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ONTOLOGY REPORT - ANNOTATIONS

Term:procollagen-lysine 5-dioxygenase activity
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Accession:GO:0008475 term browser browse the term
Definition:Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.
Synonyms:broad_synonym: lysine hydroxylase activity;   lysine,2-oxoglutarate 5-dioxygenase activity;   lysine-2-oxoglutarate dioxygenase activity;   lysyl hydroxylase activity
 related_synonym: collagen lysine hydroxylase activity;   lysylprotocollagen dioxygenase activity;   procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating);   procollagen-lysine,2-oxoglutarate 5-dioxygenase activity;   protocollagen lysine dioxygenase activity;   protocollagen lysine hydroxylase activity;   protocollagen lysyl hydroxylase activity
 xref: EC:1.14.11.4;   MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN;   RHEA:16569;   reactome:R-HSA-1981104 "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines"

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procollagen-lysine 5-dioxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLOD1 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 enables ISO (PMID:8621606)
(PMID:10934207), (PMID:9724729)		 UniProt
CAFA
RGD		 PMID:8621606 PMID:9724729 PMID:10934207 PMID:11714250 RGD:1599090 NCBI chr20:119,824,380...119,865,866 JBrowse link
G PLOD1 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 enables IEA TreeGrafter GO_REF:0000118 Ensembl chr20:119,824,380...119,865,506 JBrowse link
G PLOD2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 enables IEA Ensembl
TreeGrafter
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr15:44,489,804...44,590,284
Ensembl chr15:44,490,042...44,591,526 		JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 enables IEA UniProt
TreeGrafter
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr28:11,962,394...11,974,206
Ensembl chr28:11,962,286...11,975,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18111
    catalytic activity 5515
      catalytic activity, acting on a protein 2318
        peptidyl-lysine 5-dioxygenase activity 5
          procollagen-lysine 5-dioxygenase activity 4
Path 2
Term Annotations click to browse term
  molecular_function 18111
    catalytic activity 5515
      oxidoreductase activity 714
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 189
          2-oxoglutarate-dependent dioxygenase activity 59
            peptidyl-lysine 5-dioxygenase activity 5
              procollagen-lysine 5-dioxygenase activity 4
paths to the root