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ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor 7 signaling pathway
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Accession:GO:0034154 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 7.
Synonyms:exact_synonym: TLR7 signaling pathway;   toll-like receptor 7 signalling pathway

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toll-like receptor 7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in ISO (MGI:5437532|PMID:22842346) UniProt PMID:22842346 MGI:5437532 NCBI chr23:59,479,794...59,501,532
Ensembl chr23:59,475,826...59,500,836 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5305504|PMID:22187458) UniProt PMID:22187458 MGI:5305504 NCBI chr 9:89,750,792...89,875,309 JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in ISO (MGI:5913054|PMID:28098138) UniProt PMID:28098138 MGI:5913054 NCBI chr16:4,616,325...4,643,791 JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:4,617,279...4,628,308 JBrowse link
G TLR7 toll like receptor 7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:11,348,520...11,372,132 JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:6,537,198...6,549,457
Ensembl chr 1:6,537,273...6,549,450 		JBrowse link
negative regulation of toll-like receptor 7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LILRA4 leukocyte immunoglobulin like receptor A4 involved_in ISO (PMID:16735691) UniProt PMID:16735691 NCBI chr 6:47,023,469...47,038,665
Ensembl chr 6:47,023,620...47,037,336 		JBrowse link
positive regulation of toll-like receptor 7 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDX3X DEAD-box helicase 3 X-linked involved_in ISO (PMID:30341167) UniProt PMID:30341167 NCBI chr  X:38,513,251...38,539,982
Ensembl chr  Y:689,380...706,092 		JBrowse link
G LOC103222345 trem-like transcript 4 protein involved_in ISO (PMID:25848864)
(MGI:5775261|PMID:25848864)		 UniProt PMID:25848864 MGI:5775261 NCBI chr17:30,907,797...30,923,226
Ensembl chr17:30,915,052...30,923,486 		JBrowse link
G LOC119623506 trem-like transcript 4 protein involved_in IEA TreeGrafter GO_REF:0000118
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:19,792,807...19,855,784
Ensembl chr20:19,793,083...19,855,827 		JBrowse link
G RSAD2 radical S-adenosyl methionine domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:100,778,801...100,804,205
Ensembl chr14:100,778,302...100,798,044 		JBrowse link
G SLC15A4 solute carrier family 15 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:124,170,785...124,204,358
Ensembl chr11:124,169,732...124,204,200 		JBrowse link
G TASL TLR adaptor interacting with endolysosomal SLC15A4 involved_in ISO (PMID:32433612) UniProt PMID:32433612 NCBI chr  X:28,953,805...28,973,055
Ensembl chr  X:28,954,266...28,955,171 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17093
    cellular process 16013
      signal transduction 5578
        intracellular signal transduction 2958
          intracellular receptor signaling pathway 393
            cytoplasmic pattern recognition receptor signaling pathway 185
              endolysosomal toll-like receptor signaling pathway 50
                toll-like receptor 7 signaling pathway 14
                  negative regulation of toll-like receptor 7 signaling pathway 1
                  positive regulation of toll-like receptor 7 signaling pathway 7
                  regulation of toll-like receptor 7 signaling pathway + 8
Path 2
Term Annotations click to browse term
  biological_process 17093
    response to stimulus 8707
      response to biotic stimulus 1639
        response to external biotic stimulus 1591
          response to other organism 1588
            defense response to other organism 1130
              defense response to symbiont 1016
                innate immune response 833
                  regulation of innate immune response 446
                    positive regulation of innate immune response 374
                      activation of innate immune response 300
                        innate immune response-activating signaling pathway 278
                          pattern recognition receptor signaling pathway 272
                            cytoplasmic pattern recognition receptor signaling pathway 185
                              endolysosomal toll-like receptor signaling pathway 50
                                toll-like receptor 7 signaling pathway 14
                                  negative regulation of toll-like receptor 7 signaling pathway 1
                                  positive regulation of toll-like receptor 7 signaling pathway 7
                                  regulation of toll-like receptor 7 signaling pathway + 8
paths to the root