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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:obesity
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Accession:DOID:9970 term browser browse the term
Definition:An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. (DO)
Synonyms:narrow_synonym: MONOGENIC NON-SYNDROMIC OBESITY;   Maternal Obesity;   OBESITY DUE TO SIM1 DEFICIENCY;   OBESITY, MILD, EARLY-ONSET;   Obesity, Late-Onset;   Obesity, autosomal dominant;   severe obesity and type II diabetes
 related_synonym: ADIPQTL2;   ADIPQTL3;   BMIQ1;   BMIQ10;   BMIQ11;   BMIQ12;   BMIQ14;   BMIQ18;   BMIQ4;   BMIQ7;   BMIQ8;   BMIQ9;   Body Mass Index Quantitative Trait Locus 1;   Body Mass Index Quantitative Trait Locus 10;   Body Mass Index Quantitative Trait Locus 11;   Body Mass Index Quantitative Trait Locus 12;   Body Mass Index Quantitative Trait Locus 14;   Body Mass Index Quantitative Trait Locus 18;   Body Mass Index Quantitative Trait Locus 19;   Body Mass Index Quantitative Trait Locus 4;   Body Mass Index Quantitative Trait Locus 7;   Body Mass Index Quantitative Trait Locus 8;   Body Mass Index Quantitative Trait Locus 9;   CAQ14;   CAQ5;   CIRCULATING ADIPONECTIN QUANTITATIVE TRAIT LOCUS ON CHROMOSOME 14;   CIRCULATING ADIPONECTIN QUANTITATIVE TRAIT LOCUS ON CHROMOSOME 5;   LEANNESS;   MELANOCORTIN 4 RECEPTOR POLYMORPHISM;   OBESITY, AGE AT ONSET OF;   OBESITY, ASSOCIATION WITH;   OBESITY, EARLY-ONSET, SUSCEPTIBILITY TO;   OBESITY, RESISTANCE TO;   UCP3 polymorphism G/A;   obesity, variation in;   serum level of adiponectin, quantitative trait locus 2;   serum level of adiponectin, quantitative trait locus 3
 primary_id: MESH:D009765
 alt_id: MESH:D000079262;   OMIM:300306;   OMIM:601665;   OMIM:602025;   OMIM:603188;   OMIM:606641;   OMIM:606770;   OMIM:606771;   OMIM:607447;   OMIM:607514;   OMIM:608410;   OMIM:612459;   OMIM:612460;   OMIM:615457
 xref: ICD10CM:E66.9;   ICD9CM:278.00;   NCI:C159658;   NCI:C3283
For additional species annotation, visit the Alliance of Genome Resources.



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obesity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AACS acetoacetyl-CoA synthetase ISO mRNA:altered expression:thalamus, hypothalamus (rat) RGD PMID:19219059 RGD:2326191 NCBI chr14:28,109,845...28,169,261
Ensembl chr14:28,109,841...28,169,609
JBrowse link
G ABCA1 ATP binding cassette subfamily A member 1 susceptibility
disease_progression
ISO DNA:SNP:exon:p.R230C (rs9282541) (human)
mRNA:increased expression:liver (rat)
RGD PMID:17287470 PMID:25612518 RGD:15045599 RGD:1601092 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 ISO RGD PMID:21726512 RGD:14688050 NCBI chr15:75,402,296...75,487,092
Ensembl chr15:75,400,766...75,486,403
JBrowse link
G ABCG5 ATP binding cassette subfamily G member 5 disease_progression ISO mRNA:increased expression:liver (rat) RGD PMID:25612518 RGD:15045599 NCBI chr 3:96,616,304...96,656,893
Ensembl chr 3:96,616,246...96,656,893
JBrowse link
G ABCG8 ATP binding cassette subfamily G member 8 ISO RGD PMID:15331430 RGD:1601095 NCBI chr 3:96,596,975...96,616,224
Ensembl chr 3:96,594,778...96,616,229
JBrowse link
G ACACB acetyl-CoA carboxylase beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr14:41,621,574...41,739,916 JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 6:137,541,481...137,575,544
Ensembl chr 6:137,541,380...137,595,108
JBrowse link
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 no_association ISO protein:increased expression:liver RGD PMID:17164796 PMID:19361967 RGD:1601115 RGD:2325227 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,639
JBrowse link
G ACHE acetylcholinesterase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29273807 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link
G ACLY ATP citrate lyase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr12:20,796,678...20,841,301
Ensembl chr12:20,796,749...20,841,298
JBrowse link
G ACP1 acid phosphatase 1 severity ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:2373509 PMID:9198310 RGD:1625289 RGD:2313187 NCBI chr 3:132,671,408...132,684,793
Ensembl chr 3:132,667,045...132,684,674
JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 2:70,206,159...70,209,855
Ensembl chr 2:70,206,159...70,208,328
JBrowse link
G ACSL1 acyl-CoA synthetase long chain family member 1 ISO mRNA, protein:increased expression:adipose tissue, liver
mRNA:decreased expression:subcutaneous adipose tissue
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:1543733 PMID:16788709 PMID:20882379 RGD:1625735 RGD:1625737 NCBI chr15:45,866,858...45,936,327
Ensembl chr15:45,866,851...46,090,099
JBrowse link
G ADA adenosine deaminase ISO protein:increased expression:serum RGD PMID:16501670 RGD:1624289 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,495...47,072,245
JBrowse link
G ADARB1 adenosine deaminase RNA specific B1 ISO associated with Hyperphagia RGD PMID:17567573 RGD:10450894 NCBI chr13:207,746,915...207,791,809
Ensembl chr13:207,693,698...207,791,796
JBrowse link
G ADCY3 adenylate cyclase 3 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19
CTD
ClinVar
PMID:29311635 PMID:29311636 PMID:29311637 NCBI chr 3:113,875,005...113,969,053
Ensembl chr 3:113,875,512...113,988,372
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic
associated with Diabetes Mellitus, Type 2
associated with myocardial infarction; protein:decreased expression:plasma
associated with Pulmonary Disease, Chronic Obstructive; protein:decreased expression:plasma
CTD
RGD
PMID:10092513 PMID:11549668 PMID:14617771 PMID:16092047 PMID:18303100 More... RGD:14975146 RGD:1599149 RGD:2313239 RGD:5686809 RGD:5686813 RGD:8695927 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G ADIPOR1 adiponectin receptor 1 ISO mRNA:decreased expression:lymphocyte RGD PMID:17391161 RGD:1625761 NCBI chr10:24,907,491...24,923,540 JBrowse link
G ADIPOR2 adiponectin receptor 2 treatment
severity
ISO mRNA:decreased expression:liver (rat)
associated with non-alcoholic fatty liver disease
mRNA:increased expression:liver
RGD PMID:16483885 PMID:23838384 PMID:30131158 PMID:30225267 RGD:1625763 RGD:21406435 RGD:25824942 RGD:8695926 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G ADM adrenomedullin ISO mRNA, protein:increased expression:adipose tissue RGD PMID:16793965 RGD:1625297 NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866
JBrowse link
G ADORA1 adenosine A1 receptor ISO protein:increased expression:visceral adipose tissue:increased density of ligand binding sites on VAT in African American women compared to Caucasian women RGD PMID:16507638 RGD:1625369 NCBI chr 9:113,835,279...113,875,899
Ensembl chr 9:113,835,920...113,875,719
JBrowse link
G ADRA2B adrenoceptor alpha 2B ISO RGD PMID:10404816 RGD:1300265 NCBI chr 3:45,760,966...45,762,306
Ensembl chr 3:45,758,268...45,764,178
JBrowse link
G ADRB1 adrenoceptor beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12032746 NCBI chr14:124,400,330...124,401,739
Ensembl chr14:124,400,189...124,401,739
JBrowse link
G ADRB2 adrenoceptor beta 2 no_association
susceptibility
ISO DNA:polymorphisms: :p.R16G, p.Q27E OMIM
RGD
PMID:17027833 PMID:17221209 RGD:1601119 RGD:1601122 NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,032,782...150,035,591
JBrowse link
G ADRB3 adrenoceptor beta 3 no_association ISO DNA:missense mutation:cds:p.W64R rs4994 (human) OMIM
RGD
PMID:11882399 RGD:5684409 NCBI chr15:48,468,803...48,478,370 JBrowse link
G AFF4 AF4/FMR2 family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25730767 NCBI chr 2:135,196,067...135,283,931
Ensembl chr 2:135,200,076...135,283,916
JBrowse link
G AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 ISO RGD PMID:20068140 RGD:13838849 NCBI chr 5:23,015,777...23,035,943
Ensembl chr 5:23,015,777...23,033,519
JBrowse link
G AGER advanced glycosylation end-product specific receptor ISO protein:decreased expression:plasma (human) RGD PMID:22761461 PMID:23046363 RGD:7243247 RGD:7243250 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,116...24,228,756
JBrowse link
G AGRP agouti related neuropeptide ISO OMIM NCBI chr 6:28,132,614...28,135,594
Ensembl chr 6:28,132,615...28,133,743
JBrowse link
G AGT angiotensinogen susceptibility ISO DNA:polymorphism: :p.M235T
DNA:polymorphism: :p.T174M
RGD PMID:16514903 PMID:16713443 RGD:1601142 RGD:1601143 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:15793237 RGD:2313554 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388
JBrowse link
G AHI1 Abelson helper integration site 1 ISO mRNA:increased expression:vastus lateralis RGD PMID:20045148 RGD:11537398 NCBI chr 1:28,566,279...28,760,471
Ensembl chr 1:28,566,266...28,760,468
JBrowse link
G AHR aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:27020609 PMID:30813227 PMID:31306034 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G AHSG alpha 2-HS glycoprotein susceptibility ISO protein:increased expression:serum RGD PMID:17011519 PMID:19228823 RGD:1625793 RGD:2313809 NCBI chr13:124,426,313...124,438,848
Ensembl chr13:124,426,308...124,438,840
JBrowse link
G AK1 adenylate kinase 1 ISO protein:increased expression:skeletal muscle RGD PMID:15855311 RGD:1601154 NCBI chr 1:268,355,032...268,365,659
Ensembl chr 1:268,355,032...268,365,598
JBrowse link
G AKAP1 A-kinase anchoring protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20975297 NCBI chr12:33,396,473...33,410,395
Ensembl chr12:33,396,473...33,411,441
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr10:65,650,223...65,679,878
Ensembl chr10:65,576,464...65,678,248
JBrowse link
G AKT1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23954404
G AKT2 AKT serine/threonine kinase 2 ISO protein:decreased expression:plantaris (rat)
protein:decreased activity:rectus abdominis (human)
RGD PMID:12663464 PMID:17923673 PMID:18508911 RGD:2313320 RGD:2313406 RGD:2313409 NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,789...48,587,919
JBrowse link
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 7:53,748,585...53,794,777
Ensembl chr 7:53,748,585...53,794,706
JBrowse link
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 7:97,360,583...97,381,885
Ensembl chr 7:97,357,952...97,381,841
JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein ISO mRNA:increased expression:adipose tissue (mouse)
mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD PMID:17379835 PMID:19596146 RGD:2313884 RGD:2313913 NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108
JBrowse link
G AMH anti-Mullerian hormone ISO protein:decreased expression:serum RGD PMID:17109858 RGD:1601182 NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,405,253...76,418,312
JBrowse link
G ANGPTL4 angiopoietin like 4 resistance ISO CTD Direct Evidence: therapeutic RGD
CTD
PMID:17210919 PMID:28842503 RGD:1625353 NCBI chr 2:70,905,767...70,912,892
Ensembl chr 2:70,904,531...70,912,974
JBrowse link
G APCDD1 APC down-regulated 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28242765 NCBI chr 6:97,991,418...98,026,590
Ensembl chr 6:97,992,228...98,026,768
JBrowse link
G APLN apelin ISO mRNA:increased expression:subcutaneous adipose tissue RGD PMID:17594060 RGD:1626170 NCBI chr  X:106,236,746...106,246,563
Ensembl chr  X:106,236,748...106,246,378
JBrowse link
G APOA1 apolipoprotein A1 ISO protein:decreased expression RGD PMID:9933608 PMID:12725089 RGD:1601185 RGD:2313959 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
G APOA2 apolipoprotein A2 ISO protein:increased expression:serum RGD PMID:9002300 PMID:9933608 RGD:1601191 RGD:2313959 NCBI chr 4:89,237,514...89,239,126
Ensembl chr 4:89,237,511...89,240,320
JBrowse link
G APOB apolipoprotein B ISO associated with Insulin Resistance;protein:increased expression:plasma RGD PMID:16752182 PMID:19592617 RGD:1601202 RGD:2313974 NCBI chr 3:117,250,096...117,316,200
Ensembl chr 3:117,250,096...117,316,200
JBrowse link
G APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 ISO mRNA:increased expression:liver RGD PMID:8781289 RGD:1626278 NCBI chr 5:62,811,819...62,820,532
Ensembl chr 5:62,810,879...62,820,173
JBrowse link
G APOC2 apolipoprotein C2 ISO protein:increased expression:serum RGD PMID:9002300 RGD:1601191 NCBI chr 6:51,404,219...51,406,302 JBrowse link
G APOC3 apolipoprotein C3 ISO protein:increased expression:serum RGD PMID:9002300 RGD:1601191 NCBI chr 9:44,211,171...44,213,538 JBrowse link
G APOD apolipoprotein D ISO DNA:polymorphism RGD PMID:7913935 RGD:2311179 NCBI chr13:132,514,546...132,562,594
Ensembl chr13:132,514,949...132,562,599
JBrowse link
G APOE apolipoprotein E ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
RGD
CTD
PMID:9002300 PMID:17192461 PMID:20975297 RGD:1601191 RGD:1601230 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,259...51,377,794
JBrowse link
G APP amyloid beta precursor protein treatment ISO mRNA,protein:increased expression:adipocyte,plasma: RGD PMID:19672057 RGD:10054260 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,434,869...189,716,057
JBrowse link
G AQP7 aquaporin 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16325777 NCBI chr10:33,098,746...33,130,245 JBrowse link
G AR androgen receptor susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:repeat: :CAG
DNA:repeats: :GGN, CAG
RGD PMID:12532157 PMID:18805913 RGD:1601246 RGD:2306771 NCBI chr  X:53,609,113...53,806,778
Ensembl chr  X:53,609,176...53,805,578
JBrowse link
G ARL13B ADP ribosylation factor like GTPase 13B ISO protein:decreased expression:hypothalamus, cilium (mouse) RGD PMID:22581473 RGD:11553936 NCBI chr13:165,829,772...165,910,959
Ensembl chr13:165,828,059...165,911,011
JBrowse link
G ASIP agouti signaling protein susceptibility ISO DNA, mRNA:deletion, insertions, increased expression: multiple organs
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:1473152 PMID:7987393 PMID:8146154 PMID:25447408 PMID:25448685 More... RGD:1625724 NCBI chr17:37,542,615...37,718,787 JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 susceptibility ISO RGD PMID:16286513 RGD:1601250 NCBI chr 4:90,341,316...90,371,040
Ensembl chr 4:90,291,344...90,396,160
JBrowse link
G ATP4B ATPase H+/K+ transporting subunit beta treatment ISO RGD PMID:25822172 RGD:14696745 NCBI chr11:78,780,013...78,785,143
Ensembl chr11:78,780,013...78,785,116
JBrowse link
G ATP5F1B ATP synthase F1 subunit beta treatment ISO RGD PMID:26880535 RGD:13782133 NCBI chr 5:21,984,750...21,992,393
Ensembl chr 5:21,984,580...21,992,407
JBrowse link
G ATP5F1C ATP synthase F1 subunit gamma ISO RGD PMID:19549744 RGD:14696798 NCBI chr10:63,584,288...63,599,537
Ensembl chr10:63,583,693...63,599,453
JBrowse link
G ATP5F1D ATP synthase F1 subunit delta treatment ISO RGD PMID:27874268 RGD:13792665 NCBI chr 2:77,216,430...77,219,301
Ensembl chr 2:77,216,433...77,222,749
JBrowse link
G ATP5MC2 ATP synthase membrane subunit c locus 2 ISO RGD PMID:26709097 RGD:11535661 NCBI chr 5:18,871,025...18,879,933
Ensembl chr 5:18,871,027...18,878,838
JBrowse link
G ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 6:164,830,623...164,858,741
Ensembl chr 6:164,830,617...164,862,218
JBrowse link
G ATRN attractin ISO RGD PMID:10086355 RGD:734623 NCBI chr17:32,054,240...32,239,576
Ensembl chr17:32,054,242...32,239,574
JBrowse link
