RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: meningitis
Accession: DOID:9471
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Definition: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
Synonyms: exact_synonym: Meningitides; Pachymeningitides; Pachymeningitis
primary_id: MESH:D008581 ; RDO:0004900
xref: ICD9CM:322.9 ; NCI:C26828
For additional species annotation, visit the
Alliance of Genome Resources .
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C8a
complement C8 alpha chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9759902
NCBI chr 5:124,348,536...124,403,117
Ensembl chr 5:124,348,461...124,403,195
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C8b
complement C8 beta chain
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8098723
NCBI chr 5:124,298,269...124,338,055
Ensembl chr 5:124,300,477...124,338,053
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Ccr3
C-C motif chemokine receptor 3
ISO
RGD
PMID:19887061
RGD:6892923
NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
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Crp
C-reactive protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14513990
NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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Gstp1
glutathione S-transferase pi 1
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:9262228
RGD:5491002
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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Hcn1
hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
IEP
protein:increased expression:neuron:
RGD
PMID:19409968
RGD:2316615
NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
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Hcn2
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
IEP
protein:increased expression:neuron:
RGD
PMID:19409968
RGD:2316615
NCBI chr 7:12,851,730...12,870,087
Ensembl chr 7:12,851,739...12,874,215
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Igf2
insulin-like growth factor 2
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:7521338
RGD:5510023
NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
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Plau
plasminogen activator, urokinase
ISO
associated with Angiostrongyliasis
RGD
PMID:20584616
RGD:6484124
NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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Plaur
plasminogen activator, urokinase receptor
disease_progression
ISO
RGD
PMID:21971819
RGD:6484118
NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
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Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:5108595 PMID:5109917 PMID:5536438
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Il6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10888991
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Ache
acetylcholinesterase
ISO
RGD
PMID:21303225
RGD:5688130
NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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Bche
butyrylcholinesterase
ISO
protein:increased expression:blood
RGD
PMID:21303225
RGD:5688130
NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
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Bdnf
brain-derived neurotrophic factor
ISO IEP
mRNA, protein:increased expression:hippocampus mRNA:decreased expression:hippocampus,cerebral cortex:
RGD
PMID:16141791 , PMID:22683802
RGD:5684920 , RGD:8655554
NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
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Cd46
CD46 molecule
ISO
RGD
PMID:16948860
RGD:6483465
NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
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Chi3l1
chitinase 3 like 1
severity
ISO
protein:increased secretion:cerebrospinal fluid (human)
RGD
PMID:11986266
RGD:4892662
NCBI chr13:51,022,844...51,030,797
Ensembl chr13:51,022,681...51,030,802
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Crp
C-reactive protein
ISO
protein:increased expression:serum:
RGD
PMID:6122844
RGD:9491388
NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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Mmp9
matrix metallopeptidase 9
ISO
RGD
PMID:10430840
RGD:8547971
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Ngf
nerve growth factor
IEP
mRNA:decreased expression:hippocampus:
RGD
PMID:22683802
RGD:8655554
NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
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Ntrk2
neurotrophic receptor tyrosine kinase 2
ISO
mRNA, protein:increased expression:hippocampus
RGD
PMID:16141791
RGD:5684920
NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
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Parp1
poly (ADP-ribose) polymerase 1
susceptibility
ISO
DNA:snp:cds:p.V762A rs1136410 (human)
RGD
PMID:21651918
RGD:5683901
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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S100b
S100 calcium binding protein B
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:15105355
RGD:5508818
NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
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Cd274
CD274 molecule
treatment
ISO
RGD
PMID:29058791
RGD:41412178
NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
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Mbl2
mannose binding lectin 2
susceptibility
ISO
associated with HIV Infections;DNA:polymorphism:cds:
RGD
PMID:21592999
RGD:12910861
NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
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Pdcd1
programmed cell death 1
treatment
