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ONTOLOGY REPORT - ANNOTATIONS

Term:histone H4K20 demethylase activity
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Accession:GO:0035575 term browser browse the term
Definition:Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
Synonyms:exact_synonym: histone H4-K20 demethylase activity;   histone H4-methyl-lysine-20 demethylase activity;   histone H4K20me demethylase activity;   histone demethylase activity (H4-K20 specific);   histone demethylase activity (H4K20-specific)
 xref: reactome:R-HSA-2172678 "PHF8 demethylates histone H4K20me1"


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histone H4K20 demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm7a lysine demethylase 7A enables ISO (PMID:20622853) RGD PMID:20622853 NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998 		JBrowse link
G Phf2 PHD finger protein 2 enables ISO (MGI:6716956|PMID:22921934) RGD PMID:22921934 MGI:6716956 NCBI chr17:15,783,221...15,851,209
Ensembl chr17:15,781,864...15,851,208 		JBrowse link
G Phf8 PHD finger protein 8 enables ISO (PMID:20622853) RGD PMID:20622853 NCBI chr  X:20,524,103...20,623,459
Ensembl chr  X:20,524,558...20,623,410 		JBrowse link
G Rsbn1 round spermatid basic protein 1 enables ISO (MGI:6874521|PMID:28867287)
(PMID:28867287)		 RGD PMID:28867287 MGI:6874521 NCBI chr 2:191,416,631...191,470,711
Ensembl chr 2:191,416,631...191,470,711 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20729
    catalytic activity 6109
      oxidoreductase activity 859
        dioxygenase activity 97
          2-oxoglutarate-dependent dioxygenase activity 63
            histone H4K20 demethylase activity 4
Path 2
Term Annotations click to browse term
  molecular_function 20729
    catalytic activity 6109
      demethylase activity 42
        protein demethylase activity 30
          histone demethylase activity 30
            histone H4 demethylase activity 5
              histone H4K20 demethylase activity 4
paths to the root