G B2M beta-2-microglobulin ISO protein:increased expression:urine RGD PMID:15517379 RGD:1601309 NCBI chr 1:126,865,767...126,878,501
Ensembl chr 1:126,835,143...126,981,582
JBrowse link
G BAD BCL2 associated agonist of cell death ISO protein:increased expression:heart left ventricle RGD PMID:18070754 RGD:2292682 NCBI chr 2:7,831,192...7,842,864
Ensembl chr 2:7,830,920...7,842,863
JBrowse link
G BAMBI BMP and activin membrane bound inhibitor ISO mRNA:decreased expression:adipose tissue RGD PMID:22187378 RGD:14390162 NCBI chr10:40,053,368...40,058,590
Ensembl chr10:40,053,354...40,060,323
JBrowse link
G BBS1 Bardet-Biedl syndrome 1 no_association ISO DNA:mutation: :p.M390R (human) RGD PMID:14993910 RGD:1601314 NCBI chr 2:5,886,989...5,906,468 JBrowse link
G BBS2 Bardet-Biedl syndrome 2 susceptibility ISO DNA:SNPs RGD PMID:17003356 RGD:1601311 NCBI chr 6:18,542,383...18,575,338
Ensembl chr 6:18,542,383...18,575,524
JBrowse link
G BBS4 Bardet-Biedl syndrome 4 onset ISO DNA:SNPs RGD PMID:17003356 RGD:1601311 NCBI chr 7:60,631,913...60,693,359 JBrowse link
G BCHE butyrylcholinesterase ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:18452903 PMID:23000450 PMID:23073171 PMID:27163854 NCBI chr13:104,946,732...105,007,568 JBrowse link
G BDKRB1 bradykinin receptor B1 ISO ob/ob mice mRNA:decreased expression:brown adipose tissue, heart mRNA:increased expression:white adipose tissue, hypothalamus RGD PMID:17184856 RGD:1625733 NCBI chr 7:117,491,350...117,492,410
Ensembl chr 7:117,491,350...117,492,410
JBrowse link
G BDNF brain derived neurotrophic factor ISO protein:decreased expression:plasma
ClinVar Annotator: match by term: Obesity
RGD
ClinVar
PMID:17151862 PMID:25741868 RGD:10059350 NCBI chr 2:32,623,668...32,679,293
Ensembl chr 2:32,623,268...32,679,164
JBrowse link
G BNIP3 BCL2 interacting protein 3 ISO RGD PMID:18070754 RGD:2292682 NCBI chr14:140,362,123...140,371,951
Ensembl chr14:140,362,127...140,371,881
JBrowse link
G BRD2 bromodomain containing 2 ISO RGD PMID:19883376 RGD:9586446 NCBI chr 7:25,096,579...25,162,591
Ensembl chr 7:25,150,658...25,165,433
JBrowse link
G BRS3 bombesin receptor subtype 3 ISO RGD PMID:9367152 RGD:734661 NCBI chr  X:111,615,695...111,620,124
Ensembl chr  X:111,615,695...111,623,998
JBrowse link
G C3 complement C3 treatment ISO RGD PMID:23118029 RGD:7411625 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,499...72,528,112
JBrowse link
G C5AR1 complement C5a receptor 1 treatment ISO RGD PMID:23118029 RGD:7411625 NCBI chr 6:53,097,162...53,111,563
Ensembl chr 6:53,097,164...53,117,020
JBrowse link
G CA3 carbonic anhydrase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 4:51,227,485...51,237,861
Ensembl chr 4:51,219,736...51,237,846
JBrowse link
G CADM2 cell adhesion molecule 2 ISO DNA:SNP: :rs13078807 (human) RGD PMID:31341224 RGD:15092077 NCBI chr13:169,681,947...170,753,114
Ensembl chr13:169,688,940...170,752,425
JBrowse link
G CANX calnexin ISO protein:increased expression:subcutaneous adipose tissue RGD PMID:18567819 RGD:2314284 NCBI chr 2:78,879,031...78,915,828
Ensembl chr 2:78,879,031...78,915,816
JBrowse link
G CAPN10 calpain 10 ISO DNA:SNPs RGD PMID:16752174 RGD:1625047 NCBI chr15:139,557,643...139,568,764
Ensembl chr15:139,557,666...139,570,181
JBrowse link
G CARTPT CART prepropeptide no_association ISO DNA:polymorphism:3' utr (human)
DNA:deletion, substitution: :1457delA, 1475A>G (human)
OMIM
RGD
PMID:10574510 PMID:10805512 RGD:2313633 RGD:2313634 NCBI chr16:48,043,558...48,045,592
Ensembl chr16:48,043,407...48,045,590
JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22325453 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CAV1 caveolin 1 ISO RGD PMID:22492718 RGD:6784520 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G CAV2 caveolin 2 ISO RGD PMID:22492718 RGD:6784520 NCBI chr18:29,699,012...29,707,277
Ensembl chr18:29,699,020...29,707,277
JBrowse link
G CCKAR cholecystokinin A receptor ISO DNA:deletion RGD PMID:9192855 PMID:9530226 RGD:7257724 RGD:734711 NCBI chr 8:20,187,324...20,200,273
Ensembl chr 8:20,186,189...20,199,477
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 ISO protein, mRNA:increased expression:plasma, fat
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
RGD
CTD
PMID:17803693 PMID:18469848 PMID:29035695 RGD:2306993 RGD:2307038 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CCL4 C-C motif chemokine ligand 4 ISO RGD PMID:21862610 RGD:5683906 NCBI chr12:39,479,190...39,480,511
Ensembl chr12:39,478,885...39,557,358
JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO protein:increased expression:serum RGD PMID:18469848 RGD:2307038 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO mRNA:increased expression:adipose tissue RGD PMID:18492752 RGD:6483834 NCBI chr13:29,251,950...29,286,470
Ensembl chr13:29,251,959...29,376,346
JBrowse link
G CD163 CD163 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,146...63,334,498
JBrowse link
G CD36 CD36 molecule ISO protein:increased expression:skeletal muscle, T-tubule
mRNA, protein:increased expression:liver, gastrocnemius
RGD PMID:20435456 PMID:22615812 PMID:23743348 PMID:25477422 RGD:11041118 RGD:11041132 RGD:6893497 RGD:6893542 NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105
JBrowse link
G CD40 CD40 molecule treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:21670556 PMID:29035695 RGD:7248753 NCBI chr17:48,286,116...48,298,188
Ensembl chr17:48,286,029...48,298,528
JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:serum RGD PMID:20660932 PMID:21817098 RGD:5490592 RGD:5490970 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,711
JBrowse link
G CD68 CD68 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chr12:52,874,754...52,877,256
Ensembl chr12:52,874,785...52,877,695
JBrowse link
G CDK4 cyclin dependent kinase 4 susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:intron:IVS4-40G>A (human) RGD PMID:19634152 RGD:2314609 NCBI chr 5:23,039,206...23,041,959
Ensembl chr 5:23,038,889...23,042,061
JBrowse link
G CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 ISO ClinVar Annotator: match by term: Obesity ClinVar NCBI chr 7:15,910,645...16,569,643
Ensembl chr 7:15,910,666...16,685,053
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO protein:decreased expression:liver RGD PMID:23357529 RGD:10045356 NCBI chr 5:59,731,224...59,735,831
Ensembl chr 5:59,731,206...59,735,831
JBrowse link
G CDO1 cysteine dioxygenase type 1 ISO RGD PMID:16627576 RGD:2301355 NCBI chr 2:119,927,768...119,940,690
Ensembl chr 2:119,892,691...119,940,665
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:28242765 NCBI chr 6:43,083,200...43,085,884
Ensembl chr 6:43,083,203...43,085,836
JBrowse link
G CENPO centromere protein O ISO ClinVar Annotator: match by term: BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19 ClinVar PMID:29311637 NCBI chr 3:113,968,735...113,979,201 JBrowse link
G CFD complement factor D ISO mRNA, protein:decreased expression:adipocyte, serum RGD PMID:2197880 PMID:14564690 RGD:1624324 RGD:1624327 NCBI chr 2:77,509,792...77,511,988
Ensembl chr 2:77,509,795...77,511,974
JBrowse link
G CIDEA cell death inducing DFFA like effector a ISO protein:amino acid substitution:V115F
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:16186410 PMID:20975297 RGD:1625390 NCBI chr 6:97,253,074...97,268,355 JBrowse link
G CNR1 cannabinoid receptor 1 no_association ISO DNA:polymorphism: :1256C>A, 1419+1G>C (human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:exon:3813A>G (human)
RGD
CTD
PMID:17292652 PMID:17405839 PMID:18722357 PMID:19325539 PMID:19530697 RGD:1626325 RGD:1626326 RGD:2314629 RGD:2314630 NCBI chr 1:56,466,022...56,493,275
Ensembl chr 1:56,466,027...56,492,602
JBrowse link
G CNTF ciliary neurotrophic factor no_association ISO DNA:point mutation:intron:G>A RGD PMID:12404108 PMID:14747836 RGD:1626113 RGD:1626114 NCBI chr 2:12,492,777...12,495,401 JBrowse link
G COMT catechol-O-methyltransferase susceptibility ISO DNA:polymorphism:exon RGD PMID:17497175 RGD:2289713 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
G COX7C cytochrome c oxidase subunit 7C ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 2:94,345,436...94,347,709
Ensembl chr 2:94,345,438...94,353,027
JBrowse link
G CPB2 carboxypeptidase B2 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression, increased activity:plasma
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:11836301 PMID:16959692 RGD:2313645 NCBI chr11:21,234,447...21,298,250
Ensembl chr11:21,234,447...21,298,244
JBrowse link
G CPE carboxypeptidase E no_association ISO DNA:transition:CDS:729T>C, amino acid S202P; decreased activity results in decrease in processing of proinsulin
no association between obesity or diabetes and three SNPs (-53G>T, -144G>A, 219G>A) in Japanese patients
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:7663508 PMID:9662053 PMID:15358678 PMID:23434795 RGD:1626181 RGD:1626184 NCBI chr 8:43,568,744...43,695,475
Ensembl chr 8:43,503,667...43,695,628
JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 ISO RGD PMID:15481768 RGD:2303517 NCBI chr15:113,210,038...113,339,086
Ensembl chr15:113,209,999...113,339,078
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A ISO mRNA:decreased expression:liver RGD PMID:16751799 RGD:2311345 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,984
JBrowse link
G CRH corticotropin releasing hormone ISO RGD PMID:11564446 RGD:5508830 NCBI chr 4:68,481,696...68,486,122
Ensembl chr 4:68,483,977...68,486,118
JBrowse link
G CRHBP corticotropin releasing hormone binding protein ISO mRNA:decreased expression:anterior pituitary gland (rat) RGD PMID:10600923 RGD:5508840 NCBI chr 2:85,814,399...85,830,598
Ensembl chr 2:85,816,815...85,831,180
JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO DNA:SNP:CDS:861C>T (human) RGD PMID:14724656 RGD:1626226 NCBI chr12:17,251,361...17,306,308
Ensembl chr12:17,252,018...17,306,319
JBrowse link
G CRP C-reactive protein, pentraxin-related disease_progression ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:liver (rat)
protein:increased expression:serum
CTD
RGD
PMID:20660932 PMID:24042701 PMID:25612518 RGD:15045599 RGD:5490970 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,722,352...90,805,236
JBrowse link
G CS citrate synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 5:21,669,778...21,700,737
Ensembl chr 5:21,666,510...21,700,736
JBrowse link
G CST3 cystatin C ISO protein:increased expression:serum (human)
protein:increased expression:plasma (rat)
RGD PMID:18374694 PMID:18946178 RGD:2314297 RGD:2314346 NCBI chr17:30,471,056...30,474,486
Ensembl chr17:30,470,855...30,474,590
JBrowse link
G CTF1 cardiotrophin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21803294 NCBI chr 3:17,539,927...17,545,250
Ensembl chr 3:17,540,499...17,545,240
JBrowse link
G CTSC cathepsin C ISO RGD PMID:3705543 RGD:1599645 NCBI chr 9:21,726,628...21,761,796
Ensembl chr 9:21,722,035...21,761,473
JBrowse link
G CTSS cathepsin S ISO CTD Direct Evidence: marker/mechanism CTD PMID:21156398 NCBI chr 4:98,415,273...98,442,952
Ensembl chr 4:98,390,250...98,442,936
JBrowse link
G CX3CR1 C-X3-C motif chemokine receptor 1 ISO DNA:SNP: :p.T280M (human) RGD PMID:20523302 RGD:4891903 NCBI chr13:23,944,386...23,957,567
Ensembl chr13:23,944,369...23,957,486
JBrowse link
G CXCR4 C-X-C motif chemokine receptor 4 ISO RGD PMID:25016030 RGD:13673852 NCBI chr15:15,663,652...15,666,706
Ensembl chr15:15,663,494...15,667,233
JBrowse link
G CYB5A cytochrome b5 type A ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 1:149,737,584...149,773,222
Ensembl chr 1:149,737,571...149,783,623
JBrowse link
G CYCS cytochrome c, somatic ISO CTD Direct Evidence: marker/mechanism CTD PMID:16317704 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27036855 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,206,750
JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 3:70,573,551...70,593,416
Ensembl chr 3:70,572,197...70,593,408
JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphisms:promoter, intron:g.-1260C>A, g.2838T>C (human) RGD PMID:17223345 RGD:2307312 NCBI chr 5:23,053,129...23,058,865
Ensembl chr 5:23,050,114...23,058,470
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased activity:liver,fat
CTD
RGD
PMID:17049493 PMID:23954404 RGD:1626307 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
G CYTB cytochrome b ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:12905068 PMID:25741868 NCBI chr MT:15,342...16,481
Ensembl chr MT:15,342...16,481
JBrowse link
G DCN decorin ISO RGD PMID:17244723 RGD:1600551 NCBI chr 5:91,678,601...91,713,925
Ensembl chr 5:91,678,608...91,714,235
JBrowse link
G DCXR dicarbonyl and L-xylulose reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr12:978,131...980,042
Ensembl chr12:978,139...982,263
JBrowse link
G DDHD2 DDHD domain containing 2 ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:23176823 PMID:24337409 PMID:24517879 PMID:25417924 PMID:25741868 More... NCBI chr15:48,239,932...48,292,413
Ensembl chr15:48,238,740...48,292,181
JBrowse link
G DDIT3 DNA damage inducible transcript 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26655953 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,441...22,791,134
JBrowse link
G DEAF1 DEAF1 transcription factor ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:25741868 NCBI chr 2:404,514...427,584
Ensembl chr 2:404,532...427,542
JBrowse link
G DEFB1 defensin beta 1 ISO mRNA:decreased expression:kidney RGD PMID:11340353 RGD:4892260
G DGAT1 diacylglycerol O-acyltransferase 1 no_association
treatment
ISO DNA:polymorphism:C97T RGD PMID:10802663 PMID:14569040 PMID:18183944 RGD:10401058 RGD:1625597 RGD:734536 NCBI chr 4:452,890...463,665
Ensembl chr 4:452,861...466,883
JBrowse link
G DIO2 iodothyronine deiodinase 2 no_association ISO protein:substitution:Thr92Ala RGD PMID:17077128 RGD:1626439 NCBI chr 7:103,096,414...103,110,749
Ensembl chr 7:103,096,425...103,323,258
JBrowse link
G DIP2C disco interacting protein 2 homolog C ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:25741868 NCBI chr10:68,770,149...69,141,876
Ensembl chr10:68,770,163...69,141,871
JBrowse link
G DIXDC1 DIX domain containing 1 ISO ClinVar Annotator: match by term: Obesity ClinVar NCBI chr 9:39,666,454...39,734,909 JBrowse link
G DPYD dihydropyrimidine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 4:119,931,471...120,712,461
Ensembl chr 4:119,931,458...120,712,462
JBrowse link
G DRD1 dopamine receptor D1 treatment ISO protein:increased serine phosphorylation:renal proximal tubule, membrane (rat) RGD PMID:15983225 PMID:17191082 RGD:7248449 RGD:7248552 NCBI chr16:49,189,555...49,193,722
Ensembl chr16:49,188,936...49,193,709
JBrowse link
G DRD2 dopamine receptor D2 ISO mRNA:decreased expression:ventral tegmental area (rat)
DNA:polymorphisms, haplotype:enhancer, promoter, intron:multiple
RGD PMID:15939106 PMID:17108814 PMID:18477764 RGD:1600904 RGD:1600905 RGD:2311581 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599
JBrowse link
G DRD4 dopamine receptor D4 ISO protein:decreased expression:kidney (rat) RGD PMID:20810614 RGD:7248616 NCBI chr 2:398,766...401,539
Ensembl chr 2:398,766...401,432
JBrowse link
G DUSP1 dual specificity phosphatase 1 susceptibility ISO RGD PMID:16814733 RGD:2298673 NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086