ISO
RGD
PMID:29058791 , PMID:29058791
RGD:41412178 , RGD:41412178
NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845 Ensembl chr 9:101,307,764...101,319,845
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Fcgr2a
Fc fragment of IgG receptor IIa
susceptibility
ISO
associated with Anemia, Sickle Cell;DNA:polymorphism:cds:p.H131R(human)
RGD
PMID:8648541
RGD:11040885
NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036 Ensembl chr13:91,168,973...91,198,036
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Fcgr3a
Fc fragment of IgG receptor IIIa
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26773105
NCBI chr13:89,385,775...89,396,047
Ensembl chr13:89,385,859...89,396,051
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Ina
internexin neuronal intermediate filament protein, alpha
severity
ISO
RGD
PMID:20559547
RGD:40886275
NCBI chr 1:266,782,835...266,794,389
Ensembl chr 1:266,781,617...266,794,431
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Itgam
integrin subunit alpha M
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26773105
NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
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Selp
selectin P
ISO
RGD
PMID:20179168
RGD:6478687
NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
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Cd274
CD274 molecule
ISO
RGD
PMID:23230000
RGD:41410802
NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
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Clec12a
C-type lectin domain family 12, member A
disease_progression
ISO
RGD
PMID:31451663
RGD:41412202
NCBI chr 4:163,112,100...163,130,979
Ensembl chr 4:163,112,301...163,126,864
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Il1rl1
interleukin 1 receptor-like 1
severity
ISO
RGD
PMID:25829541
RGD:40400708
NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
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Il21r
interleukin 21 receptor
ISO
RGD
PMID:19478140
RGD:6892934
NCBI chr 1:196,996,405...197,024,185
Ensembl chr 1:196,996,581...197,024,166
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Ncr1
natural cytotoxicity triggering receptor 1
ISO
RGD
PMID:30995287
RGD:40818298
NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
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Nfkb1
nuclear factor kappa B subunit 1
severity
ISO
RGD
PMID:20565293
RGD:40902858
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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Nfkb2
nuclear factor kappa B subunit 2
disease_progression
ISO
RGD
PMID:20565293
RGD:40902858
NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
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Pdcd1
programmed cell death 1
treatment
ISO
RGD
PMID:30726291 , PMID:23230000
RGD:40818232 , RGD:41410802
NCBI chr 9:101,305,742...101,319,937
Ensembl chr 9:101,307,764...101,319,845 Ensembl chr 9:101,307,764...101,319,845
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Was
WASP actin nucleation promoting factor
ISO
RGD
PMID:23141740
RGD:38676258
NCBI chr X:15,155,246...15,164,099
Ensembl chr X:15,155,230...15,164,105
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Il4r
interleukin 4 receptor
ISO
protein:decreased expression:serum
RGD
PMID:21251883
RGD:5128510
NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
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Tnf
tumor necrosis factor
ISO
RGD
PMID:10318940
RGD:10449456
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Tlr2
toll-like receptor 2
ISO
mRNA:increased expression: :
RGD
PMID:12781911
RGD:7794740
NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
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Tlr4
toll-like receptor 4
ISO
mRNA:increased expression: :
RGD
PMID:12781911
RGD:7794740
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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Tlr7
toll-like receptor 7
ISO
mRNA:increased expression: :
RGD
PMID:12781911
RGD:7794740
NCBI chr X:28,486,836...28,513,004
Ensembl chr X:28,486,869...28,512,957
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C9
complement C9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9570574
NCBI chr 2:55,775,562...55,823,807
Ensembl chr 2:55,775,274...55,823,826
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Cd46
CD46 molecule
ISO
RGD
PMID:12869763
RGD:6483466
NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
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Cfp
complement factor properdin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8530058 PMID:10909851
NCBI chr X:1,311,121...1,316,683
Ensembl chr X:1,311,121...1,316,682
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Marco
macrophage receptor with collagenous structure
IEP
protein:increased expression:sub-cortical, meninges, astrocyte
RGD
PMID:21299846
RGD:41412190
NCBI chr16:85,115,199...85,147,683
Ensembl chr16:85,115,201...85,135,859
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Mmp13
matrix metallopeptidase 13
IEP
RGD
PMID:10430840
RGD:8547971
NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
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Mmp9
matrix metallopeptidase 9
IEP
RGD
PMID:10430840
RGD:8547971
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Nod2
nucleotide-binding oligomerization domain containing 2
susceptibility
ISO
DNA:SNP,haplotype: :SNP8(human)
RGD
PMID:23691182
RGD:7800668
NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
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Slc11a1
solute carrier family 11 member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16597321
NCBI chr 9:81,655,590...81,666,697
