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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Arbovirus Encephalitis
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Accession:DOID:9008926 term browser browse the term
Definition:Infections of the brain caused by arthropod-borne viruses (i.e., arboviruses) primarily from the families TOGAVIRIDAE; FLAVIVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; and RHABDOVIRIDAE. Life cycles of these viruses are characterized by ZOONOSES, with birds and lower mammals serving as intermediate hosts. The virus is transmitted to humans by the bite of mosquitoes (CULICIDAE) or TICKS. Clinical manifestations include fever, headache, alterations of mentation, focal neurologic deficits, and COMA. (From Clin Microbiol Rev 1994 Jan;7(1):89-116; Walton, Brain's Diseases of the Nervous System, 10th ed, p321)
Synonyms:exact_synonym: Arbovirus Encephalitides;   Arthropod Borne Encephalitis;   Arthropod Borne Viral Encephalitis;   Arthropod-Borne Encephalitides;   Arthropod-Borne Viral Encephalitides;   Mosquito Borne Encephalitis;   Mosquito-Borne Encephalitides
 primary_id: MESH:D004671

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Japanese encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO RGD PMID:17010311 RGD:18337278 NCBI chr20:112,064,718...112,068,505
Ensembl chr20:112,065,581...112,067,256 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:32265853 RGD:127229907 NCBI chr24:1,318,265...1,322,610
Ensembl chr24:1,318,216...1,322,462 		JBrowse link
tick-borne encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566 		JBrowse link
G CD40LG CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:111,655,301...111,667,602
Ensembl chr  X:111,655,397...111,666,639 		JBrowse link
West Nile encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFIH1 interferon induced with helicase C domain 1 ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr10:47,676,799...47,732,310
Ensembl chr10:47,676,920...47,732,264 		JBrowse link
G LCN2 lipocalin 2 ISO mRNA,protein:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr12:9,976,278...9,981,087
Ensembl chr12:9,976,614...9,980,870 		JBrowse link
G RIGI RNA sensor RIG-I ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr12:47,729,040...47,800,995
Ensembl chr12:47,729,076...47,799,570 		JBrowse link
G RNASEL ribonuclease L disease_progression ISO RGD PMID:16809306 RGD:40902815 NCBI chr25:46,779,221...46,795,854
Ensembl chr25:46,779,700...46,795,842 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 severity ISO RGD PMID:31415679 RGD:39128224 NCBI chr23:42,153,576...42,160,903
Ensembl chr23:42,153,026...42,160,907 		JBrowse link
G TLR3 toll like receptor 3 ISO mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 7:131,991,068...132,014,366
Ensembl chr 7:131,991,029...132,016,232 		JBrowse link
West Nile fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCR5 C-C motif chemokine receptor 5 susceptibility ISO ClinVar Annotator: match by term: West Nile virus, susceptibility to ClinVar
OMIM		 PMID:8639485 PMID:8751444 PMID:8756719 PMID:9055842 PMID:9132277 More... NCBI chr22:7,803,794...7,818,112 JBrowse link
G IRF5 interferon regulatory factor 5 disease_progression ISO RGD PMID:25031348 RGD:40924561 NCBI chr21:97,536,803...97,549,576
Ensembl chr21:97,537,790...97,549,945 		JBrowse link
G MAVS mitochondrial antiviral signaling protein severity ISO RGD PMID:28094802 RGD:40903045 NCBI chr 2:34,534,433...34,555,406
Ensembl chr 2:34,541,229...34,552,823 		JBrowse link
G RFC1 replication factor C subunit 1 susceptibility ISO DNA:silent mutation:CDS:p.P847P (rs2066786) (human) RGD PMID:21881118 RGD:41410434 NCBI chr27:10,936,445...11,013,457
Ensembl chr27:10,936,461...11,006,679 		JBrowse link
G S100B S100 calcium binding protein B ISO RGD PMID:19790244 RGD:5508797 NCBI chr 2:90,188,820...90,194,986
Ensembl chr 2:90,188,639...90,195,023 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15416
    disease by infectious agent 2092
      viral infectious disease 1606
        Arbovirus Infections 53
          Arbovirus Encephalitis 15
            Eastern equine encephalitis 0
            Japanese encephalitis 2
            La Crosse encephalitis 0
            St. Louis encephalitis 0
            West Nile fever + 11
            tick-borne encephalitis + 2
Path 2
Term Annotations click to browse term
  disease 15416
    disease of anatomical entity 15079
      nervous system disease 13229
        central nervous system disease 11816
          brain disease 11084
            encephalitis 139
              Infectious Encephalitis 117
                viral encephalitis 117
                  Arbovirus Encephalitis 15
                    Eastern equine encephalitis 0
                    Japanese encephalitis 2
                    La Crosse encephalitis 0
                    St. Louis encephalitis 0
                    West Nile fever + 11
                    tick-borne encephalitis + 2
paths to the root