JBrowse link
G ECH1 enoyl-CoA hydratase 1 treatment ISO RGD PMID:31961704 RGD:21408561 NCBI chr 6:47,627,056...47,638,961
Ensembl chr 6:47,627,056...47,639,437
JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr14:141,340,320...141,348,870
Ensembl chr14:141,335,990...141,349,030
JBrowse link
G EDN1 endothelin 1 ISO DNA:polymorphism:exon:p.K198N (human) RGD PMID:17444275 RGD:1625065 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G EFNB1 ephrin B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24098442 NCBI chr  X:54,947,339...54,961,403
Ensembl chr  X:54,948,342...54,973,629
JBrowse link
G EGFR epidermal growth factor receptor ISO protein:decreased phosphorylation:liver (mouse) RGD PMID:3624263 RGD:5131534 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,478,882
JBrowse link
G EHD1 EH domain containing 1 ISO RGD PMID:21365757 RGD:8661255 NCBI chr 2:7,299,295...7,321,580
Ensembl chr 2:7,298,259...7,321,577
JBrowse link
G ELOVL6 ELOVL fatty acid elongase 6 ISO mRNA,protein:increased expression:liver: RGD PMID:31988048 RGD:21403676 NCBI chr 8:112,038,670...112,190,079
Ensembl chr 8:111,750,960...112,191,274
JBrowse link
G EMC1 ER membrane protein complex subunit 1 ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:28492532 NCBI chr 6:77,723,374...77,747,780
Ensembl chr 6:77,718,840...77,747,771
JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO OMIM NCBI chr 1:31,724,290...31,796,594
Ensembl chr 1:31,722,721...31,796,595
JBrowse link
G ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29273807 NCBI chr17:30,908,747...30,930,774
Ensembl chr17:30,908,252...30,934,189
JBrowse link
G EP300 E1A binding protein p300 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26441656 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760
JBrowse link
G ESR1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:11095962 PMID:20667977 PMID:22230815 RGD:8553065 RGD:8553199 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 ISO RGD PMID:22230815 RGD:8553199 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,722,164...193,906,565
JBrowse link
G ESRRA estrogen related receptor alpha no_association ISO RGD PMID:16755280 RGD:1625637 NCBI chr 2:7,803,504...7,812,868
Ensembl chr 2:7,803,510...7,813,836
JBrowse link
G ETFDH electron transfer flavoprotein dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 8:47,608,499...47,655,889
Ensembl chr 8:47,608,689...47,657,436
JBrowse link
G F2 coagulation factor II, thrombin ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:21210148 PMID:22841818 PMID:23628972 RGD:5147773 RGD:7387310 NCBI chr 2:15,793,257...15,819,151
Ensembl chr 2:15,791,451...15,819,138
JBrowse link
G F7 coagulation factor VII ISO associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased activity:plasma (human) RGD PMID:9258277 PMID:14513073 PMID:16739871 PMID:19329212 RGD:1625710 RGD:2312379 RGD:2312395 RGD:2312404 NCBI chr11:78,512,389...78,518,668
Ensembl chr11:78,512,158...78,518,671
JBrowse link
G FAAH fatty acid amide hydrolase ISO DNA:polymorphism
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:15809662 PMID:19103437 PMID:20716455 RGD:1625726 NCBI chr 6:165,060,279...165,079,340
Ensembl chr 6:165,060,287...165,079,769
JBrowse link
G FABP1 fatty acid binding protein 1 ISO Western diet-induced obesity; DNA:mutation::Fabp1 knockout mice RGD PMID:17058218 RGD:1626440 NCBI chr 3:57,850,511...57,854,966
Ensembl chr 3:57,850,499...57,854,964
JBrowse link
G FABP2 fatty acid binding protein 2 onset
no_association
ISO Early onset of obesity and resistance to reducing visceral white adipose tissue; DNA:polymorphism:CDS:amino acid A54T, in Japanese women with a BMI > 25
DNA:polymorphism:CDS:p.A54T (human)
DNA:polymorphism:CDS:amino acid A54T, in Chilean Aymara and Mapuche ethnic groups
RGD PMID:14981227 PMID:15620432 PMID:17211557 RGD:1578458 RGD:1626400 RGD:1626407 NCBI chr 8:104,464,342...104,468,059
Ensembl chr 8:104,464,342...104,470,480
JBrowse link
G FABP3 fatty acid binding protein 3 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA:decreased expression:skeletal muscle RGD PMID:17515913 RGD:2307328 NCBI chr 6:87,943,003...87,950,708
Ensembl chr 6:87,942,790...87,951,610
JBrowse link
G FABP4 fatty acid binding protein 4, adipocyte ISO RGD PMID:8910278 RGD:737747 NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,897
JBrowse link
G FADD Fas associated via death domain ISO protein:increased expression:heart left ventricle RGD PMID:18202171 RGD:2293027 NCBI chr 2:3,191,718...3,194,820
Ensembl chr 2:3,186,744...3,194,792
JBrowse link
G FADS1 fatty acid desaturase 1 ISO protein:decreased expression:microsomes, liver RGD PMID:8446010 RGD:1625421 NCBI chr 2:9,735,425...9,747,405
Ensembl chr 2:9,735,293...9,749,671
JBrowse link
G FANCA FA complementation group A ISO RGD PMID:22482891 RGD:11046266 NCBI chr 6:253,207...300,159
Ensembl chr 6:253,224...300,155
JBrowse link
G FANCC FA complementation group C ISO RGD PMID:22482891 RGD:11046266 NCBI chr10:26,796,546...27,055,271 JBrowse link
G FASN fatty acid synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr12:922,405...937,560
Ensembl chr12:920,507...937,559
JBrowse link
G FBXO11 F-box protein 11 ISO ClinVar Annotator: match by term: Obesity ClinVar NCBI chr 3:92,696,402...92,792,623
Ensembl chr 3:92,696,441...92,792,619
JBrowse link
G FFAR4 free fatty acid receptor 4 susceptibility ISO ClinVar Annotator: match by term: Body mass index quantitative trait locus 10
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:22343897 PMID:27068006 Ensembl chr14:105,011,922...105,037,498 JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 ISO ClinVar Annotator: match by term: Obesity ClinVar NCBI chr 5:41,571,054...41,636,058 JBrowse link
G FGF21 fibroblast growth factor 21 ISO CTD Direct Evidence: therapeutic CTD PMID:24184811 PMID:26797127 NCBI chr 6:54,082,653...54,084,532
Ensembl chr 6:54,080,739...54,084,604
JBrowse link
G FGFR1 fibroblast growth factor receptor 1 ISO mRNA:increased expression:adipose tissue:
mRNA:increased expression:hypothalamus:
RGD PMID:21430024 RGD:10402094 NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,746
JBrowse link
G FGG fibrinogen gamma chain ISO protein:decreased expression:plasma RGD PMID:22134356 RGD:11352709 NCBI chr 8:74,553,040...74,562,151
Ensembl chr 8:74,553,105...74,686,118
JBrowse link
G FGGY FGGY carbohydrate kinase domain containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:29220483 NCBI chr 6:152,754,923...153,213,179
Ensembl chr 6:152,754,921...153,213,170
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:27071101 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G FOXA2 forkhead box A2 ISO RGD PMID:12865419 RGD:1627574 NCBI chr17:29,997,397...30,001,704
Ensembl chr17:29,997,400...30,001,707
JBrowse link
G FOXC2 forkhead box C2 ISO DNA:polymorphism:5'ut:-512C>T(human) RGD PMID:15601967 RGD:1601218 NCBI chr 6:2,552,141...2,555,041
Ensembl chr 6:2,552,862...2,554,367
JBrowse link
G FOXO3 forkhead box O3 ISO protein:increased expression:myocardium:
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:16467659 PMID:23954404 RGD:10402201 NCBI chr 1:74,626,673...74,760,323
Ensembl chr 1:74,628,217...74,760,328
JBrowse link
G FTL ferritin light chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 6:54,231,121...54,232,756
Ensembl chr 6:54,227,164...54,232,752
JBrowse link
G FTO FTO alpha-ketoglutarate dependent dioxygenase susceptibility ISO CTD Direct Evidence: marker/mechanism OMIM
CTD
PMID:17496892 PMID:19079260 PMID:19079261 PMID:19151714 PMID:19918250 More... NCBI chr 6:31,177,112...31,564,674
Ensembl chr 6:31,174,569...31,564,707
JBrowse link
G FXN frataxin ISO DNA:deletion:exon (mouse) RGD PMID:17404227 RGD:2307045 NCBI chr 1:222,412,485...222,433,224
Ensembl chr 1:222,412,500...222,461,943
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase ISO mRNA, protein:increased expression:white fat
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:liver
RGD PMID:15923630 PMID:19230846 RGD:2307340 RGD:2307347 NCBI chr  X:125,029,147...125,041,040
Ensembl chr  X:125,025,257...125,041,033
JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO DNA:polymorphism:3' utr:1519T>C, abdominal obesity and hypercortisolism RGD PMID:12080446 RGD:1626491 NCBI chr16:61,855,698...61,872,503
Ensembl chr16:61,856,212...61,872,359
JBrowse link
G GAL galanin and GMAP prepropeptide no_association ISO protein:increased expression:plasma RGD PMID:11220530 PMID:15930442 RGD:1624334 RGD:1625748 NCBI chr 2:4,351,113...4,357,167
Ensembl chr 2:4,350,909...4,357,170
JBrowse link
G GALP galanin like peptide ISO mRNA:decreased expression:arcuate nucleus RGD PMID:15256810 RGD:2313739 NCBI chr 6:60,485,612...60,493,591
Ensembl chr 6:60,485,596...60,495,074
JBrowse link
G GALR1 galanin receptor 1 no_association ISO RGD PMID:15930442 RGD:1625748 NCBI chr 1:147,442,977...147,466,731
Ensembl chr 1:147,443,821...147,463,542
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase treatment ISO RGD PMID:27987997 RGD:13792668 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,680...64,133,991
JBrowse link
G GAS7 growth arrest specific 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19270708 NCBI chr12:54,752,436...54,974,535
Ensembl chr12:54,752,507...54,973,515
JBrowse link
G GCG glucagon ISO CTD Direct Evidence: therapeutic CTD PMID:20065960 NCBI chr15:68,800,557...68,810,268
Ensembl chr15:68,800,561...68,810,244
JBrowse link
G GCKR glucokinase regulator no_association ISO DNA:mutations:CDS:no association with mutations P446L, R590Y, R227X or R518Q in obese French patients despite localization of gene within a QTL for obesity-related phenotypes RGD PMID:12739015 RGD:1626607 NCBI chr 3:111,649,557...111,683,539
Ensembl chr 3:111,644,158...111,683,660
JBrowse link
G GFPT1 glutamine--fructose-6-phosphate transaminase 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:11118009 PMID:20882379 RGD:1625423 NCBI chr 3:73,028,750...73,086,191
Ensembl chr 3:72,983,188...73,085,319
JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO OMIM NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,316,436...66,452,917
JBrowse link
G GHSR growth hormone secretagogue receptor ISO DNA:point mutation:exon:F279L RGD PMID:16511600 RGD:1625270 NCBI chr13:110,981,465...111,006,149
Ensembl chr13:110,981,604...111,107,423
JBrowse link
G GIP gastric inhibitory polypeptide ISO protein:increased expression:plasma (rat)
associated with Polycystic Ovary Syndrome; protein:increased expression:plasma (human)
RGD PMID:3546047 PMID:18063845 PMID:19375579 RGD:2312547 RGD:2312551 RGD:2312588 NCBI chr12:25,160,783...25,167,952
Ensembl chr12:25,160,789...25,167,940
JBrowse link
G GIPR gastric inhibitory polypeptide receptor susceptibility ISO DNA:polymorphism:intron 1 C>A (rs2302382) (human)
mRNA:reduced expression:fat tissue (human)
mRNA:splice variant:pancreatic islet (mouse)
RGD PMID:12068290 PMID:17395281 PMID:17971513 PMID:19254363 RGD:2312612 RGD:2312615 RGD:2312616 RGD:737714 NCBI chr 6:52,022,667...52,033,959
Ensembl chr 6:52,022,681...52,033,954
JBrowse link
G GJA5 gap junction protein alpha 5 ISO mRNA, protein:decreased expression:mesenteric artery RGD PMID:18324386 RGD:7207466 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,288
JBrowse link
G GLDC glycine decarboxylase ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:10873393 PMID:11286506 PMID:12126939 PMID:15670722 PMID:15791207 More... NCBI chr 1:215,608,854...215,715,062
Ensembl chr 1:215,608,849...215,715,061
JBrowse link
G GLP1R glucagon like peptide 1 receptor ISO mRNA:decreased expression:hypothalamus medial zone RGD PMID:15279492 RGD:1624351 NCBI chr 7:34,497,779...34,534,356
Ensembl chr 7:34,497,759...34,534,629
JBrowse link
G GLRX glutaredoxin ISO protein:increased expression:renal visceral adipose: RGD PMID:23404913 RGD:9686064 NCBI chr 2:102,425,580...102,437,851 JBrowse link
G GLUL glutamate-ammonia ligase ISO CTD Direct Evidence: marker/mechanism
protein:increased activity:skeletal muscle:activity is increased in Zucker fa/fa genetically obese but not dietary obese (fa/?) rats vs non-obese (fa/?) rats
CTD
RGD
PMID:15481771 PMID:20882379 RGD:2301479 NCBI chr 9:123,751,551...123,762,575
Ensembl chr 9:123,751,548...123,762,547
JBrowse link
G GNAS GNAS complex locus ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Obesity
associated with Polycystic Ovary Syndrome;DNA:polymorphism: :393T>C (human)
CTD
ClinVar
RGD
PMID:17062894 PMID:25741868 RGD:11568045 NCBI chr17:58,985,580...59,053,022
Ensembl chr17:58,998,981...59,053,021
JBrowse link
G GNB3 G protein subunit beta 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15961981 PMID:16141801 NCBI chr 5:63,863,656...63,871,352
Ensembl chr 5:63,863,661...63,870,433
JBrowse link
G GNPDA2 glucosamine-6-phosphate deaminase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19079261 NCBI chr 8:35,192,509...35,219,527
Ensembl chr 8:35,134,652...35,219,476
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 ISO protein:increased expression:skeletal muscle tissue, T-tubule (rat) RGD PMID:23743348 RGD:11041118 NCBI chr 6:20,407,203...20,431,849
Ensembl chr 6:20,407,198...20,432,068
JBrowse link
G GPAM glycerol-3-phosphate acyltransferase, mitochondrial ISO mRNA:increased expression:pancreatic islet RGD PMID:9032096 RGD:2313659 NCBI chr14:122,538,600...122,582,390
Ensembl chr14:122,538,600...122,724,131
JBrowse link
G GPR17 G protein-coupled receptor 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34144038 NCBI chr15:59,692,992...59,702,513
Ensembl chr15:59,692,992...59,701,266
JBrowse link
G GPT2 glutamic--pyruvic transaminase 2 ISO protein:increased expression, activity:liver: RGD PMID:25865565 RGD:11342811 NCBI chr 6:37,625,428...37,669,695
Ensembl chr 6:37,625,105...37,669,669
JBrowse link
G GPX1 glutathione peroxidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15184668 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GPX3 glutathione peroxidase 3 ISO mRNA:decreased expression:adipose tissue (rat)
protein:decreased expression, activity:plasma (mouse)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:11328671 PMID:18562625 PMID:19212806 PMID:19270708 RGD:2307430 RGD:2312633 NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026
JBrowse link
G GRIA4 glutamate ionotropic receptor AMPA type subunit 4 ISO ClinVar Annotator: match by term: Obesity ClinVar NCBI chr 9:35,442,060...35,803,989
Ensembl chr 9:35,441,999...35,805,361
JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase ISO protein:increased expression:skeletal muscle
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:16088331 PMID:20882379 RGD:2302228 NCBI chr 8:113,952,561...114,005,510
Ensembl chr 8:113,950,033...114,005,512
JBrowse link
G HCRT hypocretin neuropeptide precursor ISO mRNA:increased expression:perifornical nucleus
CTD Direct Evidence: marker/mechanism
protein:decreased expression:plasma:orexin A NOT orexin B polypeptide, expression inversely related to degree of obesity
protein:increased expression:plasma:fasting patients, no change after weight loss due to gastric banding
RGD
CTD
PMID:12560202 PMID:15970339 PMID:16135994 PMID:27071101 RGD:1358428 RGD:1600932 RGD:1600933 NCBI chr12:20,588,597...20,589,991
Ensembl chr12:20,581,022...20,589,988
