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ONTOLOGY REPORT - ANNOTATIONS

Term:N-acetylgalactosamine-6-sulfatase activity
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Accession:GO:0043890 term browser browse the term
Definition:Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
Synonyms:exact_synonym: N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity;   N-acetylgalactosamine-6-sulfate sulfatase activity;   acetylgalactosamine 6-sulfatase activity;   galactose-6-sulfate sulfatase activity
 broad_synonym: chondroitin sulfatase;   chondroitinase;   chondroitinsulfatase
 xref: EC:3.1.6.4;   MetaCyc:3.1.6.4-RXN;   Reactome:R-HSA-2263490 "Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate";   reactome:R-HSA-1630304 "GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate"


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N-acetylgalactosamine-6-sulfatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arsb arylsulfatase B enables ISO MGI:3800577 (PMID:24240681) RGD PMID:24240681 NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671 		JBrowse link
G Galns galactosamine (N-acetyl)-6-sulfatase enables IEA
ISO		 GO_REF:0000003
(PMID:14583446)		 UniProt
RGD		 PMID:14583446 GO_REF:0000003 NCBI chr19:50,628,639...50,662,477
Ensembl chr19:50,628,552...50,662,246 		JBrowse link
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  molecular_function 20633
    catalytic activity 6032
      hydrolase activity 2585
        hydrolase activity, acting on ester bonds 814
          sulfuric ester hydrolase activity 14
            N-acetylgalactosamine-6-sulfatase activity 2
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