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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:cell surface pattern recognition receptor signaling pathway
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Accession:GO:0002752 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a cell surface pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
Synonyms:exact_synonym: cell surface PAMP receptor signaling pathway;   cell surface PRR signaling pathway;   cell surface pathogen receptor signaling pathway;   cell surface pattern recognition receptor signalling pathway

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cell surface pattern recognition receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in ISO (PMID:15294986) AgBase PMID:15294986 NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993 		JBrowse link
G CLEC7A C-type lectin domain containing 7A acts_upstream_of_or_within ISO (PMID:12719478) MGI PMID:12719478 NCBI chr11:9,989,520...10,007,442
Ensembl chr11:9,995,203...10,006,746 		JBrowse link
G FCN1 ficolin 1 involved_in ISO (PMID:21037097) UniProt PMID:21037097 NCBI chr12:3,227,790...3,236,161 JBrowse link
G FCN1 ficolin 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr12:3,231,325...3,236,174 JBrowse link
G FFAR2 free fatty acid receptor 2 involved_in ISO (PMID:21037097) UniProt PMID:21037097 NCBI chr 6:30,375,607...30,379,479
Ensembl chr 6:30,377,427...30,378,419 		JBrowse link
G LBP lipopolysaccharide binding protein involved_in ISO (PMID:15294986) AgBase PMID:15294986 NCBI chr 2:25,375,364...25,407,181
Ensembl chr 2:25,374,755...25,406,839 		JBrowse link
G MBL2 mannose binding lectin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079 		JBrowse link
G TLR2 toll like receptor 2 acts_upstream_of_or_within ISO (PMID:12719478) MGI PMID:12719478 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRRFIP2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) MGI PMID:19265123 NCBI chr15:2,231,423...2,362,394
Ensembl chr15:2,231,525...2,361,544 		JBrowse link
negative regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOD1 aconitate decarboxylase 1 involved_in ISO (MGI:5490396|PMID:23609450) UniProt PMID:23609450 MGI:5490396 NCBI chr 3:56,037,628...56,048,509
Ensembl chr 3:56,042,149...56,047,680 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:4456928|PMID:20385881) UniProt PMID:20385881 MGI:4456928 NCBI chr 8:51,919,656...52,057,376
Ensembl chr 8:51,919,808...52,057,959 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:10,158,951...10,268,286
Ensembl chr 8:10,159,421...10,268,323 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 acts_upstream_of_or_within ISO (PMID:15220916) MGI PMID:15220916 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G TLR6 toll like receptor 6 involved_in ISO (PMID:22198949) ARUK-UCL PMID:22198949 NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6695864|PMID:31134514) ARUK-UCL PMID:31134514 MGI:6695864 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
negative regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOD1 aconitate decarboxylase 1 involved_in ISO (MGI:5490396|PMID:23609450) UniProt PMID:23609450 MGI:5490396 NCBI chr 3:56,037,628...56,048,509
Ensembl chr 3:56,042,149...56,047,680 		JBrowse link
G BPIFB1 BPI fold containing family B member 1 involved_in ISO (PMID:21900486) UniProt PMID:21900486 NCBI chr 2:37,612,111...37,638,397 JBrowse link
G BPIFB1 BPI fold containing family B member 1 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr 2:37,615,068...37,633,307 JBrowse link
G DAB2IP DAB2 interacting protein involved_in ISO (PMID:19948740) UniProt PMID:19948740 NCBI chr12:17,802,030...18,017,648
Ensembl chr12:17,801,831...17,830,890 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:4456928|PMID:20385881) UniProt PMID:20385881 MGI:4456928 NCBI chr 8:51,919,656...52,057,376
Ensembl chr 8:51,919,808...52,057,959 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:10,158,951...10,268,286
Ensembl chr 8:10,159,421...10,268,323 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 involved_in ISO (PMID:18511497) BHF-UCL PMID:18511497 NCBI chr16:66,078,990...66,086,927
Ensembl chr16:66,079,089...66,090,685 		JBrowse link
G RAB7B RAB7B, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:23,341,090...23,367,414
Ensembl chr25:23,341,490...23,367,398 		JBrowse link
G SQSTM1 sequestosome 1 involved_in ISO (PMID:31281713) UniProt PMID:31281713 NCBI chr23:81,536,271...81,571,061
Ensembl chr23:81,558,082...81,574,830 		JBrowse link
G TAX1BP1 Tax1 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:30,539,867...30,629,372