JBrowse link
G HDAC4 histone deacetylase 4 ISO mRNA,protein:decreased expression:mononuclear cell, adipose tissue: RGD PMID:24086512 RGD:9681453 NCBI chr15:138,378,237...138,657,266
Ensembl chr15:138,381,627...138,614,301
JBrowse link
G HFE homeostatic iron regulator ISO associated with Diabetes Mellitus, Type 2;DNA:missense mutations:CDS:p.C282Y, p.H63D (human) RGD PMID:10705106 RGD:1601449 NCBI chr 7:20,758,604...20,767,004
Ensembl chr 7:20,758,741...20,768,741
JBrowse link
G HGF hepatocyte growth factor ISO protein:increased expression:serum RGD PMID:12706940 RGD:1642704 NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,437,087...98,513,156
JBrowse link
G HK1 hexokinase 1 susceptibility ISO RGD PMID:131232 PMID:12524468 RGD:1601527 RGD:1601528 NCBI chr14:72,383,328...72,460,927
Ensembl chr14:72,351,149...72,460,925
JBrowse link
G HK2 hexokinase 2 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:gastrocnemius
CTD
RGD
PMID:11319725 PMID:16555472 PMID:20882379 RGD:1624365 RGD:2313227 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,145,890...68,231,615
JBrowse link
G HMGA2 high mobility group AT-hook 2 ISO RGD PMID:10742101 RGD:1601569 NCBI chr 5:30,188,521...30,329,635 JBrowse link
G HMGB2 high mobility group box 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr14:16,709,966...16,712,288
Ensembl chr14:16,710,047...16,717,126
JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO protein:decreased activity:liver (rat) RGD PMID:1685984 RGD:2326155 NCBI chr16:27,936,225...27,957,261
Ensembl chr16:27,936,217...27,957,194
JBrowse link
G HMOX1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18334666 PMID:18375438 PMID:19171794
G HOXB5 homeobox B5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22484627 NCBI chr12:24,845,224...24,849,639
Ensembl chr12:24,845,225...24,847,845
JBrowse link
G HP haptoglobin treatment ISO protein:increased expression:serum
mRNA:increased expression:white fat
RGD PMID:11807829 PMID:15181041 PMID:17161237 PMID:19917068 RGD:1626339 RGD:1626346 RGD:1626349 RGD:9685197 NCBI chr 6:14,980,382...14,985,245 JBrowse link
G HRH3 histamine receptor H3 ISO RGD PMID:17189541 RGD:1626405 NCBI chr17:61,622,865...61,627,278
Ensembl chr17:61,622,703...61,627,633
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:adipose tissue:13-fold higher in obese subjects than controls, protein expression also increased
CTD
RGD
PMID:15131764 PMID:16612591 PMID:16914598 PMID:17628001 PMID:21786805 RGD:1625071 RGD:1625072 RGD:1625073 NCBI chr 9:133,231,451...133,278,396
Ensembl chr 9:133,231,451...133,278,396
JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 resistance ISO transgenic mice expressing human HSD11B2
mRNA:increased expression:adipose tissue:subcutaneous not retroperitoneal fat
RGD PMID:15793240 PMID:17208436 RGD:1625081 RGD:1625083 NCBI chr 6:28,084,087...28,089,256
Ensembl chr 6:28,083,955...28,089,672
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26655953 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B ISO protein:increase expression:arcuate nucleus RGD PMID:10564740 RGD:1626450 NCBI chr 1:88,597,510...88,598,682
Ensembl chr 1:88,596,215...88,601,047
JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A susceptibility
no_association
ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter:-1438G>A
CTD
RGD
PMID:16328014 PMID:16491645 PMID:17097612 RGD:1624369 RGD:1624370 NCBI chr11:20,555,939...20,620,225
Ensembl chr11:20,555,961...20,619,629
JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C susceptibility ISO associated with Schizophrenia and Psychotic Disorders;DNA:polymorphisms:promoter:multiple
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter:-759C>T
RGD
CTD
PMID:15048662 PMID:17016522 PMID:17702092 PMID:19142110 RGD:1624982 RGD:1624991 NCBI chr  X:94,053,415...94,313,352
Ensembl chr  X:94,053,456...94,313,356
JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:submandibular gland (rat)
CTD Direct Evidence: marker/mechanism
protein:increased secretion:plasma (human)
RGD
CTD
PMID:11782876 PMID:20004360 PMID:20973827 RGD:4145329 RGD:4145463 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 ISO RGD PMID:14969338 RGD:1626475 NCBI chr15:111,341,153...111,362,330
Ensembl chr15:111,341,152...111,362,280
JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27020609 NCBI chr17:9,245,283...9,260,140
Ensembl chr17:9,245,196...9,260,491
JBrowse link
G IFNG interferon gamma ISO associated with Asthma;protein:increased expression:serum RGD PMID:19575934 RGD:2311494 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO mRNA:decreased expression:heart (rat) RGD PMID:11009458 RGD:12904882 NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,925...137,690,666
JBrowse link
G IGF2 insulin like growth factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11528401 NCBI chr 2:1,469,183...1,496,417 JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:17259371 PMID:17426323 PMID:22537059 RGD:1626478 RGD:1626479 NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 ISO mRNA, protein:decreased expression:pancreatic fat pad RGD PMID:22067319 RGD:10402755 NCBI chr18:50,002,921...50,009,425 JBrowse link
G IGFBP6 insulin like growth factor binding protein 6 ISO human transgene overexpressed in mouse brain RGD PMID:15889232 RGD:2301717 NCBI chr 5:18,352,884...18,357,225 JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta ISO protein:increased expression:liver: RGD PMID:15685173 RGD:10045952 NCBI chr17:11,289,607...11,348,557
Ensembl chr17:11,289,690...11,348,553
JBrowse link
G IL10 interleukin 10 ISO protein:increase expression:serum RGD PMID:18787467 PMID:28843383 RGD:14975146 RGD:2308945 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G IL15 interleukin 15 ISO mRNA, protein:altered expression:skeletal muscle, plasma RGD PMID:18697873 RGD:2313573 NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,307...85,740,911
JBrowse link
G IL18 interleukin 18 treatment ISO RGD PMID:16732281 PMID:20490358 RGD:14695532 RGD:7175343 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO mRNA, protein:increased expression:adipose tissue RGD PMID:12716739 PMID:12975454 RGD:1626664 RGD:1626665
G IL6 interleukin 6 ISO DNA:polymorphism>promoter:174G>C
mRNA:increased expression:islet of Langerhans
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:16493118 PMID:19228869 PMID:20141834 PMID:21826222 PMID:24042701 RGD:10402828 RGD:1601582 RGD:2307257 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G IL6R interleukin 6 receptor susceptibility ISO DNA:duplication
DNA:SNP, haplotypes:promoter:-208G>A (rs4845617) (human)
protein:increased expression:serum
DNA:polymorphism: :p.D358A
RGD PMID:12917504 PMID:16817825 PMID:17434052 PMID:17984249 RGD:10402807 RGD:1625428 RGD:1625429 RGD:1625430 NCBI chr 4:95,322,426...95,381,393
Ensembl chr 4:95,322,426...95,381,282
JBrowse link
G IL7 interleukin 7 ISO CTD Direct Evidence: therapeutic CTD PMID:20376352 NCBI chr 4:57,677,895...57,744,713
Ensembl chr 4:57,685,069...57,753,797
JBrowse link
G INPP5E inositol polyphosphate-5-phosphatase E treatment ISO protein:increased expression:skeletal muscle, white adipose tissue
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:19668215 PMID:23349329 RGD:12911211
G INPPL1 inositol polyphosphate phosphatase like 1 ISO DNA:SNPs: :rs2276047,snp8,rs9886(human) RGD PMID:15220217 RGD:1626127 NCBI chr 9:6,793,971...6,807,286
Ensembl chr 9:6,792,884...6,808,028
JBrowse link
G INS insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:2777199 PMID:8923850 PMID:11528401 PMID:29035695 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G IRS1 insulin receptor substrate 1 ISO protein:decreased tyrosine phosphorylation, increased serine phosphorylation:skeletal muscle
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:22982470 PMID:23954404 RGD:7207062 NCBI chr15:128,245,846...128,307,321
Ensembl chr15:128,245,846...128,308,335
JBrowse link
G ITGAM integrin subunit alpha M ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chr 3:17,216,719...17,272,134
Ensembl chr 3:17,136,161...17,273,657
JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 ISO RGD PMID:22134356 RGD:11352709 NCBI chr13:34,928,455...34,948,250
Ensembl chr13:34,915,855...34,948,229
JBrowse link
G JAK2 Janus kinase 2 ISO protein:decreased expression:hypothalamus
mRNA:decreased expression:omental adipose tissue:by microarray
RGD PMID:14630696 PMID:23397595 RGD:10411893 RGD:1627661 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,686...217,002,148
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:7889573 PMID:9024139 PMID:9927399 PMID:10753933 PMID:10973849 More... NCBI chr18:6,242,826...6,279,154
Ensembl chr18:6,243,524...6,279,111
JBrowse link
G KCNMA1 potassium calcium-activated channel subfamily M alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27605626 NCBI chr14:79,345,382...80,106,337
Ensembl chr14:79,352,396...80,106,258
JBrowse link
G KCTD15 potassium channel tetramerization domain containing 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19079261 NCBI chr 6:43,528,677...43,545,834
Ensembl chr 6:43,529,806...43,544,186
JBrowse link
G KDM3A lysine demethylase 3A ISO RGD PMID:19875498 RGD:9590220 NCBI chr 3:58,300,109...58,355,000
Ensembl chr 3:58,299,706...58,354,941
JBrowse link
G KDSR 3-ketodihydrosphingosine reductase ISO mRNA, protein:decreased expression:heart left ventricle RGD PMID:18202171 RGD:2293027 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G KIF4A kinesin family member 4A ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:25741868 NCBI chr  X:56,319,453...56,447,560
Ensembl chr  X:56,296,984...56,448,230
JBrowse link
G KITLG KIT ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:23954404 NCBI chr 5:94,016,992...94,110,219
Ensembl chr 5:94,017,384...94,110,216
JBrowse link
G LACTB lactamase beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:18344982 NCBI chr 1:108,909,690...108,924,509
Ensembl chr 1:108,909,690...108,924,511
JBrowse link
G LBP lipopolysaccharide binding protein treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19917068 PMID:23349936 RGD:9685197 NCBI chr17:41,398,935...41,429,467
Ensembl chr17:41,393,818...41,429,551
JBrowse link
G LCN2 lipocalin 2 ISO mRNA:increased expression:epididymal fat pad, adipose cell (rat)
protein:increased expression:serum
mRNA:decreased expression:ovary, testicle
RGD PMID:18292240 PMID:21143924 PMID:32627017 RGD:126790490 RGD:126790530 RGD:2316514 NCBI chr 1:268,609,975...268,614,651 JBrowse link
G LDLR low density lipoprotein receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25554529 NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,823
JBrowse link
G LEP leptin no_association
treatment
ISO protein:increased expression:serum
CTD Direct Evidence: marker/mechanism|therapeutic
ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity
in a US Caucasian population
mouse protein in a rat model
DNA:nonsense mutation:cds:
RGD
CTD
ClinVar
PMID:7624776 PMID:9202122 PMID:9502777 PMID:9826672 PMID:10029567 More... RGD:10053612 RGD:10053638 RGD:12904911 RGD:1643130 RGD:2311132 RGD:2311134 RGD:5128551 RGD:5128629 RGD:8549777 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,447
JBrowse link
G LEPR leptin receptor disease_progression
sexual_dimorphism
treatment
no_association
susceptibility
ISO DNA:missense mutation:CDS:p.Q269P (rat)
compared to age-matched lean +/fa rats
compared to BN
compared to heterozygous controls +/fa
ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity
ClinVar Annotator: match by term: Obesity
mRNA:decreased expression:lung
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:exon:p.Q223R (human)
protein:increased expression:hippocampus, astrocyte
RGD
ClinVar
CTD
PMID:3519326 PMID:8666155 PMID:8702432 PMID:8841178 PMID:9545018 More... RGD:10411891 RGD:10412018 RGD:10412023 RGD:10412038 RGD:12910507 RGD:12911217 RGD:1600612 RGD:5128855 RGD:5129154 RGD:628581 RGD:628910 RGD:729297 RGD:7365117 NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,798,979...146,896,108
JBrowse link
G LEPROT leptin receptor overlapping transcript ISO ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity ClinVar PMID:28492532 NCBI chr 6:146,974,641...146,987,261
Ensembl chr 6:146,974,633...146,987,363
JBrowse link
G LIPC lipase C, hepatic type ISO protein:altered expression:liver, plasma (rat)
associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:plasma (human)
RGD PMID:11544558 PMID:12843191 RGD:2308784 RGD:2308835 NCBI chr 1:113,433,684...113,604,139
Ensembl chr 1:113,433,679...113,604,306
JBrowse link
G LIPE lipase E, hormone sensitive type ISO mRNA:decreased expression:white fat RGD PMID:17712951 RGD:2313580 NCBI chr 6:49,543,671...49,560,126
Ensembl chr 6:49,540,907...49,560,126
JBrowse link
G LIPG lipase G, endothelial type ISO protein:increased expression:plasma RGD PMID:16772345 RGD:1641819 NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,876
JBrowse link
G LOC100516390 ankyrin repeat domain-containing protein 26 ISO RGD PMID:18162531 RGD:9681744 NCBI chr10:48,694,806...48,795,783 JBrowse link
G LOC106504546 serpin A12 treatment ISO RGD PMID:16030142 RGD:1547845 NCBI chr 7:115,720,892...115,734,810
Ensembl chr 7:115,720,677...115,734,816
JBrowse link
G LOC110255234 liver carboxylesterase-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:20975297
G LOC110256000 membrane primary amine oxidase-like ISO RGD PMID:17977742 RGD:2313916 NCBI chr12:19,996,324...20,007,006 JBrowse link
G LOC110258578 interleukin-1 beta-like treatment ISO protein:increased expression:kidney (rat)
protein:increased expression:plasma (mouse)
RGD PMID:16567518 PMID:20490358 PMID:23150506 PMID:24146106 PMID:28843383 RGD:10450599 RGD:14975146 RGD:1626637 RGD:7175086 RGD:7175343
G LPL lipoprotein lipase treatment ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:white fat
CTD
RGD
PMID:17712951 PMID:18344982 PMID:18952837 PMID:27160499 PMID:28514832 RGD:13793401 RGD:13794378 RGD:2313300 RGD:2313580 NCBI chr14:4,104,761...4,134,964
Ensembl chr14:4,104,772...4,135,814
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO protein:increased phosphorylation:endometrium (human) RGD PMID:20074784 RGD:13782055 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO protein:increased phosphorylation:endometrium (human) RGD PMID:20074784 RGD:13782055 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPT microtubule associated protein tau ISO RGD PMID:25257559 RGD:13800921 NCBI chr12:17,098,259...17,211,483
Ensembl chr12:17,095,587...17,211,368
JBrowse link
G MBL2 mannose binding lectin 2 ISO DNA:missense mutations:cds:p.R52C, p.G57E (human) RGD PMID:16955210 RGD:4889156 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,894...97,108,936
JBrowse link
G MC3R melanocortin 3 receptor susceptibility ISO ClinVar Annotator: match by term: Body mass index quantitative trait locus 9
CTD Direct Evidence: marker/mechanism
DNA:point mutation:I183N
OMIM
ClinVar
CTD
RGD
PMID:11889220 PMID:15276649 PMID:15292330 PMID:18231126 PMID:21047972 RGD:1625178 NCBI chr17:56,868,525...56,869,605
Ensembl chr17:56,868,525...56,869,605
JBrowse link
G MC4R melanocortin 4 receptor ISO mRNA:decreased expression:hypothalamus (rat)
ClinVar Annotator: match by term: Obesity
