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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of actin filament polymerization
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Accession:GO:0030837 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
Comment:Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835').
Synonyms:exact_synonym: down regulation of actin filament polymerization;   downregulation of actin filament polymerization;   negative regulation of actin polymerization
 narrow_synonym: inhibition of actin filament polymerization
 broad_synonym: negative regulation of actin polymerization and/or depolymerization


show annotations for term's descendants           Sort by:
negative regulation of actin filament polymerization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Add1 adducin 1 IMP RGD PMID:8675693 RGD:7174724 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182 		JBrowse link
G Arfgef1 ARF guanine nucleotide exchange factor 1 involved_in ISO
IEA
ISS		 (PMID:22084092)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:22084092 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:8,982,061...9,076,326
Ensembl chr 5:8,981,540...9,076,326 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 acts_upstream_of_or_within ISO MGI:3055492 (PMID:23716571) RGD PMID:23716571 NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607 		JBrowse link
G Capn1 calpain 1 IMP RGD PMID:25653381 RGD:13792590 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Cyrib CYFIP related Rac1 interactor B involved_in ISO (PMID:30250061) RGD PMID:30250061 NCBI chr 7:95,633,876...95,760,588
Ensembl chr 7:95,633,876...95,697,686 		JBrowse link
G Fhod3 formin homology 2 domain containing 3 acts_upstream_of_or_within ISO (PMID:19706596) RGD PMID:19706596 NCBI chr18:15,993,079...16,425,796
Ensembl chr18:15,993,324...16,425,796 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (PMID:17318189) RGD PMID:17318189 NCBI chr12:32,590,164...32,618,841
Ensembl chr12:32,590,165...32,618,734 		JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:18458160)
GO_REF:0000033
(PMID:17996375)		 RGD
GO_Central		 PMID:17996375 PMID:18458160 GO_REF:0000033 NCBI chr 1:232,381,720...232,500,834
Ensembl chr 1:222,877,622...223,074,514 		JBrowse link
G Kank2 KN motif and ankyrin repeat domains 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:28,587,770...28,617,212
Ensembl chr 8:20,311,676...20,340,900 		JBrowse link
G Kank3 KN motif and ankyrin repeat domains 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:15,296,538...15,309,838
Ensembl chr 7:14,594,422...14,607,675 		JBrowse link
G Kank4 KN motif and ankyrin repeat domains 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:113,401,491...113,465,526
Ensembl chr 5:113,402,468...113,465,555 		JBrowse link
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO (PMID:23716571) RGD PMID:23716571 NCBI chr 3:124,201,877...124,221,142
Ensembl chr 3:124,201,877...124,220,162 		JBrowse link
G Myadm myeloid-associated differentiation marker involved_in ISO
IEA		 (PMID:23264465)
GO_REF:0000107		 RGD
Ensembl		 PMID:23264465 GO_REF:0000107 NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 IDA RGD PMID:17662049 RGD:7240703 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pfn1 profilin 1 involved_in ISO
IEA		 (PMID:7758455)
GO_REF:0000107		 RGD
Ensembl		 PMID:7758455 GO_REF:0000107 NCBI chr10:55,863,882...55,866,587
Ensembl chr10:55,365,262...55,527,631 		JBrowse link
G Pfn2 profilin 2 involved_in ISO
IEA		 (PMID:7758455)
GO_REF:0000107		 RGD
Ensembl		 PMID:7758455 GO_REF:0000107 NCBI chr 2:142,067,102...142,072,938
Ensembl chr 2:142,067,104...142,072,938 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:16940418)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16940418 GO_REF:0000024 GO_REF:0000107 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Slit2 slit guidance ligand 2 involved_in ISO
IEA		 (PMID:19759280)
GO_REF:0000107		 RGD
Ensembl		 PMID:19759280 GO_REF:0000107 NCBI chr14:66,829,661...67,168,517
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Ssh1 slingshot protein phosphatase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:42,621,127...42,683,262
Ensembl chr12:42,621,135...42,683,274 		JBrowse link
G Ssh2 slingshot protein phosphatase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:62,057,400...62,309,328
Ensembl chr10:62,057,044...62,306,563 		JBrowse link
G Ssh3 slingshot protein phosphatase 3 involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 1:201,557,167...201,565,577
Ensembl chr 1:201,557,169...201,564,753 		JBrowse link
G Tlr2 toll-like receptor 2 involved_in ISO ComplexPortal:CPX-1134 (PMID:22198949) RGD PMID:22198949 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tmsb15b2 thymosin beta 15B2 acts_upstream_of_or_within ISO (PMID:19233202) RGD PMID:19233202 NCBI chr  X:105,090,980...105,093,094
