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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 1 type immune response
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Accession:GO:0042088 term browser browse the term
Definition:An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.
Synonyms:exact_synonym: Th1 immune response


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T-helper 1 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL3 BCL3 transcription coactivator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9009202) Ensembl
MGI		 PMID:9009202 GO_REF:0000107 NCBI chr 6:51,256,033...51,264,923
Ensembl chr 6:51,256,033...51,265,351 		JBrowse link
G HRAS HRas proto-oncogene, GTPase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21444916) Ensembl
MGI		 PMID:21444916 GO_REF:0000107 NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501 		JBrowse link
G IL18 interleukin 18 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL18BP interleukin 18 binding protein involved_in ISO (PMID:10023777) UniProt PMID:10023777 NCBI chr 9:6,586,602...6,596,423
Ensembl chr 9:6,488,808...6,591,333 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7845467) Ensembl
MGI		 PMID:7845467 GO_REF:0000107 NCBI chr 6:51,444,670...51,480,350
Ensembl chr 6:51,444,664...51,480,319 		JBrowse link
G RNF121 ring finger protein 121 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:6,488,756...6,587,426
Ensembl chr 9:6,488,806...6,587,324 		JBrowse link
G TRAF6 TNF receptor associated factor 6 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14499111) MGI
Ensembl		 PMID:14499111 GO_REF:0000107 NCBI chr 2:24,602,749...24,628,263
Ensembl chr 2:24,602,804...24,626,072 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:15034080 RGD:1580562 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:1,558,459...1,560,112
Ensembl chr 2:1,558,459...1,560,112 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (PMID:16424184) MGI PMID:16424184 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (PMID:16020505) BHF-UCL PMID:16020505 NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (PMID:9670042) BHF-UCL PMID:9670042 NCBI chr 9:115,535,185...115,857,457
Ensembl chr 9:115,550,569...115,659,263 		JBrowse link
negative regulation of T-helper 1 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:66,138,157...66,160,568
Ensembl chr16:66,139,535...66,160,538 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:51,868,549...51,902,454
Ensembl chr 3:51,846,792...51,951,383 		JBrowse link
G IL33 interleukin 33 involved_in ISO (PMID:18268038) BHF-UCL PMID:18268038 NCBI chr 1:215,899,830...215,941,944
Ensembl chr 1:215,899,436...215,941,840 		JBrowse link
positive regulation of T-helper 1 cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARID5A AT-rich interaction domain 5A involved_in ISO (PMID:27671645) UniProt PMID:27671645 NCBI chr 3:46,701,628...46,714,121
Ensembl chr 3:46,701,632...46,714,113 		JBrowse link
G IL18 interleukin 18 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL18R1 interleukin 18 receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:51,803,383...51,844,758
Ensembl chr 3:51,803,175...51,844,684 		JBrowse link
G IL1B interleukin 1 beta involved_in ISS UniProt GO_REF:0000024 NCBI chr 3:43,670,126...43,677,125 JBrowse link
G IL1R1 interleukin 1 receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:52,192,912...52,334,734
Ensembl chr 3:52,192,915...52,288,485 		JBrowse link
G LOC110258578 interleukin-1 beta-like involved_in ISO (PMID:10653850) UniProt PMID:10653850
G SLAMF1 signaling lymphocytic activation molecule family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:89,870,359...89,907,114
Ensembl chr 4:89,870,539...89,908,231 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
G XCL1 chemokine (C motif) ligand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:82,432,845...82,436,150
Ensembl chr 4:82,432,204...82,436,180 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,306...226,432,279 		JBrowse link
G CCL19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15845453) BHF-UCL PMID:15845453 NCBI chr10:32,110,366...32,112,529
Ensembl chr10:32,110,065...32,112,734 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr10:10,263,441...10,269,882
Ensembl chr10:10,264,244...10,269,879 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894097) Ensembl
MGI		 PMID:11894097 GO_REF:0000107 NCBI chr 4:47,026,558...47,075,133
Ensembl chr 4:47,027,098...47,074,704 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:93,777,402...93,925,859
Ensembl chr 3:93,783,964...93,925,863 		JBrowse link
positive regulation of T-helper 1 type immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR2 C-C motif chemokine receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,285,012...29,376,343 		JBrowse link
