diabetes mellitus - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	diabetes mellitus	go back to main search page
Accession:	DOID:9351	browse the term
Definition:	A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. (DO)
Synonyms:	exact_synonym:	diabetes
	narrow_synonym:	monogenic diabetes; transient neonatal diabetes
	primary_id:	MESH:D003920
	alt_id:	DOID:0081062
	xref:	EFO:0000400; EFO:1001511; ICD10CM:E08-E13; ICD9CM:250; NCI:C2985

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Genes (1451)

diabetes mellitus

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 2210016L21 gene

ClinVar Annotator: match by term: Monogenic diabetes

PMID:9075818 PMID:9392505 PMID:10333057 PMID:10482964 PMID:11942313 More...

NCBI chr 5:115,080,213...115,086,610
Ensembl chr 5:115,080,217...115,087,842

G

non-agouti

associated with Obesity;DNA:mutation (mouse)

RGD

NCBI chr 2:154,792,519...154,892,932
Ensembl chr 2:154,633,322...154,892,932

G

ATP-binding cassette, sub-family C member 8

ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes

PMID:3202066 PMID:9618169 PMID:9648840 PMID:10204114 PMID:10685979 More...

NCBI chr 7:45,753,952...45,829,441
Ensembl chr 7:45,753,947...45,829,457

G

ATP binding cassette subfamily G member 2 (Junior blood group)

protein:increased expression:kidney

RGD

NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661

G

acid phosphatase 1, soluble

RGD

NCBI chr12:30,943,325...30,961,616
Ensembl chr12:30,943,325...30,961,588

G

adenosine deaminase

treatment

RGD

NCBI chr 2:163,565,703...163,592,154
Ensembl chr 2:163,568,504...163,592,159

G

adiponectin, C1Q and collagen domain containing

CTD Direct Evidence: marker/mechanism

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

adrenergic receptor, beta 1

CTD Direct Evidence: marker/mechanism

NCBI chr19:56,710,549...56,713,582
Ensembl chr19:56,710,631...56,721,545

G

advanced glycosylation end product-specific receptor

susceptibility

protein:decreased expression:plasma (human)

RGD

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

1-acylglycerol-3-phosphate O-acyltransferase 2

ClinVar Annotator: match by term: Monogenic diabetes

PMID:11967537 PMID:12826327 PMID:22831748 PMID:25741868 PMID:26336158 More...

NCBI chr 2:26,483,069...26,494,429
Ensembl chr 2:26,483,069...26,494,429

G

aldolase B, fructose-bisphosphate

mRNA:reduced expression:pancreatic islet (mouse)

RGD

NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546

G

ALMS1, centrosome and basal body associated

ClinVar Annotator: match by term: Monogenic diabetes

PMID:18154657 PMID:21157496 PMID:21943378 PMID:22876109 PMID:23033341 More...

NCBI chr 6:85,564,482...85,698,973
Ensembl chr 6:85,564,513...85,679,735

G

alpha-kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:127,460,367...127,574,195
Ensembl chr 3:127,463,959...127,574,176

G

amine oxidase, copper containing 3

CTD Direct Evidence: marker/mechanism

NCBI chr11:101,221,432...101,230,256
Ensembl chr11:101,221,431...101,232,764

G

apolipoprotein B

protein:increased expression:serum

RGD

NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835

G

apolipoprotein C2

protein:increased expression:serum

RGD

NCBI chr 7:19,405,504...19,411,866
Ensembl chr 7:19,405,504...19,411,866

G

apolipoprotein E

treatment

RGD

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

apolipoprotein H

protein:increased expression:plasma
mRNA:increased expression:retina

RGD

PMID:9377806 PMID:18695102

RGD:2313991, RGD:2313982

NCBI chr11:108,286,123...108,305,222
Ensembl chr11:108,234,180...108,305,222

G

aquaporin 1

protein:altered localization:retina

RGD

NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540

G

aquaporin 4

RGD

NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039

G

actin related protein 2/3 complex, subunit 3

associated with Obesity, Morbid;mRNA:decreased expression:omentum, adipose tissue (human)

RGD

NCBI chr 5:122,529,941...122,544,244
Ensembl chr 5:122,529,941...122,552,247

G

B lymphoid kinase

ClinVar Annotator: match by term: Monogenic diabetes

PMID:18204098 PMID:18414213 PMID:19667185 PMID:24023612 PMID:24033266 More...

NCBI chr14:63,610,286...63,654,636
Ensembl chr14:63,610,285...63,654,486

G

basic helix-loop-helix ARNT like 1

NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333

G

BSCL2 lipid droplet biogenesis associated, seipin

ClinVar Annotator: match by term: Monogenic diabetes

PMID:18690553 PMID:23430896 PMID:23963299 PMID:25588603 PMID:25741868 More...

NCBI chr19:8,814,831...8,826,047
Ensembl chr19:8,814,831...8,826,047
Ensembl chr 2:8,814,831...8,826,047

G

caspase 3

protein:increased expression:ovary

RGD

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

catalase

CTD Direct Evidence: marker/mechanism

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

caveolin 1, caveolae protein

ClinVar Annotator: match by term: Monogenic diabetes

PMID:25741868 PMID:28492532

NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451

G

caveolae associated 1

ClinVar Annotator: match by term: Monogenic diabetes

PMID:25741868 PMID:28492532

NCBI chr11:100,847,562...100,861,443
Ensembl chr11:100,847,559...100,861,713

G

C-C motif chemokine ligand 5

protein:increased expression:serum

RGD

NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344

G

CD36 molecule

protein:increased expression:macrophage

RGD

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD40 ligand

associated with Coronary Arteriosclerosis, Myocardial Infarction; protein:increased expression:serum

RGD

NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402

G

cadherin 1

associated with lung adenocarcinoma and lung squamous cell carcinoma; protein:decreased expression:lung (human)

RGD

NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878

G

CDK5 regulatory subunit associated protein 1-like 1

DNA:snp: :rs10946398(human)

RGD

NCBI chr13:29,375,729...30,039,665
Ensembl chr13:29,375,729...30,039,657

G

carboxyl ester lipase

ClinVar Annotator: match by term: Monogenic diabetes

PMID:18414213 PMID:25741868 PMID:28492532 PMID:32906201

NCBI chr 2:28,445,831...28,453,415
Ensembl chr 2:28,445,807...28,453,415

G

chymotrypsin-like elastase family, member 2A

ClinVar Annotator: match by term: Diabetes | ClinVar Annotator: match by term: Monogenic diabetes

PMID:25741868 PMID:31358993

NCBI chr 4:141,542,265...141,553,316
Ensembl chr 4:141,542,273...141,553,471

G

clock circadian regulator

NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639

G

ceruloplasmin

CTD Direct Evidence: marker/mechanism

NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309

G

carboxypeptidase B2

protein:increased expression, increased activity:plasma

RGD

NCBI chr14:75,479,727...75,520,995
Ensembl chr14:75,479,727...75,520,995

G

carnitine palmitoyltransferase 1a, liver

CTD Direct Evidence: marker/mechanism

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

colony stimulating factor 1 receptor

associated with hepatocellular��carcinoma;DNA:hypermethylation:promoter (human)

RGD

NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221

G

cathepsin B

onset

DNA:transversion:cds:p.L26V (human)

RGD

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

C-X3-C motif chemokine receptor 1

RGD

NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945

G

cytochrome b5 reductase 4

RGD

NCBI chr 9:86,904,082...86,959,827
Ensembl chr 9:86,904,067...86,959,827

G

cytochrome b-245, beta polypeptide

CTD Direct Evidence: marker/mechanism

NCBI chr X:9,301,493...9,354,005
Ensembl chr X:9,301,491...9,354,010

G

steroid-11-beta-hydroxylase

DNA:polymorphisms:5' utr, cds:-344C>T, p.K173R (human)

RGD

NCBI chr15:74,706,741...74,713,492
Ensembl chr15:74,705,974...74,713,492

G

cytochrome P450, family 11, subfamily b, polypeptide 2

DNA:polymorphisms:5' utr, cds:-344C>T, p.K173R (human)

NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167

G

cytochrome P450, family 1, subfamily a, polypeptide 1

associated with Smoking Inhalation Injury; DNA:polymorphism:3' UTR:5639T>C (human)

RGD

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 2, subfamily c, polypeptide 65

associated with Thromboembolism; DNA:polymorphism:cds:R144C, I359L (human)
DNA:polymorphism:multiple (human)

PMID:16303885 PMID:16788382

RGD:2307151 RGD:2307153

NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388

G

cytochrome P450, family 51

mRNA,protein:decreased expression:liver

RGD

NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746

G

dicer 1, ribonuclease type III

RGD

NCBI chr12:104,654,001...104,718,331
Ensembl chr12:104,654,001...104,718,211

G

delta like canonical Notch ligand 4

ameliorates

protein:increased expression:skin:

RGD

PMID:30886104 PMID:29386132 PMID:30886104

RGD:155646129, RGD:155663360, RGD:155646129

NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443

G

epidermal growth factor receptor

associated with lung squamous cell carcinoma; protein:increased expression:lung (human)

RGD

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

eukaryotic translation initiation factor 2 alpha kinase 3

ClinVar Annotator: match by term: Monogenic diabetes

PMID:25741868 PMID:28492532

NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229

G

coagulation factor III

protein:decreased expression:urine
protein:increased expression:plasma

RGD

PMID:9212353 PMID:8914465

RGD:2313869, RGD:11060253

NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697

G

coagulation factor VII

no_association

protein:increased activity:plasma (rat)

RGD

PMID:10899350 PMID:15258325 PMID:10910004

RGD:1598920, RGD:2312391, RGD:2312393

NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809

G

fibronectin 1

protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20551625 PMID:11213886

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

forkhead box P3

ClinVar Annotator: match by term: Monogenic diabetes

PMID:11137993 PMID:23313429 PMID:25741868 PMID:28492532 PMID:29193502 More...

NCBI chr X:7,445,915...7,461,482
Ensembl chr X:7,439,883...7,461,484

G

fucosidase, alpha-L- 1, tissue

protein:decreased activity:blood platelets

RGD

NCBI chr 4:135,648,037...135,667,611
Ensembl chr 4:135,648,046...135,667,622

G

frataxin

associated with Friedrich Ataxia; DNA:repeats:intron:GAA (human)
DNA:deletion:exon (mouse)

RGD

PMID:8815938 PMID:12925693

RGD:2307047, RGD:2307048

NCBI chr19:24,236,909...24,257,954
Ensembl chr19:24,238,817...24,257,969

G

glucose-6-phosphate dehydrogenase X-linked

protein:decreased activity:blood

RGD

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

glutamate decarboxylase 1

NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358

G

GATA binding protein 6

ClinVar Annotator: match by term: Monogenic diabetes

PMID:18414213 PMID:20581743 PMID:22158542 PMID:23223019 PMID:24310933 More...

NCBI chr18:11,052,510...11,085,636
Ensembl chr18:11,052,064...11,085,635

G

vitamin D binding protein

protein:increased expression:ascitic fluid

RGD

NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757

G

glucokinase

neonatal-onset diabetes mellitus,OMIM:606176;DNA:point mutation:exon:T228M
ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes

PMID:1354782 PMID:1464666 PMID:1502186 PMID:7542040 PMID:7553875 More...

NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081

G

gamma-glutamyltransferase 1

associated with Cystic Fibrosis; protein:increased activity:plasma

RGD

NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034

G

growth hormone

protein:decreased expression:vitreous body
protein:increased secretion:plasma

RGD

PMID:19463895 PMID:1132599

RGD:2315653, RGD:2315658

NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691

G

gastric inhibitory polypeptide receptor

human gene, mouse model

RGD

NCBI chr 7:18,889,988...18,904,173
Ensembl chr 7:18,889,986...18,900,052

G

GLIS family zinc finger 3

ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes

PMID:18414213 PMID:25741868 PMID:27899417 PMID:28492532 PMID:29146476 More...

