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ONTOLOGY REPORT - ANNOTATIONS

Term:N-acetylgalactosamine-4-sulfatase activity
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Accession:GO:0003943 term browser browse the term
Definition:Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.
Synonyms:exact_synonym: N-acetylgalactosamine-4-sulphatase activity;   arylsulfatase B
 broad_synonym: chondroitinsulfatase
 related_synonym: N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity;   N-acetylgalactosamine 4-sulfate sulfohydrolase activity;   acetylgalactosamine 4-sulfatase activity
 xref: EC:3.1.6.12;   MetaCyc:3.1.6.12-RXN;   Reactome:R-HSA-2282889 "Defective ARSB does not hydrolyse C4S/C6S chains";   Reactome:R-HSA-9036065 "Defective ARSB does not hydrolyse DS";   Wikipedia:Arylsulfatase_B;   reactome:R-HSA-1606789 "ARSB hydrolyses DS";   reactome:R-HSA-1793207 "ARSB hydrolyses C4S/C6S chains"


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N-acetylgalactosamine-4-sulfatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arsb arylsulfatase B enables ISO
ISS		 (PMID:19306108)
GO_REF:0000024		 RGD
UniProt		 PMID:19306108 GO_REF:0000024 NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671 		JBrowse link
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  molecular_function 20633
    catalytic activity 6032
      hydrolase activity 2585
        hydrolase activity, acting on ester bonds 814
          sulfuric ester hydrolase activity 14
            N-acetylgalactosamine-4-sulfatase activity 1
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