RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Respiratory Tract Infections
Accession: DOID:9008680
browse the term
Definition: Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
Synonyms: exact_synonym: Respiratory Infections; Respiratory Tract Infection; Upper Respiratory Infection; Upper Respiratory Infections; Upper Respiratory Tract Infections
xref: MESH:D012141 ; MONDO:0024355
GViewer not supported for the selected species.
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Bdnf
brain derived neurotrophic factor
ISO
protein:decreased expression:platelet, serum
RGD
PMID:17317133
RGD:4891069
NCBI chrNW_004955476:6,773,244...6,822,201
Ensembl chrNW_004955476:6,772,088...6,822,588
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:19039768
RGD:4892119
NCBI chrNW_004955475:11,148,928...11,152,313
Ensembl chrNW_004955475:11,148,879...11,152,596
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Fbln5
fibulin 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12189163
NCBI chrNW_004955438:14,073,927...14,144,644
Ensembl chrNW_004955438:14,071,410...14,145,070
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Il13
interleukin 13
ISO
Severe Acute Respiratory Syndrome
RGD
PMID:14633438
RGD:4145665
NCBI chrNW_004955408:4,046,406...4,049,795
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Il16
interleukin 16
ISO
protein:increased expression:serum
RGD
PMID:14633438
RGD:4145665
NCBI chrNW_004955416:11,876,317...11,987,548
Ensembl chrNW_004955416:11,893,801...11,987,548 Ensembl chrNW_004955416:11,893,801...11,987,548
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Il4
interleukin 4
ISO
associated with Asthma
RGD
PMID:20573437
RGD:5128554
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
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Il6r
interleukin 6 receptor
ISO
DNA:polymorphisms:promoter, exon:-183G>A (human)
RGD
PMID:20951753
RGD:5128631
NCBI chrNW_004955545:932,814...979,359
Ensembl chrNW_004955545:950,765...981,762
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Irf1
interferon regulatory factor 1
ISO
RGD
PMID:10497103
RGD:5128721
NCBI chrNW_004955408:3,882,282...3,887,965
Ensembl chrNW_004955408:3,880,155...3,887,973
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Irf3
interferon regulatory factor 3
ISO
RGD
PMID:17027894
RGD:5128795
NCBI chrNW_004955559:1,223,986...1,228,671
Ensembl chrNW_004955559:1,224,874...1,228,624
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Lepr
leptin receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17229951
NCBI chrNW_004955423:25,108,897...25,185,315
Ensembl chrNW_004955423:25,111,266...25,185,407
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Mbl2
mannose binding lectin 2
susceptibility
ISO
protein:decreased secretion:serum (human) DNA:polymorphisms:5' utr, exon:multiple (human) DNA:SNP:exon:p.G54D(rs1800450)(human)
RGD
PMID:15249448 PMID:19169708 PMID:19767106
RGD:4889439 RGD:4889453 RGD:8693755
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Rpgr
retinitis pigmentosa GTPase regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12920075
NCBI chrNW_004955601:398,772...453,271
Ensembl chrNW_004955601:400,633...453,313
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Tnf
tumor necrosis factor
ISO
Severe Acute Respiratory Syndrome; protein:increased expression:serum
RGD
PMID:14633438
RGD:4145665
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Ccl17
C-C motif chemokine ligand 17
ISO
associated with Cystic Fibrosis
RGD
PMID:17898016
RGD:4145612
NCBI chrNW_004955433:15,052,616...15,054,732
Ensembl chrNW_004955433:15,053,061...15,054,572
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Ccr2
C-C motif chemokine receptor 2
ISO
RGD
PMID:10946288
RGD:8661731
NCBI chrNW_004955420:25,641,184...25,664,413
Ensembl chrNW_004955420:25,640,367...25,664,518
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Cftr
CF transmembrane conductance regulator
ISO
DNA:mutations: :
RGD
PMID:11243954
RGD:4140482
NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382
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Icam1
intercellular adhesion molecule 1
ISO
RGD
PMID:7743671
RGD:8547590
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Il1a
interleukin 1 alpha
ISO
RGD
PMID:8699818
RGD:7794730
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
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Mbl2
mannose binding lectin 2
susceptibility
ISO
Chronic Necrotizing Pulmonary Aspergillosis; DNA:missense mutation:exon:p.R52C (human) DNA:SNP:intron:1011G>A(human)
RGD
PMID:11474427 PMID:16487239
RGD:4889577 RGD:8693711
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Tlr9
toll like receptor 9
susceptibility
ISO
DNA:SNP:promoter:g.-1237T>C (rs5743836) (human)
RGD
PMID:18275280 PMID:18936185
RGD:5130858 RGD:5130863
NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582
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Tnf
tumor necrosis factor
ISO
RGD
PMID:8699818
RGD:7794730
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tnfrsf1a