NCBI chr19:28,236,251...28,657,684
Ensembl chr19:28,236,251...28,657,477

G

glutamate dehydrogenase 1

ClinVar Annotator: match by term: Monogenic diabetes

PMID:25741868 PMID:28492532

NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222

G

guanine nucleotide binding protein (G protein), beta 3

no_association

DNA:polymorphism: :multiple (human)

RGD

NCBI chr 6:124,811,203...124,817,238
Ensembl chr 6:124,811,203...124,817,238

G

guanine nucleotide binding protein (G protein), gamma 3

ClinVar Annotator: match by term: Monogenic diabetes

PMID:25741868 PMID:26467025

NCBI chr19:8,814,293...8,816,610
Ensembl chr19:8,814,297...8,816,558

G

glutathione peroxidase 3

mRNA:decreased expression:skeletal muscle (mouse)

RGD

PMID:18936159 PMID:18562625

RGD:2312632, RGD:2312633

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

glutathione reductase

protein:decreased activity:blood:

RGD

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, mu 1

susceptibility

RGD

NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289

G

glutathione S-transferase, theta 1

susceptibility

DNA:deletion: :

RGD

NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418

G

hydroxyacyl-Coenzyme A dehydrogenase

ClinVar Annotator: match by term: Monogenic diabetes

PMID:19417036 PMID:21347589 PMID:22662265 PMID:25741868 PMID:27104957 More...

NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750

G

hes family bHLH transcription factor 1

protein:increased expression:skin:

RGD

NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614

G

hes family bHLH transcription factor 5

protein:increased expression:skin:

RGD

NCBI chr 4:155,042,358...155,046,829
Ensembl chr 4:155,045,380...155,046,828

G

hairy/enhancer-of-split related with YRPW motif 1

protein:increased expression:skin:

RGD

PMID:30886104 PMID:30886104

RGD:155646129, RGD:155646129

NCBI chr 3:8,728,419...8,732,098
Ensembl chr 3:8,728,419...8,732,316

G

homeostatic iron regulator

DNA:missense mutation: :p.C282Y (rs1800562) (human)

RGD

NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837

G

hepatocyte growth factor

mRNA, protein:increased expression:cornea

RGD

NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

RGD

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

HNF1 homeobox A

ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes
ClinVar Annotator: match by term: Diabetes | ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes

PMID:1985954 PMID:8866553 PMID:8945470 PMID:9032114 PMID:9045858 More...

NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153

G

HNF1 homeobox B

ClinVar Annotator: match by term: Monogenic diabetes

PMID:15930087 PMID:16249435 PMID:18065799 PMID:19639018 PMID:20633866 More...

NCBI chr11:83,741,035...83,796,743
Ensembl chr11:83,740,889...83,796,645

G

hepatic nuclear factor 4, alpha

ClinVar Annotator: match by term: Monogenic diabetes

PMID:193395 PMID:9243109 PMID:9267996 PMID:9294105 PMID:9313765 More...

NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830

G

haptoglobin

RGD

NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804

G

HtrA serine peptidase 1

associated with lung adenocarcinoma and lung squamous cell carcinoma; protein:decreased expression:lung (human)

RGD

NCBI chr 7:130,537,933...130,587,388
Ensembl chr 7:130,537,841...130,587,390

G

islet cell autoantigen 1

RGD

NCBI chr 6:8,630,527...8,778,531
Ensembl chr 6:8,630,527...8,778,488

G

intercellular adhesion molecule 1

protein:increased expression:serum

RGD

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

insulin-like growth factor 1

mRNA,protein:decreased expression:corpus cavernosum:

RGD

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

insulin-like growth factor I receptor

associated with lung adenocarcinoma and lung squamous cell carcinoma; protein:increased expression:lung (human)

RGD

PMID:16642022 PMID:27411924

RGD:2311506, RGD:152975631

NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416

G

interleukin 10

RGD

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 2 receptor, alpha chain

RGD

NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004

G

interleukin 33

protein:increased expression:serum,ovary

RGD

NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118

G

interleukin 6

susceptibility

protein:increased expression:extracellular space (human)
mRNA:decreased expression:dendritic cell (mouse)
associated with Dementia; protein:increased expression:brain (human)
DNA:polymorphism:promoter:-174G>C (human)

RGD

PMID:19442860 PMID:19120268 PMID:19139294 PMID:18689695

RGD:2307180, RGD:2307278, RGD:2307273, RGD:2307293

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

insulin I

ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes

PMID:11921414 PMID:17855560 PMID:18162506 PMID:18171712 PMID:18192540 More...

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

insulin II

DNA, protein:missense mutations, altered processing:exons, endoplasmic reticulum:multiple
ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes
CTD Direct Evidence: marker/mechanism
CTD Direct Evidence: marker/mechanism|therapeutic
protein:altered localization :endoplasmic reticulum
DNA, protein:missense mutations:exons:multiple
DNA:point mutation (mouse)

ClinVar
CTD
RGD

PMID:2055425 PMID:7294224 PMID:7624867 PMID:8400068 PMID:11446671 More...

RGD:2317262, RGD:2317260, RGD:2317259, RGD:2311115, RGD:2311109

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

insulin receptor

DNA:deletions, missense mutation:multiple (human)
ClinVar Annotator: match by term: Monogenic diabetes

PMID:2040394 PMID:2211730 PMID:2983222 PMID:8257688 PMID:8432414 More...

NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617

G

insulin receptor substrate 1

CTD Direct Evidence: marker/mechanism

NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137

G

integrin alpha 2

protein:increased expression:monocyte (human)

RGD

NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636

G

inositol 1,4,5-trisphosphate receptor 1

susceptibility

DNA:deletion:exon:p.Q1715_R1731del (mouse)

RGD

NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070

G

potassium inwardly rectifying channel, subfamily J, member 11

DNA:mutation: :p.V59M (mouse)
ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes
Diabetes Mellitus, permanent neonatal, OMIM:606176

PMID:2270156 PMID:2462236 PMID:8897013 PMID:10338089 PMID:12524280 More...

RGD:2311536, RGD:1625256, RGD:1625279

NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188

G

kinesin family member 1A

CTD Direct Evidence: marker/mechanism

NCBI chr 1:92,943,180...93,029,760
Ensembl chr 1:92,943,186...93,029,673

G

kinesin family member 5B

CTD Direct Evidence: marker/mechanism

NCBI chr18:6,201,005...6,241,524
Ensembl chr18:6,201,002...6,242,174

G

Kruppel-like transcription factor 11

ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes

PMID:15774581 PMID:17130512 PMID:18414213 PMID:18593768 PMID:19122346 More...

NCBI chr12:24,701,370...24,712,781
Ensembl chr12:24,701,273...24,712,788

G

leptin

ClinVar Annotator: match by term: Monogenic diabetes

PMID:25741868 PMID:28492532

NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876

G

leptin receptor

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Monogenic diabetes

PMID:15028607 PMID:25741868 PMID:28492532

NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549

G

lamin A

ClinVar Annotator: match by term: Monogenic diabetes

PMID:2007407 PMID:2270059 PMID:10580070 PMID:10587585 PMID:10655060 More...

NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263

G

low density lipoprotein receptor-related protein 1

treatment

RGD

NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017

G

MAF bZIP transcription factor A

treatment

RGD

NCBI chr15:75,617,350...75,620,170
Ensembl chr15:75,617,339...75,620,077

G

mitogen-activated protein kinase kinase kinase 5

CTD Direct Evidence: marker/mechanism

NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499

G

macrophage receptor with collagenous structure

protein:decreased expression:Alveolar macrophage

RGD

NCBI chr 1:120,402,267...120,432,753
Ensembl chr 1:120,402,267...120,432,753

G

melanocortin 4 receptor

ClinVar Annotator: match by term: Monogenic diabetes

PMID:9267995 PMID:10078568 PMID:10199800 PMID:10592235 PMID:10903341 More...

NCBI chr18:66,990,776...66,993,558
Ensembl chr18:66,990,775...66,993,577

G

microRNA 142

RNA:increased expression:blood:

RGD

NCBI chr11:87,647,690...87,647,753
Ensembl chr11:87,647,690...87,647,753

G

microRNA 145a

miRNA:decreased expression:blood plasma (rat)

RGD

NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965

G

microRNA 221

RNA:increased expression:mandible

RGD

NCBI chr X:19,012,533...19,012,627
Ensembl chr X:19,012,533...19,012,627

G

microRNA 222

RNA:increased expression:mandible

RGD

NCBI chr X:19,013,132...19,013,210
Ensembl chr X:19,013,132...19,013,210

G

microRNA 223

RNA:decreased expression:blood mononuclear cell

RGD

NCBI chr X:95,286,423...95,286,532
Ensembl chr X:95,286,423...95,286,532

G

microRNA 29a

exacerbates

RNA:increased expression:blood:
RNA:increased expression:sciatic nerve:

RGD

PMID:32544883 PMID:32544883

RGD:243065126, RGD:243065126

NCBI chr 6:31,039,595...31,039,682
Ensembl chr 6:31,039,595...31,039,682

G

microRNA 7b

exacerbates

RNA:increased expression:sciatic nerve:

RGD

NCBI chr17:56,549,988...56,550,098
Ensembl chr17:56,549,988...56,550,098

G

matrix metallopeptidase 10

RGD

NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241

G

matrix metallopeptidase 3

mRNA:increased expression:retina

RGD

NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975

G

ATP synthase 6, mitochondrial

CTD Direct Evidence: marker/mechanism

NCBI chr MT:7,927...8,607
Ensembl chr MT:7,927...8,607

G

NADH dehydrogenase 4L, mitochondrial

DNA:deletion: :m.8213_13992 (human)

RGD

NCBI chr MT:9,877...10,173
Ensembl chr MT:9,877...10,173

G

metallothionein 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

G

methylenetetrahydrofolate reductase

no_association

DNA:transition:cds:g.677C>T (human)

RGD

NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008

G

N-acetyltransferase 2 (arylamine N-acetyltransferase)

DNA:polymorphism

RGD

NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236

G

neutrophil cytosolic factor 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479

G

neurogenic differentiation 1

ClinVar Annotator: match by term: Monogenic diabetes

PMID:12639765 PMID:18414213 PMID:25741868 PMID:27420379 PMID:28492532 More...

NCBI chr 2:79,282,981...79,286,980
Ensembl chr 2:79,282,865...79,287,095

G

natriuretic peptide type B

onset

RGD

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

nuclear receptor subfamily 0, group B, member 2

mRNA:increased expression:pancreatic islet

RGD

NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847

G

nuclear receptor subfamily 1, group I, member 2

CTD Direct Evidence: marker/mechanism

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

nuclear receptor subfamily 1, group I, member 3

CTD Direct Evidence: marker/mechanism

NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270

G

paired box 4

ClinVar Annotator: match by term: Monogenic diabetes

PMID:15509590 PMID:18414213 PMID:25741868 PMID:28492532

NCBI chr 6:28,442,333...28,449,339
Ensembl chr 6:28,442,333...28,449,352

G

pancreatic and duodenal homeobox 1

mRNA, decreased expression:pancreatic islet (mouse)
ClinVar Annotator: match by term: Monogenic diabetes

PMID:10545530 PMID:10545531 PMID:10720084 PMID:11022198 PMID:11270685 More...

NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658

G

perilipin 1

ClinVar Annotator: match by term: Monogenic diabetes

PMID:18414213 PMID:25741868 PMID:28492532

NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651

G

phosphomannomutase 2

ClinVar Annotator: match by term: Diabetes mellitus

PMID:9140401 PMID:9497260 PMID:9781039 PMID:10386614 PMID:10527672 More...

NCBI chr16:8,455,467...8,475,472
Ensembl chr16:8,455,538...8,480,331

G

pro-opiomelanocortin-alpha

CTD Direct Evidence: marker/mechanism

NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642

G

paraoxonase 1

CTD Direct Evidence: marker/mechanism

PMID:16229851 PMID:19022366

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

peroxisome proliferator activated receptor alpha

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

peroxisome proliferator activated receptor gamma

CTD Direct Evidence: therapeutic
ClinVar Annotator: match by term: Monogenic diabetes

PMID:16168052 PMID:19748282 PMID:25741868 PMID:27749844 PMID:28492532

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

protein phosphatase 1, regulatory subunit 3A

ClinVar Annotator: match by term: Monogenic diabetes

PMID:12118251 PMID:25741868 PMID:28492532

NCBI chr 6:14,713,821...14,755,273
Ensembl chr 6:14,713,976...14,755,273

G

prominin 1

NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374

G

phosphatase and tensin homolog

protein:increased expression, increased phosphorylation:inferior vena cava

RGD

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

pancreas specific transcription factor, 1a

ClinVar Annotator: match by term: Monogenic diabetes

PMID:25741868 PMID:25775927 PMID:28492532

NCBI chr 2:19,450,474...19,452,312
Ensembl chr 2:19,450,474...19,452,312

G

prostaglandin-endoperoxide synthase 2

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:15885672 PMID:15885672

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

protein tyrosine phosphatase, non-receptor type 1

protein:increased expression:skin of forearm (human)

RGD

NCBI chr 2:167,772,670...167,821,305
Ensembl chr 2:167,773,977...167,821,305

G

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

DNA: snp: cds: C1858T

RGD

NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563

G

protein tyrosine phosphatase receptor type D

disease_progression

DNA:SNP:intron: (rs17584499) (human)

RGD

NCBI chr 4:75,859,474...78,132,282
Ensembl chr 4:75,859,475...78,130,198

G

Rac family small GTPase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791

G

regulatory factor X, 6

ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes

PMID:15592663 PMID:18414213 PMID:20148032 PMID:25741868 PMID:28492532 More...

NCBI chr10:51,553,856...51,606,525
Ensembl chr10:51,553,852...51,606,528

G

serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

RGD

NCBI chr X:137,979,998...137,985,985
Ensembl chr X:137,980,006...137,985,985

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

treatment

RGD

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

sex hormone binding globulin

protein:increased expression:plasma

RGD

NCBI chr11:69,501,108...69,508,852
Ensembl chr11:69,505,630...69,508,731

G

shieldin complex subunit 2

ClinVar Annotator: match by term: Monogenic diabetes

PMID:25741868 PMID:28492532

NCBI chr14:33,958,905...34,032,528
Ensembl chr14:33,958,990...34,032,450

G

single-minded family bHLH transcription factor 1

ClinVar Annotator: match by term: Monogenic diabetes

PMID:2152513 PMID:16924270 PMID:21512513 PMID:23778136 PMID:23778139 More...

NCBI chr10:50,770,794...50,865,252
Ensembl chr10:50,770,850...50,865,248

G

sirtuin 1

CTD Direct Evidence: marker/mechanism

NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483

G

solute carrier family 19 (thiamine transporter), member 2

ClinVar Annotator: match by term: Monogenic diabetes

PMID:25741868 PMID:28492532 PMID:10391221

NCBI chr 1:164,076,615...164,092,954
Ensembl chr 1:164,076,615...164,092,954

G

solute carrier family 22 (organic anion/cation transporter), member 12

protein:decreased expression:kidney

RGD

NCBI chr19:6,585,884...6,593,100
Ensembl chr19:6,585,875...6,593,062

G

solute carrier family 2 (facilitated glucose transporter), member 1

RGD

NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180

G

solute carrier family 2 (facilitated glucose transporter), member 2

ClinVar Annotator: match by term: Monogenic diabetes

PMID:8027028 PMID:8063045 PMID:11810292 PMID:23986439 PMID:25741868 More...

NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508

G

solute carrier family 2 (facilitated glucose transporter), member 3

RGD

NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599

G

suppressor of cytokine signaling 1

ameliorates

RGD

NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400

G

superoxide dismutase 1, soluble

CTD Direct Evidence: marker/mechanism

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 3, extracellular

RGD

NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760

G

serine peptidase inhibitor, Kazal type 1

ClinVar Annotator: match by term: Diabetes mellitus

PMID:10835640 PMID:15980664 PMID:16849362 PMID:18978175 PMID:23017645 More...

NCBI chr18:43,861,134...43,870,302
Ensembl chr18:43,861,147...43,870,622

G

steroid 5 alpha-reductase 2

RGD

NCBI chr17:74,321,886...74,354,855
Ensembl chr17:74,323,950...74,354,911

G

transcription factor 7 like 2, T cell specific, HMG box

associated with Cystic Fibrosis;DNA:SNP (human)

RGD

NCBI chr19:55,730,227...55,922,091
Ensembl chr19:55,730,252...55,922,086

G

tissue factor pathway inhibitor

protein:increased expression:plasma:

RGD

NCBI chr 2:84,263,199...84,307,119
Ensembl chr 2:84,263,199...84,307,119

G

transforming growth factor, beta 1

associated with lung adenocarcinoma and lung squamous cell carcinoma; protein:increased expression:lung (human)

RGD

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

thrombospondin 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:14,885,762...14,914,524
Ensembl chr17:14,885,762...14,914,497

G

tissue inhibitor of metalloproteinase 1

protein:decreased expression:glomerulus

RGD

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

toll-like receptor 4

protein:increased expression:monocyte

RGD

PMID:19210958 PMID:15632890

RGD:2312485, RGD:1580736

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor receptor superfamily, member 8

RGD

NCBI chr 4:144,993,702...145,041,734
Ensembl chr 4:144,993,707...145,041,734

G

tyrosinase

ClinVar Annotator: match by term: Monogenic diabetes

PMID:18463683 PMID:25216246 PMID:27734839 PMID:28492532

NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720

G

uncoupling protein 3 (mitochondrial, proton carrier)

RGD

NCBI chr 7:100,122,198...100,135,639
Ensembl chr 7:100,122,197...100,135,639

G

vitamin D (1,25-dihydroxyvitamin D3) receptor

no_association

DNA:SNPs: :rs731236, rs1544410, rs7975232 (human)

RGD

NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511

G

vimentin

associated with lung adenocarcinoma and lung squamous cell carcinoma; protein:increased expression:lung (human)

RGD

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

Von Willebrand factor

treatment

RGD

NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642

G

wolframin ER transmembrane glycoprotein

onset

DNA:missense mutations:cds:p.R456H, p.R611H (rs1801206, rs1801214) (human)
ClinVar Annotator: match by term: Diabetes | ClinVar Annotator: match by term: Diabetes mellitus | ClinVar Annotator: match by term: Monogenic diabetes

PMID:10521293 PMID:10624825 PMID:10679252 PMID:11161832 PMID:11244483 More...

RGD:8694404, RGD:149735331

NCBI chr 5:37,123,448...37,146,326
Ensembl chr 5:37,123,448...37,146,549

G

zinc finger protein 57

ClinVar Annotator: match by term: Monogenic diabetes
CTD Direct Evidence: marker/mechanism

PMID:18414213 PMID:18622393 PMID:23748067 PMID:25741868 PMID:28492532 More...

NCBI chr17:37,307,060...37,326,196
Ensembl chr17:37,312,055...37,321,527

autosomal dominant Wolfram syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin dependent kinase 13

ClinVar Annotator: match by term: Wolfram-like disorder

PMID:25741868 PMID:28492532 PMID:33879837

NCBI chr13:17,885,309...17,979,960
Ensembl chr13:17,884,900...17,979,682

G

wolframin ER transmembrane glycoprotein

ClinVar Annotator: match by term: HEARING LOSS, PROGRESSIVE, WITH OPTIC ATROPHY AND/OR IMPAIRED GLUCOSE REGULATION | ClinVar Annotator: match by term: Wolfram-like syndrome, autosomal dominant
CTD Direct Evidence: marker/mechanism

OMIM
ClinVar
CTD

PMID:9771706 PMID:9817917 PMID:9856492 PMID:10521293 PMID:10679252 More...

NCBI chr 5:37,123,448...37,146,326
Ensembl chr 5:37,123,448...37,146,549

background diabetic retinopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

treatment

RGD

NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186

G

catalase

associated withDiabetes Mellitus, Type 2; mRNA,protein:decreased expression, decreased activity:blood,l serum:

RGD

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

FMS-like tyrosine kinase 1

protein:decreased expression:aqueous humor:

RGD

NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821

G

mitogen-activated protein kinase kinase kinase 8

protein:increased activity:serum:

RGD

NCBI chr18:4,331,325...4,352,978
Ensembl chr18:4,331,327...4,353,015

G

platelet derived growth factor, B polypeptide

protein:decreased expression:vitreous:

RGD

NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178

Bone Marrow Failure and Diabetes Mellitus Syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

deoxyuridine triphosphatase

ClinVar Annotator: match by term: Bone marrow failure and diabetes mellitus syndrome

PMID:9548420 PMID:25741868 PMID:28073829 PMID:35611808 PMID:35931051

NCBI chr 2:125,089,168...125,100,969
Ensembl chr 2:125,089,110...125,100,528

chromosome 17q11.2 deletion syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ring finger protein 135

CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Chromosome 17q11.2 deletion syndrome, 1.4Mb | ClinVar Annotator: match by term: Macrocephaly, macrosomia, facial dysmorphism syndrome

PMID:17632510 PMID:21681106 PMID:25741868 PMID:27535533 PMID:28135719 More...