DNA:nonsense mutation:cds:p.K314X (rat)
ClinVar Annotator: match by term: Obesity, autosomal dominant
CTD Direct Evidence: marker/mechanism
RGD
ClinVar
CTD
PMID:9019399 PMID:9267995 PMID:10078568 PMID:10199800 PMID:10577903 More... RGD:13825242 RGD:1600756 RGD:6478803 RGD:6484144 RGD:6484210 NCBI chr 1:160,772,013...160,774,124
Ensembl chr 1:160,772,013...160,774,124
JBrowse link
G MCHR1 melanin concentrating hormone receptor 1 ISO mRNA:increased expression:hypothalamus RGD PMID:15363890 RGD:1624360 NCBI chr 5:7,735,752...7,752,006
Ensembl chr 5:7,735,823...7,738,701
JBrowse link
G ME1 malic enzyme 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19270708 NCBI chr 1:82,799,878...82,989,895
Ensembl chr 1:82,794,964...82,991,104
JBrowse link
G MFN2 mitofusin 2 ISO mRNA:decreased expression:skeletal muscle tissue (human)
mRNA:decreased expression:liver (rat)
RGD PMID:12598526 PMID:25336449 RGD:12880438 RGD:1601412 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,026,722...72,056,439
JBrowse link
G MGRN1 mahogunin ring finger 1 ISO RGD PMID:16638826 RGD:1641947 NCBI chr 3:37,694,798...37,748,106
Ensembl chr 3:37,689,708...37,748,068
JBrowse link
G MIF macrophage migration inhibitory factor ISO DNA:polymorphisms:promoter
mRNA, protein:increased expression:mononuclear cell, plasma
RGD PMID:15472203 PMID:16247506 RGD:1641950 RGD:1641953 NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,862,317
JBrowse link
G MIR107 microRNA mir-107 ISO RNA:decreased expression:liver: RGD PMID:21120623 RGD:14975298 NCBI chr14:101,420,743...101,420,829
Ensembl chr14:101,420,743...101,420,829
JBrowse link
G MIR125A microRNA mir-125a ISO RNA:decreased expression:liver RGD PMID:31988048 RGD:21403676 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645
JBrowse link
G MIR130A microRNA mir-130a ISO CTD Direct Evidence: marker/mechanism CTD PMID:28242765 NCBI chr 2:13,296,695...13,296,773
Ensembl chr 2:13,296,695...13,296,773
JBrowse link
G MIR155 microRNA mir-155 ISO miRNA:decreased expression:serum RGD PMID:27856635 PMID:28970282 PMID:29479888 RGD:21079445 RGD:21079446 RGD:24922220 NCBI chr13:189,138,822...189,138,902
Ensembl chr13:189,138,822...189,138,902
JBrowse link
G MIR184 microRNA mir-184 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23954404 NCBI chr 7:48,345,017...48,345,099
Ensembl chr 7:48,345,017...48,345,099
JBrowse link
G MIR21 microRNA mir-21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23954404 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358
JBrowse link
G MKKS MKKS centrosomal shuttling protein no_association ISO unlikely to play a major role in the pathogenesis of nonsyndromic obesity
protein:substitution:A242S possible contribution
RGD PMID:10973251 PMID:15483080 RGD:1581208 RGD:1601414 NCBI chr17:19,341,024...19,363,007
Ensembl chr17:19,340,977...19,362,871
JBrowse link
G MMP19 matrix metallopeptidase 19 ISO mRNA:increased expression:adipose tissue RGD PMID:12529376 PMID:15169894 RGD:1642022 RGD:1642023 NCBI chr 5:21,279,514...21,285,943
Ensembl chr 5:21,280,130...21,285,774
JBrowse link
G MMP9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma
CTD
RGD
PMID:17512313 PMID:21156398 RGD:1642026 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264
JBrowse link
G MMUT methylmalonyl-CoA mutase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 7:43,597,313...43,624,603
Ensembl chr 7:43,597,292...43,624,609
JBrowse link
G MRAP2 melanocortin 2 receptor accessory protein 2 susceptibility ISO ClinVar Annotator: match by term: Obesity
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
CTD
PMID:23869016 NCBI chr 1:53,248,311...53,318,111
Ensembl chr 1:53,256,006...53,318,107
JBrowse link
G MRC1 mannose receptor C-type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chr10:44,107,926...44,226,734
Ensembl chr10:44,107,072...44,244,410
JBrowse link
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 ISO DNA:missense mutation: :p.A64V (human) RGD PMID:16060290 RGD:2300401 NCBI chr MT:3,922...4,876
Ensembl chr MT:3,922...4,876
JBrowse link
G MT3 metallothionein 3 ISO RGD PMID:21726645 RGD:6480475 NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,721...18,789,137
JBrowse link
G MTCH2 mitochondrial carrier 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19079261 NCBI chr 2:14,982,991...15,005,214
Ensembl chr 2:14,983,154...15,005,213
JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO mRNA, protein:decreased expression:hypothalamus RGD PMID:25807795 RGD:11570513 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
G MTTP microsomal triglyceride transfer protein susceptibility ISO DNA:polymorphisms RGD PMID:15635487 RGD:1625486 NCBI chr 8:120,820,660...120,871,468
Ensembl chr 8:120,819,142...120,879,388
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISO mRNA:decreased expression:pancreas (rat) RGD PMID:22421529 RGD:7240547 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G MYH9 myosin heavy chain 9 ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:25741868 PMID:31064749 NCBI chr 5:11,365,603...11,456,475 JBrowse link
G MYOD1 myogenic differentiation 1 ISO mRNA:decreased expression:plantaris RGD PMID:18508911 PMID:22349736 RGD:2313320 RGD:9686079 NCBI chr 2:41,422,522...41,424,236
Ensembl chr 2:41,415,735...41,425,234
JBrowse link
G MYOG myogenin ISO mRNA:decreased expression:plantaris RGD PMID:18508911 RGD:2313320 NCBI chr 9:113,783,233...113,785,312
Ensembl chr 9:113,782,469...113,785,362
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum
CTD
RGD
PMID:17618961 PMID:23834033 RGD:1642336 NCBI chr 9:106,119,896...106,162,126
Ensembl chr 9:106,119,899...106,294,587
JBrowse link
G NCF2 neutrophil cytosolic factor 2 ISO protein:increased expression:artery RGD PMID:17515452 RGD:2314435 NCBI chr 9:124,776,516...124,813,358
Ensembl chr 9:124,773,498...124,812,928
JBrowse link
G NCOA3 nuclear receptor coactivator 3 ISO DNA:polymorphism:CDS:C-terminus polyglutamine repeat, combination of long polyglutamine repeat in NCOA3 and homozygous A1/A1 Progesterone Receptor genotype associated with obesity in 301 postmenopausal women with breast cancer RGD PMID:14557830 RGD:1642050 NCBI chr17:49,528,275...49,660,471
Ensembl chr17:49,528,164...49,663,203
JBrowse link
G NDUFB6 NADH:ubiquinone oxidoreductase subunit B6 ISO mRNA:decreased expression:epididymal fat pad RGD PMID:20559011 RGD:13822707 NCBI chr10:33,849,206...33,865,080
Ensembl chr10:33,470,106...33,865,231
JBrowse link
G NEGR1 neuronal growth regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19079261 NCBI chr 6:140,780,397...141,652,414
Ensembl chr 6:140,780,452...141,647,813
JBrowse link
G NEIL1 nei like DNA glycosylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16446448 PMID:21285402 NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,761...58,283,092
JBrowse link
G NEUROD1 neuronal differentiation 1 ISO mRNA:increased expression:pancreas RGD PMID:15979049 RGD:1625044 NCBI chr15:87,175,629...87,179,953
Ensembl chr15:87,175,764...87,179,961
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 ISO protein:decreased expression:hepatocyte:
protein:decreased expression:liver macrophage:
RGD PMID:32102936 RGD:21201281 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NHLH2 nescient helix-loop-helix 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20808804 NCBI chr 4:104,852,287...104,858,042
Ensembl chr 4:104,857,635...104,858,042
JBrowse link
G NMB neuromedin B susceptibility ISO protein:increased expression:central hypothalamus:concentrations higher in obese (fa/fa) than in lean (Fa/?) male Zucker rats, not affected by weight loss
DNA:polymorphism:CDS:217C>A, amino acid P73T, associated with disinhibition toward food (p=0.03), susceptibility to hunger (p=0.01) and increased percent body fat (p<0.05)
DNA:polymorphism:CDS:401G>A, silent mutation in stop codon, associated with body weight (p=0.02)
RGD PMID:1709601 PMID:11194934 PMID:15585758 RGD:1642059 RGD:1642062 RGD:1642063 NCBI chr 7:52,880,817...52,886,651 JBrowse link
G NMU neuromedin U susceptibility ISO DNA:polymorphisms:cds:p.R165W,p.A19E RGD PMID:15448684 PMID:16984985 PMID:17706946 RGD:1642093 RGD:1642094 RGD:1642095 NCBI chr 8:54,952,333...54,978,577
Ensembl chr 8:54,952,339...54,978,574
JBrowse link
G NNT nicotinamide nucleotide transhydrogenase ISO protein:decreased expression:gastrocnemius, soleus RGD PMID:25761734 RGD:13513980 NCBI chr16:28,157,192...28,248,732
Ensembl chr16:28,157,307...28,250,961
JBrowse link
G NOS1 nitric oxide synthase 1 ISO RGD PMID:16316351 RGD:1642132 NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,972
JBrowse link
G NOS2 nitric oxide synthase 2 ISO protein:increased expression:sputum
protein:increased expression:liver, gastrocnemius muscle, adipose tissue (mouse)
RGD PMID:18098375 PMID:21896669 RGD:4891935 RGD:5509059 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,944...44,327,111
JBrowse link
G NOS3 nitric oxide synthase 3 treatment ISO protein:decreased expression:artery RGD PMID:17623751 PMID:29180887 RGD:13504728 RGD:2292133 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G NPC1 NPC intracellular cholesterol transporter 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19151714 NCBI chr 6:108,403,126...108,450,486
Ensembl chr 6:108,402,877...108,450,990
JBrowse link
G NPPA natriuretic peptide A ISO associated with Heart Failure; RGD PMID:23566312 RGD:7247714 NCBI chr 6:71,919,557...71,921,345
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G NPPB natriuretic peptide B ISO associated with Diabetes Mellitus, Type 2
mRNA:decreased expression:heart
RGD PMID:21959345 PMID:24009719 RGD:5685647 RGD:7327171 NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G NPY neuropeptide Y ISO mRNA, protein:increased expression:hypothalamus RGD PMID:17447163 RGD:10448938 NCBI chr18:47,985,796...47,993,726
Ensembl chr18:47,985,725...47,993,289
JBrowse link
G NPY1R neuropeptide Y receptor Y1 susceptibility ISO associated with Hyperinsulinemia
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:hypothalamus
RGD
CTD
PMID:9861026 PMID:17447163 PMID:20975297 RGD:10448938 RGD:1642306 NCBI chr 8:52,152,649...52,163,080
Ensembl chr 8:52,152,651...52,162,943
JBrowse link
G NPY2R neuropeptide Y receptor Y2 ISO mRNA:increased expression:hypothalamus
DNA:SNP:promoter:−4448C>A, NCBI refSNP ID=rs12649641; Danish white subjects
RGD PMID:17019604 PMID:17447163 RGD:10448938 RGD:1642379 NCBI chr 8:74,039,959...74,048,398
Ensembl chr 8:74,039,609...74,047,817
JBrowse link
G NPY5R neuropeptide Y receptor Y5 susceptibility ISO mRNA:increased expression:hypothalamus
DNA:polymorphisms
CTD Direct Evidence: marker/mechanism
RGD
CTD
PMID:10849579 PMID:17447163 RGD:10448938 RGD:1625493 NCBI chr 8:52,173,906...52,183,336
Ensembl chr 8:52,174,299...52,183,334
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17405841 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 ISO OMIM NCBI chr 6:84,225,670...84,228,156
Ensembl chr 6:84,225,694...84,228,094
JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 disease_progression ISO mRNA:increased expression:liver (rat)
DNA:polymorphism:multiple
RGD PMID:17108812 PMID:20939869 PMID:25612518 RGD:13506790 RGD:15045599 RGD:1626248 NCBI chr 6:55,238,536...55,245,457
Ensembl chr 6:55,237,953...55,245,456
JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 disease_progression ISO DNA:polymorphism:multiple
mRNA:increased expression:liver (rat)
RGD PMID:17108812 PMID:25612518 RGD:15045599 RGD:1626248 NCBI chr 2:15,315,283...15,336,785
Ensembl chr 2:15,270,789...15,334,820
JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 disease_progression ISO mRNA:increased expression:liver (rat) RGD PMID:25612518 RGD:15045599 NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,288...83,684,604
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20869355 NCBI chr13:140,373,571...140,406,129
Ensembl chr13:140,364,075...140,406,112
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20869355 NCBI chr 4:89,226,314...89,231,781
Ensembl chr 4:89,226,690...89,236,450
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 no_association ISO protein:polymorphism:N363S
associated with Depressive Disorder, Major;DNA:SNP:intron:IVS2+646C>G (human)
RGD PMID:16725041 PMID:18246526 PMID:20723946 RGD:1601498 RGD:4892206 RGD:7174717 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,937...144,956,095
JBrowse link
G NRXN1 neurexin 1 ISO ClinVar Annotator: match by term: Obesity ClinVar NCBI chr 3:89,799,426...90,914,205
Ensembl chr 3:89,799,543...90,914,205
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Obesity
CTD
ClinVar
PMID:15494731 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,379...30,429,882
JBrowse link
G NUCB2 nucleobindin 2 ISO protein:increased expression:adipose tissue: RGD PMID:22641054 RGD:9831187 NCBI chr 2:41,782,594...41,829,829 JBrowse link
G NUDC nuclear distribution C, dynein complex regulator ISO ClinVar Annotator: match by term: Obesity, mild, early-onset ClinVar PMID:11136233 NCBI chr 6:84,238,695...84,252,046
Ensembl chr 6:84,237,737...84,252,046
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29709520 NCBI chr13:66,038,669...66,045,478 JBrowse link
G OTC ornithine transcarbamylase ISO protein:increased activity:liver (rat) RGD PMID:1330956 RGD:4144087 NCBI chr  X:34,322,398...34,391,711
Ensembl chr  X:34,322,298...34,391,837
JBrowse link
G OXCT1 3-oxoacid CoA-transferase 1 ISO mRNA:decreased expression:thalamus (rat) RGD PMID:19219059 RGD:2326191 NCBI chr16:26,514,497...26,659,739
Ensembl chr16:26,512,396...26,659,845
JBrowse link
G P14ARF p14ARF protein ISO RGD PMID:22194422 RGD:8552660 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,774,496...200,798,854
JBrowse link
G PACS1 phosphofurin acidic cluster sorting protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23563609 NCBI chr 2:6,138,345...6,277,309
Ensembl chr 2:6,138,348...6,211,684
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20561897 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,938,896
JBrowse link
G PCSK1 proprotein convertase subtilisin/kexin type 1 ISO ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity
ClinVar Annotator: match by term: Body mass index quantitative trait locus 12
CTD Direct Evidence: marker/mechanism
RGD
ClinVar
CTD
PMID:9207799 PMID:18604207 PMID:28492532 RGD:1601274 NCBI chr 2:103,004,794...103,050,707
Ensembl chr 2:103,004,794...103,050,839
JBrowse link
G PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor ISO protein:increased expression:brainstem RGD PMID:11680901 PMID:15012590 RGD:1642350 RGD:1642351 NCBI chr  X:42,947,688...42,952,222
Ensembl chr  X:42,947,686...42,952,221
JBrowse link
G PDE3A phosphodiesterase 3A ISO mRNA:decreased expression:heart RGD PMID:9648839 RGD:2300415 NCBI chr 5:52,413,503...52,737,771
Ensembl chr 5:52,413,105...52,738,829
JBrowse link
G PDP1 pyruvate dehydrogenase phosphatase catalytic subunit 1 ISO protein:decreased activity:circulating lymphocytes RGD PMID:15897476 RGD:1642637 NCBI chr 4:42,769,232...42,777,936
Ensembl chr 4:42,764,432...42,777,904
JBrowse link
G PDX1 pancreatic and duodenal homeobox 1 ISO mRNA:increased expression:exocrine pancreas (human) RGD PMID:15979049 RGD:1625044 NCBI chr11:5,303,609...5,309,063
Ensembl chr11:5,303,639...5,310,843
JBrowse link
