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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Lead Poisoning
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Accession:DOID:9008914 term browser browse the term
Definition:Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.
Synonyms:exact_synonym: Lead Poisonings
 primary_id: MESH:D007855;   RDO:0005965
For additional species annotation, visit the Alliance of Genome Resources.


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Lead Poisoning term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase IDA
ISO
IEP
CTD Direct Evidence: marker/mechanism
protein:decreased activity:blood (rat)
CTD PMID:21396434 PMID:23792432 PMID:24631795, PMID:16597373, PMID:19647414 RGD:1599014, RGD:4144142 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Hfe homeostatic iron regulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:20659343 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16700817 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt4 metallothionein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19921116 NCBI chr19:11,339,767...11,341,863
Ensembl chr19:11,339,767...11,341,863
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP RGD PMID:28178683 RGD:13440092 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Qdpr quinoid dihydropteridine reductase IEP protein:increased activity:brain, caudate nucleus (rat) RGD PMID:2359144 RGD:5128598 NCBI chr14:70,164,682...70,178,284
Ensembl chr14:70,164,650...70,178,284
JBrowse link
G Vdr vitamin D receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20692022 PMID:23433214 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Xpo5 exportin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28042866 NCBI chr 9:17,125,201...17,163,170
Ensembl chr 9:17,125,201...17,163,170
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23803535 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348
JBrowse link
Lead Poisoning, Nervous System term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21439310 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Ep300 E1A binding protein p300 IEP mRNA:increased expression:hippocampus RGD PMID:24291742 RGD:9588309 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
Lead Poisoning, Nervous System, Adult term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc6a1 solute carrier family 6 member 1 IEP protein:increased expression:brain, synaptosome RGD PMID:15149801 RGD:1643208 NCBI chr 4:146,258,842...146,292,176
Ensembl chr 4:146,276,862...146,292,213
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16091
    Chemically-Induced Disorders 1201
      Poisoning 656
        Lead Poisoning 11
          Lead Poisoning, Nervous System + 3
paths to the root