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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:cannabis abuse
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Accession:DOID:9505 term browser browse the term
Definition:A substance abuse that involves the recurring use of cannabis despite negative consequences. (DO)
Synonyms:exact_synonym: Hashish Abuse;   cannabis related disorder;   cannabis use disorder;   marihuana abuse;   marijuana abuse
 primary_id: MESH:D002189
 xref: ICD10CM:F12;   ICD10CM:F12.1;   ICD9CM:305.2


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cannabis abuse term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:19625010 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21041608 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apol2 apolipoprotein L2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558 		JBrowse link
G Bche butyrylcholinesterase ISO protein:increased activity:blood plasma (human) RGD PMID:30707402 RGD:401960085 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Calm1 calmodulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19016476 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility
onset		 ISO DNA:SNP:cd: p.V158M (human)
associated with alcohol use disorder; DNA:hypermethylation:promoter		 RGD PMID:19259017 PMID:30790675 PMID:33781176 RGD:401959590, RGD:401959592, RGD:401959741 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Drd4 dopamine receptor D4 susceptibility ISO DNA:duplication:promoter: 120bp repeat RGD PMID:33544778 RGD:401959602 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Gcc1 GRIP and coiled-coil domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr 4:57,030,817...57,042,682
Ensembl chr 4:57,032,314...57,042,663 		JBrowse link
G Ngf nerve growth factor ISO protein:decreased expression:serum RGD PMID:18774699 RGD:401965396 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nrg1 neuregulin 1 ISO associated with schizophrenia;protein:increased expression:blood: RGD PMID:30799217 RGD:405112241 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17205118 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    Chemically-Induced Disorders 1385
      substance-related disorder 702
        substance abuse 234
          cannabis abuse 15
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      nervous system disease 14059
        central nervous system disease 12398
          brain disease 11633
            disease of mental health 8300
              substance-related disorder 702
                substance abuse 234
                  cannabis abuse 15
paths to the root