Ensembl chr21:30,540,791...30,629,345 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:19412184) UniProt PMID:19412184 NCBI chr23:18,831,361...18,855,476
Ensembl chr23:18,833,262...18,833,969 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6152919|PMID:29407460)
(PMID:29407460)
(PMID:31134514)
(MGI:6695864|PMID:31134514)		 ARUK-UCL PMID:29407460 PMID:31134514 MGI:6152919 MGI:6695864 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
G TRIM32 tripartite motif containing 32 involved_in ISO (PMID:28898289) UniProt PMID:28898289 NCBI chr12:22,893,689...22,906,913
Ensembl chr12:22,894,886...22,896,847 		JBrowse link
negative regulation of toll-like receptor 5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:35,537,103...35,553,396
Ensembl chr13:35,537,102...35,549,197 		JBrowse link
positive regulation of toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (MGI:5788395|PMID:16267105) UniProt PMID:16267105 MGI:5788395 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G LOC103233451 cytochrome b-245 light chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:74,023,134...74,030,793
Ensembl chr 5:74,023,082...74,030,750 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:10,158,951...10,268,286
Ensembl chr 8:10,159,421...10,268,323 		JBrowse link
G PJA2 praja ring finger ubiquitin ligase 2 involved_in ISO (PMID:28471450) UniProt PMID:28471450 NCBI chr23:12,753,505...12,825,279
Ensembl chr23:12,753,513...12,796,482 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in ISO (PMID:19509286) BHF-UCL PMID:19509286 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G TLR1 toll like receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:11,482,307...11,490,847
Ensembl chr27:11,488,294...11,490,654 		JBrowse link
positive regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in ISO (MGI:5645195|PMID:24380872) UniProt PMID:24380872 MGI:5645195 NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (MGI:5788395|PMID:16267105)
(PMID:16267105)		 UniProt PMID:16267105 MGI:5788395 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G IFI35 interferon induced protein 35 involved_in ISO (PMID:29038465) UniProt PMID:29038465 NCBI chr16:63,276,493...63,284,196
Ensembl chr16:63,273,829...63,284,283 		JBrowse link
G LBP lipopolysaccharide binding protein involved_in ISO (PMID:11528597) BHF-UCL PMID:11528597 NCBI chr 2:25,375,364...25,407,181
Ensembl chr 2:25,374,755...25,406,839 		JBrowse link
G LTF lactotransferrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:7,867,332...7,896,403
Ensembl chr22:7,867,286...7,894,521 		JBrowse link
G NINJ1 ninjurin 1 involved_in ISO (MGI:6694429|PMID:25860173) UniProt PMID:25860173 MGI:6694429 NCBI chr12:103,509,950...103,523,158
Ensembl chr12:103,510,454...103,523,084 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:18,041,495...18,061,196
Ensembl chr 1:18,041,830...18,051,501 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19734906) Ensembl
MGI		 PMID:19734906 GO_REF:0000107 NCBI chr14:42,864,857...42,930,315
Ensembl chr14:42,864,897...42,930,394 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:19,792,807...19,855,784
Ensembl chr20:19,793,083...19,855,827 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:22685567)
(PMID:19412184)		 UniProt PMID:19412184 PMID:22685567 NCBI chr23:18,831,361...18,855,476
Ensembl chr23:18,833,262...18,833,969 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in ISO (PMID:19509286) BHF-UCL PMID:19509286 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G WDFY1 WD repeat and FYVE domain containing 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:109,815,043...109,889,120
Ensembl chr10:109,818,422...109,889,023 		JBrowse link
G ZNRF1 zinc and ring finger 1 involved_in ISO (PMID:28593998) UniProt PMID:28593998 NCBI chr 5:60,568,582...60,590,699 JBrowse link
G ZNRF1 zinc and ring finger 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:52,702,740...52,703,165 JBrowse link
regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (MGI:6270783|PMID:27219021)
(PMID:27219021)		 UniProt PMID:27219021 MGI:6270783 NCBI chr22:18,546,694...18,591,239
Ensembl chr22:18,546,751...18,589,552 		JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:100,400,093...100,469,234
Ensembl chr11:100,400,084...100,462,507 		JBrowse link
G FLOT1 flotillin 1 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chr17:41,714,354...41,725,820
Ensembl chr17:41,714,402...41,725,397 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:64,321,296...64,406,188
Ensembl chr 4:64,321,078...64,406,519 		JBrowse link
