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ONTOLOGY REPORT - ANNOTATIONS

Term:miRNA processing
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Accession:GO:0035196 term browser browse the term
Definition:A process leading to the generation of a functional miRNA. Includes the cleavage of stem-loop RNA precursors into microRNAs (miRNAs). miRNAs are a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts.
Synonyms:exact_synonym: gene silencing by miRNA, production of miRNAs;   miRNA biosynthetic process;   miRNA maturation;   miRNA-mediated gene silencing, production of miRNAs;   microRNA-mediated gene silencing, production of microRNAs;   production of miRNAs involved in gene silencing by miRNA;   production of microRNAs involved in gene silencing by microRNA
 broad_synonym: microRNA processing
 related_synonym: miRNA biogenesis;   microRNA biogenesis;   microRNA biosynthesis;   microRNA biosynthetic process;   microRNA metabolic process;   microRNA metabolism
 alt_id: GO:0030918
 never_in_taxon: NCBITaxon:4896 ! Schizosaccharomyces pombe

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miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase RNA specific acts_upstream_of_or_within ISO (PMID:23622242) MGI PMID:23622242 NCBI chrNW_004955545:1,078,319...1,106,938
Ensembl chrNW_004955545:1,078,319...1,106,938 		JBrowse link
G Ago1 argonaute RISC component 1 involved_in ISO (PMID:22795694) BHF-UCL PMID:22795694 NCBI chrNW_004955452:13,935,028...13,967,281
Ensembl chrNW_004955452:13,934,346...13,968,624 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:19966796), (PMID:23661684)
(PMID:20424607)		 BHF-UCL
MGI		 PMID:19966796 PMID:20424607 PMID:23661684 NCBI chrNW_004955461:14,194,268...14,260,949
Ensembl chrNW_004955461:14,205,748...14,253,861 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 involved_in ISO (PMID:22795694) BHF-UCL PMID:22795694 NCBI chrNW_004955452:13,977,487...14,108,729
Ensembl chrNW_004955452:13,977,481...14,094,259 		JBrowse link
G Ago4 argonaute RISC component 4 involved_in ISO (PMID:22795694) BHF-UCL PMID:22795694 NCBI chrNW_004955452:13,882,416...13,922,590
Ensembl chrNW_004955452:13,882,416...13,922,590 		JBrowse link
G Dicer1 dicer 1, ribonuclease III involved_in
acts_upstream_of_or_within		 ISO (PMID:23322395), (PMID:26435691)
(PMID:16462742)
(PMID:16040801)
(PMID:20463238), (PMID:20805985), (PMID:24209619)
(PMID:15713842)
(PMID:15973356), (PMID:23661684)		 ARUK-UCL
MGI
BHF-UCL
UniProt		 PMID:15713842 PMID:15973356 PMID:16040801 PMID:16462742 PMID:20463238 More... NCBI chrNW_004955438:17,374,899...17,431,599
Ensembl chrNW_004955438:17,382,493...17,431,797 		JBrowse link
G Nup155 nucleoporin 155 acts_upstream_of_or_within_positive_effect ISO (PMID:31481660) MGI PMID:31481660 NCBI chrNW_004955426:21,997,208...22,057,205
Ensembl chrNW_004955426:21,997,208...22,057,205 		JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 involved_in ISO (PMID:23661684) BHF-UCL PMID:23661684 NCBI chrNW_004955403:18,394,609...18,410,381
Ensembl chrNW_004955403:18,373,375...18,410,627 		JBrowse link
G Pum1 pumilio RNA binding family member 1 involved_in ISO (PMID:28431233) UniProt PMID:28431233 NCBI chrNW_004955452:9,487,725...9,623,565
Ensembl chrNW_004955452:9,487,725...9,624,066 		JBrowse link
G Pum2 pumilio RNA binding family member 2 involved_in ISO (PMID:28431233) UniProt PMID:28431233 NCBI chrNW_004955469:2,810,825...2,886,911
Ensembl chrNW_004955469:2,810,573...2,886,611 		JBrowse link
G Rbm3 RNA binding motif protein 3 acts_upstream_of_or_within ISO (PMID:15684048) MGI PMID:15684048 NCBI chrNW_004955543:166,891...173,987
Ensembl chrNW_004955543:166,891...170,488 		JBrowse link
G Snip1 Smad nuclear interacting protein 1 involved_in ISO (PMID:18632581) UniProt PMID:18632581 NCBI chrNW_004955452:15,352,080...15,365,545