G IL12B interleukin 12B involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929 		JBrowse link
G IL12RB1 interleukin 12 receptor subunit beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:59,707,958...59,736,282
Ensembl chr 2:59,707,961...59,736,282 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:21,732,416...21,733,981
Ensembl chr 5:21,732,165...21,734,267 		JBrowse link
G IL23R interleukin 23 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:145,337,765...145,401,909
Ensembl chr 6:145,335,741...145,401,510 		JBrowse link
G IL27RA interleukin 27 receptor subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11057672) Ensembl
MGI		 PMID:11057672 GO_REF:0000107 NCBI chr 2:65,127,278...65,149,665
Ensembl chr 2:65,127,287...65,149,740 		JBrowse link
G PLA2G4A phospholipase A2 group IVA involved_in ISO (PMID:16172261) UniProt PMID:16172261 NCBI chr 9:127,853,581...128,164,825
Ensembl chr 9:127,859,051...128,162,638 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894097) Ensembl
MGI		 PMID:11894097 GO_REF:0000107 NCBI chr 4:47,026,558...47,075,133
Ensembl chr 4:47,027,098...47,074,704 		JBrowse link
G SLA-DQB1 SLA-DQ beta1 domain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:24,969,034...24,977,238
Ensembl chr 7:24,963,208...24,977,386 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18984740) Ensembl
MGI		 PMID:18984740 GO_REF:0000107 NCBI chr15:120,434,100...120,446,396
Ensembl chr15:120,433,952...120,446,396 		JBrowse link
regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL27 interleukin 27 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:18,421,962...18,427,916
Ensembl chr 3:18,421,981...18,427,915 		JBrowse link
T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRACR2A calcium release activated channel regulator 2A involved_in ISO (PMID:29987160) UniProt PMID:29987160 NCBI chr 5:66,574,758...66,650,447
Ensembl chr 5:66,533,033...66,647,748 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr10:10,263,441...10,269,882
Ensembl chr10:10,264,244...10,269,879 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:15944249) UniProt PMID:15944249 NCBI chr11:7,195,556...7,321,071 JBrowse link
G IL18R1 interleukin 18 receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10227969) Ensembl
MGI		 PMID:10227969 GO_REF:0000107 NCBI chr 3:51,803,383...51,844,758
Ensembl chr 3:51,803,175...51,844,684 		JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of ISO (PMID:16424184) MGI PMID:16424184 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G LEF1 lymphoid enhancer binding factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:113,824,511...113,944,078
Ensembl chr 8:113,825,161...113,944,070 		JBrowse link
G LOC100736717 signal transducer and activator of transcription 4 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr15:95,656,077...95,763,472 JBrowse link
G NFKBIZ NFKB inhibitor zeta involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:157,261,419...157,273,119
Ensembl chr13:157,261,419...157,272,688 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16081776) Ensembl
MGI		 PMID:16081776 GO_REF:0000107 NCBI chr 6:51,444,670...51,480,350
Ensembl chr 6:51,444,664...51,480,319 		JBrowse link
G SEMA4A semaphorin 4A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:93,865,054...93,892,995
Ensembl chr 4:93,865,057...93,886,371 		JBrowse link
G STAT4 signal transducer and activator of transcription 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:95,656,206...95,764,099
Ensembl chr15:95,656,077...95,763,472 		JBrowse link
G TMEM98 transmembrane protein 98 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:42,087,691...42,101,152
Ensembl chr12:42,083,553...42,100,494 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G SPN sialophorin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:17,978,731...17,982,222
Ensembl chr 3:17,978,801...17,982,864 		JBrowse link
G STAT6 signal transducer and activator of transcription 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20706986) Ensembl
MGI		 PMID:20706986 GO_REF:0000107 NCBI chr 5:22,406,356...22,422,412
Ensembl chr 5:22,406,368...22,421,989 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17668
    response to stimulus 10007
      immune response 1648
        adaptive immune response 410
          adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 322
            T-helper 1 type immune response 50
              T-helper 1 cell cytokine production + 9
              T-helper 1 cell differentiation + 25
              negative regulation of T-helper 1 type immune response + 7
              positive regulation of T-helper 1 type immune response + 19
              regulation of T-helper 1 type immune response + 31
paths to the root