G PEX11A peroxisomal biogenesis factor 11 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:30585412 NCBI chr 7:55,256,239...55,264,253
Ensembl chr 7:55,255,675...55,320,357
JBrowse link
G PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr10:64,776,315...64,859,118
Ensembl chr10:64,776,315...64,859,051
JBrowse link
G PGF placental growth factor ISO associated with Pre-eclampsia;protein:increased expression:serum
associated with pancreatic cancer;protein:increased expression:plasma (human)
RGD PMID:16020476 PMID:16769024 PMID:26861455 RGD:14349030 RGD:1642384 RGD:1642385 NCBI chr 7:98,149,510...98,162,784 JBrowse link
G PGR progesterone receptor ISO DNA:polymorphism:CDS:PROGINS polymorphism, combination of long polyglutamine repeat in NCOA3 and homozygous A1/A1 PGR PROGINS genotype associated with obesity in 301 postmenopausal women with breast cancer RGD PMID:14557830 RGD:1642050 NCBI chr 9:32,035,684...32,129,776
Ensembl chr 9:32,035,684...32,129,221
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:21949398 RGD:6482700 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO protein:decreased expression:soleus
protein:decreased tyrosine phosphorylation:skeletal muscle, liver
RGD PMID:9399964 PMID:16123202 RGD:1625218 RGD:1625220 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,434,873...46,523,609
JBrowse link
G PKLR pyruvate kinase L/R ISO mRNA, protein:decreased expression:liver RGD PMID:12958186 RGD:1625583 NCBI chr 4:94,536,978...94,546,561
Ensembl chr 4:94,536,954...94,547,591
JBrowse link
G PLAT plasminogen activator, tissue type ISO RGD PMID:12818410 RGD:2311677 NCBI chr17:11,195,599...11,223,821
Ensembl chr17:11,195,602...11,224,032
JBrowse link
G PLAUR plasminogen activator, urokinase receptor ISO RGD PMID:21372607 RGD:6484121 NCBI chr 6:50,489,773...50,505,453
Ensembl chr 6:50,489,777...50,505,418
JBrowse link
G PLIN1 perilipin 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:snp:intron:g.11482G>A (human)
CTD
RGD
PMID:11371650 PMID:15001633 PMID:15985482 RGD:1581041 RGD:737723 NCBI chr 7:55,237,517...55,250,797
Ensembl chr 7:55,235,426...55,250,797
JBrowse link
G PMCH pro-melanin concentrating hormone ISO CTD Direct Evidence: marker/mechanism
associated with Hyperphagia;protein:increased expression:hypothalamus
CTD
RGD
PMID:12355323 PMID:12453827 PMID:15363890 RGD:1624360 RGD:1642486 NCBI chr 5:82,018,915...82,020,267
Ensembl chr 5:82,018,915...82,020,818
JBrowse link
G PNLIP pancreatic lipase susceptibility ISO RGD PMID:15883013 RGD:1358859 NCBI chr14:126,771,920...126,789,097
Ensembl chr14:126,771,920...126,789,160
JBrowse link
G PNPLA3 patatin like phospholipase domain containing 3 ISO RGD PMID:11431482 RGD:14985224 NCBI chr 5:5,075,608...5,092,599
Ensembl chr 5:5,075,622...5,092,515
JBrowse link
G POGZ pogo transposable element derived with ZNF domain ISO ClinVar Annotator: match by term: Obesity ClinVar NCBI chr 4:97,776,579...97,833,287
Ensembl chr 4:97,776,589...97,833,285
JBrowse link
G POMC proopiomelanocortin ISO OMIM NCBI chr 3:113,661,712...113,668,558 JBrowse link
G PON2 paraoxonase 2 ISO protein:increased expression:white adipose tissue RGD PMID:21365757 RGD:8661255 NCBI chr 9:75,027,270...75,051,441
Ensembl chr 9:75,027,097...75,051,422
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:11089532 PMID:30738174 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G PPARD peroxisome proliferator activated receptor delta ISO CTD Direct Evidence: therapeutic CTD PMID:16168052 PMID:20176998 NCBI chr 7:31,222,533...31,295,221
Ensembl chr 7:31,222,589...31,295,212
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma susceptibility ISO DNA:polymorphism OMIM
RGD
PMID:18683148 RGD:2301847 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha treatment ISO mRNA:increased expression:retroperitoneal fat pad (rat) RGD PMID:22401878 PMID:23180161 PMID:23256146 RGD:7241848 RGD:7242011 RGD:7242183 NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,961,909
JBrowse link
G PPARGC1B PPARG coactivator 1 beta resistance ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Obesity, variation in
DNA:polymorphism: :p.A203P
CTD
ClinVar
RGD
PMID:15863669 PMID:30738174 RGD:1642501 NCBI chr 2:150,823,338...150,924,871
Ensembl chr 2:150,823,373...150,919,378
JBrowse link
G PPIA peptidylprolyl isomerase A ISO mRNA:increased expression:blood (human) RGD PMID:32496587 RGD:150383342 NCBI chr18:50,563,130...50,566,857 JBrowse link
G PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L ISO CTD Direct Evidence: marker/mechanism CTD PMID:18344982 NCBI chr13:100,442,445...100,759,968
Ensembl chr13:100,443,210...100,756,054
JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:29367455 NCBI chr12:11,662,344...11,681,490
Ensembl chr12:11,662,347...11,681,202
JBrowse link
G PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20975297 NCBI chr 9:106,851,044...106,957,519
Ensembl chr 9:106,851,018...106,957,519
JBrowse link
G PRKCB protein kinase C beta ISO mRNA, protein:increased expression:mononuclear cell RGD PMID:17180352 RGD:1625512 NCBI chr 3:21,995,227...22,383,628
Ensembl chr 3:21,995,231...22,383,264
JBrowse link
G PRKCD protein kinase C delta ISO protein:decreased expression:heart ventricle RGD PMID:11478406 RGD:1642533 NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,264...35,323,356
JBrowse link
G PRKCH protein kinase C eta ISO CTD Direct Evidence: marker/mechanism CTD PMID:23563609 NCBI chr 1:190,205,041...190,439,433
Ensembl chr 1:190,205,678...190,439,433
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 ISO protein:increased expression:kidney, glomerulus RGD PMID:23454089 RGD:7777114 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,560,785...98,793,318
JBrowse link
G PRL prolactin ISO RGD PMID:8388614 RGD:1642559 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,741
JBrowse link
G PRLH prolactin releasing hormone ISO RGD PMID:15854142 RGD:1641829 NCBI chr15:137,230,209...137,232,178
Ensembl chr15:137,230,247...137,230,954
JBrowse link
G PRLHR prolactin releasing hormone receptor ISO RGD PMID:15854142 RGD:1641829 NCBI chr14:128,617,352...128,619,419
Ensembl chr14:128,614,128...128,619,461
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:liver
CTD
RGD
PMID:21156398 PMID:21978752 RGD:5508307 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10744717 PMID:20075852 NCBI chr17:52,017,100...52,086,747
Ensembl chr17:52,017,104...52,086,736
JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO protein:increased expression, increased activity:subcutaneous adipose tissue:2.03-fold higher activity in obese than lean individuals (P < 0.001)
protein:increased activity, increased expression:skeletal muscle:activity increased to 140-170% of control in insulin-resistant obese (BMI>30) nondiabetic subjects (p<0.05); activity decreased to 39% in obese NIDDM subjects (p<0.05)
protein:increased expression:skeletal muscle:increased 42% in insulin-resistant obese (fa/fa) and 50% in diabetic (ZDF/Drt-fa/fa) Zucker rats (P<0.05)
RGD PMID:7666792 PMID:7769120 PMID:9218523 RGD:1642727 RGD:1642732 RGD:1642733 NCBI chr 6:167,656,674...167,743,750
Ensembl chr 6:167,656,680...167,743,721
JBrowse link
G PYY peptide YY ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Obesity
CTD
ClinVar
PMID:10898754 PMID:11825645 PMID:16368708 NCBI chr12:19,190,703...19,208,373 JBrowse link
G RAI1 retinoic acid induced 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15459175 PMID:19116176 NCBI chr12:60,751,159...60,854,710
Ensembl chr12:60,750,091...60,855,287
JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29273807 NCBI chr 5:78,101,286...78,134,150
Ensembl chr 5:78,101,289...78,134,103
JBrowse link
G RARRES2 retinoic acid receptor responder 2 ISO protein:increased expression:serum: RGD PMID:30873215 PMID:31284705 RGD:15036824 RGD:15036825 NCBI chr18:55,903,693...55,906,976
Ensembl chr18:55,903,699...55,906,945
JBrowse link
G RB1 RB transcriptional corepressor 1 ISO mRNA:decreased expression:adipose tissue RGD PMID:23315497 RGD:8547988 NCBI chr11:19,186,754...19,317,642
Ensembl chr11:19,186,759...19,317,690
JBrowse link
G RBP4 retinol binding protein 4 ISO mRNA, protein:decreased expression:adipose tissue, serum RGD PMID:18401839 RGD:2302016 NCBI chr14:105,037,360...105,044,552
Ensembl chr14:105,036,770...105,044,765
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO RGD PMID:18356846 RGD:2298856 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G REN renin ISO mRNA:increased expression:abdomen, subcutaneous adipose tissue, mesenchymal stem cell (human) RGD PMID:22648117 RGD:6784503 NCBI chr 9:64,809,143...64,822,605
Ensembl chr 9:64,809,146...64,822,636
JBrowse link
G RETN resistin ISO DNA:SNP:promoter:-420C>G (human)
mRNA, protein:increased expression:subcutaneous adipose tissue, serum
RGD PMID:11201732 PMID:17598818 PMID:22816026 RGD:7207072 RGD:7207155 RGD:7207158 NCBI chr 2:71,484,164...71,485,577
Ensembl chr 2:71,484,169...71,485,616
JBrowse link
G RHOA ras homolog family member A ISO protein:increased expression:membrane, aorta, skeletal muscle RGD PMID:16267124 RGD:2298881 NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,836...32,003,722
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 ISO protein:increased phosphorylation:skeletal muscle RGD PMID:15604215 RGD:1642978 NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376
JBrowse link
G RSRC2 arginine and serine rich coiled-coil 2 ISO ClinVar Annotator: match by term: Obesity ClinVar NCBI chr14:30,242,063...30,261,166
Ensembl chr14:30,242,142...30,261,602
JBrowse link
G RXRA retinoid X receptor alpha susceptibility ISO RGD PMID:15936932 RGD:1643104 NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,503...273,797,622
JBrowse link
G RYR1 ryanodine receptor 1 ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:25741868 PMID:28492532 NCBI chr 6:47,339,759...47,458,457 JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr  X:19,908,037...19,910,553
Ensembl chr  X:19,907,900...19,910,895
JBrowse link
G SCAPER S-phase cyclin A associated protein in the ER ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:25741868 PMID:30723319 NCBI chr 7:56,583,247...57,012,312
Ensembl chr 7:56,583,151...57,012,312
JBrowse link
G SDC1 syndecan 1 ISO mRNA:increased expression:liver RGD PMID:11522680 RGD:1643129 NCBI chr 3:117,987,585...118,011,886
Ensembl chr 3:117,987,557...118,011,885
JBrowse link
G SDC3 syndecan 3 ISO OMIM NCBI chr 6:87,495,041...87,535,689
Ensembl chr 6:87,495,041...87,535,845
JBrowse link
G SELP selectin P ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:altered localization:platelet RGD PMID:19228864 RGD:2312291 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,406,203
JBrowse link
G SERPINE1 serpin family E member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23819014 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,564
JBrowse link
G SERPINF1 serpin family F member 1 ISO protein:increased expression:serum (rat) RGD PMID:17491674 PMID:24424059 RGD:2312347 RGD:8633067 NCBI chr12:47,949,004...47,959,471
Ensembl chr12:47,943,051...47,959,472
JBrowse link
G SFTPA1 surfactant protein A1 ISO protein:increased expression:lung RGD PMID:15136884 RGD:4143472 NCBI chr14:82,091,178...82,095,393
Ensembl chr14:82,091,178...82,107,675
JBrowse link
G SFTPB surfactant protein B ISO protein:increased expression:lung RGD PMID:15136884 RGD:4143472 NCBI chr 3:59,101,940...59,113,442
Ensembl chr 3:59,101,952...59,111,834
JBrowse link
G SH2B1 SH2B adaptor protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19079261 NCBI chr 3:18,533,282...18,543,133
Ensembl chr 3:18,524,820...18,543,136
JBrowse link
G SIM1 SIM bHLH transcription factor 1 ISO DNA:translocation
ClinVar Annotator: match by term: Obesity
ClinVar Annotator: match by term: Obesity due to SIM1 deficiency
RGD
ClinVar
PMID:2152513 PMID:10587584 PMID:16924270 PMID:19401419 PMID:21512513 More... RGD:1624165 NCBI chr 1:67,213,685...67,294,455
Ensembl chr 1:67,214,337...67,294,397
JBrowse link
G SIRT1 sirtuin 1 treatment ISO protein:decreased expression:ovary
CTD Direct Evidence: therapeutic
RGD
CTD
PMID:24135502 PMID:24184811 PMID:24773342 RGD:9585762 RGD:9586064 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,157...71,123,299
JBrowse link
G SIRT3 sirtuin 3 ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:21901160 PMID:23956348 RGD:9586047 NCBI chr 2:38,465...55,074
Ensembl chr 2:38,470...55,101
JBrowse link
G SIRT6 sirtuin 6 ISO protein:decreased expression:ovary RGD PMID:24135502 RGD:9586064 NCBI chr 2:74,568,539...74,577,774
Ensembl chr 2:74,568,436...74,577,772
JBrowse link
G SLC10A1 solute carrier family 10 member 1 disease_progression ISO mRNA:increased expression:liver (rat) RGD PMID:25612518 RGD:15045599 NCBI chr 7:93,400,037...93,421,989
Ensembl chr 7:93,397,602...93,421,985
JBrowse link
G SLC16A7 solute carrier family 16 member 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 5:24,713,009...24,871,891
Ensembl chr 5:24,713,267...24,875,003
JBrowse link
G SLC22A1 solute carrier family 22 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20956498 NCBI chr 1:7,340,442...7,365,543
Ensembl chr 1:7,340,116...7,365,520
JBrowse link
G SLC22A2 solute carrier family 22 member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27401566 NCBI chr 1:7,289,278...7,323,418
Ensembl chr 1:7,289,831...7,323,146
JBrowse link
G SLC22A3 solute carrier family 22 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27401566 NCBI chr 1:7,105,486...7,207,395
Ensembl chr 1:7,110,072...7,207,402
JBrowse link
G SLC27A1 solute carrier family 27 member 1 susceptibility ISO DNA:gene knockout::Slc27a1-/- mice resistant to diet-induced obesity and metabolic syndrome
protein:increased expression:soleus muscle, protein:decreased expression:gastrocnemius muscle
RGD PMID:15281014 PMID:16611988 RGD:1642790 RGD:1642794 NCBI chr 2:60,203,374...60,235,689
Ensembl chr 2:60,203,374...60,235,652
JBrowse link
G SLC27A4 solute carrier family 27 member 4 ISO mRNA:increased expression:subcutaneous adipose tissue RGD PMID:15168018 RGD:1625638 NCBI chr 1:268,773,792...268,788,208
Ensembl chr 1:268,756,680...268,788,791
JBrowse link
G SLC2A1 solute carrier family 2 member 1 treatment ISO associated with Polycystic Ovary Syndrome RGD PMID:24842895 RGD:12879503 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,534,655...168,690,095
JBrowse link
G SLC6A1 solute carrier family 6 member 1 ISO RGD PMID:11191352 RGD:1643191 NCBI chr13:67,156,786...67,199,092
Ensembl chr13:67,156,824...67,199,087
JBrowse link
G SLC6A14 solute carrier family 6 member 14 susceptibility ISO DNA:SNPs RGD PMID:15331564 RGD:1625271 NCBI chr  X:95,482,494...95,507,200
Ensembl chr  X:95,482,451...95,527,340
JBrowse link
G SLC6A3 solute carrier family 6 member 3 susceptibility
no_association
ISO DNA:polymorphism RGD PMID:12490667 PMID:16674552 RGD:1625653 RGD:1625655 NCBI chr16:79,186,114...79,220,302
Ensembl chr16:79,186,108...79,220,297
JBrowse link
G SLC9A3 solute carrier family 9 member A3 ISO protein:decreased expression:kidney cortex RGD PMID:16757903 RGD:1625672 NCBI chr16:79,625,555...79,704,084
Ensembl chr16:79,625,262...79,704,082
JBrowse link
G SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:28492532 NCBI chr 2:69,717,175...69,810,301