NCBI chr11:80,074,652...80,090,581
Ensembl chr11:80,074,677...80,090,583

Cleft Palate, Proliferative Retinopathy, and Developmental Delay

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

leucine rich repeat containing 32

ClinVar Annotator: match by term: Cleft palate, proliferative retinopathy, and developmental delay

PMID:25741868 PMID:30976112

NCBI chr 7:98,138,515...98,151,038
Ensembl chr 7:98,138,490...98,151,388

Combined Cerebellar and Peripheral Ataxia with Hearing Loss and Diabetes Mellitus

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DnaJ heat shock protein family (Hsp40) member C3

ClinVar Annotator: match by term: Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus

PMID:25466870 PMID:25741868 PMID:28940199 PMID:32738013 PMID:33486469

NCBI chr14:119,175,371...119,219,114
Ensembl chr14:119,175,388...119,219,109

G

DnaJ heat shock protein family (Hsp40) member C6

ClinVar Annotator: match by term: Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus

PMID:2256350 PMID:22563501 PMID:24220513 PMID:32214227 PMID:33983693

NCBI chr 4:101,353,751...101,499,996
Ensembl chr 4:101,353,828...101,499,996

G

MAF bZIP transcription factor A

ClinVar Annotator: match by term: Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus

NCBI chr15:75,617,350...75,620,170
Ensembl chr15:75,617,339...75,620,077

Developmental Delay, Epilepsy, and Neonatal Diabetes

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium inwardly rectifying channel, subfamily J, member 11

ClinVar Annotator: match by term: DEND syndrome

PMID:15580558 PMID:15718250 PMID:25741868 PMID:26448950

NCBI chr 7:45,746,545...45,750,215
Ensembl chr 7:45,743,377...45,750,188

Diabetes Complications

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family C member 4

CTD Direct Evidence: marker/mechanism

NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631

G

aldo-keto reductase family 1 member B

CTD Direct Evidence: marker/mechanism

PMID:25304492 PMID:25541468

NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413

G

aldehyde dehydrogenase 2, mitochondrial

CTD Direct Evidence: therapeutic

NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887

G

bradykinin receptor, beta 1

RGD

NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687

G

bradykinin receptor, beta 2

RGD

NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496

G

caspase 9

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

cytochrome P450, family 2, subfamily c, polypeptide 55

RGD

NCBI chr19:38,995,384...39,031,134
Ensembl chr19:38,995,463...39,031,137

G

cytochrome P450, family 2, subfamily c, polypeptide 65

NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

Associated with obesity

RGD

NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057

G

ghrelin

protein: decreased expression: serum

RGD

NCBI chr 6:113,693,080...113,696,872
Ensembl chr 6:113,693,080...113,696,841

G

glyoxalase 1

no_association

DNA:SNP: :419C>A (human)

RGD

NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845

G

histone deacetylase 4

CTD Direct Evidence: marker/mechanism

NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421

G

hypoxia inducible factor 1, alpha subunit

CTD Direct Evidence: marker/mechanism

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

haptoglobin

CTD Direct Evidence: marker/mechanism

NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804

G

microRNA 126a

associated with type 1 diabetes mellitus;

RGD

NCBI chr 2:26,481,369...26,481,441
Ensembl chr 2:26,481,369...26,481,441

G

microRNA 140

CTD Direct Evidence: marker/mechanism

NCBI chr 8:108,277,876...108,277,945
Ensembl chr 8:108,277,876...108,277,945

G

microRNA 26a-1

CTD Direct Evidence: marker/mechanism

NCBI chr 9:118,860,864...118,860,953
Ensembl chr 9:118,860,864...118,860,953

G

mucin 1, transmembrane

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688

G

nuclear receptor subfamily 0, group B, member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847

G

phospholamban

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:diaphragm

RGD

NCBI chr10:53,213,782...53,222,095
Ensembl chr10:53,213,763...53,222,083

G

paraoxonase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

protein kinase, AMP-activated, alpha 1 catalytic subunit

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380

G

solute carrier family 10, member 2

CTD Direct Evidence: marker/mechanism

NCBI chr 8:5,133,219...5,155,287
Ensembl chr 8:5,133,219...5,155,351

G

solute carrier family 51, alpha subunit

CTD Direct Evidence: marker/mechanism

NCBI chr16:32,294,396...32,306,697
Ensembl chr16:32,293,322...32,306,697

G

solute carrier family 51, beta subunit

CTD Direct Evidence: marker/mechanism

NCBI chr 9:65,320,035...65,330,055
Ensembl chr 9:65,319,996...65,330,237

G

solute carrier family 9 (sodium/hydrogen exchanger), member 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:133,097,022...133,151,013
Ensembl chr 4:133,097,017...133,151,013

G

vascular endothelial growth factor A

CTD Direct Evidence: marker/mechanism

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

Diabetes Mellitus, Congenital Autoimmune

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor necrosis factor (ligand) superfamily, member 8

CTD Direct Evidence: marker/mechanism

NCBI chr 4:63,749,439...63,779,745
Ensembl chr 4:63,749,545...63,779,584

Diabetes Mellitus, New-Onset after Transplantation

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mechanistic target of rapamycin kinase

RGD

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

Diabetes, Deafness, Developmental Delay, and Short Stature Syndrome

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mesencephalic astrocyte-derived neurotrophic factor

ClinVar Annotator: match by term: Diabetes, deafness, developmental delay, and short stature syndrome

PMID:26077850 PMID:33500254

NCBI chr 9:106,765,952...106,769,137
Ensembl chr 9:106,715,511...106,769,178

diabetic angiopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 3

PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More...

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

adenylate cyclase 3

CTD Direct Evidence: marker/mechanism

NCBI chr12:4,183,397...4,263,525
Ensembl chr12:4,183,103...4,263,525

G

adenylate cyclase 8

CTD Direct Evidence: marker/mechanism

NCBI chr15:64,570,884...64,794,145
Ensembl chr15:64,568,933...64,794,145

G

advanced glycosylation end product-specific receptor

CTD Direct Evidence: marker/mechanism

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

albumin

CTD Direct Evidence: marker/mechanism

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

argininosuccinate synthetase 1

CTD Direct Evidence: therapeutic

NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684

G

bradykinin receptor, beta 1

RGD

NCBI chr12:105,570,350...105,571,770
Ensembl chr12:105,569,344...105,571,687

G

caspase 3

CTD Direct Evidence: marker/mechanism

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

C-C motif chemokine ligand 2

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

CD28 antigen

associated with Diabetes Mellitus, Insulin-Dependent;protein:decreased expression:T cell

RGD

NCBI chr 1:60,785,547...60,812,521
Ensembl chr 1:60,755,959...60,812,518

G

CD40 ligand

protein:increased expression:serum

RGD

NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402

G

cAMP responsive element modulator

CTD Direct Evidence: marker/mechanism

NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748

G

C-X-C motif chemokine ligand 12

susceptibility

associated with Diabetic Foot;DNA:polymorphism:3' utr (human)

RGD

NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328

G

erythropoietin

ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 2

NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504

G

coagulation factor III

associated with Diabetes Mellitus, Non-Insulin-Dependent
protein:increased expression:plasma

RGD

PMID:16371118 PMID:9285207

RGD:2313861, RGD:2313868

NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697

G

Fas cell surface death receptor

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fas ligand

associated with Diabetes Mellitus, Non-Insulin-Dependent
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:25381014 PMID:15803113

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

fibronectin 1

RGD

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

GTP cyclohydrolase 1

associated with type 2 diabetes mellitus;DNA:SNV: :C59038T (human)

RGD

NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870

G

glycoprotein 1b, alpha polypeptide

RGD

NCBI chr11:70,529,928...70,534,812
Ensembl chr11:70,529,948...70,532,862

G

glutathione peroxidase 1

cardiovascular complications in type 2 diabetics

RGD

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione reductase

cardiovascular complications in type 2 diabetics

RGD

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

histocompatibility 2, class II antigen E beta

susceptibility

associated with Diabetes Mellitus Type 1;DNA:polymorphism: :HLA-DRB1*03:01(human)

RGD

NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648

G

homeostatic iron regulator

ClinVar Annotator: match by term: MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 7 | ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 7

PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More...

NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837

G

heme oxygenase 1

CTD Direct Evidence: therapeutic

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

haptoglobin

CTD Direct Evidence: marker/mechanism

NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804

G

intercellular adhesion molecule 1

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:aorta

RGD

PMID:18093596 PMID:18796303

RGD:2306988, RGD:2313473

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

insulin-like growth factor binding protein 1

DNA:SNPs

RGD

NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546

G

interleukin 1 receptor antagonist

ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 4

PMID:25741868 PMID:28492532

NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506

G

integrin alpha M

protein:increased expression:neutrophil (human)

RGD

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

matrix metallopeptidase 14 (membrane-inserted)

RGD

NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821

G

methylenetetrahydrofolate reductase

CTD Direct Evidence: marker/mechanism

NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008

G

nitric oxide synthase 2, inducible

associated with Diabetes Mellitus, Experimental; protein:increased expression:cochlea

RGD

PMID:19241604 PMID:19587355

RGD:4891384, RGD:2313210

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

treatment

associated with Diabetes Mellitus, Experimental; protein:increased expression:cochlea
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12124201 PMID:19241604 PMID:29329611

RGD:4891384, RGD:13504708

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

platelet/endothelial cell adhesion molecule 1

associated with Diabetes Mellitus, Experimental;protein:increased tyrosine phosphorylation:conceptus

RGD

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

plasminogen activator, tissue

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

paraoxonase 1

associated with Diabetes Mellitus;DNA:polymorphisms: p.L55M, p.Q192R (human)
ClinVar Annotator: match by term: RETINOPATHY, DIABETIC, SUSCEPTIBILITY TO

PMID:9011577 PMID:9661650 PMID:11335891 PMID:11788650 PMID:11889198 More...

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

PTK2 protein tyrosine kinase 2 beta

treatment

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501

G

retinol binding protein 4, plasma

disease_progression

protein:increased expression:blood serum (human)

RGD

NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

CTD Direct Evidence: marker/mechanism

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

susceptibility

associated with Diabetes Mellitus, Type 2;DNA:deletion, haplotype:promoter:g.-676_-674delG (human)

RGD

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

serine (or cysteine) peptidase inhibitor, clade F, member 1

CTD Direct Evidence: marker/mechanism

NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527

G

superoxide dismutase 1, soluble

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

ClinVar Annotator: match by term: SUPEROXIDE DISMUTASE 2 POLYMORPHISM

PMID:8633092 PMID:10425186 PMID:12624725 PMID:15591282 PMID:16538174 More...

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

secreted acidic cysteine rich glycoprotein

associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:mesentery, blood vessel

RGD

NCBI chr11:55,284,985...55,310,906
Ensembl chr11:55,285,326...55,314,009

G

thrombospondin 1

CTD Direct Evidence: marker/mechanism

NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614

G

thrombospondin 2

CTD Direct Evidence: marker/mechanism

NCBI chr17:14,885,762...14,914,524
Ensembl chr17:14,885,762...14,914,497

G

tumor necrosis factor

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:c.-308G>A (human)

RGD

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

vascular endothelial growth factor A

protein:increased expression:cochlea:
ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 1

OMIM
ClinVar
RGD

PMID:11978667 PMID:19241604

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

Diabetic Cardiomyopathies

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186

G

angiotensin I converting enzyme

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

angiotensin converting enzyme 2

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416

G

acyl-CoA thioesterase 1

associated with type 2 diabetes mellitus

RGD

NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145

G

adiponectin, C1Q and collagen domain containing

associated with Diabetes Mellitus, Type2;mRNA, protein:decreased expression:heart, serum

RGD

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

adiponectin receptor 1

associated with Diabetes Mellitus, Type2;mRNA, protein:decreased expression:heart, serum

RGD

NCBI chr 1:134,343,116...134,361,089
Ensembl chr 1:134,343,116...134,361,089

G

advanced glycosylation end product-specific receptor

treatment

associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:heart (rat)

PMID:23251674 PMID:23251674

RGD:7244283, RGD:7244283

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

angiotensinogen

CTD Direct Evidence: marker/mechanism

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

angiotensin II receptor, type 2

CTD Direct Evidence: marker/mechanism

PMID:15587404 PMID:16025228

NCBI chr X:21,350,863...21,355,072
Ensembl chr X:21,350,783...21,355,403

G

thymoma viral proto-oncogene 1

ameliorates

RGD

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

apolipoprotein A-I

CTD Direct Evidence: therapeutic

NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764

G

activating transcription factor 6

ameliorates

RGD

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:16685413 PMID:21441944

NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288

G

ATPase, copper transporting, alpha polypeptide

treatment

RGD

NCBI chr X:105,070,830...105,171,766
Ensembl chr X:105,070,882...105,168,532

G

BCL2-associated agonist of cell death

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-associated X protein

ameliorates

RGD

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

treatment

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:increased phosphorylation:myocardium (mouse)

RGD

PMID:21296063 PMID:21474815

RGD:10053697, RGD:11522727

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

caspase 12

treatment

associated with Experimental Diabetes Mellitus

RGD

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 3

treatment

RGD

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

treatment

RGD

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

treatment

RGD

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

calsequestrin 2

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 3:101,993,731...102,053,830
Ensembl chr 3:101,993,731...102,053,830