regulation of toll-like receptor 6 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6695864|PMID:31134514) ARUK-UCL PMID:31134514 MGI:6695864 NCBI chr17:30,965,091...30,999,073
Ensembl chr17:30,994,357...30,999,087 		JBrowse link
TIRAP-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TIRAP TIR domain containing adaptor protein involved_in ISO (PMID:11544529) BHF-UCL PMID:11544529 NCBI chr 1:117,417,561...117,419,870 JBrowse link
toll-like receptor 2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGB1 high mobility group box 1 involved_in ISO (PMID:14660645) UniProt PMID:14660645 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10549626) Ensembl
MGI		 PMID:10549626 GO_REF:0000107 NCBI chr  X:128,433,462...128,443,126
Ensembl chr  X:128,433,465...128,443,043 		JBrowse link
G LOC103242599 galectin-9 NOT|involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr16:21,421,034...21,439,583 JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 acts_upstream_of ISO (PMID:15220916) MGI PMID:15220916 NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5305503|PMID:22187460) UniProt PMID:22187460 MGI:5305503 NCBI chr 9:89,750,792...89,875,309 JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11894098) MGI
Ensembl		 PMID:11894098 GO_REF:0000107 NCBI chr 8:84,843,391...84,881,087
Ensembl chr 8:84,843,471...84,881,303 		JBrowse link
G TLR2 toll like receptor 2 involved_in ISO (PMID:17128265) BHF-UCL PMID:17128265 NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795 		JBrowse link
G TNIP2 TNFAIP3 interacting protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:46,001,814...46,017,676
Ensembl chr27:46,001,872...46,018,494 		JBrowse link
toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:93,219,374...93,263,077
Ensembl chr 9:93,219,383...93,262,700 		JBrowse link
G ECSIT ECSIT signaling integrator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:10,430,333...10,440,047
Ensembl chr 6:10,430,446...10,439,830 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:14660645) UniProt PMID:14660645 NCBI chr 3:9,353,333...9,357,765 JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 acts_upstream_of_or_within ISO (PMID:10549626) MGI PMID:10549626 NCBI chr  X:128,433,462...128,443,126
Ensembl chr  X:128,433,465...128,443,043 		JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:46,204,600...46,279,863
Ensembl chr22:46,204,893...46,278,260 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in ISO (PMID:25636800) UniProt PMID:25636800 NCBI chr 6:42,835,285...42,841,487
Ensembl chr 6:42,831,203...42,840,796 		JBrowse link
G LOC103242599 galectin-9 NOT|involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr16:21,421,034...21,439,583 JBrowse link
G LY96 lymphocyte antigen 96 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:69,591,885...69,629,939
Ensembl chr 8:69,591,941...69,630,274 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:5913054|PMID:28098138) UniProt PMID:28098138 MGI:5913054 NCBI chr 8:51,919,656...52,057,376
Ensembl chr 8:51,919,808...52,057,959 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO (PMID:25371197) UniProt PMID:25371197 NCBI chr13:15,284,927...15,360,539
Ensembl chr13:15,284,923...15,360,832 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:1,276,804...1,281,811
Ensembl chr15:1,276,798...1,281,166 		JBrowse link
G NAGLU N-acetyl-alpha-glucosaminidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29624734) Ensembl
MGI		 PMID:29624734 GO_REF:0000107 NCBI chr16:63,735,411...63,744,365 JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18261938) Ensembl
TreeGrafter
MGI		 PMID:18261938 GO_REF:0000107 GO_REF:0000118 NCBI chr24:12,211,619...12,216,185
Ensembl chr24:12,210,281...12,214,854 		JBrowse link
G NMI N-myc and STAT interactor involved_in ISO (MGI:6099204|PMID:29038465) UniProt PMID:29038465 MGI:6099204 NCBI chr10:36,702,056...36,722,494
Ensembl chr10:36,702,068...36,715,809 		JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 involved_in ISO (PMID:30078389) ARUK-UCL PMID:30078389 NCBI chr11:108,163,203...108,176,191
Ensembl chr11:108,163,299...108,176,193 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in ISO (MGI:5305503|PMID:22187460), (MGI:5305504|PMID:22187458) UniProt PMID:22187458 PMID:22187460 MGI:5305503 MGI:5305504 NCBI chr 9:89,750,792...89,875,309 JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in ISO (PMID:25355951) UniProt PMID:25355951 NCBI chr 1:8,576,059...8,585,561
Ensembl chr 1:8,576,542...8,586,516 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894098) Ensembl
MGI		 PMID:11894098 GO_REF:0000107 NCBI chr 8:84,843,391...84,881,087
Ensembl chr 8:84,843,471...84,881,303 		JBrowse link
