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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of T cell differentiation in thymus
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Accession:GO:0033085 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: negative regulation of thymic T cell differentiation;   negative regulation of thymocyte cell differentiation;   negative regulation of thymocyte differentiation
 related_synonym: negative regulation of T cell development in thymus


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negative regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO (PMID:12421925) RGD PMID:12421925 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Foxj1 forkhead box J1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16339515)		 Ensembl
RGD		 PMID:16339515 GO_REF:0000107 NCBI chr10:101,566,299...101,570,370
Ensembl chr10:101,566,304...101,570,237 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (PMID:19109233) RGD PMID:19109233 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Nfkbid NFKB inhibitor delta acts_upstream_of_or_within ISO (PMID:11931770) RGD PMID:11931770 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447 		JBrowse link
G Rag2 recombination activating 2 IMP RGD PMID:30206106 RGD:38508903 NCBI chr 3:87,902,373...87,910,227
Ensembl chr 3:87,902,238...87,911,066 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:10981962)		 Ensembl
RGD		 PMID:10981962 GO_REF:0000107 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Zc3h8 zinc finger CCCH type containing 8 involved_in ISO (PMID:12153508) RGD PMID:12153508 NCBI chr 3:116,176,779...116,193,752
Ensembl chr 3:116,176,798...116,193,787 		JBrowse link
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:12421925)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:12421925 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:15964995) RGD PMID:15964995 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Clec4g C-type lectin domain family 4, member G acts_upstream_of_or_within ISO MGI:5510586 (PMID:23487419) RGD PMID:23487419 NCBI chr12:1,780,370...1,785,027
Ensembl chr12:1,780,371...1,784,985 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:16230479)		 Ensembl
RGD		 PMID:16230479 GO_REF:0000107 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Ihh Indian hedgehog signaling molecule involved_in ISO (PMID:19109233) RGD PMID:19109233 NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532 		JBrowse link
G Tmem131l transmembrane 131 like involved_in ISO (PMID:23690469) RGD PMID:23690469 NCBI chr 2:169,257,659...169,391,773
Ensembl chr 2:169,258,289...169,391,711 		JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:22080863)		 UniProt
Ensembl
RGD		 PMID:22080863 GO_REF:0000024 GO_REF:0000107 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    immune system process 3008
      leukocyte activation 1056
        lymphocyte activation 856
          lymphocyte differentiation 444
            T cell differentiation 330
              T cell differentiation in thymus 104
                negative regulation of T cell differentiation in thymus 12
                  negative regulation of immature T cell proliferation in thymus 6
                  negative regulation of positive thymic T cell selection 1
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      cellular developmental process 4781
        cell differentiation 4780
          cell development 3325
            hemopoiesis 1075
              leukocyte differentiation 681
                mononuclear cell differentiation 546
                  lymphocyte differentiation 444
                    T cell differentiation 330
                      T cell differentiation in thymus 104
                        regulation of T cell differentiation in thymus 28
                          negative regulation of T cell differentiation in thymus 12
                            negative regulation of immature T cell proliferation in thymus 6
                            negative regulation of positive thymic T cell selection 1
paths to the root