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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topoisomerase activity
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Accession:GO:0003916 term browser browse the term
Definition:Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
Synonyms:alt_id: GO:0009387


show annotations for term's descendants           Sort by:
DNA topoisomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Top2a DNA topoisomerase II alpha IDA RGD PMID:11334111 RGD:1580614 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
DNA negative supercoiling activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Top2a DNA topoisomerase II alpha enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
DNA topoisomerase type I (single strand cut, ATP-independent) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Top1 DNA topoisomerase I enables IDA
ISO
IBA
IEA		 (PMID:16261531), (PMID:7842491), (PMID:9094096)
GO_REF:0000033
GO_REF:0000104
(PMID:14594810), (PMID:14654701), (PMID:17355975), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)
GO_REF:0000003		 RGD
GO_Central
UniProt		 PMID:7842491 PMID:8567649 PMID:8631793 PMID:8631794 PMID:9094096 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000104, RGD:1580856 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623 		JBrowse link
G Top1mt DNA topoisomerase I mitochondrial enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000104		 UniProt
GO_Central		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 NCBI chr 7:107,338,092...107,368,125
Ensembl chr 7:107,342,527...107,366,049 		JBrowse link
G Top3a DNA topoisomerase III alpha enables ISO
IBA		 (PMID:20445207)
GO_REF:0000033		 RGD
GO_Central		 PMID:20445207 GO_REF:0000033 NCBI chr10:45,419,219...45,457,356
Ensembl chr10:45,419,217...45,457,559 		JBrowse link
G Top3b DNA topoisomerase III beta enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:84,097,018...84,125,474
Ensembl chr11:84,097,026...84,125,392 		JBrowse link
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spo11 SPO11 initiator of meiotic double strand breaks enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:161,755,299...161,770,930
Ensembl chr 3:161,757,519...161,770,925 		JBrowse link
G Top2a DNA topoisomerase II alpha enables IDA
ISO
IEA		 (PMID:12711669), (PMID:16611985)
GO_REF:0000117
SGD:S000005032 (PMID:1331984), (PMID:7842491), (PMID:7937150), (PMID:9094096)		 RGD
UniProt		 PMID:1331984 PMID:7842491 PMID:7937150 PMID:9094096 PMID:12711669 More... GO_REF:0000117, RGD:1580614 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Top2b DNA topoisomerase II beta enables ISO (PMID:10684600), (PMID:31409799), (PMID:32128574)
(PMID:31409799)		 RGD PMID:10684600 PMID:31409799 PMID:32128574 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20626
    catalytic activity 6028
      isomerase activity 212
        DNA topoisomerase activity 7
          DNA topoisomerase type I (single strand cut, ATP-independent) activity 4
          DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity + 3
          reverse gyrase activity 0
Path 2
Term Annotations click to browse term
  molecular_function 20626
    catalytic activity 6028
      catalytic activity, acting on a nucleic acid 649
        catalytic activity, acting on DNA 283
          DNA topoisomerase activity 7
            DNA topoisomerase type I (single strand cut, ATP-independent) activity 4
            DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity + 3
            reverse gyrase activity 0
paths to the root