic anhydrase 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23881097) Ensembl
MGI		 PMID:23881097 GO_REF:0000107 NCBI chr 6:27,548,647...27,563,966
Ensembl chr 6:27,548,706...27,563,861 		JBrowse link
positive regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UBE3A ubiquitin protein ligase E3A involved_in ISO PMID:23447592
(PMID:23447592)		 CACAO PMID:23447592 RGD:15023469 NCBI chr 1:141,887,179...142,001,595
Ensembl chr 1:141,887,227...141,995,003 		JBrowse link
regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC9A7 solute carrier family 9 member A7 involved_in ISO (PMID:30335141) UniProt PMID:30335141 NCBI chr  X:41,233,308...41,399,032
Ensembl chr  X:41,236,246...41,398,999 		JBrowse link
G SLC9A8 solute carrier family 9 member A8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:51,401,061...51,477,276
Ensembl chr17:51,401,621...51,477,220 		JBrowse link
vacuolar acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP6V0A1 ATPase H+ transporting V0 subunit a1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:20,288,409...20,344,142
Ensembl chr12:20,288,411...20,344,127 		JBrowse link
G ATP6V0A4 ATPase H+ transporting V0 subunit a4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr18:10,868,208...10,966,801
Ensembl chr18:10,919,422...10,966,410 		JBrowse link
G ATP6V0D1 ATPase H+ transporting V0 subunit d1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:28,090,180...28,132,080
Ensembl chr 6:28,090,183...28,131,985 		JBrowse link
G ATP6V0D2 ATPase H+ transporting V0 subunit d2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:50,694,188...50,749,373
Ensembl chr 4:50,694,189...50,749,378 		JBrowse link
G ATP6V1B1 ATPase H+ transporting V1 subunit B1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:71,560,102...71,591,885
Ensembl chr 3:71,561,236...71,591,845 		JBrowse link
G ATP6V1B2 ATPase H+ transporting V1 subunit B2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:4,289,257...4,318,587
Ensembl chr14:4,289,339...4,318,584 		JBrowse link
G CLIC4 chloride intracellular channel 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19197003) Ensembl
MGI		 PMID:19197003 GO_REF:0000107 NCBI chr 6:82,401,041...82,483,038
Ensembl chr 6:82,401,188...82,483,724 		JBrowse link
G DMXL1 Dmx like 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:123,003,077...123,142,865
Ensembl chr 2:123,003,086...123,141,060 		JBrowse link
G DMXL2 Dmx like 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:120,138,249...120,298,603
Ensembl chr 1:120,138,336...120,298,586 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11067873), (PMID:18984740)
(PMID:9670047)		 Ensembl
MGI		 PMID:9670047 PMID:11067873 PMID:18984740 GO_REF:0000107 NCBI chr15:120,434,100...120,446,396
Ensembl chr15:120,433,952...120,446,396 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17667
    biological regulation 12821
      regulation of biological quality 3233
        regulation of intracellular pH 80
          intracellular pH reduction 47
            Golgi lumen acidification + 3
            endosomal lumen acidification 4
            negative regulation of cellular pH reduction + 1
            phagosome acidification + 7
            positive regulation of cellular pH reduction + 6
            regulation of cellular pH reduction + 9
            vacuolar acidification + 24
Path 2
Term Annotations click to browse term
  biological_process 17667
    homeostatic process 1901
      chemical homeostasis 1145
        monoatomic ion homeostasis 626
          monoatomic cation homeostasis 612
            regulation of pH 103
              regulation of cellular pH 88
                regulation of intracellular pH 80
                  intracellular pH reduction 47
                    Golgi lumen acidification + 3
                    endosomal lumen acidification 4
                    negative regulation of cellular pH reduction + 1
                    phagosome acidification + 7
                    positive regulation of cellular pH reduction + 6
                    regulation of cellular pH reduction + 9
                    vacuolar acidification + 24
paths to the root