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EXPERIMENTAL FACTOR ONTOLOGY - ANNOTATIONS

Term:CCL5 measurement
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Accession:EFO:0005117 term browser browse the term
Definition:Is the quantification of Chemokine (C-C motif) ligand 5.\nCCL5 is a Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).\n
Synonyms:exact_synonym: RANTES;   Regulated on Activation, Normal T cell Expressed and Secreted
 external_ontology: is_about EFO:PR:000002094


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  experimental factor 0
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      measurement 0
        inflammatory biomarker measurement 0
          CCL5 measurement 0
Path 2
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  experimental factor 0
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        protein measurement 0
          cytokine measurement 0
            CCL5 measurement 0
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