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ONTOLOGY REPORT - ANNOTATIONS

Term:isoprenoid biosynthetic process
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Accession:GO:0008299 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
Synonyms:exact_synonym: isoprenoid anabolism;   isoprenoid biosynthesis;   isoprenoid formation;   isoprenoid synthesis
 narrow_synonym: polyisoprenoid anabolism;   polyisoprenoid biosynthesis;   polyisoprenoid biosynthetic process;   polyisoprenoid formation;   polyisoprenoid synthesis;   polyterpene biosynthesis;   polyterpene biosynthetic process
 alt_id: GO:0009241
 xref: MetaCyc:POLYISOPRENSYN-PWY


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isoprenoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coq2 coenzyme Q2, polyprenyltransferase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr14:8,941,429...8,961,418
Ensembl chr14:8,941,461...8,960,891 		JBrowse link
G Crppa CDP-L-ribitol pyrophosphorylase A involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:53,120,264...53,397,030
Ensembl chr 6:53,121,438...53,397,028 		JBrowse link
G ENSRNOG00000062441 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr17:61,602,519...61,608,185 JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fdps farnesyl diphosphate synthase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 involved_in IEA
IBA		 GO_REF:0000043
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000043 NCBI chr17:51,263,262...51,282,471
Ensembl chr17:51,263,263...51,276,220 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 involved_in ISO
IEA		 (PMID:8806705)
GO_REF:0000043		 RGD
UniProt		 PMID:8806705 GO_REF:0000043 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Idi2 isopentenyl-diphosphate delta isomerase 2 involved_in ISO (PMID:17202134) RGD PMID:17202134 NCBI chr17:61,331,385...61,334,987
Ensembl chr17:61,331,669...61,334,285 		JBrowse link
G LOC120097764 isopentenyl-diphosphate delta-isomerase 2-like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:61,338,622...61,349,795
Ensembl chr17:61,347,251...61,349,795
Ensembl chr17:61,347,251...61,349,795 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase involved_in ISO (PMID:11792727), (PMID:14680974) RGD PMID:11792727 PMID:14680974 NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971 		JBrowse link
G Mvk mevalonate kinase involved_in IDA
ISO		 (PMID:14680974), (PMID:14730012) RGD PMID:14680974 PMID:14730012 PMID:7904598 RGD:2316851 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Pdss1 decaprenyl diphosphate synthase subunit 1 involved_in ISO
IBA		 (PMID:16262699)
GO_REF:0000033		 RGD
GO_Central		 PMID:16262699 GO_REF:0000033 NCBI chr17:85,059,953...85,098,739
Ensembl chr17:85,060,106...85,098,730 		JBrowse link
G Pdss2 decaprenyl diphosphate synthase subunit 2 involved_in ISO
IBA
IEA		 (PMID:16262699)
GO_REF:0000033
GO_REF:0000043		 RGD
GO_Central
UniProt		 PMID:16262699 GO_REF:0000033 GO_REF:0000043 NCBI chr20:46,709,631...46,938,704
Ensembl chr20:46,709,649...46,938,708 		JBrowse link
G Pex5 peroxisomal biogenesis factor 5 NOT|acts_upstream_of_or_within ISO MGI:2154454 (PMID:11420171) RGD PMID:11420171 NCBI chr 4:157,270,671...157,296,432
Ensembl chr 4:157,270,672...157,296,431 		JBrowse link
G Rusc1 RUN and SH3 domain containing 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:174,487,921...174,497,266
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:11876656)		 Ensembl
RGD		 PMID:11876656 GO_REF:0000107 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 acts_upstream_of_or_within ISO (PMID:11876656) RGD PMID:11876656 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 acts_upstream_of_or_within ISO (PMID:11876656) RGD PMID:11876656 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 involved_in ISO
ISS		 (PMID:11304534)
GO_REF:0000024		 RGD
UniProt		 PMID:11304534 GO_REF:0000024 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241 		JBrowse link
G Rdh9 retinol dehydrogenase 9 acts_upstream_of_or_within ISO (PMID:11876656) RGD PMID:11876656 NCBI chr 7:63,642,305...63,645,149 JBrowse link
dolichol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 involved_in TAS PMID:10806397 UniProt PMID:10806397 RGD:2326086 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821 		JBrowse link
G Dhdds dehydrodolichyl diphosphate synthase subunit involved_in ISO (PMID:28842490) RGD PMID:28842490 NCBI chr 5:146,198,359...146,224,479
Ensembl chr 5:146,197,457...146,224,454 		JBrowse link
G Dhrsx dehydrogenase/reductase X-linked involved_in ISO (PMID:38821050) RGD PMID:38821050 NCBI chr12:16,299,768...16,304,553
Ensembl chr12:16,299,808...16,304,552 		JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:25066056)
GO_REF:0000033		 RGD
GO_Central		 PMID:25066056 GO_REF:0000033 NCBI chr20:31,811,817...31,838,562
Ensembl chr20:31,811,817...31,838,561 		JBrowse link
G Srd5a3 steroid 5 alpha-reductase 3 involved_in IBA
ISS
IEA
ISO		 GO_REF:0000033
GO_REF:0000024
GO_REF:0000107
(PMID:38821050)		 GO_Central
UniProt
Ensembl
RGD		 PMID:38821050 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747 		JBrowse link
farnesyl diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdps farnesyl diphosphate synthase involved_in IDA
IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central
RGD		 PMID:8188698 GO_REF:0000033 GO_REF:0000041, RGD:2316305 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr17:51,263,262...51,282,471
Ensembl chr17:51,263,263...51,276,220 		JBrowse link
farnesyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 involved_in IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
geranyl diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdps farnesyl diphosphate synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr17:51,263,262...51,282,471