G

calcium-sensing receptor

protein:decreased expression:myocardium (rat)

RGD

NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503

G

cofilin 1, non-muscle

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr19:5,540,483...5,544,059
Ensembl chr19:5,540,483...5,545,229

G

catenin beta 1

mRNA,protein:increased expression:heart

RGD

NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573

G

DNA-damage inducible transcript 3

ameliorates

RGD

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

erb-b2 receptor tyrosine kinase 2

associated with Diabetes Mellitus, Experimental;mRNA:decreased expresssion:left ventricle myocardium

RGD

NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542

G

erb-b2 receptor tyrosine kinase 4

associated with Diabetes Mellitus, Experimental;mRNA:decreased expresssion:left ventricle myocardium

RGD

NCBI chr 1:68,071,063...69,147,756
Ensembl chr 1:68,071,345...69,147,218

G

H19, imprinted maternally expressed transcript

ameliorates

RGD

PMID:27796346 PMID:27903964 PMID:36044268

RGD:156430325, RGD:156451660, RGD:156430337

NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917

G

heme oxygenase 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

PMID:23853776 PMID:23453443

RGD:9586347, RGD:10412713

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heat shock protein 90, beta (Grp94), member 1

ameliorates

RGD

NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373

G

heat shock protein 5

ameliorates

RGD

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

insulin-like growth factor 1

CTD Direct Evidence: therapeutic

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

insulin-like growth factor 2 receptor

CTD Direct Evidence: marker/mechanism

NCBI chr17:12,901,293...12,988,593
Ensembl chr17:12,901,293...12,988,551

G

interleukin 10

treatment

RGD

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

insulin I

CTD Direct Evidence: therapeutic

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

insulin II

CTD Direct Evidence: therapeutic

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

kallikrein 1

CTD Direct Evidence: therapeutic

NCBI chr 7:43,874,784...43,879,046
Ensembl chr 7:43,874,784...43,879,042

G

leptin receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549

G

mitogen-activated protein kinase kinase kinase 7

associated with type 2 diabetes mellitus;protein:decreased expression:myocardium of ventricle (rat)

RGD

NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467

G

mitogen-activated protein kinase 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

microRNA 140

ameliorates

RGD

PMID:36044268 PMID:31078585

RGD:156430337, RGD:329347833

NCBI chr 8:108,277,876...108,277,945
Ensembl chr 8:108,277,876...108,277,945

G

mechanistic target of rapamycin kinase

ameliorates

RGD

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

myosin, light polypeptide kinase 2, skeletal muscle

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 2:152,753,265...152,764,985
Ensembl chr 2:152,753,272...152,764,988

G

nuclear factor, erythroid derived 2, like 2

treatment
ameliorates

associated with Diabetes Mellitus, Experimental

RGD

PMID:23453443 PMID:36044268 PMID:23353773

RGD:10412713, RGD:156430337, RGD:10412721

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nitric oxide synthase 3, endothelial cell

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

notch 1

treatment

RGD

NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675

G

natriuretic peptide precursor type A

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

neuregulin 1

treatment

associated with Diabetes Mellitus, Experimental;protein:decreased expresssion:left ventricle myocardium

RGD

PMID:22285193 PMID:32828943

RGD:10449013, RGD:405650202

NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825

G

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

ameliorates

RGD

NCBI chr 3:32,451,203...32,520,256
Ensembl chr 3:32,451,820...32,522,635

G

phospholamban

associated with Diabetes Mellitus, Experimental;protein:increased expression:heart left ventricle

RGD

NCBI chr10:53,213,782...53,222,095
Ensembl chr10:53,213,763...53,222,083

G

peroxisome proliferator activated receptor alpha

RGD

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

ryanodine receptor 2, cardiac

CTD Direct Evidence: marker/mechanism

NCBI chr13:11,567,985...12,121,831
Ensembl chr13:11,567,988...12,121,831

G

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4

CTD Direct Evidence: therapeutic

NCBI chr 8:46,660,205...46,664,099
Ensembl chr 8:46,659,834...46,664,321

G

solute carrier family 8 (sodium/calcium exchanger), member 1

treatment

RGD

NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806

G

secreted phosphoprotein 1

CTD Direct Evidence: marker/mechanism

NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916

G

telomerase reverse transcriptase

treatment

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962

G

tumor necrosis factor

CTD Direct Evidence: marker/mechanism

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

xanthine dehydrogenase

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191

diabetic cataract

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione reductase

RGD

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

Diabetic Cystopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis-inducing factor, mitochondrion-associated 1

protein:increased expression:nuclei:

RGD

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

BCL2-associated agonist of cell death

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

caspase 12

associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:urinary bladder detrusor smooth muscle

RGD

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

Diabetic Embryopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fas associated via death domain

RGD

NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200

diabetic encephalopathy

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

advanced glycosylation end product-specific receptor

treatment

associated with Diabetes Mellitus, Experimental

RGD

PMID:23529380 PMID:24291733

RGD:7244255, RGD:8553040

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

amyloid beta precursor protein

treatment

associated with type 2 diabetes mellitus

RGD

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

dual specificity phosphatase 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102

G

glycogen synthase kinase 3 beta

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

insulin degrading enzyme

associated with type 2 diabetes mellitus

RGD

NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010

G

nerve growth factor

treatment

associated with Diabetes Mellitus, Experimental
associated with Experimental Diabetes Mellitus

RGD

PMID:23528019 PMID:32681844

RGD:7242845, RGD:402463968

NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329

G

nerve growth factor receptor (TNFR superfamily, member 16)

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561

G

peroxisome proliferator activated receptor gamma

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

Diabetic Foot

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

protein:decreased expression:plasma

RGD

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

advanced glycosylation end product-specific receptor

associated with Diabetes Mellitus, Type 2;protein:decreased expression:blood

RGD

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

C-reactive protein, pentraxin-related

disease_progression

protein:increased expression:blood:

RGD

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

gap junction protein, alpha 1

protein:increased expression:dermis

RGD

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

H19, imprinted maternally expressed transcript

ameliorates

RNA:increased expression:foot (human)

RGD

PMID:33174326 PMID:33174326

RGD:156451663, RGD:156451663

NCBI chr 7:142,129,267...142,131,883
Ensembl chr 7:142,129,262...142,131,917

G

hypoxia inducible factor 1, alpha subunit

mRNA,protein:decreased expression:blood serum, foot (human)

RGD

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

heat shock protein 1B

severity

DNA:polymorphism: :1538G>A (human)

RGD

NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214

G

insulin-like growth factor 1

protein:decreased expression:fibroblast of dermis,stratum basale of epidermis:

RGD

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

interleukin 15

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:dermis, endothelial cell

RGD

NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851

G

integrin alpha M

protein:increased expression:pes (human)

RGD

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

mannose-binding lectin (protein C) 2

protein:increased expression:serum:

RGD

NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087

G

microRNA 17

NCBI chr14:115,281,103...115,281,186
Ensembl chr14:115,281,103...115,281,186

G

microRNA 210

miRNA:increased expression:blood serum, foot (human)

RGD

NCBI chr 7:140,801,297...140,801,406
Ensembl chr 7:140,801,297...140,801,406

G

matrix metallopeptidase 9

severity

RGD

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

notch 1

protein:increased expression:skin, epidermis:

RGD

NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675

G

plasminogen activator, tissue

RGD

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

pentraxin related gene

protein:decreased expression:plasma (human)

RGD

NCBI chr 3:66,127,308...66,133,227
Ensembl chr 3:66,127,331...66,133,226

G

toll-like receptor 4

susceptibility

DNA:SNPs,haplotype: :rs4986790,rs4986791,rs10759931,rs1927911(human);

RGD

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

diabetic ketoacidosis

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aquaporin 2

RGD

NCBI chr15:99,476,937...99,482,426
Ensembl chr15:99,476,936...99,482,428

G

insulin II

CTD Direct Evidence: therapeutic

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

insulin receptor

RGD

NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617

G

paired box 4

ClinVar Annotator: match by term: Diabetes mellitus, ketosis-prone | ClinVar Annotator: match by term: Diabetes mellitus, ketosis-prone, susceptibility to

PMID:9536098 PMID:15509590 PMID:17576681 PMID:18414213 PMID:25741868 More...

NCBI chr 6:28,442,333...28,449,339
Ensembl chr 6:28,442,333...28,449,352

G

serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

protein:decreased expression:serum

RGD

NCBI chr X:137,979,998...137,985,985
Ensembl chr X:137,980,006...137,985,985

Diabetic Nephropathies

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

treatment
no_association
susceptibility

CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:insertion/deletion
associated with Diabetes Mellitus, Type 1;DNA:insertion/deletion
associated with Diabetes Mellitus, Type 1;DNA:deletion:intron:IVS16+1464-1751del (human)

CTD
RGD

PMID:7909524 PMID:10099885 PMID:10857950 PMID:23733546 PMID:28468961 More...

RGD:2311449, RGD:11039044, RGD:8548885, RGD:8548872, RGD:7829780, RGD:7829777, RGD:1331525

NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790

G

angiotensin converting enzyme 2

no_association

associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphisms: :multiple (human)
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Diabetes Mellitus, Experimental
mRNA, protein:altered expression:kidney
associated with Diabetes Mellitus, Non-Insulin Dependent;mRNA, protein:decreased expression:kidney

CTD
RGD

PMID:12623933 PMID:17600118 PMID:20844835 PMID:18235039 PMID:18235039 More...

RGD:2313800, RGD:2313800, RGD:2313796, RGD:2313797

NCBI chr X:162,922,338...162,971,414
Ensembl chr X:162,922,328...162,971,416

G

actinin, alpha 1

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr12:80,214,316...80,307,165
Ensembl chr12:80,214,321...80,307,145

G

activin A receptor, type 1

associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:kidney

RGD

NCBI chr 2:58,336,450...58,456,840
Ensembl chr 2:58,278,656...58,457,169

G

adiponectin, C1Q and collagen domain containing

disease_progression
no_association

protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum
associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs1501299 (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs2241766 (human)

CTD
RGD

PMID:17942768 PMID:21945031 PMID:17970779 PMID:23260797 PMID:23260797

RGD:5686409, RGD:8694475, RGD:8694443, RGD:8694443

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

adenosine A1 receptor

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169

G

adrenergic receptor, alpha 2b

associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism (human)

RGD

NCBI chr 2:127,205,099...127,209,141
Ensembl chr 2:127,205,128...127,209,141

G

adrenergic receptor, beta 3

associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.W64R rs4994 (human)

RGD

NCBI chr 8:27,715,804...27,720,833
Ensembl chr 8:27,715,804...27,740,644

G

advanced glycosylation end product-specific receptor

susceptibility
treatment

ISO
IMP
IEP
IDA

associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney cortex, glomerulus
associated with Diabetes Mellitus, Type 2;DNA:polymorphism: :1704G>T (human)
associated with Diabetes Mellitus;DNA:polymorphisms, haplotype:cds, intron:p.G82S, g.2184A>G (rs2070600, rs3134940) (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum
associated with Diabetes Mellitus, Type 2; protein:increased expression:renal cortex (mouse)

RGD

PMID:19142024 PMID:14747204 PMID:21533139 PMID:23091285 PMID:12651605 More...

RGD:2325651, RGD:8695982, RGD:7244187, RGD:7244174, RGD:7243248, RGD:7243852, RGD:7243248, RGD:7243248

NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910

G

angiotensinogen

disease_progression
no_association

CTD Direct Evidence: therapeutic
associated with Diabetes Mellitus, Type 2;DNA:polymorphism: :p.M235T (human)
associated with Diabetes Mellitus, Type 1;DNA:polymorphism: :p.M235T (human)

CTD
RGD

PMID:17890855 PMID:20383342 PMID:15118671 PMID:19014923 PMID:11938025 More...