TNF receptor superfamily member 1A
susceptibility
ISO
DNA:snps:5' utr, exon:g.-609G>T rs4149570, g.36A>G rs767455 (human)
RGD
PMID:20646338
RGD:5131174
NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021
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Abcb1
ATP binding cassette subfamily B member 1
severity
ISO
DNA:snp:exon:c.1236C>T (human)
RGD
PMID:24040855
RGD:8657076
NCBI chrNW_004955432:4,911,774...5,085,349
Ensembl chrNW_004955432:4,912,184...5,007,188
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Bcl2
BCL2 apoptosis regulator
ISO
mRNA, protein:increased expression:nasal mucosa (rat)
RGD
PMID:15362690
RGD:11522724
NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485
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Cat
catalase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29028686
NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
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Ccl26
C-C motif chemokine ligand 26
ISO
protein:increased expression:oronasal secretion (human)
RGD
PMID:23883806
RGD:7364793
NCBI chrNW_004955456:14,554,583...14,558,967
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Cd40
CD40 molecule
ISO
protein:increased expression:lymphocyte
RGD
PMID:19086656
RGD:8547782
NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093
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Cd40lg
CD40 ligand
ISO
protein:increased expression:lymphocyte
RGD
PMID:19086656
RGD:8547782
NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746
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Cldn7
claudin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chrNW_004955467:9,652,093...9,654,291
Ensembl chrNW_004955467:9,652,093...9,654,291
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Ctla4
cytotoxic T-lymphocyte associated protein 4
treatment
ISO
RGD
PMID:10436391
RGD:11344920
NCBI chrNW_004955457:11,028,707...11,034,898
Ensembl chrNW_004955457:11,028,698...11,073,460
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F2
coagulation factor II, thrombin
ISO
protein:increased expression:nasal mucus
RGD
PMID:21711961
RGD:5147783
NCBI chrNW_004955422:1,356,675...1,367,788
Ensembl chrNW_004955422:1,356,769...1,367,517
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Gria1
glutamate ionotropic receptor AMPA type subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34624383
NCBI chrNW_004955408:7,912,223...8,226,241
Ensembl chrNW_004955408:7,912,592...8,223,570
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Gria2
glutamate ionotropic receptor AMPA type subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34624383
NCBI chrNW_004955471:9,970,396...10,108,871
Ensembl chrNW_004955471:9,970,403...10,108,898
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Hmox1
heme oxygenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36127783
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
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Hrh1
histamine receptor H1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23333628
NCBI chrNW_004955429:14,022,332...14,069,931
Ensembl chrNW_004955429:14,067,405...14,068,853
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Ifng
interferon gamma
treatment
ISO
associated with Asthma CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12787306 PMID:18510219 PMID:29871060
RGD:10755770 RGD:7829803
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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Il10
interleukin 10
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:23253209 PMID:23883806 PMID:36127783
RGD:7364793 RGD:7364818
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il13
interleukin 13
susceptibility no_association
ISO
CTD Direct Evidence: marker/mechanism DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human)
OMIM CTD RGD
PMID:12928861
RGD:8549516
NCBI chrNW_004955408:4,046,406...4,049,795
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Il13ra2
interleukin 13 receptor subunit alpha 2
ISO
protein:increased expression:serum
RGD
PMID:21462799
RGD:8549521
NCBI chrNW_004955490:708,144...758,195
Ensembl chrNW_004955490:709,446...758,272
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Il17a
interleukin 17A
susceptibility
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human) DNA:snp:promoter:c.-444A>G (human)
RGD
PMID:21535180 PMID:22507625
RGD:5147409 RGD:9068429
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il18
interleukin 18
no_association severity
ISO
DNA:SNP:promoter:-140C>G (rs360721) (human) DNA:SNP:promoter:-137G>C (rs187238) (human)
RGD
PMID:22840759
RGD:8655914
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il1b
interleukin 1 beta
ISO
protein:increased expression:nasal mucus
RGD
PMID:7750009
RGD:7401199
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il2
interleukin 2
ISO
RGD
PMID:12592663
RGD:8662963
NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
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Il4
interleukin 4