Ensembl chr17:51,263,263...51,276,220 		JBrowse link
geranylgeranyl diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggps1 geranylgeranyl diphosphate synthase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr17:51,263,262...51,282,471
Ensembl chr17:51,263,263...51,276,220 		JBrowse link
isopentenyl diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idi1 isopentenyl-diphosphate delta isomerase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Idi2 isopentenyl-diphosphate delta isomerase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:61,331,385...61,334,987
Ensembl chr17:61,331,669...61,334,285 		JBrowse link
G Idi2l2 isopentenyl-diphosphate delta isomerase 2 like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:61,372,853...61,386,459
Ensembl chr17:61,373,678...61,386,454 		JBrowse link
G Idi2l3 isopentenyl-diphosphate delta isomerase 2 like 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:61,518,138...61,535,484
Ensembl chr17:61,519,390...61,531,603 		JBrowse link
G LOC102551575 isopentenyl-diphosphate delta-isomerase 2-like involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:61,504,294...61,507,015
Ensembl chr17:61,504,535...61,507,015 		JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate diphosphate decarboxylase involved_in IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000104
GO_REF:0000002		 GO_Central
UniProt
InterPro
RGD		 PMID:197206 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104, RGD:2316852 NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971 		JBrowse link
G Mvk mevalonate kinase involved_in IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000041		 GO_Central
UniProt
RGD		 PMID:197206 GO_REF:0000033 GO_REF:0000041, RGD:2316852 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Pmvk phosphomevalonate kinase involved_in IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000041		 GO_Central
UniProt
RGD		 PMID:197206 GO_REF:0000033 GO_REF:0000041, RGD:2316852 NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364 		JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 involved_in ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Prmt3 protein arginine methyltransferase 3 involved_in ISO
ISS
IEA		 (PMID:33495566)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:33495566 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435 		JBrowse link
polyprenol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhdds dehydrodolichyl diphosphate synthase subunit involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:146,198,359...146,224,479
Ensembl chr 5:146,197,457...146,224,454 		JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rdh10 retinol dehydrogenase 10 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
G Rdh16 retinol dehydrogenase 16 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 7:63,616,711...63,625,053
Ensembl chr 7:63,597,536...63,624,124 		JBrowse link
retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 involved_in IEP
ISO
ISS
IMP		 (PMID:29240402), (PMID:33565183)
GO_REF:0000024		 RGD
UniProt		 PMID:29240402 PMID:33565183 PMID:15950969 PMID:21138835 GO_REF:0000024, RGD:6771322, RGD:6771354 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 involved_in
acts_upstream_of_or_within		 IEP
ISO
ISS
IEA
IMP		 (PMID:14623956)
(PMID:11013254), (PMID:11044606), (PMID:16241904)
(PMID:27759097)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:11013254 PMID:11044606 PMID:14623956 PMID:16241904 PMID:27759097 More... GO_REF:0000024 GO_REF:0000107, RGD:6771322, RGD:6771354 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379 		JBrowse link
G Dhrs9 dehydrogenase/reductase 9 IEP
IDA		 RGD PMID:15950969 PMID:21138835 RGD:6771322, RGD:6771354 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241 		JBrowse link
G Rbp1 retinol binding protein 1 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743 		JBrowse link
G Rdh10 retinol dehydrogenase 10 acts_upstream_of_or_within ISO (PMID:17473173) RGD PMID:17473173 NCBI chr 5:3,186,671...3,215,572
Ensembl chr 5:3,188,445...3,215,572 		JBrowse link
triterpenoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lss lanosterol synthase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
zeaxanthin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpe65 retinoid isomerohydrolase RPE65 involved_in ISO
ISS
IBA		 (PMID:28874556)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:28874556 GO_REF:0000024 GO_REF:0000033 NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        biosynthetic process 8469
          lipid biosynthetic process 723
            isoprenoid biosynthetic process 42
              apocarotenoid biosynthetic process + 0
              isopentenyl diphosphate biosynthetic process + 8
              isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate 0
              isoprenoid biosynthetic process via mevalonate + 2
              polyprenol biosynthetic process + 5
              prenol biosynthetic process 0
              terpene biosynthetic process + 0
              terpenoid biosynthetic process + 19
Path 2
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11949
        primary metabolic process 10579
          lipid metabolic process 1452
            isoprenoid metabolic process 131
              isoprenoid biosynthetic process 42
                apocarotenoid biosynthetic process + 0
                isopentenyl diphosphate biosynthetic process + 8
                isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate 0
                isoprenoid biosynthetic process via mevalonate + 2
                polyprenol biosynthetic process + 5
                prenol biosynthetic process 0
                terpene biosynthetic process + 0
                terpenoid biosynthetic process + 19
paths to the root