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ONTOLOGY REPORT - ANNOTATIONS


Term:ATP-activated inward rectifier potassium channel activity
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Accession:GO:0015272 term browser browse the term
Definition:Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
Synonyms:xref: Reactome:R-HSA-5683209 "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)"



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ATP-activated inward rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ1 potassium inwardly rectifying channel subfamily J member 1 enables ISO PMID:7680431
PMID:7611454
RGD
UniProt
PMID:7611454 PMID:7680431 RGD:1581458 RGD:729173 NCBI chr 9:55,779,020...55,812,761
Ensembl chr 9:55,780,257...55,781,375
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 enables ISO
IEA
RGD
InterPro
PMID:15163199 PMID:17097686 GO_REF:0000002 RGD:1598646 RGD:1625274 NCBI chr 2:41,756,637...41,760,340
Ensembl chr 2:41,757,356...41,765,555
JBrowse link
G KCNJ8 potassium inwardly rectifying channel subfamily J member 8 enables ISO
IEA
IBA
RGD
InterPro
Ensembl
GO_Central
PMID:7890693 PMID:17097686 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 RGD:1566541 RGD:1625274 NCBI chr 5:51,695,927...51,704,402
Ensembl chr 5:51,696,188...51,703,813
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18634
    transporter activity 1193
      transmembrane transporter activity 1096
        monoatomic ion transmembrane transporter activity 722
          monoatomic ion channel activity 439
            ligand-gated monoatomic ion channel activity 185
              ligand-gated monoatomic cation channel activity 130
                inward rectifier potassium channel activity 25
                  ATP-activated inward rectifier potassium channel activity 3
Path 2
Term Annotations click to browse term
  molecular_function 18634
    transporter activity 1193
      transmembrane transporter activity 1096
        passive transmembrane transporter activity 499
          channel activity 499
            gated channel activity 327
              voltage-gated channel activity 182
                voltage-gated monoatomic ion channel activity 178
                  voltage-gated monoatomic cation channel activity 150
                    voltage-gated potassium channel activity 102
                      inward rectifier potassium channel activity 25
                        ATP-activated inward rectifier potassium channel activity 3
paths to the root