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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Arbovirus Encephalitis
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Accession:DOID:9008926 term browser browse the term
Definition:Infections of the brain caused by arthropod-borne viruses (i.e., arboviruses) primarily from the families TOGAVIRIDAE; FLAVIVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; and RHABDOVIRIDAE. Life cycles of these viruses are characterized by ZOONOSES, with birds and lower mammals serving as intermediate hosts. The virus is transmitted to humans by the bite of mosquitoes (CULICIDAE) or TICKS. Clinical manifestations include fever, headache, alterations of mentation, focal neurologic deficits, and COMA. (From Clin Microbiol Rev 1994 Jan;7(1):89-116; Walton, Brain's Diseases of the Nervous System, 10th ed, p321)
Synonyms:exact_synonym: Arbovirus Encephalitides;   Arthropod Borne Encephalitis;   Arthropod Borne Viral Encephalitis;   Arthropod-Borne Encephalitides;   Arthropod-Borne Viral Encephalitides;   Mosquito Borne Encephalitis;   Mosquito-Borne Encephalitides
 primary_id: MESH:D004671


show annotations for term's descendants           Sort by:
Japanese encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 IEP RGD PMID:17010311 RGD:18337278 NCBI chr 4:138,182,459...138,187,437
Ensembl chr 4:138,181,625...138,187,434 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 ameliorates IMP RGD PMID:32265853 RGD:127229907 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322 		JBrowse link
tick-borne encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 antigen ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
West Nile encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifih1 interferon induced with helicase C domain 1 IEP mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 2:62,426,137...62,476,599
Ensembl chr 2:62,426,142...62,476,599 		JBrowse link
G Lcn2 lipocalin 2 IEP mRNA,protein:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Rigi RNA sensor RIG-I IEP mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 4:40,203,775...40,239,843
Ensembl chr 4:40,203,773...40,239,828 		JBrowse link
G Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) disease_progression IMP RGD PMID:16809306 RGD:40902815 NCBI chr 1:153,625,089...153,644,441
Ensembl chr 1:153,625,172...153,639,967 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 severity IMP RGD PMID:31415679 RGD:39128224 NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607 		JBrowse link
G Tlr3 toll-like receptor 3 IEP mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
West Nile fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr5 C-C motif chemokine receptor 5 susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: West Nile virus, susceptibility to		 CTD
ClinVar
OMIM		 PMID:8639485 PMID:8751444 PMID:8756719 PMID:9055842 PMID:9132277 More... NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Irf5 interferon regulatory factor 5 disease_progression IMP RGD PMID:25031348 RGD:40924561 NCBI chr 6:29,526,129...29,541,874
Ensembl chr 6:29,526,624...29,541,870 		JBrowse link
G Mavs mitochondrial antiviral signaling protein severity IMP RGD PMID:28094802 RGD:40903045 NCBI chr 2:131,075,445...131,089,945
Ensembl chr 2:131,075,983...131,089,945 		JBrowse link
G Rfc1 replication factor C (activator 1) 1 susceptibility ISO DNA:silent mutation:CDS:p.P847P (rs2066786) (human) RGD PMID:21881118 RGD:41410434 NCBI chr 5:65,419,195...65,492,988
Ensembl chr 5:65,419,193...65,493,013 		JBrowse link
G S100b S100 protein, beta polypeptide, neural ISO RGD PMID:19790244 RGD:5508797 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16269
    disease by infectious agent 2239
      viral infectious disease 1728
        Arbovirus Infections 56
          Arbovirus Encephalitis 15
            Eastern equine encephalitis 0
            Japanese encephalitis 2
            La Crosse encephalitis 0
            St. Louis encephalitis 0
            West Nile fever + 11
            tick-borne encephalitis + 2
Path 2
Term Annotations click to browse term
  disease 16269
    disease of anatomical entity 15860
      nervous system disease 13796
        central nervous system disease 12311
          brain disease 11551
            encephalitis 140
              Infectious Encephalitis 118
                viral encephalitis 118
                  Arbovirus Encephalitis 15
                    Eastern equine encephalitis 0
                    Japanese encephalitis 2
                    La Crosse encephalitis 0
                    St. Louis encephalitis 0
                    West Nile fever + 11
                    tick-borne encephalitis + 2
paths to the root