Ensembl chrNW_004955452:15,353,182...15,365,459 		JBrowse link
G Spout1 SPOUT domain containing methyltransferase 1 involved_in ISO (PMID:28431233) UniProt PMID:28431233 NCBI chrNW_004955570:1,202,987...1,211,052
Ensembl chrNW_004955570:1,204,040...1,211,020 		JBrowse link
G Tarbp2 TARBP2 subunit of RISC loading complex involved_in ISO (PMID:15973356), (PMID:23661684) UniProt PMID:15973356 PMID:23661684 NCBI chrNW_004955458:793,753...798,755
Ensembl chrNW_004955458:793,759...798,806 		JBrowse link
G Trim71 tripartite motif containing 71 involved_in ISO (PMID:28431233) UniProt PMID:28431233 NCBI chrNW_004955421:97,130...174,326
Ensembl chrNW_004955421:97,772...168,432 		JBrowse link
G Zc3h7a zinc finger CCCH-type containing 7A involved_in ISO (PMID:28431233) UniProt PMID:28431233 NCBI chrNW_004955442:6,847,224...6,884,537
Ensembl chrNW_004955442:6,853,936...6,886,079 		JBrowse link
G Zc3h7b zinc finger CCCH-type containing 7B involved_in ISO (PMID:28431233) UniProt PMID:28431233 NCBI chrNW_004955413:26,907,883...26,951,352
Ensembl chrNW_004955413:26,925,943...26,951,040 		JBrowse link
negative regulation of miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnf1a HNF1 homeobox A ISO RGD PMID:23674172 RGD:150540303 NCBI chrNW_004955455:10,694,102...10,717,613
Ensembl chrNW_004955455:10,694,102...10,717,613 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (PMID:21522133) MGI PMID:21522133 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
G Zc3h10 zinc finger CCCH-type containing 10 involved_in ISO (PMID:28431233) UniProt PMID:28431233 NCBI chrNW_004955458:3,720,451...3,725,196
Ensembl chrNW_004955458:3,720,709...3,725,196 		JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO (PMID:21522133) MGI PMID:21522133 NCBI chrNW_004955537:82,724...134,609
Ensembl chrNW_004955537:81,920...134,609 		JBrowse link
negative regulation of pre-miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcdin3d BCDIN3 domain containing RNA methyltransferase involved_in ISO (PMID:23063121) UniProt PMID:23063121 NCBI chrNW_004955547:427,127...432,482
Ensembl chrNW_004955547:427,432...432,455 		JBrowse link
G Lin28a lin-28 homolog A involved_in ISO (PMID:21247876) UniProt PMID:21247876 NCBI chrNW_004955452:5,793,583...5,808,662
Ensembl chrNW_004955452:5,793,583...5,808,662 		JBrowse link
G Lin28b lin-28 homolog B involved_in ISO (PMID:18951094) CACAO PMID:18951094 NCBI chrNW_004955411:30,381,208...30,499,678 JBrowse link
negative regulation of primary miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 acts_upstream_of ISO (PMID:31507089) ARUK-UCL PMID:31507089 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Lin28b lin-28 homolog B involved_in ISO (PMID:18951094) CACAO PMID:18951094 NCBI chrNW_004955411:30,381,208...30,499,678 JBrowse link
G Mecp2 methyl-CpG binding protein 2 ISO RGD PMID:24636259 RGD:12789709 NCBI chrNW_004955580:674,014...737,586
Ensembl chrNW_004955580:679,109...735,288 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO (PMID:31507089) ARUK-UCL PMID:31507089 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687 		JBrowse link
positive regulation of miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ripk1 receptor interacting serine/threonine kinase 1 acts_upstream_of ISO (PMID:26020802) ARUK-UCL PMID:26020802 NCBI chrNW_004955465:10,127,907...10,167,895
Ensembl chrNW_004955465:10,128,931...10,168,399 		JBrowse link
positive regulation of pre-miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgcr8 DGCR8 microprocessor complex subunit involved_in ISO (PMID:15574589), (PMID:32926445) UniProt PMID:15574589 PMID:32926445 NCBI chrNW_004955442:17,998,565...18,034,247
Ensembl chrNW_004955442:17,998,565...18,030,831 		JBrowse link
G Trub1 TruB pseudouridine synthase family member 1 involved_in ISO (PMID:32926445) UniProt PMID:32926445 NCBI chrNW_004955431:19,840,827...19,877,930