RGD:1331525, RGD:11039058, RGD:8548885, RGD:8548872, RGD:8548868

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

angiotensin II receptor, type 1a

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:polymorphism: :1166A>C (human)

RGD

PMID:12172324 PMID:12476891

RGD:6903861, RGD:8548891

NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850

G

angiotensin II receptor, type 2

associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:kidney

RGD

NCBI chr X:21,350,863...21,355,072
Ensembl chr X:21,350,783...21,355,403

G

alpha-2-HS-glycoprotein

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum

RGD

NCBI chr16:22,710,793...22,718,193
Ensembl chr16:22,710,027...22,718,199

G

aldo-keto reductase family 1 member B

susceptibility

associated with Diabetes Mellitus, Type 1;DNA:promoter:repeat:g.?(AC)n (human)

RGD

PMID:9215310 PMID:9000706

RGD:734542, RGD:8548641

NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413

G

albumin

associated with Metabolic Syndrome X;protein:increased expression:urine
CTD Direct Evidence: therapeutic
associated with Diabetes Mellitus, Experimental;protein:increased expression:urine
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine

CTD
RGD

PMID:16380483 PMID:19424163 PMID:21441310 PMID:19397971 PMID:19246226

RGD:2306882, RGD:5135032, RGD:2306885, RGD:2306886

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

alpha-kinase 1

CTD Direct Evidence: marker/mechanism

NCBI chr 3:127,460,367...127,574,195
Ensembl chr 3:127,463,959...127,574,176

G

amine oxidase, copper containing 3

CTD Direct Evidence: marker/mechanism

NCBI chr11:101,221,432...101,230,256
Ensembl chr11:101,221,431...101,232,764

G

apolipoprotein A-I

RGD

NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764

G

apolipoprotein A-II

associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:serum

RGD

PMID:11126402 PMID:9829487

RGD:2313958, RGD:2313960

NCBI chr 1:171,049,133...171,053,948
Ensembl chr 1:171,052,623...171,053,948

G

apolipoprotein B

associated with Diabetes Mellitus, Non-Insulin-Dependent

RGD

NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835

G

apolipoprotein C-I

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:very-low-density lipoprotein particle

RGD

NCBI chr 7:19,423,405...19,426,584
Ensembl chr 7:19,423,406...19,426,585

G

apolipoprotein C-III

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-455T>C

RGD

NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934

G

apolipoprotein E

susceptibility
no_association

DNA:missense mutations, haplotype:cds:p.C112R, p.R158C (human)
associated with Diabetes Mellitus, type 1;
associated with Diabetes Mellitus, Experimental

RGD

PMID:21127830 PMID:11495633 PMID:22859852

RGD:6903840, RGD:7771553, RGD:6902935

NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113

G

apolipoprotein H

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum

RGD

NCBI chr11:108,286,123...108,305,222
Ensembl chr11:108,234,180...108,305,222

G

aquaporin 2

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased secretion:urine

RGD

NCBI chr15:99,476,937...99,482,426
Ensembl chr15:99,476,936...99,482,428

G

arginase type II

RGD

NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075

G

ATP synthase F1 subunit beta

treatment

mRNA:decreased expression:renal glomerulus (rat)

RGD

NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260

G

AXL receptor tyrosine kinase

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12644472 PMID:15619028

NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130

G

antizyme inhibitor 1

treatment

RGD

NCBI chr15:38,487,674...38,523,506
Ensembl chr15:38,487,671...38,519,510

G

bradykinin receptor, beta 2

susceptibility

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496

G

brain derived neurotrophic factor

RGD

NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352

G

beclin 1, autophagy related

protein:increased expression:kidney

RGD

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

bone gamma carboxyglutamate protein

associated with Diabetes Mellitus, Type2; protein:increased expression:serum:

RGD

NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771

G

bone morphogenetic protein 7

RGD

NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114

G

complement component 3

associated with Diabetes Mellitus, Type 1; protein:increased expression:kidney:
associated with Diabetes Mellitus, Type 2

RGD

PMID:19200691 PMID:25662584

RGD:7183082, RGD:11040807

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

calcium channel, voltage-dependent, N type, alpha 1B subunit

treatment

RGD

NCBI chr 2:24,493,872...24,653,210
Ensembl chr 2:24,493,899...24,653,164

G

calpain 10

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:92,862,130...92,875,670
Ensembl chr 1:92,862,098...92,875,663

G

caspase 12

associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney

RGD

NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032

G

caspase 3

treatment

associated with Diabetes Mellitus, Experimental;protein:increased activity:kidney
associated with Diabetes Mellitus, Experimental
associated with type 2 diabetes mellitus

RGD

PMID:19601660 PMID:29606028 PMID:28456626

RGD:2311440, RGD:13792586, RGD:13782304

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 7

treatment

associated with type 2 diabetes mellitus

RGD

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 8

treatment

associated with type 2 diabetes mellitus
associated with Diabetes Mellitus, Experimental

RGD

PMID:28456626 PMID:29606028

RGD:13782304, RGD:13792586

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

treatment

associated with Diabetes Mellitus, Experimental

RGD

PMID:30038056 PMID:29606028

RGD:13782342, RGD:13792586

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

rat gene in db/db mice
associated with experimentally induced diabetes

RGD

PMID:22315314 PMID:20299359 PMID:21525431 PMID:21686137

RGD:7205651, RGD:7205676, RGD:7205665, RGD:7205662

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

caveolin 1, caveolae protein

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451

G

C-C motif chemokine ligand 11

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr11:81,948,658...81,953,781
Ensembl chr11:81,948,649...81,953,781

G

C-C motif chemokine ligand 2

susceptibility
disease_progression

associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney
protein:increased expression:urine
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine
associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA:increased expression:kidney

CTD
RGD

PMID:16374426 PMID:17968528 PMID:19369290 PMID:19409809 PMID:19097668 More...

RGD:2306991, RGD:2306980, RGD:2306979, RGD:2306982, RGD:2306989

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 20

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888

G

C-C motif chemokine ligand 5

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-28C>G
associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:urine

RGD

PMID:12610055 PMID:18326229

RGD:2307107, RGD:2307063

NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344

G

cellular communication network factor 2

associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:kidney (rat)
associated with Diabetes Mellitus, Experimental; protein:increased expression:kidney, glomerulus (rat)

RGD

PMID:19065061 PMID:19895808

RGD:2314604, RGD:2314366

NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581

G

cyclin E1

protein:increased expression:kidney

RGD

NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959

G

C-C motif chemokine receptor 2

no_association

associated with Diabetes Mellitus, Insulin-Dependent
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.V64I (human)

RGD

PMID:17631861 PMID:11756347

RGD:2313558, RGD:2313563

NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594

G

C-C motif chemokine receptor 5

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:59029G>A (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP: :59029G>A (human)

RGD

PMID:12610055 PMID:17428349

RGD:2307107, RGD:8549756

NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736

G

CD36 molecule

protein:increased expression:renal proximal tubule, endothelial cell

RGD

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD38 antigen

associated with Diabetes Mellitus, Experimental

RGD

PMID:19073639 PMID:19300526

RGD:2307227, RGD:2307228

NCBI chr 5:44,026,153...44,069,714
Ensembl chr 5:44,025,895...44,069,717

G

CD40 ligand

associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:serum

RGD

NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402

G

cyclin dependent kinase inhibitor 1A

CTD Direct Evidence: marker/mechanism

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

protein:increased expression:kidney
mRNA, protein:increased expression:kidney, glomerulus

RGD

PMID:16805985 PMID:15698433

RGD:2293619, RGD:2293628

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

cofilin 1, non-muscle

associated with Diabetes Mellitus, Experimental;protein:increased phosphorylation:renal glomerulus (rat)

RGD

NCBI chr19:5,540,483...5,544,059
Ensembl chr19:5,540,483...5,545,229

G

clusterin

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996

G

carnosine dipeptidase 1

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:17942768 PMID:21393041 PMID:21573905 PMID:21393041

NCBI chr18:84,628,509...84,668,359
Ensembl chr18:84,628,634...84,668,220

G

CNDP dipeptidase 2

CTD Direct Evidence: marker/mechanism

NCBI chr18:84,685,590...84,703,827
Ensembl chr18:84,685,590...84,703,827

G

collagen, type I, alpha 1

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:renal glomerulus (rat)

RGD

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type I, alpha 2

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544

G

collagen, type IV, alpha 1

associated with Diabetes Mellitus, Non-Insulin Dependent;mRNA:increased expression:kidney
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental

CTD
RGD

PMID:18682491 PMID:27997345 PMID:19466391 PMID:17582205

RGD:2311340, RGD:2311342

NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826

G

collagen, type VI, alpha 3

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr 1:90,694,582...90,771,710
Ensembl chr 1:90,693,645...90,771,693

G

carboxypeptidase B2

susceptibility

DNA:SNP:cds:1040C>T(human)
protein:increased expression:plasma

RGD

PMID:22932273 PMID:12574207

RGD:7243116, RGD:7243123

NCBI chr14:75,479,727...75,520,995
Ensembl chr14:75,479,727...75,520,995

G

cAMP responsive element binding protein 1

susceptibility

RGD

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

C-reactive protein, pentraxin-related

disease_progression

associated with Diabetes Mellitus, Type 1
associated with Diabetes Mellitus, Type 2;protein:increased expression:urine

RGD

PMID:22885250 PMID:22590912

RGD:6906965, RGD:6906967

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

colony stimulating factor 1 receptor

disease_progression

associated with Diabetes Mellitus, Type 2
mRNA,protein:increased expression:kidney (rat)

RGD

PMID:19466391 PMID:32141565

RGD:2311340, RGD:151665767

NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221

G

cystatin C

protein:increased expression:plasma (rat)
protein:increased expression:serum (human)

RGD

PMID:18946178 PMID:19132849

RGD:2314297, RGD:2314328

NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612

G

cytotoxic T-lymphocyte-associated protein 4

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:plasma:

RGD

NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991

G

cathepsin D

CTD Direct Evidence: marker/mechanism

NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775

G

cubilin

RGD

NCBI chr 2:13,281,149...13,496,687
Ensembl chr 2:13,281,149...13,496,624

G

C-X-C motif chemokine ligand 10

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
associated with Diabetes Mellitus, Insulin-Dependent

RGD

PMID:17425653 PMID:19073786

RGD:2311359, RGD:2311357

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine receptor 2

treatment

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405

G

cytochrome b-245, alpha polypeptide

associated with Diabetes Mellitus, Type 2;DNA:SNP: :242C>T (human)

RGD

NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669

G

cytochrome P450, family 11, subfamily b, polypeptide 2

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:-344C>T (human)

RGD

NCBI chr15:74,722,467...74,728,080
Ensembl chr15:74,722,859...74,728,167

G

cytochrome P450, family 19, subfamily a, polypeptide 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394

G

cytochrome P450, family 2, subfamily j, polypeptide 6

associated with Diabetes Mellitus, Experimental;

RGD

NCBI chr 4:96,404,375...96,449,835
Ensembl chr 4:96,404,375...96,441,898

G

cytochrome P450, family 2, subfamily j, polypeptide 9

associated with Diabetes Mellitus, Experimental;

NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815

G

decorin

associated with Diabetes Mellitus, Insulin-Dependent
protein:increased expression:plasma, urine
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Insulin-Dependent;mRNA, protein:decreased expression:kidney cortex, glomerulus