Ensembl chr  X:100,298,514...100,300,886 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked involved_in ISO (PMID:1447300), (PMID:1999398) RGD PMID:1447300 PMID:1999398 NCBI chr  X:30,761,611...30,763,612
Ensembl chr  X:27,128,610...27,146,667
Ensembl chr10:27,128,610...27,146,667 		JBrowse link
G Twf1 twinfilin actin-binding protein 1 involved_in IEA
IMP
ISO		 GO_REF:0000002
(PMID:12807912)		 InterPro
RGD		 PMID:12807912 PMID:33963280 GO_REF:0000002, RGD:596938166 NCBI chr 7:127,595,210...127,607,821
Ensembl chr 7:125,716,015...125,727,894 		JBrowse link
G Twf2 twinfilin actin-binding protein 2 involved_in ISO (PMID:12807912) RGD PMID:12807912 NCBI chr 8:106,845,253...106,858,298
Ensembl chr 8:106,845,253...106,858,298 		JBrowse link
actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsn gelsolin involved_in ISO (PMID:19666531)
(PMID:23325791)		 RGD PMID:19666531 PMID:23325791 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Myh9 myosin, heavy chain 9 NOT|involved_in ISO (PMID:23325791) RGD PMID:23325791 NCBI chr 7:111,224,291...111,304,963
Ensembl chr 7:109,343,706...109,424,457 		JBrowse link
G Scin scinderin involved_in ISO (PMID:19666531) RGD PMID:19666531 NCBI chr 6:57,109,500...57,188,123
Ensembl chr 6:57,109,403...57,188,242 		JBrowse link
G Spta1 spectrin, alpha, erythrocytic 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr13:86,203,504...86,279,371
Ensembl chr13:86,203,504...86,279,371 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:33,639,020...33,703,890
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Sptb spectrin, beta, erythrocytic involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 6:95,310,342...95,437,221
Ensembl chr 6:95,310,326...95,437,118 		JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr14:108,042,629...108,217,884
Ensembl chr14:103,842,684...104,008,507 		JBrowse link
G Sptbn2 spectrin, beta, non-erythrocytic 2 involved_in IEA GO_REF:0000043
GO_REF:0000104		 UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr 1:202,002,970...202,045,343
Ensembl chr 1:202,002,970...202,044,283 		JBrowse link
G Sptbn4 spectrin, beta, non-erythrocytic 4 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 1:82,650,750...82,738,345
Ensembl chr 1:82,650,751...82,737,228 		JBrowse link
G Tpm1 tropomyosin 1 IDA RGD PMID:15779917 RGD:1600523 NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:67,635,479...67,662,802 		JBrowse link
G Tpm1_v7 tropomyosin 1, variant 7 IDA RGD PMID:15779917 RGD:1600523
G Vil1 villin 1 involved_in ISO (PMID:16921170), (PMID:17182858), (PMID:19808673) RGD PMID:16921170 PMID:17182858 PMID:19808673 NCBI chr 9:83,440,248...83,467,963
Ensembl chr 9:75,991,141...76,018,858 		JBrowse link
barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 4933400A11Rik similar to RIKEN cDNA 4933400A11 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr  X:24,389,645...24,393,849 JBrowse link
G Add1 adducin 1 involved_in ISO
IBA		 (PMID:8626479)
GO_REF:0000033		 RGD
GO_Central		 PMID:8626479 GO_REF:0000033 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182 		JBrowse link
G Add2 adducin 2 involved_in ISO
IEA
IBA		 (PMID:8626479)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:8626479 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:118,444,594...118,538,505
Ensembl chr 4:118,497,416...118,538,505 		JBrowse link
G Add3 adducin 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124 		JBrowse link
G Avil advillin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:62,825,459...62,844,103
Ensembl chr 7:62,826,025...62,844,071 		JBrowse link
G Capg capping actin protein, gelsolin like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856 		JBrowse link
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000104
(PMID:17656356)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:17656356 GO_REF:0000033 GO_REF:0000104 NCBI chr 2:192,319,696...192,364,755
Ensembl chr 2:192,319,702...192,364,480 		JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033
GO_REF:0000104		 InterPro
GO_Central
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 NCBI chr 4:45,978,142...46,014,032
Ensembl chr 4:45,977,807...46,013,864 		JBrowse link
G Capza3 capping actin protein of muscle Z-line subunit alpha 3 involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 4:174,660,446...174,661,659
Ensembl chr 4:172,928,887...172,932,535 		JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409 		JBrowse link
G Dbnl drebrin-like NOT|acts_upstream_of_or_within ISO (PMID:10637315) RGD PMID:10637315 NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155 		JBrowse link
G ENSRNOG00000066279 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr20:36,411,605...36,413,032 JBrowse link
G ENSRNOG00000069335 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 4:33,576,404...33,578,930 JBrowse link
G Eps8 EGFR pathway substrate 8, signaling adaptor involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:15558031), (PMID:20532239), (PMID:23314863)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:15558031 PMID:20532239 PMID:23314863 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873 		JBrowse link