Ensembl chrNW_004955431:19,840,662...19,877,930 		JBrowse link
positive regulation of primary miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:18548003) BHF-UCL PMID:18548003 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303 		JBrowse link
G Tgfb1 transforming growth factor beta 1 involved_in ISO (PMID:18548003) BHF-UCL PMID:18548003 NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441 		JBrowse link
pre-miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adar adenosine deaminase RNA specific acts_upstream_of_or_within ISO (PMID:23622242) MGI PMID:23622242 NCBI chrNW_004955545:1,078,319...1,106,938
Ensembl chrNW_004955545:1,078,319...1,106,938 		JBrowse link
G Ago1 argonaute RISC component 1 involved_in ISO (PMID:19966796) BHF-UCL PMID:19966796 NCBI chrNW_004955452:13,935,028...13,967,281
Ensembl chrNW_004955452:13,934,346...13,968,624 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 involved_in ISO (PMID:16357216)
(PMID:16424907), (PMID:17671087), (PMID:18178619), (PMID:19966796), (PMID:23661684)		 BHF-UCL
ComplexPortal		 PMID:16357216 PMID:16424907 PMID:17671087 PMID:18178619 PMID:19966796 More... NCBI chrNW_004955461:14,194,268...14,260,949
Ensembl chrNW_004955461:14,205,748...14,253,861 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 involved_in ISO (PMID:19966796) BHF-UCL PMID:19966796 NCBI chrNW_004955452:13,977,487...14,108,729
Ensembl chrNW_004955452:13,977,481...14,094,259 		JBrowse link
G Ago4 argonaute RISC component 4 involved_in ISO (PMID:19966796) BHF-UCL PMID:19966796 NCBI chrNW_004955452:13,882,416...13,922,590
Ensembl chrNW_004955452:13,882,416...13,922,590 		JBrowse link
G Bcdin3d BCDIN3 domain containing RNA methyltransferase involved_in ISO (PMID:33664453) ARUK-UCL PMID:33664453 NCBI chrNW_004955547:427,127...432,482
Ensembl chrNW_004955547:427,432...432,455 		JBrowse link
G Dicer1 dicer 1, ribonuclease III involved_in
acts_upstream_of_or_within		 ISO (PMID:15973356), (PMID:16357216), (PMID:18178619), (PMID:23661684), (PMID:25549615)
(PMID:18604195)		 BHF-UCL
MGI		 PMID:15973356 PMID:16357216 PMID:18178619 PMID:18604195 PMID:23661684 More... NCBI chrNW_004955438:17,374,899...17,431,599
Ensembl chrNW_004955438:17,382,493...17,431,797 		JBrowse link
G Drosha drosha ribonuclease III acts_upstream_of_or_within ISO (PMID:18604195) MGI PMID:18604195 NCBI chrNW_004955426:17,387,595...17,505,126
Ensembl chrNW_004955426:17,387,534...17,502,294 		JBrowse link
G Lin28a lin-28 homolog A involved_in
acts_upstream_of_or_within		 ISO (PMID:19703396)
(PMID:18604195)
(PMID:18292307), (PMID:18604195)		 UniProt
MGI		 PMID:18292307 PMID:18604195 PMID:19703396 NCBI chrNW_004955452:5,793,583...5,808,662
Ensembl chrNW_004955452:5,793,583...5,808,662 		JBrowse link
G Lin28b lin-28 homolog B involved_in ISO (PMID:19703396) UniProt PMID:19703396 NCBI chrNW_004955411:30,381,208...30,499,678 JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 involved_in ISO (PMID:16424907), (PMID:23661684) BHF-UCL PMID:16424907 PMID:23661684 NCBI chrNW_004955403:18,394,609...18,410,381
Ensembl chrNW_004955403:18,373,375...18,410,627 		JBrowse link
G Tarbp2 TARBP2 subunit of RISC loading complex involved_in ISO (PMID:15973356), (PMID:16357216), (PMID:16424907), (PMID:18178619), (PMID:23661684) BHF-UCL PMID:15973356 PMID:16357216 PMID:16424907 PMID:18178619 PMID:23661684 NCBI chrNW_004955458:793,753...798,755
Ensembl chrNW_004955458:793,759...798,806 		JBrowse link
G Tut4 terminal uridylyl transferase 4 involved_in ISO (PMID:25979828)
(PMID:19703396)		 UniProt PMID:19703396 PMID:25979828 NCBI chrNW_004955464:6,610,350...6,734,606
Ensembl chrNW_004955464:6,646,245...6,734,066 		JBrowse link
G Tut7 terminal uridylyl transferase 7 involved_in ISO (PMID:25979828) UniProt PMID:25979828 NCBI chrNW_004955432:1,268,217...1,330,385
Ensembl chrNW_004955432:1,268,103...1,329,436 		JBrowse link