RGD

PMID:12187087 PMID:11259366 PMID:17884968 PMID:16868749

RGD:2311415, RGD:2311416, RGD:2311411, RGD:2311412

NCBI chr10:97,315,362...97,354,025
Ensembl chr10:97,315,471...97,354,005

G

diacylglycerol kinase, eta

CTD Direct Evidence: marker/mechanism

NCBI chr14:78,796,789...78,970,169
Ensembl chr14:78,796,190...78,970,216

G

dickkopf WNT signaling pathway inhibitor 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065

G

endothelin 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased secretion:plasma (human)

RGD

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

endothelin receptor type A

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093

G

epidermal growth factor

RGD

NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965

G

engulfment and cell motility 1

CTD Direct Evidence: marker/mechanism

NCBI chr13:20,274,677...20,792,523
Ensembl chr13:20,274,766...20,792,523

G

endoglin

associated with Diabetes Mellitus, Insulin-Dependent; mRNA:increased expression:kidney

RGD

NCBI chr 2:32,536,607...32,572,681
Ensembl chr 2:32,536,607...32,572,681

G

glutamyl aminopeptidase

CTD Direct Evidence: marker/mechanism

NCBI chr 3:129,062,826...129,126,398
Ensembl chr 3:129,062,824...129,126,369

G

ectonucleotide pyrophosphatase/phosphodiesterase 1

RGD

NCBI chr10:24,513,812...24,588,057
Ensembl chr10:24,513,812...24,588,057

G

E1A binding protein p300

treatment

associated with Diabetes Mellitus, Experimental; mRNA, protein:increased expression:kidney (rat)

RGD

PMID:19268536 PMID:19268536

RGD:2311716, RGD:2311716

NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278

G

endothelial PAS domain protein 1

treatment

associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental

RGD

PMID:17967803 PMID:17914354

RGD:10395374, RGD:10395377

NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838

G

epoxide hydrolase 2, cytoplasmic

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949

G

erythropoietin

DNA:snp:promoter:-1125T>G(rs1617640)(human)
associated with Diabetes Mellitus, Experimental;

RGD

PMID:19619913 PMID:18458324 PMID:19356735

RGD:2313832, RGD:2313838, RGD:2313833

NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504

G

ERBB receptor feedback inhibitor 1

associated with Diabetes Mellitus, Experimental; mRNA:increased expression:kidney:

RGD

NCBI chr 4:150,938,253...150,953,346
Ensembl chr 4:150,938,376...150,953,349

G

estrogen receptor 1 (alpha)

associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression:glomerulus
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:snps:introns: multiple(human)

RGD

PMID:16464734 PMID:15550505 PMID:18305958

RGD:2314020, RGD:2314023, RGD:2314005

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

coagulation factor II

disease_progression

protein:increased expression:plasma (human)
DNA:polymorphism: :20210G>A(human)

RGD

PMID:21955218 PMID:14983223 PMID:21574459

RGD:6893574, RGD:2313643, RGD:6893575

NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759

G

coagulation factor III

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma

RGD

NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697

G

fatty acid binding protein 2, intestinal

RGD

NCBI chr 3:122,688,721...122,693,155
Ensembl chr 3:122,688,721...122,693,155

G

Fas cell surface death receptor

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:kidney
associated with Diabetes Mellitus, Experimental;protein:increased expression:renal distal tubule (rat)
mRNA:increased expression:kidney

RGD

PMID:17851466 PMID:12861046 PMID:18287563

RGD:2315705, RGD:8686421, RGD:2312739

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fas ligand

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:kidney

RGD

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

fibrillin 1

onset

associated with Diabetes Mellitus, Experimental

RGD

PMID:16395273 PMID:16380460

RGD:7365077, RGD:7365080

NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913

G

F-box and WD-40 domain protein 13

CTD Direct Evidence: marker/mechanism

NCBI chr 9:109,008,295...109,025,043
Ensembl chr 9:109,008,295...109,025,043

G

fibroblast growth factor 2

mRNA:increased expression:kidney

RGD

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

fibroblast growth factor 21

protein:increased expression:serum:

RGD

NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914

G

fibroblast growth factor 23

severity

mRNA,protein:increased expression:kidney:

RGD

NCBI chr 6:127,049,865...127,059,257
Ensembl chr 6:127,049,865...127,058,371

G

FMS-like tyrosine kinase 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:urine

RGD

NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821

G

fibromodulin

associated with Diabetes Mellitus, Insulin-Dependent;mRNA:decreased expression:kidney cortex
mRNA,protein:increased expression:Kidney Glomerulus

RGD

PMID:16868749 PMID:11259366

RGD:2311412, RGD:2311416

NCBI chr 1:133,964,992...133,976,018
Ensembl chr 1:133,964,992...133,976,015

G

fibronectin 1

treatment

associated with Diabetes Mellitus, Experimental; mRNA:increased expression:kidney
mRNA:increased expression:nephron tubule (human)
CTD Direct Evidence: marker/mechanism
protein:increased expression:kidney cortex:

CTD
RGD

PMID:24413998 PMID:16301823 PMID:35592524 PMID:22736507

RGD:7206843, RGD:401851916, RGD:10402169

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

FTO alpha-ketoglutarate dependent dioxygenase

susceptibility

associated with diabetes mellitus;DNA:SNP: :rs17817449 (human)
associated with type 2 diabetes mellitus;DNA:SNPs: :rs1121980, rs1421085, rs17817449 (human)
associated with type 2 diabetes mellitus;DNA:SNP: :rs7204609 (human)

RGD

PMID:29154870 PMID:29410390 PMID:34134115

RGD:329813082, RGD:329901856, RGD:329813084

NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067

G

fucosidase, alpha-L- 1, tissue

associated with Diabetes Mellitus, Insulin-Dependent;protein:decreased activity;urine

RGD

NCBI chr 4:135,648,037...135,667,611
Ensembl chr 4:135,648,046...135,667,622

G

glucose-6-phosphate dehydrogenase X-linked

treatment

associated with Hypertension

RGD

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

growth arrest specific 6

CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:12644472 PMID:15619028

NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490

G

glycine amidinotransferase (L-arginine:glycine amidinotransferase)

RGD

NCBI chr 2:122,424,954...122,441,758
Ensembl chr 2:122,424,948...122,441,784

G

glutamine fructose-6-phosphate transaminase 1

RGD

NCBI chr 6:87,019,828...87,069,189
Ensembl chr 6:87,019,828...87,069,179

G

glutamine fructose-6-phosphate transaminase 2

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP:3' utr

RGD

NCBI chr11:49,684,981...49,729,448
Ensembl chr11:49,685,005...49,729,440

G

growth hormone receptor

susceptibility

associated with Diabetes Mellitus
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:kidney

RGD

PMID:10541297 PMID:15066219 PMID:10614635 PMID:10990443

RGD:2307370, RGD:2307364, RGD:2307369, RGD:2307368

NCBI chr15:3,347,237...3,612,834
Ensembl chr15:3,347,242...3,612,974

G

gastric inhibitory polypeptide receptor

RGD

NCBI chr 7:18,889,988...18,904,173
Ensembl chr 7:18,889,986...18,900,052

G

glyoxalase 1

no_association

DNA:SNP:promoter:-7C>T (human)

PMID:21738003 PMID:21738003

RGD:7242569, RGD:7242569

NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845

G

glutathione peroxidase 1

treatment

protein:increased expression:glomerulus
associated with Experimental Diabetes Mellitus
associated with Diabetes Mellitus, Type 1

RGD

PMID:17609286 PMID:32592386 PMID:16249459

RGD:2306609, RGD:401827869, RGD:11068479

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione peroxidase 3

treatment

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression:serum (human)
associated with Experimental Diabetes Mellitus

RGD

PMID:17269729 PMID:32592386

RGD:2312635, RGD:401827869

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

G protein-coupled receptor kinase 2

treatment

RGD

NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250

G

G protein-coupled receptor kinase 3

treatment

RGD

NCBI chr 5:113,058,344...113,163,518
Ensembl chr 5:113,058,348...113,163,657

G

G protein-coupled receptor kinase 4

protein:decreased expression:cortex of kidney (rat)

RGD

NCBI chr 5:34,817,641...34,912,649
Ensembl chr 5:34,817,723...34,912,649

G

G protein-coupled receptor kinase 6

treatment

RGD

NCBI chr13:55,592,865...55,608,740
Ensembl chr13:55,592,885...55,608,740

G

glycogen synthase kinase 3 beta

treatment

RGD

NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446

G

glutathione reductase

treatment

associated with Diabetes Mellitus, Type 2;protein:decreased activity:kidney
associated with Diabetes Mellitus, Experimental

RGD

PMID:23626958 PMID:24947049

RGD:7257582, RGD:10401899

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, mu 1

no_association

associated with Diabetes Mellitus, Type 1;DNA:deletion:cds: (human)

RGD

NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289

G

glutathione S-transferase, theta 1

disease_progression
no_association

associated with Diabetes Mellitus, Type 2;DNA:deletion:cds (human)
associated with Diabetes Mellitus, Type 1;DNA:deletion:cds (human)

RGD

PMID:15927971 PMID:19752172

RGD:2306630, RGD:7495818

NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418

G

histocompatibility 2, class II, locus DMa

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr17:34,338,667...34,358,075
Ensembl chr17:34,338,515...34,358,075

G

histocompatibility 2, class II, locus Mb1

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr17:34,372,165...34,379,203
Ensembl chr17:34,372,046...34,379,204

G

histocompatibility 2, class II antigen E alpha

mRNA:increased expression:nephron tubule (human)

NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618

G

histocompatibility 2, M region locus 2

mRNA:increased expression:nephron tubule (human)

NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443

G

hyaluronan synthase 2

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:renal medulla

RGD

NCBI chr15:56,529,023...56,557,942
Ensembl chr15:56,529,023...56,557,935

G

hepatitis A virus cellular receptor 1

disease_progression

protein:increased expression:plasma
associated with Diabetes mellitus, Type 1;
associated with Diabetes Mellitus,Type 2;protein:increased expression:urine:

RGD

PMID:22997966 PMID:20980978 PMID:22015481

RGD:7245497, RGD:7246890, RGD:7245960

NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405

G

hemolytic complement

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr 2:34,873,341...34,958,518
Ensembl chr 2:34,873,343...34,951,450

G

histone deacetylase 2

mRNA,protein:increased expression:kidney:

RGD

PMID:24717296 PMID:24717296 PMID:24717296

RGD:9590311, RGD:9590311, RGD:9590311

NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885

G

histone deacetylase 4

treatment

mRNA,protein:increased expression:kidney:

RGD

PMID:24717296 PMID:24717296 PMID:24717296 PMID:24717296

RGD:9590311, RGD:9590311, RGD:9590311, RGD:9590311

NCBI chr 1:91,856,501...92,123,424
Ensembl chr 1:91,856,501...92,123,421

G

histone deacetylase 5

mRNA,protein:increased expression:kidney:

RGD

PMID:24717296 PMID:24717296 PMID:24717296

RGD:9590311, RGD:9590311, RGD:9590311

NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992

G

homeostatic iron regulator

associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.C282Y (human)

RGD

NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837

G

hepatocyte growth factor

RGD

NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150

G

hypoxia inducible factor 1, alpha subunit

treatment

associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental

RGD

PMID:17967803 PMID:17914354

RGD:10395374, RGD:10395377

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

heme oxygenase 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

hepatic nuclear factor 4, alpha

mRNA:decreased expression:kidney, liver

RGD

NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830

G

hydroxysteroid 11-beta dehydrogenase 1

susceptibility

DNA:SNO:intron: (rs17389016, rs11799643) (human)