Ensembl chr 9:81,655,629...81,666,706
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Tlr2
toll-like receptor 2
susceptibility
ISO
DNA:haplotype: :2477G>A(rs5743708)(human)
RGD
PMID:23691182
RGD:7800668
NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
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Tlr4
toll-like receptor 4
susceptibility
ISO
DNA:SNP,haplotype: :896A>G(rs4986790)(human)
RGD
PMID:23691182
RGD:7800668
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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Aif1
allograft inflammatory factor 1
IEP
protein:increased expression:brain (rat)
RGD
PMID:16150122
RGD:2313041
NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
ISO
mRNA, protein:increased expression:brain, cerebrospinal fluid
RGD
PMID:19592007
RGD:6483338
NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
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Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:1430592
NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
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Adam17
ADAM metallopeptidase domain 17
treatment
IMP
RGD
PMID:24491581
RGD:13703038
NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
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Aqp4
aquaporin 4
treatment
ISO
protein:increased expression:brain:
RGD
PMID:15695511 , PMID:15695511
RGD:8698660 , RGD:8698660
NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
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Camp
cathelicidin antimicrobial peptide
IEP
protein:increased expression:brain, coronal section (rat)
RGD
PMID:19879657
RGD:2316237
NCBI chr 8:117,930,557...117,932,371
Ensembl chr 8:117,930,546...117,932,518
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Cxcl1
C-X-C motif chemokine ligand 1
IEP
RGD
PMID:21109308
RGD:5134982
NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
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Cysltr1
cysteinyl leukotriene receptor 1
disease_progression
IEP
mRNA, protein:increased expression:brain (rat)
RGD
PMID:31933824
RGD:40903068
NCBI chr X:77,671,028...77,700,491
Ensembl chr X:77,674,150...77,700,269
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Cysltr2
cysteinyl leukotriene receptor 2
IEP
mRNA, protein:increased expression:brain (rat)
RGD
PMID:31933824
RGD:40903068
NCBI chr15:54,903,290...54,941,742
Ensembl chr15:54,905,274...54,906,203
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Ido1
indoleamine 2,3-dioxygenase 1
treatment
ISO
RGD
PMID:24844751
RGD:39939118
NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
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Il6
interleukin 6
treatment
IEP IDA IMP
protein:increased expression:brain
RGD
PMID:25443778 , PMID:8943431 , PMID:11581077
RGD:9831197 , RGD:11062107 , RGD:11060264
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Lgals3
galectin 3
IEP
mRNA, protein:increased expression:brain
RGD
PMID:17706429
RGD:9685206
NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
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Lgals9
galectin 9
IEP
RGD
PMID:17706429
RGD:9685206
NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
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Marco
macrophage receptor with collagenous structure
IEP
protein:increased expression:meninges, astrocyte
RGD
PMID:21299846
RGD:41412190
NCBI chr16:85,115,199...85,147,683
Ensembl chr16:85,115,201...85,135,859
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Mmp2
matrix metallopeptidase 2
treatment
IMP
RGD
PMID:24419461
RGD:8657111
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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Mmp9
matrix metallopeptidase 9
treatment
IEP IMP
protein:increased expression:cerebrospinal fluid
RGD
PMID:17371820 , PMID:24419461
RGD:1642043 , RGD:8657111
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Nod2
nucleotide-binding oligomerization domain containing 2
ISO
mRNA, protein:increased expression:brain
RGD
PMID:25443778
RGD:9831197
NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
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Ntrk2
neurotrophic receptor tyrosine kinase 2
IEP
mRNA:increased expression:brain
RGD
PMID:21603940
RGD:5684913
NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
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Rela
RELA proto-oncogene, NF-kB subunit
IEP
protein:increased expression:brain, nucleus
RGD
PMID:25443778
RGD:9831197
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Serping1
serpin family G member 1
treatment
ISO
RGD
PMID:17538891
RGD:8661645
NCBI chr 3:72,161,230...72,171,109
Ensembl chr 3:72,161,189...72,171,078
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Tlr2
toll-like receptor 2
ISO
mRNA:increased expression: :
RGD
PMID:12781911
RGD:7794740
NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
G
Tlr4
toll-like receptor 4
ISO
mRNA:increased expression: :
RGD
PMID:12781911
RGD:7794740
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
G
Tlr9
toll-like receptor 9
ISO
mRNA:increased expression: :
RGD
PMID:12781911
RGD:7794740
NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
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Tnf
tumor necrosis factor
disease_progression
IEP
protein:increased expression:brain mRNA:increased expression:brain (rat)
RGD
PMID:25443778 , PMID:31933824
RGD:9831197 , RGD:40903068
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
G
Tlr4
toll-like receptor 4
ISO
mRNA:increased expression: :
RGD
PMID:12781911
RGD:7794740
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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