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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:nasopharynx carcinoma
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Accession:DOID:9261 term browser browse the term
Definition:A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract. (DO)
Synonyms:exact_synonym: NPC;   NPCA;   cancer of nasopharynx;   cancer of the nasopharynx;   malignant nasopharyngeal tumor;   malignant neoplasm of nasopharynx;   nasopharyngeal cancer;   nasopharyngeal cancers;   nasopharyngeal carcinoma;   nasopharynx cancer
 related_synonym: NPCA1;   NPCA2;   NPCA3;   carcinoma of nasopharynx;   nasopharyngeal carcinoma, susceptibility to, 1;   nasopharyngeal carcinoma, susceptibility to, 2;   nasopharyngeal carcinoma, susceptibility to, 3
 primary_id: OMIM:607107
 alt_id: OMIM:161550;   OMIM:617075
 xref: GARD:7163;   ICD10CM:C11;   ICD10CM:C11.0;   ICD10CM:C11.1;   ICD10CM:C11.2;   ICD10CM:C11.3;   ICD9CM:147;   ICD9CM:147.0;   ICD9CM:147.1;   ICD9CM:147.2;   ICD9CM:147.3;   NCI:C3871;   NCI:C9321;   ORDO:150
For additional species annotation, visit the Alliance of Genome Resources.


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nasopharynx carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arid1a AT-rich interaction domain 1A disease_progression ISO protein:decreased expression:nasopharynx(human) RGD PMID:31213911 RGD:126781707 NCBI chrNW_004936474:11,148,857...11,197,312 JBrowse link
G Atm ATM serine/threonine kinase treatment ISO protein:decreased expression:epithelium of nasopharynx (human)
associated with Epstein-Barr Virus Infections;mRNA:decreased expression:nasopharyngeal tissue (human)
RGD PMID:19142888 PMID:28820634 PMID:29230817 RGD:126779560 RGD:126790562 RGD:150340692 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Atr ATR serine/threonine kinase treatment ISO RGD PMID:28820634 RGD:150340692 NCBI chrNW_004936540:4,074,543...4,178,859 JBrowse link
G Bcl2 BCL2 apoptosis regulator disease_progression ISO protein:increased expression:epithelium of nasopharynx (human) RGD PMID:12099337 RGD:11526103 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Brca1 BRCA1 DNA repair associated ISO DNA:nonsense mutation: :p.Q563* (human) RGD PMID:28857155 RGD:127229936 NCBI chrNW_004936490:17,735,444...17,801,456 JBrowse link
G Cr2 complement C3d receptor 2 susceptibility ISO DNA:SNP:5'UTR:24T>C (rs3813946)(human) RGD PMID:23612877 RGD:127338247 NCBI chrNW_004936557:5,246,770...5,256,608 JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO RGD PMID:24825912 RGD:126781774 NCBI chrNW_004936646:497,783...515,247 JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit disease_progression ISO mRNA, protein:increased expression:ventral nasal meatus RGD PMID:21300475 RGD:126779603 NCBI chrNW_004936527:5,024,077...5,069,152 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 disease_progression ISO RGD PMID:16480593 RGD:126925191 NCBI chrNW_004936472:23,442,946...23,617,523 JBrowse link
G Jak2 Janus kinase 2 severity ISO protein:increased expression:mucosa of nasopharynx (human) RGD PMID:30123088 RGD:149735327 NCBI chrNW_004936503:111,722...243,627 JBrowse link
G Kdm3a lysine demethylase 3A severity ISO protein:decreased expression:nasopharyngeal epithelium (human) RGD PMID:21541331 RGD:9590228 NCBI chrNW_004936712:1,053,210...1,097,845 JBrowse link
G Kdr kinase insert domain receptor disease_progression ISO RGD PMID:16480593 RGD:126925191 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G LOC101973029 cytochrome P450 2E1 ISO DNA:SNP: :rs2031920 (human) RGD PMID:26582733 RGD:11061495 NCBI chrNW_004936486:19,691,822...19,702,684 JBrowse link
G Mst1r macrophage stimulating 1 receptor susceptibility ISO ClinVar Annotator: match by term: Nasopharyngeal carcinoma, susceptibility to, 3 ClinVar
OMIM
PMID:26951679 NCBI chrNW_004936529:1,494,748...1,509,925 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO RGD PMID:19068094 RGD:2325214 NCBI chrNW_004936816:174,943...209,241 JBrowse link
G Ppia peptidylprolyl isomerase A ISO mRNA, protein:increased expression:blood serum, nasopharynx, extracellular exosome (human) RGD PMID:31063269 RGD:150429622 NCBI chrNW_004936478:19,669,727...19,673,355 JBrowse link
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide ISO mRNA:increased expression:nasopharynx (human) RGD PMID:24080422 RGD:10755709 NCBI chrNW_004936550:1,323,351...1,335,074 JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E ISO mRNA:increased expression:nasopharynx (human) RGD PMID:24080422 RGD:10755709 NCBI chrNW_004936567:849,300...855,214 JBrowse link
G Snrpf small nuclear ribonucleoprotein polypeptide F ISO mRNA:increased expression:nasopharynx (human) RGD PMID:24080422 RGD:10755709 NCBI chrNW_004936507:11,973,818...11,980,370 JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G ISO mRNA:increased expression:nasopharynx (human) RGD PMID:24080422 RGD:10755709 NCBI chrNW_004936491:14,442,904...14,450,717 JBrowse link
G Stat3 signal transducer and activator of transcription 3 severity ISO protein:increased expression:mucosa of nasopharynx (human) RGD PMID:30123088 RGD:149735327 NCBI chrNW_004936490:17,119,189...17,178,402 JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 severity ISO human cells in mouse model RGD PMID:32774157 RGD:150429610 NCBI chrNW_004936752:440,137...577,339 JBrowse link
G Tp53 tumor protein p53 ISO OMIM NCBI chrNW_004936595:919,807...935,367 JBrowse link
G Vegfa vascular endothelial growth factor A disease_progression
severity
ISO protein:increased expression:mucosa of nasopharynx (human) RGD PMID:16480593 PMID:30123088 RGD:126925191 RGD:149735327 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
G Wrap53 WD repeat containing antisense to TP53 ISO associated with Epstein-Barr Virus Infections; protein:increased expression:nasopharynx epithelium RGD PMID:28607398 RGD:21081524 NCBI chrNW_004936595:936,184...952,784 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13006
    disease of anatomical entity 12684
      respiratory system disease 2506
        Respiratory Tract Neoplasms 756
          respiratory system cancer 521
            nasopharynx carcinoma 25
              lymphoepithelioma-like carcinoma 0
Path 2
Term Annotations click to browse term
  disease 13006
    disease of anatomical entity 12684
      nervous system disease 10538
        sensory system disease 4958
          Otorhinolaryngologic Diseases 1164
            Pharyngeal Diseases 168
              Pharyngeal Neoplasms 141
                pharynx cancer 130
                  nasopharynx carcinoma 25
                    lymphoepithelioma-like carcinoma 0
paths to the root