Ensembl chr 2:69,662,238...69,810,298
JBrowse link
G SOCS1 suppressor of cytokine signaling 1 ISO mRNA, protein:increased expression:white fat RGD PMID:11027633 RGD:2298920 NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,969
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 ISO mRNA:decreased expression:subcutaneous adipose tissue
mRNA, protein:increased expression:white fat
mRNA:altered expression:skeletal muscle, subcutaneous adipose tissue
RGD PMID:11027633 PMID:15331532 PMID:16920065 RGD:1625676 RGD:2298920 RGD:2313790 NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,012
JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24042701 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16317704 PMID:23956348 PMID:30738174 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G SORBS1 sorbin and SH3 domain containing 1 ISO DNA:SNP: :p.T228A (human) RGD PMID:11532984 RGD:1642744 NCBI chr14:106,895,764...107,137,469
Ensembl chr14:106,895,763...107,137,767
JBrowse link
G SPARC secreted protein acidic and cysteine rich ISO mRNA:increased expression:adipose tissue RGD PMID:11294850 RGD:2300062 NCBI chr16:71,368,164...71,380,972
Ensembl chr16:71,357,703...71,381,160
JBrowse link
G SQLE squalene epoxidase ISO RGD PMID:15556298 RGD:1581399 NCBI chr 4:14,669,789...14,700,152
Ensembl chr 4:14,669,791...14,700,126
JBrowse link
G SRD5A1 steroid 5 alpha-reductase 1 ISO mRNA:increased expression:liver (rat) RGD PMID:20098742 RGD:4891511 NCBI chr16:75,309,830...75,335,438 JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10900012 NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,265
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 ISO protein:increased expression:fat cell, nucleus RGD PMID:9786926 RGD:2308843 NCBI chr 5:6,719,484...6,784,724
Ensembl chr 5:6,719,487...6,784,672
JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO protein:decreased phosphorylation:hypothalamus RGD PMID:23397595 RGD:10411893 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
G STAT4 signal transducer and activator of transcription 4 treatment ISO RGD PMID:20978234 RGD:5509594 NCBI chr15:95,656,206...95,764,099
Ensembl chr15:95,653,861...95,763,448
JBrowse link
G STK11 serine/threonine kinase 11 ISO protein:decreased expression:gastrocnemius RGD PMID:16352671 RGD:1601389 NCBI chr 2:77,229,888...77,249,322
Ensembl chr 2:77,230,372...77,249,327
JBrowse link
G STS steroid sulfatase ISO CTD Direct Evidence: therapeutic CTD PMID:24497646 NCBI chr  X:3,926,027...4,076,900
NCBI chr  Y:2,747,102...2,828,322
JBrowse link
G SUCLA2 succinate-CoA ligase ADP-forming subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr11:19,616,415...19,670,667
Ensembl chr11:19,616,499...19,675,791
JBrowse link
G SUCLG2 succinate-CoA ligase GDP-forming subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr13:48,650,851...49,090,521
Ensembl chr13:48,564,073...49,090,468
JBrowse link
G SZT2 SZT2 subunit of KICSTOR complex ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:25741868 NCBI chr 6:167,811,589...167,861,321
Ensembl chr 6:167,811,594...167,861,307
JBrowse link
G TBC1D1 TBC1 domain family member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16893906 PMID:18325908 PMID:18931681 NCBI chr 8:29,370,344...29,590,574
Ensembl chr 8:29,370,481...29,593,274
JBrowse link
G TBX3 T-box transcription factor 3 ISO ClinVar Annotator: match by term: Obesity ClinVar PMID:28492532 NCBI chr14:37,582,704...37,596,767
Ensembl chr14:37,582,822...37,596,767
JBrowse link
G TBXA2R thromboxane A2 receptor ISO mRNA:increased expression:carotid artery RGD PMID:12409963 RGD:1601447 NCBI chr 2:75,068,413...75,081,305
Ensembl chr 2:75,068,698...75,087,731
JBrowse link
G TF transferrin ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:16267817 PMID:20882379 RGD:1601520 NCBI chr13:74,930,655...74,970,599
Ensembl chr13:74,930,655...74,970,599
JBrowse link
G TFAM transcription factor A, mitochondrial ISO RGD PMID:21862610 RGD:5683906 NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,550
JBrowse link
G TFRC transferrin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:17062801 PMID:20882379 NCBI chr13:133,976,765...133,997,554
Ensembl chr13:133,970,594...134,000,278
JBrowse link
G TGFB1 transforming growth factor beta 1 severity ISO protein:increased expression:adipose tissue
protein:increased expression:platelet
associated with hypertension;protein:increased expression:blood
RGD PMID:15944724 PMID:16253647 PMID:16477387 RGD:1601561 RGD:1601563 RGD:1601579 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TH tyrosine hydroxylase resistance ISO DNA:polymorphism:intron:g.1170_1173dupTCAT (human) RGD PMID:16251897 RGD:1601632 NCBI chr 2:1,499,628...1,506,180
Ensembl chr 2:1,499,618...1,506,615
JBrowse link
G THBD thrombomodulin severity ISO protein:increased expression:plasma RGD PMID:16651309 RGD:1601640 NCBI chr17:30,219,870...30,223,499
Ensembl chr17:30,221,819...30,230,177
JBrowse link
G THBS1 thrombospondin 1 ISO mRNA,protein:increased expression:mononuclear cell, adipose tissue: RGD PMID:24086512 RGD:9681453 NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,781...131,746,115
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 ISO protein:increased expression:plasma RGD PMID:17512313 RGD:1642026 NCBI chr  X:42,103,251...42,106,289
Ensembl chr  X:42,102,172...42,106,297
JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:18787058 RGD:2312681 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,991...75,446,850
JBrowse link
G TLR4 toll like receptor 4 susceptibility ISO RGD PMID:17053832 PMID:19144836 RGD:1620653 RGD:2312510 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TMEM18 transmembrane protein 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19079261 NCBI chr 3:132,424,108...132,431,682 JBrowse link
G TNF tumor necrosis factor treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:9502777 PMID:11328671 PMID:20141834 PMID:24146106 PMID:28843383 More... RGD:10450599 RGD:14975146 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO protein:increased expression:serum RGD PMID:12935365 RGD:1624179 NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,073...64,331,909
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:11782876 NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,149
JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17347480 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,701,325
JBrowse link
G TSC1 TSC complex subunit 1 ISO DNA:hypermethylation:promoter RGD PMID:25807795 RGD:11570513 NCBI chr 1:272,636,530...272,685,948
Ensembl chr 1:272,636,532...272,685,952
JBrowse link
G TUB TUB bipartite transcription factor no_association
susceptibility
ISO DNA:splice-site mutation RGD PMID:8612280 PMID:8772727 RGD:1625564 RGD:1625565 NCBI chr 9:1,183,821...1,260,209
Ensembl chr 9:1,183,822...1,278,498
JBrowse link
G UCN urocortin treatment ISO RGD PMID:17932219 RGD:1642774 NCBI chr 3:111,834,082...111,835,932 JBrowse link
G UCP1 uncoupling protein 1 no_association ISO CTD Direct Evidence: marker/mechanism|therapeutic
DNA:polymorphism: :-3826A>G (human)
CTD
RGD
PMID:8968850 PMID:15592485 RGD:1624977 NCBI chr 8:86,522,028...86,526,162 JBrowse link
G UCP2 uncoupling protein 2 susceptibility ISO ClinVar Annotator: match by term: Body mass index quantitative trait locus 4
DNA:polymorphism, insertion:promoter:-866G>A (rs659366)(human)
CTD Direct Evidence: marker/mechanism
OMIM
ClinVar
RGD
CTD
PMID:11381268 PMID:15562023 PMID:17870627 PMID:25741868 RGD:2313512 NCBI chr 9:8,358,559...8,364,552
Ensembl chr 9:8,333,153...8,365,558
JBrowse link
G UCP3 uncoupling protein 3 no_association
susceptibility
ISO DNA:polymorphism:exon (human)
DNA:polymorphism:promoter:-55C>T (human)
OMIM
RGD
PMID:9700198 PMID:18249216 RGD:2313506 RGD:2313526 NCBI chr 9:8,378,023...8,389,452
Ensembl chr 9:8,378,019...8,386,211
JBrowse link
G ULK4 unc-51 like kinase 4 ISO ClinVar Annotator: match by term: Obesity ClinVar NCBI chr13:25,207,890...25,751,465
Ensembl chr13:25,208,065...25,751,500
JBrowse link
G UQCRC2 ubiquinol-cytochrome c reductase core protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20882379 NCBI chr 3:24,197,743...24,228,831
Ensembl chr 3:24,197,745...24,228,832
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:19260948 RGD:2312763 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
G VGF VGF nerve growth factor inducible ISO CTD Direct Evidence: therapeutic CTD PMID:12177191 NCBI chr 3:8,888,502...8,891,399
Ensembl chr 3:8,888,502...8,891,601
JBrowse link
G VLDLR very low density lipoprotein receptor susceptibility ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:11557677 PMID:20975297 RGD:1625568 NCBI chr 1:219,178,501...219,210,332
Ensembl chr 1:219,173,504...219,210,343
JBrowse link
G VWF von Willebrand factor ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma RGD PMID:16631442 PMID:16739871 RGD:1625710 RGD:1625711 NCBI chr 5:64,516,627...64,655,938
Ensembl chr 5:64,519,186...65,002,098
JBrowse link
G WNT10B Wnt family member 10B ISO DNA:SNP:CDS:amino acid C256Y, mutant unable to activate WNT/beta-catenin signaling pathway RGD PMID:16477437 PMID:17578883 RGD:2300029 RGD:2326237 NCBI chr 5:14,997,377...15,013,928
Ensembl chr 5:14,997,381...15,013,919
JBrowse link
G WNT3A Wnt family member 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28242765 NCBI chr 2:51,153,978...51,203,678
Ensembl chr 2:51,154,086...51,202,176
JBrowse link
G XDH xanthine dehydrogenase treatment ISO RGD PMID:7616299 RGD:13210504 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,986,528...108,080,151
JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29273807 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,401...94,798,588
JBrowse link
G ZC3H10 zinc finger CCCH-type containing 10 ISO CTD Direct Evidence: therapeutic CTD PMID:31775033 NCBI chr 5:21,506,510...21,513,972
Ensembl chr 5:21,508,218...21,514,626
JBrowse link
G ZFHX3 zinc finger homeobox 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29273807 NCBI chr 6:15,693,987...15,941,301
Ensembl chr 6:15,698,176...16,023,169
JBrowse link
G ZFR2 zinc finger RNA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29273807 NCBI chr 2:74,845,912...74,899,121
Ensembl chr 2:74,845,921...74,916,379
JBrowse link
G ZNF169 zinc finger protein 169 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29273807 NCBI chr 3:43,503,225...43,561,299
Ensembl chr 3:43,504,685...43,561,290
JBrowse link
Abdominal Obesity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD163 CD163 molecule exacerbates ISO protein:increased expression:blood serum (human) RGD PMID:31027316 RGD:127345132 NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,146...63,334,498
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15199296 NCBI chr 9:133,231,451...133,278,396
Ensembl chr 9:133,231,451...133,278,396
JBrowse link
abdominal obesity-metabolic syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15309680 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO mRNA:increased expression:gastrocnemius muscle (rat) RGD PMID:23320128 RGD:7241841 NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,961,909
JBrowse link
abdominal obesity-metabolic syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO protein:increased oxidation:cardiac muscle cell RGD PMID:23997093 RGD:13782087 NCBI chr14:31,674,659...31,744,981
Ensembl chr14:31,674,757...31,744,973
JBrowse link
G BAX BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G FADD Fas associated via death domain treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 2:3,191,718...3,194,820
Ensembl chr 2:3,186,744...3,194,792
JBrowse link
G FAS Fas cell surface death receptor ISO RGD PMID:30172001 RGD:13792561 NCBI chr14:100,927,305...100,954,781 JBrowse link
G KDSR 3-ketodihydrosphingosine reductase treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G LPL lipoprotein lipase treatment ISO RGD PMID:26996629 RGD:13794382 NCBI chr14:4,104,761...4,134,964
Ensembl chr14:4,104,772...4,135,814
JBrowse link
G MTTP microsomal triglyceride transfer protein ISO OMIM NCBI chr 8:120,820,660...120,871,468
Ensembl chr 8:120,819,142...120,879,388
JBrowse link
G TLR2 toll like receptor 2 susceptibility ISO RGD PMID:19841034 RGD:15090861 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,991...75,446,850
JBrowse link
abdominal obesity-metabolic syndrome 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHDC1 AT-hook DNA binding motif containing 1 ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3 ClinVar PMID:25741868 NCBI chr 6:84,735,253...84,774,554 JBrowse link
G DYRK1B dual specificity tyrosine phosphorylation regulated kinase 1B ISO OMIM NCBI chr 6:48,305,837...48,314,523
Ensembl chr 6:48,305,844...48,314,886
JBrowse link
abdominal obesity-metabolic syndrome 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LIPE lipase E, hormone sensitive type ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 4 ClinVar PMID:25741868 NCBI chr 6:49,543,671...49,560,126
Ensembl chr 6:49,540,907...49,560,126
JBrowse link
Borjeson-Forssman-Lehmann syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PHF6 PHD finger protein 6 ISO OMIM NCBI chr  X:110,249,010...110,311,503
Ensembl chr  X:110,159,873...110,303,017
JBrowse link
CHOPS Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFF4 AF4/FMR2 family member 4 ISO OMIM NCBI chr 2:135,196,067...135,283,931
Ensembl chr 2:135,200,076...135,283,916
JBrowse link
Clark-Baraitser syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRIP12 thyroid hormone receptor interactor 12 ISO OMIM NCBI chr15:130,784,567...130,940,497
Ensembl chr15:130,787,581...130,939,575
JBrowse link
Cohen syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYO7A myosin VIIA ISO ClinVar Annotator: match by term: Cohen syndrome ClinVar PMID:9382091 PMID:24033266 PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr 9:11,251,187...11,337,618
Ensembl chr 9:11,249,075...11,666,296
JBrowse link
G VPS13B vacuolar protein sorting 13 homolog B ISO OMIM NCBI chr 4:37,085,929...37,821,159
Ensembl chr 4:37,090,935...37,820,419
JBrowse link
congenital leptin deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LEP leptin ISO OMIM NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,447
JBrowse link
DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHIC FEATURES term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1 ISO ClinVar Annotator: match by term: DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHIC FEATURES
ClinVar Annotator: match by term: Developmental delay, intellectual disability, obesity, and dysmorphic features
ClinVar Annotator: match by term: DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHISM
ClinVar PMID:23033978 PMID:25741868 PMID:29209020 NCBI chr 1:87,289,964...87,329,926
Ensembl chr 1:87,290,824...87,329,717
JBrowse link
G PHIP pleckstrin homology domain interacting protein ISO OMIM NCBI chr 1:87,116,884...87,247,500
Ensembl chr 1:87,117,111...87,243,496
JBrowse link
Leptin Receptor Deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LEPR leptin receptor ISO OMIM NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,798,979...146,896,108
JBrowse link
G LEPROT leptin receptor overlapping transcript ISO ClinVar Annotator: match by term: Leptin receptor deficiency
