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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:amebiasis
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Accession:DOID:9181 term browser browse the term
Definition:A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs. (DO)
Synonyms:exact_synonym: Amebic Abscess;   Ameboma;   Amebomas;   Iodamoebiases;   Iodamoebiasis;   amebiases;   amebic abscesses;   amoebiases;   amoebiasis
 related_synonym: chronic intestinal amebiasis
 primary_id: MESH:D000562
 xref: EFO:0007144;   GARD:652;   ICD10CM:A06;   ICD9CM:006;   NCI:C157785;   NCI:C84551

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show annotations for term's descendants           Sort by:
Acanthamoeba Keratitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tlr4 toll like receptor 4 ISO mRNA,protein:increased expression:cornea RGD PMID:21155840 RGD:7777095 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
Amebic Liver Abscess term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2 interleukin 2 treatment ISO RGD PMID:10862314 RGD:14928216 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265 		JBrowse link
G Il23a interleukin 23 subunit alpha ISO RGD PMID:26809113 RGD:39458041 NCBI chrNW_004955458:3,946,964...3,949,180
Ensembl chrNW_004955458:3,947,803...3,949,312 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:10862314 RGD:14928216 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
Amoebic Dysentery due to Entamoeba Histolytica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il25 interleukin 25 ISO protein:decreased expression:intestine RGD PMID:28246365 RGD:39128243 NCBI chrNW_004955409:36,960,902...36,964,038
Ensembl chrNW_004955409:36,961,398...36,964,038 		JBrowse link
Entamoebiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:16374615 PMID:29255076 RGD:14975099 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Il2 interleukin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265 		JBrowse link
G Il5 interleukin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chrNW_004955408:3,937,128...3,951,784
Ensembl chrNW_004955408:3,937,894...3,939,358 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16374615 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 severity ISO RGD PMID:20086086 RGD:40902842 NCBI chrNW_004955496:5,842,734...5,950,995
Ensembl chrNW_004955496:5,842,600...5,927,885 		JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:15910421 RGD:7241086 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16047
    disease by infectious agent 1906
      parasitic infectious disease 262
        parasitic protozoa infectious disease 128
          amebiasis 11
            Acanthamoeba Keratitis 1
            Amebic Dysentery + 1
            Amebic Liver Abscess 3
            Entamoebiasis 8
            primary amebic meningoencephalitis + 0
paths to the root