G S100A14 S100 calcium binding protein A14 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:10,188,016...10,190,973
Ensembl chr20:10,188,866...10,190,979 		JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in ISO (MGI:5913054|PMID:28098138)
(PMID:28098138)		 UniProt PMID:28098138 MGI:5913054 NCBI chr16:4,616,325...4,643,791 JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:4,617,279...4,628,308 JBrowse link
G TBK1 TANK binding kinase 1 involved_in ISO (PMID:28747347) UniProt PMID:28747347 NCBI chr11:60,136,162...60,182,354
Ensembl chr11:60,136,232...60,182,344 		JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 involved_in ISO (PMID:12471095) UniProt PMID:12471095 NCBI chr 6:4,526,719...4,543,251
Ensembl chr 6:4,527,033...4,529,168 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:28630139) UniProt PMID:28630139 NCBI chr23:18,831,361...18,855,476
Ensembl chr23:18,833,262...18,833,969 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25549946) Ensembl
TreeGrafter
MGI		 PMID:25549946 GO_REF:0000107 GO_REF:0000118 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515 		JBrowse link
G TMEM126A transmembrane protein 126A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25549946) Ensembl
MGI		 PMID:25549946 GO_REF:0000107 NCBI chr 1:76,888,688...76,897,883
Ensembl chr 1:76,888,734...76,897,841 		JBrowse link
G TNIP3 TNFAIP3 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:68,416,674...68,519,097
Ensembl chr 7:68,422,328...68,454,143 		JBrowse link
G TRAF3 TNF receptor associated factor 3 involved_in ISO (PMID:18222170) UniProt PMID:18222170 NCBI chr24:80,735,234...80,872,104
Ensembl chr24:80,789,699...80,866,480 		JBrowse link
G TRAF6 TNF receptor associated factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:28,726,357...28,752,389
Ensembl chr 1:28,734,380...28,747,092 		JBrowse link
G TRIL TLR4 interactor with leucine rich repeats involved_in ISO (PMID:19710467) UniProt PMID:19710467 NCBI chr21:29,416,135...29,421,192 JBrowse link
toll-like receptor 5 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:1,276,804...1,281,811
Ensembl chr15:1,276,798...1,281,166 		JBrowse link
G TIRAP TIR domain containing adaptor protein NOT|involved_in ISO (MGI:3531416|PMID:12447442) BHF-UCL PMID:12447442 MGI:3531416 NCBI chr 1:117,417,561...117,419,870 JBrowse link
G TLR5 toll like receptor 5 involved_in ISO (PMID:14625549), (PMID:17128265) BHF-UCL PMID:14625549 PMID:17128265 NCBI chr25:6,418,895...6,440,433
Ensembl chr25:6,437,638...6,440,211 		JBrowse link
TRAM-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCE protein kinase C epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:61,022,903...61,570,390
Ensembl chr14:61,026,017...61,242,343 		JBrowse link
G RAB11FIP2 RAB11 family interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:110,805,236...110,846,691
Ensembl chr 9:110,805,022...110,846,830 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:19412184)
(PMID:22685567)		 UniProt PMID:19412184 PMID:22685567 NCBI chr23:18,831,361...18,855,476
Ensembl chr23:18,833,262...18,833,969 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17093
    immune system process 2515
      activation of immune response 555
        immune response-activating signaling pathway 481
          immune response-activating cell surface receptor signaling pathway 293
            innate immune response activating cell surface receptor signaling pathway 82
              cell surface pattern recognition receptor signaling pathway 75
                cell surface toll-like receptor signaling pathway + 70
                toll-like receptor 1 signaling pathway + 0
Path 2
Term Annotations click to browse term
  biological_process 17093
    response to stimulus 8707
      response to external stimulus 2474
        response to external biotic stimulus 1591
          response to other organism 1588
            defense response to other organism 1130
              defense response to symbiont 1016
                innate immune response 833
                  regulation of innate immune response 446
                    positive regulation of innate immune response 374
                      activation of innate immune response 300
                        innate immune response-activating signaling pathway 278
                          innate immune response activating cell surface receptor signaling pathway 82
                            cell surface pattern recognition receptor signaling pathway 75
                              cell surface toll-like receptor signaling pathway + 70
                              toll-like receptor 1 signaling pathway + 0
paths to the root