primary miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3 X-linked acts_upstream_of_or_within_negative_effect ISO (PMID:28819115) MGI PMID:28819115 NCBI chrNW_004955565:1,387,043...1,403,624
Ensembl chrNW_004955565:1,386,973...1,404,220 		JBrowse link
G Ddx5 DEAD-box helicase 5 involved_in ISO (PMID:18548003) BHF-UCL PMID:18548003 NCBI chrNW_004955478:7,367,049...7,375,043
Ensembl chrNW_004955478:7,366,956...7,376,358 		JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit acts_upstream_of_or_within
involved_in		 ISO (PMID:15531877), (PMID:15574589)
(PMID:15574589), (PMID:24449907), (PMID:24910438)		 MGI
BHF-UCL		 PMID:15531877 PMID:15574589 PMID:24449907 PMID:24910438 NCBI chrNW_004955442:17,998,565...18,034,247
Ensembl chrNW_004955442:17,998,565...18,030,831 		JBrowse link
G Drosha drosha ribonuclease III involved_in ISO (PMID:14508493), (PMID:15574589) WB PMID:14508493 PMID:15574589 NCBI chrNW_004955426:17,387,595...17,505,126
Ensembl chrNW_004955426:17,387,534...17,502,294 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 involved_in ISO (PMID:26321680) UniProt PMID:26321680 NCBI chrNW_004955410:28,032,193...28,042,459
Ensembl chrNW_004955410:28,032,193...28,042,459 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in ISO (PMID:25799998) UniProt PMID:25799998 NCBI chrNW_004955550:2,211,270...2,227,715
Ensembl chrNW_004955550:2,211,270...2,227,715 		JBrowse link
G Pus10 pseudouridine synthase 10 involved_in ISO (PMID:31819270) UniProt PMID:31819270 NCBI chrNW_004955424:22,830,889...22,899,420
Ensembl chrNW_004955424:22,832,882...22,899,420 		JBrowse link
G Srrt serrate, RNA effector molecule involved_in ISO (PMID:19632182) UniProt PMID:19632182 NCBI chrNW_004955573:86,975...101,538
Ensembl chrNW_004955573:87,084...101,033 		JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 involved_in ISO (PMID:33664453) ARUK-UCL PMID:33664453 NCBI chrNW_004955437:6,306,151...6,314,332
Ensembl chrNW_004955437:6,306,151...6,314,332 		JBrowse link
regulation of miRNA processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tarbp2 TARBP2 subunit of RISC loading complex acts_upstream_of_or_within ISO (PMID:27159388) MGI PMID:27159388 NCBI chrNW_004955458:793,753...798,755
Ensembl chrNW_004955458:793,759...798,806 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12600
    cellular process 12034
      metabolic process 7955
        primary metabolic process 6961
          RNA processing 596
            regulatory ncRNA processing 64
              miRNA processing 42
                negative regulation of miRNA processing + 10
                positive regulation of miRNA processing + 5
                pre-miRNA 3'-end processing 0
                pre-miRNA processing + 16
                primary miRNA processing + 15
                regulation of miRNA processing + 16
Path 2
Term Annotations click to browse term
  biological_process 12600
    biological regulation 9088
      regulation of biological process 8781
        regulation of cellular process 8493
          regulation of metabolic process 5013
            regulation of biosynthetic process 3907
              regulation of macromolecule biosynthetic process 3718
                regulation of gene expression 3611
                  negative regulation of gene expression 976
                    regulatory ncRNA-mediated gene silencing 105
                      regulatory ncRNA processing 64
                        miRNA processing 42
                          negative regulation of miRNA processing + 10
                          positive regulation of miRNA processing + 5
                          pre-miRNA 3'-end processing 0
                          pre-miRNA processing + 16
                          primary miRNA processing + 15
                          regulation of miRNA processing + 16
paths to the root