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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:amebiasis
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Accession:DOID:9181 term browser browse the term
Definition:A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs. (DO)
Synonyms:exact_synonym: Amebic Abscess;   Ameboma;   Amebomas;   Iodamoebiases;   Iodamoebiasis;   amebiases;   amebic abscesses;   amoebiases;   amoebiasis
 related_synonym: chronic intestinal amebiasis
 primary_id: MESH:D000562
 xref: EFO:0007144;   GARD:652;   ICD10CM:A06;   ICD9CM:006;   NCI:C157785;   NCI:C84551


show annotations for term's descendants           Sort by:
Acanthamoeba Keratitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TLR4 toll like receptor 4 ISO mRNA,protein:increased expression:cornea RGD PMID:21155840 RGD:7777095 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
Amebic Liver Abscess term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility ISO DNA:polymorphism, haplotype: :HLA-DQB1*04, HLA-DQB1*02 RGD PMID:25938667 RGD:36049810 NCBI chr12:2,305,307...2,307,711 JBrowse link
G HLA-DRB1 MHC class II DLA DRB1 beta chain susceptibility ISO DNA:polymorphism, haplotype: :HLA-DRB1*08 RGD PMID:25938667 RGD:36049810 NCBI chr12:2,151,409...2,164,564 JBrowse link
G IL2 interleukin 2 treatment ISO RGD PMID:10862314 RGD:14928216 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394 		JBrowse link
G IL23A interleukin 23 subunit alpha ISO mRNA:increased expression:liver (mouse) RGD PMID:26809113 RGD:39458041 NCBI chr10:635,384...640,715
Ensembl chr10:638,719...640,359 		JBrowse link
G TNF tumor necrosis factor treatment ISO RGD PMID:10862314 RGD:14928216 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
Amoebic Dysentery due to Entamoeba Histolytica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL25 interleukin 25 ISO protein:decreased expression:intestine RGD PMID:28246365 RGD:39128243 NCBI chr 8:3,621,268...3,624,689
Ensembl chr 8:3,618,161...3,624,043 		JBrowse link
Entamoebiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16374615 PMID:29255076 RGD:14975099 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr 7:5,933,285...5,937,057
Ensembl chr 7:5,933,285...5,937,057 		JBrowse link
G IL1B interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL2 interleukin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394 		JBrowse link
G IL5 interleukin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr11:20,825,469...20,827,269
Ensembl chr11:20,825,469...20,827,269 		JBrowse link
G IL6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 severity ISO RGD PMID:20086086 RGD:40902842 NCBI chr32:23,948,598...24,040,704
Ensembl chr32:23,942,954...24,040,703 		JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:15910421 RGD:7241086 NCBI chr11:71,356,390...71,367,166
Ensembl chr11:71,356,390...71,367,165 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17736
    disease by infectious agent 2111
      parasitic infectious disease 301
        parasitic protozoa infectious disease 154
          amebiasis 13
            Acanthamoeba Keratitis 1
            Amebic Dysentery + 1
            Amebic Liver Abscess 5
            Entamoebiasis 8
            primary amebic meningoencephalitis + 0
paths to the root