ClinVar Annotator: match by term: OBESITY, MORBID, NONSYNDROMIC 2
ClinVar PMID:28492532 NCBI chr 6:146,974,641...146,987,261
Ensembl chr 6:146,974,633...146,987,363
JBrowse link
MEHMO syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2S3 eukaryotic translation initiation factor 2 subunit gamma ISO OMIM NCBI chr  X:20,129,708...20,162,881 JBrowse link
morbid obesity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSS2 acyl-CoA synthetase short chain family member 2 treatment ISO RGD PMID:22384010 RGD:13831306 NCBI chr17:38,260,152...38,315,764
Ensembl chr17:38,260,147...38,315,758
JBrowse link
G ADCY3 adenylate cyclase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29311637 NCBI chr 3:113,875,005...113,969,053
Ensembl chr 3:113,875,512...113,988,372
JBrowse link
G AGER advanced glycosylation end-product specific receptor treatment ISO RGD PMID:22828946 RGD:7243249 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,116...24,228,756
JBrowse link
G APLN apelin ISO protein:increased expression:plasma
associated with Diabetes Mellitus, Non-Insulin-Dependent
RGD PMID:15970339 PMID:19756893 RGD:1600932 RGD:2313938 NCBI chr  X:106,236,746...106,246,563
Ensembl chr  X:106,236,748...106,246,378
JBrowse link
G AQP7 aquaporin 7 ISO mRNA:decreased expression:subcutaneous adipose tissue RGD PMID:17566090 RGD:1626289 NCBI chr10:33,098,746...33,130,245 JBrowse link
G BBS4 Bardet-Biedl syndrome 4 susceptibility ISO DNA:SNPs RGD PMID:17003356 RGD:1601311 NCBI chr 7:60,631,913...60,693,359 JBrowse link
G BDNF brain derived neurotrophic factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21708048 NCBI chr 2:32,623,668...32,679,293
Ensembl chr 2:32,623,268...32,679,164
JBrowse link
G CCK cholecystokinin ISO protein:decreased expression:plasma:associated with Metabolic Syndrome X (MeSH:D024821) RGD PMID:17443025 RGD:1625798 NCBI chr13:25,940,674...25,945,879
Ensembl chr13:25,937,645...25,946,197
JBrowse link
G CPE carboxypeptidase E ISO mRNA:increased expression:visceral abdominal fat:significantly higher expression in visceral fat than subcutaneous fat of morbidly obese subjects RGD PMID:12530526 RGD:1626182 NCBI chr 8:43,568,744...43,695,475
Ensembl chr 8:43,503,667...43,695,628
JBrowse link
G CTNNBL1 catenin beta like 1 susceptibility
no_association
ISO DNA:snps:introns:IVS7+3134G>T, IVS7-79A>G (rs6013029, rs6020846) (human) RGD PMID:19228371 PMID:19245693 RGD:9850251 RGD:9850253 NCBI chr17:40,809,932...40,948,844
Ensembl chr17:40,774,719...40,948,945
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO protein:increased activity::3x higher activity in morbidly obese subjects compared to non-obese, activity decreased proportionally with weight loss, activity measured as total oral chlorzoxazone clearance RGD PMID:12883487 RGD:1626305 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO RGD PMID:19188925 RGD:2313745 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,316,436...66,452,917
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO mRNA:increased expression:subcutaneous adipose tissue RGD PMID:16046292 RGD:1626320 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO protein:increased expression:serum RGD PMID:11889184 RGD:1626666
G KCNMA1 potassium calcium-activated channel subfamily M alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21708048 NCBI chr14:79,345,382...80,106,337
Ensembl chr14:79,352,396...80,106,258
JBrowse link
G KSR2 kinase suppressor of ras 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29273807 NCBI chr14:34,675,349...35,090,007
Ensembl chr14:34,675,813...35,089,984
JBrowse link
G LEP leptin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9500540 PMID:15070752 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,447
JBrowse link
G LEPR leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9537324 NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,798,979...146,896,108
JBrowse link
G LPIN1 lipin 1 ISO RGD PMID:17563064 RGD:1641822 NCBI chr 3:124,940,557...125,074,137
Ensembl chr 3:124,940,548...125,074,123
JBrowse link
G MC4R melanocortin 4 receptor ISO CTD Direct Evidence: marker/mechanism RGD
CTD
PMID:11443223 PMID:12588803 PMID:29273807 PMID:29311635 RGD:1600750 RGD:1600755 NCBI chr 1:160,772,013...160,774,124
Ensembl chr 1:160,772,013...160,774,124
JBrowse link
G MCHR1 melanin concentrating hormone receptor 1 onset ISO DNA:SNP:promoter RGD PMID:16186414 RGD:1624359 NCBI chr 5:7,735,752...7,752,006
Ensembl chr 5:7,735,823...7,738,701
JBrowse link
G NPPB natriuretic peptide B ISO protein:increased expression:serum RGD PMID:17273651 RGD:1642195 NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G NPY2R neuropeptide Y receptor Y2 ISO DNA:SNP:CDS:NCBI refSNP IDs=rs1047214, rs2880415 coding for silent Ile variants; Pima Indians, males only RGD PMID:15855352 RGD:1642381 NCBI chr 8:74,039,959...74,048,398
Ensembl chr 8:74,039,609...74,047,817
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 onset ISO protein:substitution:Y722C;severe early-onset RGD PMID:16702999 RGD:1626135 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,379...30,429,882
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO ClinVar Annotator: match by term: Morbid obesity ClinVar PMID:9753710 PMID:10690291 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G UCP3 uncoupling protein 3 ISO ClinVar Annotator: match by term: OBESITY, SEVERE ClinVar PMID:9769326 PMID:28492532 NCBI chr 9:8,378,023...8,389,452
Ensembl chr 9:8,378,019...8,386,211
JBrowse link
Morbid Obesity and Spermatogenic Failure term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEP19 centrosomal protein 19 ISO OMIM NCBI chr13:133,420,017...133,428,394
Ensembl chr13:133,420,393...133,425,642
JBrowse link
MORM Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INPP5E inositol polyphosphate-5-phosphatase E ISO OMIM
Obesity, Hyperphagia, and Developmental Delay term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NTRK2 neurotrophic receptor tyrosine kinase 2 ISO OMIM NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,379...30,429,882
JBrowse link
Pediatric Obesity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25137265 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
G APOA5 apolipoprotein A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25137265 NCBI chr 9:44,177,834...44,180,880 JBrowse link
G FTO FTO alpha-ketoglutarate dependent dioxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25137265 NCBI chr 6:31,177,112...31,564,674
Ensembl chr 6:31,174,569...31,564,707
JBrowse link
G GPR17 G protein-coupled receptor 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34144038 NCBI chr15:59,692,992...59,702,513
Ensembl chr15:59,692,992...59,701,266
JBrowse link
Prader-Willi syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP10A ATPase phospholipid transporting 10A (putative) ISO ClinVar Annotator: match by term: Prader-Willi syndrome ClinVar PMID:28631899 NCBI chr 1:141,493,551...141,667,346 JBrowse link
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 ISO ClinVar Annotator: match by term: Prader-Willi syndrome ClinVar PMID:28631899 NCBI chr 1:140,486,107...140,568,204
Ensembl chr 1:140,486,103...140,567,893
JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 ISO ClinVar Annotator: match by term: Prader-Willi syndrome ClinVar PMID:28631899 NCBI chr 1:140,566,443...140,906,516
Ensembl chr 1:140,566,287...140,905,658
JBrowse link
G GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 ISO ClinVar Annotator: match by term: Prader-Willi syndrome ClinVar PMID:28631899 NCBI chr 1:139,855,461...140,464,592
Ensembl chr 1:139,857,540...140,464,472
JBrowse link
G GHRL ghrelin and obestatin prepropeptide ISO RGD PMID:15057669 RGD:12905043 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,316,436...66,452,917
JBrowse link
G HCRT hypocretin neuropeptide precursor ISO protein:decreased expression:cerebrospinal fluid RGD PMID:15613151 RGD:1600935 NCBI chr12:20,588,597...20,589,991
Ensembl chr12:20,581,022...20,589,988
JBrowse link
G HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Prader-Willi syndrome
CTD
ClinVar
PMID:25741868 PMID:28631899 NCBI chr15:56,438,117...56,649,805
Ensembl chr15:56,438,107...56,649,796
JBrowse link
G MAGEL2 MAGE family member L2 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Prader-Willi syndrome
CTD
ClinVar
PMID:24076603 PMID:25741868 PMID:27195816 PMID:28281571 PMID:28492532 More... NCBI chr 1:142,450,414...142,454,633
Ensembl chr 1:142,448,689...142,454,697
JBrowse link
G MKRN3 makorin ring finger protein 3 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Prader-Willi syndrome
CTD
ClinVar
PMID:28631899 NCBI chr 1:142,492,089...142,500,968
Ensembl chr 1:142,496,735...142,500,982
JBrowse link
G NDN necdin, MAGE family member ISO OMIM NCBI chr 1:142,412,688...142,413,665
Ensembl chr 1:142,412,565...142,414,240
JBrowse link
G NPAP1 nuclear pore associated protein 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Prader-Willi syndrome
CTD
ClinVar
PMID:28631899 NCBI chr 1:233,074,862...233,080,760 JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein ISO ClinVar Annotator: match by term: Prader-Willi syndrome ClinVar PMID:28631899 NCBI chr15:56,657,648...56,869,920 JBrowse link
G SNRPN small nuclear ribonucleoprotein polypeptide N susceptibility ISO DNA:deletion OMIM
RGD
PMID:8723064 RGD:1601354
G SNURF SNRPN upstream open reading frame ISO ClinVar Annotator: match by term: Prader-Willi syndrome ClinVar PMID:28631899
G UBE3A ubiquitin protein ligase E3A ISO ClinVar Annotator: match by term: Prader-Willi syndrome ClinVar PMID:28631899 NCBI chr 1:141,887,179...142,001,595
Ensembl chr 1:141,887,168...141,997,241
JBrowse link
Proopiomelanocortin Deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POMC proopiomelanocortin ISO OMIM NCBI chr 3:113,661,712...113,668,558 JBrowse link
proprotein convertase 1/3 deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PCSK1 proprotein convertase subtilisin/kexin type 1 ISO OMIM NCBI chr 2:103,004,794...103,050,707
Ensembl chr 2:103,004,794...103,050,839
JBrowse link
Retinal Dystrophy and Obesity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RIC3 RIC3 acetylcholine receptor chaperone ISO ClinVar Annotator: match by term: Retinal dystrophy and obesity ClinVar PMID:25741868 PMID:28492532 NCBI chr 9:1,134,915...1,183,873
Ensembl chr 9:1,134,906...1,194,979
JBrowse link
G TUB TUB bipartite transcription factor ISO OMIM NCBI chr 9:1,183,821...1,260,209
Ensembl chr 9:1,183,822...1,278,498
JBrowse link
Schaaf-Yang syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYFIP1 cytoplasmic FMR1 interacting protein 1 ISO associated with Fragile X Syndrome;mRNA:decreased expression:leukocyte (human) RGD PMID:17435464 RGD:11558012 NCBI chr15:32,064,431...32,175,095 JBrowse link
G MAGEL2 MAGE family member L2 ISO OMIM NCBI chr 1:142,450,414...142,454,633
Ensembl chr 1:142,448,689...142,454,697
JBrowse link
G SIM1 SIM bHLH transcription factor 1 ISO ClinVar Annotator: match by term: Schaaf-yang syndrome ClinVar NCBI chr 1:67,213,685...67,294,455
Ensembl chr 1:67,214,337...67,294,397
JBrowse link
SPASTIC PARAPLEGIA, INTELLECTUAL DISABILITY, NYSTAGMUS, AND OBESITY term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KIDINS220 kinase D interacting substrate 220 ISO OMIM NCBI chr 3:127,382,587...127,477,753
Ensembl chr 3:127,382,603...127,474,276
JBrowse link
Wilson-Turner syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC8 histone deacetylase 8 ISO DNA:snp:intron:c.164+5G>A (human) RGD PMID:22889856 RGD:13208817 NCBI chr  X:58,210,182...58,450,681 JBrowse link
G LAS1L LAS1 like ribosome biogenesis factor ISO OMIM NCBI chr  X:51,753,600...51,773,416
Ensembl chr  X:51,749,601...51,773,396
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13633
    Nutritional and Metabolic Diseases 4415
      nutrition disease 692
        overnutrition 532
          obesity 532
            Abdominal Obesity + 15
            Ayazi Syndrome 0
            Biemond Syndrome II 0
            Borjeson-Forssman-Lehmann syndrome 1
            CHOPS Syndrome 1
            Camera Marugo Cohen Syndrome 0
            Clark-Baraitser syndrome 1
            Cohen syndrome 2
            Coloboma-Obesity-Hypogenitalism-Mental Retardation Syndrome 0
            DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHIC FEATURES 2
            MEHMO syndrome 1
            MOMES Syndrome 0
            MORM Syndrome 1
            Macrosomia Obesity Macrocephaly Ocular Abnormalities 0
            Midface Hypoplasia, Obesity, Developmental Delay, and Neonatal Hypotonia 0
            Obesity Hypoventilation Syndrome 0
            Obesity, Hyperphagia, and Developmental Delay 1
            Obesity, Metabolically Benign 0
            Pediatric Obesity 4
            Prader-Willi syndrome + 17
            Prolactin Deficiency with Obesity and Enlarged Testes 0
            Proopiomelanocortin Deficiency 1
            Retinal Dystrophy and Obesity 2
            SPASTIC PARAPLEGIA, INTELLECTUAL DISABILITY, NYSTAGMUS, AND OBESITY 1
            Short Stature-Obesity Syndrome 0
            Vasquez Hurst Sotos Syndrome 0
            Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome 0
            Wilson-Turner syndrome 2
            Young Hughes Syndrome 0
            morbid obesity + 28
            proprotein convertase 1/3 deficiency 1
Path 2
Term Annotations click to browse term
  disease 13633
    Nutritional and Metabolic Diseases 4415
      disease of metabolism 4415
        acquired metabolic disease 2203
          nutrition disease 692
            overnutrition 532
              obesity 532
                Abdominal Obesity + 15
                Ayazi Syndrome 0
                Biemond Syndrome II 0
                Borjeson-Forssman-Lehmann syndrome 1
                CHOPS Syndrome 1
                Camera Marugo Cohen Syndrome 0
                Clark-Baraitser syndrome 1
                Cohen syndrome 2
                Coloboma-Obesity-Hypogenitalism-Mental Retardation Syndrome 0
                DEVELOPMENTAL DELAY, INTELLECTUAL DISABILITY, OBESITY, AND DYSMORPHIC FEATURES 2
                MEHMO syndrome 1
                MOMES Syndrome 0
                MORM Syndrome 1
                Macrosomia Obesity Macrocephaly Ocular Abnormalities 0
                Midface Hypoplasia, Obesity, Developmental Delay, and Neonatal Hypotonia 0
                Obesity Hypoventilation Syndrome 0
                Obesity, Hyperphagia, and Developmental Delay 1
                Obesity, Metabolically Benign 0
                Pediatric Obesity 4
                Prader-Willi syndrome + 17
                Prolactin Deficiency with Obesity and Enlarged Testes 0
                Proopiomelanocortin Deficiency 1
                Retinal Dystrophy and Obesity 2
                SPASTIC PARAPLEGIA, INTELLECTUAL DISABILITY, NYSTAGMUS, AND OBESITY 1
                Short Stature-Obesity Syndrome 0
                Vasquez Hurst Sotos Syndrome 0
                Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome 0
                Wilson-Turner syndrome 2
                Young Hughes Syndrome 0
                morbid obesity + 28
                proprotein convertase 1/3 deficiency 1
paths to the root