RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: toxoplasmosis
Accession: DOID:9965
browse the term
Definition: A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia. (DO)
Synonyms: exact_synonym: Toxoplasma gondii infection; Toxoplasma gondii infections; disseminated toxoplasmosis; toxoplasmoses
primary_id: MESH:D014123
xref: EFO:0007517 ; ICD10CM:B58 ; ICD9CM:130 ; NCI:C3418
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Bax
BCL2 associated X, apoptosis regulator
ISO
RGD
PMID:24812878
RGD:10054127
NCBI chrNW_004624832:5,050,222...5,068,565
Ensembl chrNW_004624832:5,050,222...5,055,506
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Il27
interleukin 27
susceptibility
ISO
RGD
PMID:22981537 PMID:31548322
RGD:126790501 RGD:126790522
NCBI chrNW_004624782:13,009,450...13,015,548
Ensembl chrNW_004624782:13,009,564...13,015,440
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Nfkbia
NFKB inhibitor alpha
exacerbates
ISO
human gene in a mouse model
RGD
PMID:12626571
RGD:126925984
NCBI chrNW_004624838:1,384,337...1,387,602
Ensembl chrNW_004624838:1,384,204...1,390,205
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Ucp2
uncoupling protein 2
susceptibility
ISO
RGD
PMID:11101840
RGD:737759
NCBI chrNW_004624817:3,067,358...3,075,045
Ensembl chrNW_004624817:3,067,320...3,075,043
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Ccl5
C-C motif chemokine ligand 5
ISO
mRNA, protein:increased expression:blood vessel endothelial cell
RGD
PMID:15710456
RGD:2307183
NCBI chrNW_004624875:3,334,136...3,342,085
Ensembl chrNW_004624875:3,334,078...3,341,614
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Foxp3
forkhead box P3
ISO
mRNA:decreased expression:placenta:
RGD
PMID:21923716
RGD:38501105
NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679
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Hspd1
heat shock protein family D (Hsp60) member 1
ISO
RGD
PMID:8881756
RGD:12910478
NCBI chrNW_004624889:2,736,727...2,746,333
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Ido1
indoleamine 2,3-dioxygenase 1
ISO
RGD
PMID:31231617
RGD:39939039
NCBI chrNW_004624780:3,684,941...3,697,506
Ensembl chrNW_004624780:3,685,069...3,697,474
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Il17a
interleukin 17A
ISO
mRNA,protein:increased expression:placenta:
RGD
PMID:21923716
RGD:38501105
NCBI chrNW_004624855:3,911,349...3,914,214
Ensembl chrNW_004624855:3,911,349...3,913,136
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Il21
interleukin 21
ISO
RGD
PMID:23667536
RGD:127285360
NCBI chrNW_004624777:3,054,368...3,061,304
Ensembl chrNW_004624777:3,054,368...3,061,304
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Il23a
interleukin 23 subunit alpha
ISO
RGD
PMID:15265921
RGD:39457943
NCBI chrNW_004624802:11,662,851...11,664,444
Ensembl chrNW_004624802:11,662,753...11,665,418
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Il2rb
interleukin 2 receptor subunit beta
ameliorates
ISO
RGD
PMID:11286020
RGD:42724468
NCBI chrNW_004624752:10,662,053...10,682,891
Ensembl chrNW_004624752:10,672,432...10,683,045
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Il6
interleukin 6
ISO
mRNA:increased expression:placenta:
RGD
PMID:21923716
RGD:38501105
NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318
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Ldlr
low density lipoprotein receptor
ISO
RGD
PMID:18316222
RGD:5490254
NCBI chrNW_004624828:2,999,122...3,021,893
Ensembl chrNW_004624828:2,999,169...3,021,987
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Nr4a2
nuclear receptor subfamily 4 group A member 2
ISO
RGD
PMID:25855987
RGD:11057198
NCBI chrNW_004624732:9,572,160...9,589,624
Ensembl chrNW_004624732:9,581,779...9,589,942
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Rorc
RAR related orphan receptor C
ISO
mRNA:increased expression:placenta:
RGD
PMID:21923716
RGD:38501105
NCBI chrNW_004624772:19,478,403...19,501,184
Ensembl chrNW_004624772:19,477,093...19,501,169
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Sting1
stimulator of interferon response cGAMP interactor 1
severity
ISO
RGD
PMID:31416833
RGD:39128220
NCBI chrNW_004624743:32,277,197...32,283,346
Ensembl chrNW_004624743:32,273,385...32,283,235
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Nfkb1
nuclear factor kappa B subunit 1
severity
ISO
RGD
PMID:20156658
RGD:40902838
NCBI chrNW_004624830:5,334,273...5,430,887
Ensembl chrNW_004624830:5,333,616...5,408,723
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Anxa1
annexin A1
ISO
RGD
PMID:22740770
RGD:7421536
NCBI chrNW_004624811:765,338...782,203
Ensembl chrNW_004624811:764,940...782,198
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Il10
interleukin 10
ISO
RGD
PMID:19026704
RGD:7365028
NCBI chrNW_004624807:4,687,249...4,691,658
Ensembl chrNW_004624807:4,687,176...4,691,732
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Il17a
interleukin 17A
treatment
ISO
protein:increased expression:aqueous humor (human)
RGD
PMID:22927448
RGD:8698652
NCBI chrNW_004624855:3,911,349...3,914,214
Ensembl chrNW_004624855:3,911,349...3,913,136
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Il27
interleukin 27
disease_progression
ISO
mRNA:increased expression:eye, cervical lymph node (mouse)
RGD
PMID:29779048
RGD:126790500
NCBI chrNW_004624782:13,009,450...13,015,548
Ensembl chrNW_004624782:13,009,564...13,015,440
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Nod2
nucleotide binding oligomerization domain containing 2
susceptibility
ISO
DNA:snp:3' utr:g.*397A>C (rs3135499)(human)
RGD
PMID:23100559
RGD:8547527
NCBI chrNW_004624757:5,956,873...6,000,052
Ensembl chrNW_004624757:5,958,486...6,000,103
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all