RGD

NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383

G

heat shock protein 1A

associated with Diabetes Mellitus, Type 2

RGD

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

G

heat shock protein 1B

RGD

NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214

G

heat shock protein 5

associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney

RGD

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 8

RGD

NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383

G

heat shock protein 1

mRNA,protein:increased expression:glomerulus:
protein:increased expression:glomerulus, podocyte:

RGD

PMID:21931298 PMID:21931298

RGD:10402764, RGD:10402764

NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417

G

5-hydroxytryptamine (serotonin) receptor 2A

associated with Diabetes Mellitus, Experimental;
associated with Diabetes Mellitus Type 2;

RGD

PMID:18175064 PMID:12213354

RGD:7257686, RGD:7257687

NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934

G

intercellular adhesion molecule 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Insulin-Dependent;DNA:SNP: :p.K469E (rs5498) (human)
associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney (mouse)

RGD

PMID:18299691 PMID:19246972 PMID:18505543 PMID:20447389

RGD:2312766, RGD:2313470, RGD:2313475, RGD:4145414

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

interferon gamma

mRNA, protein:increased expression:kidney, T cell

RGD

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

insulin-like growth factor 1

protein:decreased expression:serum
associated with Diabetes Mellitus, Experimental;protein:decreased expression:serum (rat)

RGD

PMID:17194636 PMID:10444029

RGD:2313764, RGD:12904967

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

insulin-like growth factor I receptor

mRNA,protein:increased expression:kidney:

RGD

NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416

G

insulin-like growth factor 2

associated with Diabetes Mellitus, Type 2; mRNA:decreased expression:neural tissue, liver:
associates with Diabetes Mellitus; mRNA:decreased expression:brain:

RGD

PMID:9336345 PMID:8764603 PMID:9336345

RGD:5510019, RGD:5510022, RGD:5510019

NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553

G

insulin-like growth factor binding protein 1

DNA:SNPs

RGD

NCBI chr11:7,147,787...7,152,546
Ensembl chr11:7,147,782...7,152,546

G

interleukin 10

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphisms:promoter:g.-1082G>A, g.-819C>T, g.-592C>A (human)

RGD

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 1 beta

associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental

RGD

PMID:22086159 PMID:19769609

RGD:7175266, RGD:7175519

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 1 receptor antagonist

susceptibility
no_association

associated with Diabetes Mellitus, Type 2; DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)

RGD

PMID:16174285 PMID:17286233

RGD:6907371, RGD:6909120

NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506

G

interleukin 6

susceptibility

associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)
associated with Diabetes Mellitus, Type1;DNA:polymorphism:promoter:-174G>C(human)
associated with Diabetes Mellitus, Experimental; protein:increased expression:kidney (rat)

RGD

PMID:18716362 PMID:19542902 PMID:19052104

RGD:2307282, RGD:7829816, RGD:2307281

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

insulin II

resistance

CTD Direct Evidence: marker/mechanism|therapeutic

CTD
RGD

PMID:2143390 PMID:7713310 PMID:7987072 PMID:22068113

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

insulin receptor substrate 2

mRNA:increased expression:kidney tubule

RGD

NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458

G

integrin alpha 2

severity

associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:mesangial cell (human)

RGD

NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636

G

integrin beta 2

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542

G

Janus kinase 2

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

G

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

ameliorates

RGD

PMID:24733189 PMID:29425253

RGD:329955448, RGD:329969879

NCBI chr 7:24,069,750...24,084,635
Ensembl chr 7:24,069,688...24,086,115

G

lysine (K)-specific demethylase 6A

associated with Diabetes Mellitus, Type 1;protein:increased expression:kidney (mouse)

RGD

NCBI chr X:18,027,101...18,147,061
Ensembl chr X:18,028,814...18,146,175

G

kinase insert domain protein receptor

CTD Direct Evidence: marker/mechanism

NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118

G

kelch-like ECH-associated protein 1

RGD

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

G

klotho

treatment

protein:decreased expression:kidney:

RGD

NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282

G

kallikrein 1

CTD Direct Evidence: therapeutic

NCBI chr 7:43,874,784...43,879,046
Ensembl chr 7:43,874,784...43,879,042

G

kallikrein B, plasma 1

disease_progression

associated with Diabetes Mellitus, Type 1; protein:increased expression:plasma:

RGD

NCBI chr 8:45,719,725...45,747,872
Ensembl chr 8:45,719,726...45,747,896

G

kininogen 1

associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism: :7965C>T (human)

RGD

NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828

G

laminin, beta 2

RGD

NCBI chr 9:108,357,080...108,367,729
Ensembl chr 9:108,356,935...108,367,729

G

lipocalin 2

protein:increased expression:urine
associated with Diabetes Mellitus,Type 2;protein:increased expression:urine:

RGD

PMID:22997966 PMID:22015481

RGD:7245497, RGD:7245960

NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264

G

leptin

RGD

NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876

G

leptin receptor

CTD Direct Evidence: marker/mechanism

PMID:28130181 PMID:29988851 PMID:36066211

NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549

G

lamin A

associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:cds:1908C>T (human)

RGD

NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263

G

leucyl/cystinyl aminopeptidase

RGD

NCBI chr17:17,747,985...17,846,303
Ensembl chr17:17,741,672...17,845,312

G

lipoprotein lipase

susceptibility

RGD

NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100

G

lymphotoxin A

DNA:polymorphism

RGD

NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327

G

mitogen-activated protein kinase 1

RGD

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 14

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased activity:kidney

RGD

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

midkine

CTD Direct Evidence: marker/mechanism

NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642

G

mitofusin 2

treatment

associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:27997345 PMID:27997345 PMID:26123583

RGD:12910740, RGD:11053290

NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161

G

microRNA 145a

CTD Direct Evidence: marker/mechanism

NCBI chr18:61,780,896...61,780,965
Ensembl chr18:61,780,896...61,780,965

G

microRNA 146

exacerbates

RGD

NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288

G

microRNA 21a

RNA:increased expression:kidney

RGD

NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984

G

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 4:87,688,162...87,951,652
Ensembl chr 4:87,688,162...87,951,601

G

matrix metallopeptidase 12

RGD

NCBI chr 9:7,344,397...7,360,461
Ensembl chr 9:7,344,381...7,369,499

G

matrix metallopeptidase 2

treatment
ameliorates

associated with Diabetes Mellitus, Experimental

RGD

PMID:23384615 PMID:37643020

RGD:13204971, RGD:401827835

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 3

protein: decreased expression: glomerulus

RGD

NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975

G

matrix metallopeptidase 9

treatment

associated with Diabetes Mellitus, Type 2;DNA:repeat:promoter
associated with Diabetes Mellitus, Experimental

RGD

PMID:11576356 PMID:23384615

RGD:8547866, RGD:13204971

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

methylenetetrahydrofolate reductase

susceptibility
no_association

associated with Diabetes Mellitus, Type 2; DNA:transition:cds:g.677C>T (human)

RGD

PMID:14737040 PMID:18280442

RGD:6893524, RGD:6893576

NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008

G

mechanistic target of rapamycin kinase

susceptibility

DNA:SNP,haplotype: :rs7212142(human)
associated with Diabetes Mellitus, Experimental

RGD

PMID:21606597 PMID:28536139 PMID:23827786

RGD:7245564, RGD:13506787, RGD:10003168

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Associated with Diabetes Mellitus, Type 1;DNA:SNP:cds:66A>G, (rs1801394) (human)

RGD

NCBI chr13:68,708,897...68,730,273
Ensembl chr13:68,708,899...68,730,268

G

N-acetyltransferase 2 (arylamine N-acetyltransferase)

associated with Diabetes Mellitus, Insulin-Dependent

RGD

NCBI chr 8:67,947,527...67,955,296
Ensembl chr 8:67,947,510...67,955,236

G

NADH:ubiquinone oxidoreductase core subunit S3

treatment

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:kidney,glomerulus
associated with Diabetes Mellitus, Experimental

RGD

PMID:22903132 PMID:22591908

RGD:8552684, RGD:13792578

NCBI chr 2:90,724,971...90,735,065
Ensembl chr 2:90,724,978...90,735,171

G

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

protein:increased expression:nucleus

RGD

NCBI chr18:80,649,418...80,756,286
Ensembl chr18:80,649,420...80,756,286

G

nuclear factor, erythroid derived 2, like 2

treatment

CTD Direct Evidence: therapeutic
associated with Diabetes Mellitus, Experimental

CTD
RGD

PMID:20103708 PMID:21439372 PMID:23064900

RGD:6893386, RGD:10412718

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nitric oxide synthase 1, neuronal

treatment

associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental

RGD

PMID:23548923 PMID:10966937

RGD:7257655, RGD:13824991

NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905

G

nitric oxide synthase 3, endothelial cell

susceptibility
treatment
no_association

associated with Diabetes Mellitus, Type 2;DNA:duplication:intron:IVS4?-?+27 (human)
associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism

CTD
RGD

PMID:20042665 PMID:10868974 PMID:29336891 PMID:10741691

RGD:7421530, RGD:13504726, RGD:7421534

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

NADPH oxidase 4

associated with Diabetes Mellitus, Experimental;mRNA:increased expression:kidney cortex

RGD

PMID:17511984 PMID:16135519

RGD:2324670, RGD:2324673

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

nephrosis 1, nephrin

treatment

associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Experimental;protein:decreased expression:kidney (mouse)

RGD

PMID:17624267 PMID:21617141 PMID:24173355 PMID:30862474

RGD:38596322, RGD:7241083, RGD:38599008, RGD:38596325

NCBI chr 7:30,157,259...30,188,048
Ensembl chr 7:30,157,740...30,186,648

G

natriuretic peptide precursor type A

no_association
disease_progression

DNA:polymorphism:intron
associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma
associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism: :2238T>C (human)
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:blood

RGD

PMID:9681733 PMID:10404802 PMID:15111511 PMID:10381153

RGD:2313593, RGD:7247731, RGD:2313590, RGD:2313592

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

natriuretic peptide type B

associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma

RGD

PMID:10404802 PMID:16917760

RGD:7247731, RGD:7248603

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

NAD(P)H dehydrogenase, quinone 1

treatment

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

neurotrophic tyrosine kinase, receptor, type 2

RGD

NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784

G

poly (ADP-ribose) polymerase family, member 1

associated with Diabetes Mellitus, Experimental

RGD

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

paired box 2

associated with Diabetes Mellitus, Experimental;protein:increased expression:kidney cortex

RGD

NCBI chr19:44,735,040...44,826,708
Ensembl chr19:44,735,057...44,826,310

G

platelet derived growth factor, alpha

associated with Diabetes Mellitus, Non-Insulin Dependent;mRNA, protein:increased expression:kidney

RGD

NCBI chr 5:138,961,761...138,986,336
Ensembl chr 5:138,961,769...138,983,125

G

platelet derived growth factor, B polypeptide

associated with Diabetes Mellitus, Non-Insulin Dependent

RGD

NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178

G

platelet derived growth factor receptor, alpha polypeptide

mRNA:increased expression:nephron tubule (human)

RGD

NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876

G

platelet derived growth factor receptor, beta polypeptide

associated with Diabetes Mellitus, Non-Insulin Dependent

RGD

NCBI chr18:61,178,194...61,218,139
Ensembl chr18:61,178,222...61,218,133

G

platelet/endothelial cell adhesion molecule 1

associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA:increased expression:glomerulus

RGD

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

placental growth factor

disease_progression

associated with Diabetes Mellitus, Type 1

RGD