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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:amebiasis
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Accession:DOID:9181 term browser browse the term
Definition:A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs. (DO)
Synonyms:exact_synonym: Amebic Abscess;   Ameboma;   Amebomas;   Iodamoebiases;   Iodamoebiasis;   amebiases;   amebic abscesses;   amoebiases;   amoebiasis
 related_synonym: chronic intestinal amebiasis
 primary_id: MESH:D000562
 xref: EFO:0007144;   GARD:652;   ICD10CM:A06;   ICD9CM:006;   NCI:C157785;   NCI:C84551


show annotations for term's descendants           Sort by:
Acanthamoeba Keratitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr4 toll-like receptor 4 ISO mRNA,protein:increased expression:cornea RGD PMID:21155840 RGD:7777095 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
Amebic Liver Abscess term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 susceptibility ISO DNA:polymorphism, haplotype: :HLA-DQB1*04, HLA-DQB1*02 RGD PMID:25938667 RGD:36049810 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta susceptibility ISO DNA:polymorphism, haplotype: :HLA-DRB1*08 RGD PMID:25938667 RGD:36049810 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G Il2 interleukin 2 treatment ISO RGD PMID:10862314 RGD:14928216 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 IEP
IMP		 mRNA:increased expression:liver (mouse) RGD PMID:26809113 PMID:26809113 RGD:39458041, RGD:39458041 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:10862314 RGD:14928216 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Amoebic Dysentery due to Entamoeba Histolytica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il25 interleukin 25 IEP protein:decreased expression:intestine RGD PMID:28246365 RGD:39128243 NCBI chr14:55,170,152...55,173,294
Ensembl chr14:55,170,152...55,173,294 		JBrowse link
Entamoebiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16374615 PMID:29255076 RGD:14975099 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il5 interleukin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 severity IMP RGD PMID:20086086 RGD:40902842 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Tlr4 toll-like receptor 4 IMP RGD PMID:15910421 RGD:7241086 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18246
    disease by infectious agent 2181
      parasitic infectious disease 318
        parasitic protozoa infectious disease 167
          amebiasis 13
            Acanthamoeba Keratitis 1
            Amebic Dysentery + 1
            Amebic Liver Abscess 5
            Entamoebiasis 8
            primary amebic meningoencephalitis + 0
paths to the root