G Flii FLII, actin remodeling protein involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:45,893,566...45,907,547
Ensembl chr10:45,394,032...45,407,970 		JBrowse link
G Gsn gelsolin involved_in IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Rdx radixin IDA RGD PMID:2500445 RGD:8693627 NCBI chr 8:61,275,792...61,348,260
Ensembl chr 8:52,379,494...52,437,678 		JBrowse link
G Scin scinderin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:57,109,500...57,188,123
Ensembl chr 6:57,109,403...57,188,242 		JBrowse link
G Svil supervillin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:52,648,502...52,844,114
Ensembl chr17:52,648,502...52,793,404 		JBrowse link
G Twf1 twinfilin actin-binding protein 1 involved_in IBA
ISO		 GO_REF:0000033
(PMID:18837697)		 GO_Central
RGD		 PMID:18837697 GO_REF:0000033 NCBI chr 7:127,595,210...127,607,821
Ensembl chr 7:125,716,015...125,727,894 		JBrowse link
G Twf2 twinfilin actin-binding protein 2 involved_in IBA
ISO		 GO_REF:0000033
(PMID:18837697)		 GO_Central
RGD		 PMID:18837697 GO_REF:0000033 NCBI chr 8:106,845,253...106,858,298
Ensembl chr 8:106,845,253...106,858,298 		JBrowse link
G Vil1 villin 1 involved_in ISO (PMID:15272027) RGD PMID:15272027 NCBI chr 9:83,440,248...83,467,963
Ensembl chr 9:75,991,141...76,018,858 		JBrowse link
G Vill villin-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:118,776,718...118,794,983
Ensembl chr 8:118,776,742...118,794,983 		JBrowse link
negative regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carmil1 capping protein regulator and myosin 1 linker 1 involved_in ISO (PMID:16054028) RGD PMID:16054028 NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 involved_in ISO (PMID:26466680) RGD PMID:26466680 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965 		JBrowse link
G Cracd capping protein inhibiting regulator of actin dynamics involved_in ISO
IBA		 (PMID:30361697)
GO_REF:0000033		 RGD
GO_Central		 PMID:30361697 GO_REF:0000033 NCBI chr14:31,284,066...31,520,103
Ensembl chr14:31,284,184...31,522,431 		JBrowse link
G Washc2c WASH complex subunit 2C involved_in ISO (PMID:20498093) RGD PMID:20498093 NCBI chr 4:149,267,851...149,325,850
Ensembl chr 4:149,267,924...149,325,851 		JBrowse link
pointed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmod1 leiomodin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:46,754,048...46,796,186
Ensembl chr13:46,754,033...46,794,900 		JBrowse link
G Lmod2 leiomodin 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120 		JBrowse link
G Lmod3 leiomodin 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:129,843,964...129,858,684
Ensembl chr 4:129,843,970...129,858,244 		JBrowse link
G Tmod1 tropomodulin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:60,316,445...60,393,957
Ensembl chr 5:60,338,512...60,393,956 		JBrowse link
G Tmod2 tropomodulin 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:85,197,222...85,250,627
Ensembl chr 8:76,325,667...76,365,720 		JBrowse link
G Tmod3 tropomodulin 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:85,131,295...85,191,477
Ensembl chr 8:76,248,979...76,310,977 		JBrowse link
G Tmod4 tropomodulin 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540 		JBrowse link
positive regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc2 actin related protein 2/3 complex, subunit 2 IMP RGD PMID:15252126 RGD:2306210 NCBI chr 9:83,269,884...83,300,610
Ensembl chr 9:75,820,770...75,851,471 		JBrowse link
G Cfl1 cofilin 1 IMP RGD PMID:23704350 RGD:11570555 NCBI chr 1:212,227,124...212,230,656
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtpn myotrophin involved_in ISO
IBA
ISS		 (PMID:16895918)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:16895918 GO_REF:0000024 GO_REF:0000033 NCBI chr 4:64,159,273...64,186,686
Ensembl chr 4:64,157,641...64,186,724 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20553
    cellular process 19543
      negative regulation of cellular process 5591
        negative regulation of cellular component organization 802
          negative regulation of supramolecular fiber organization 189
            negative regulation of actin filament polymerization 69
              actin filament capping + 46
Path 2
Term Annotations click to browse term
  biological_process 20553
    cellular process 19543
      cellular component organization or biogenesis 7196
        cellular component organization 6911
          organelle organization 3697
            cytoskeleton organization 1586
              actin cytoskeleton organization 765
                actin filament organization 501
                  actin polymerization or depolymerization 207
                    regulation of actin polymerization or depolymerization 171
                      regulation of actin filament polymerization 151
                        negative regulation of actin filament polymerization 69
                          actin filament capping + 46
paths to the root