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:8908280 PMID:9893928 PMID:14653048 PMID:24620662 PMID:36127783
RGD:11522769 RGD:7829796 RGD:7829802 RGD:7829827
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
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Il5
interleukin 5
treatment
ISO
RGD
PMID:23934070 PMID:24620662
RGD:11354976 RGD:11522769
NCBI chrNW_004955408:3,937,128...3,951,784
Ensembl chrNW_004955408:3,937,894...3,939,358
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Itgb2
integrin subunit beta 2
treatment
ISO
RGD
PMID:12046991
RGD:9698435
NCBI chrNW_004955407:41,779,849...41,805,637
Ensembl chrNW_004955407:41,777,777...41,800,201
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Mrc1
mannose receptor C-type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36127783
NCBI chrNW_004955429:10,139,398...10,232,541
Ensembl chrNW_004955429:10,139,355...10,232,600
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Muc1
mucin 1, cell surface associated
severity
ISO
mRNA,protein:decreased expression:nasal mucosa
RGD
PMID:31425778
RGD:127345100
NCBI chrNW_004955545:1,657,728...1,662,112
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
ISO
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:22972875
RGD:7364746
NCBI chrNW_004955476:11,061,405...11,084,294
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Nod2
nucleotide binding oligomerization domain containing 2
ISO
mRNA:increased expression:nasal mucosa (human)
RGD
PMID:23858718
RGD:8547523
NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
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Ocln
occludin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chrNW_004955575:163,646...210,379
Ensembl chrNW_004955575:163,646...210,379
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Pon1
paraoxonase 1
severity
ISO
protein:decreased activity:plasma (human)
RGD
PMID:23406590
RGD:8547583
NCBI chrNW_004955432:11,893,473...11,923,035
Ensembl chrNW_004955432:11,893,473...11,923,339
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Prkg1
protein kinase cGMP-dependent 1
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:24012634
RGD:7775060
NCBI chrNW_004955425:6,176,335...7,335,867
Ensembl chrNW_004955425:6,176,432...7,331,446
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16979129
NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171
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Scgb1a1
secretoglobin family 1A member 1
ISO
mRNA:decreased expression:nasal mucosa, lung
RGD
PMID:17882576
RGD:5144135
NCBI chrNW_004955599:688,414...690,644
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Scgb3a2
secretoglobin family 3A member 2
susceptibility
ISO
DNA:SNP: :rs7726552 (human)
RGD
PMID:21410962
RGD:5144225
NCBI chrNW_004955415:6,332,121...6,335,474
Ensembl chrNW_004955415:6,331,535...6,335,462
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Serpine1
serpin family E member 1
ISO
mRNA:increased expression:nasal mucosa (mouse)
RGD
PMID:21339035
RGD:8547809
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
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Tacr1
tachykinin receptor 1
ISO
mRNA:increased expression:nasal mucosa
RGD
PMID:12768696
RGD:5147835
NCBI chrNW_004955424:10,614,340...10,761,872
Ensembl chrNW_004955424:10,614,340...10,761,872
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Tgfb1
transforming growth factor beta 1
treatment
ISO
RGD
PMID:31368266
RGD:14995445
NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441
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Tlr2
toll like receptor 2
severity
ISO
protein:increased expression:neutrophil: mRNA:decreased expression:nasal mucosa: DNA:polymorphism:cds:p.R753Q(human)
RGD
PMID:18219831 PMID:18381801 PMID:22402138 PMID:22555057
RGD:7800732 RGD:7800742 RGD:8552972 RGD:8552993
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
no_association treatment susceptibility severity
ISO
protein:decreased expression:nasal mucosa: DNA:polymorphism: :4216G>C(human) protein:increased expression:nasal lavage,leukocyte, bone marrow: DNA:SNP: :rs1927911(human) DNA:polymorphism:cds:p.D299G(human)
RGD
PMID:17069098 PMID:19763595 PMID:22402138 PMID:22555057 PMID:22577387 PMID:23639307 More...
RGD:4145354 RGD:7800732 RGD:7800736 RGD:7800738 RGD:7800740 RGD:8552993
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tlr9
toll like receptor 9
ISO
protein:decreased expression:nasal mucosa:
RGD
PMID:22577387
RGD:7800740
NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582
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Ager
advanced glycosylation end-product specific receptor
ISO
DNA:SNP:promoter:-374T>A (human)
RGD
PMID:22114731
RGD:8695981
NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
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Ccl19
C-C motif chemokine ligand 19
ISO
associated with Neutropenia;mRNA:increased expression:lung
RGD
PMID:19783686
RGD:5130908
NCBI chrNW_004955472:1,444,598...1,446,488
Ensembl chrNW_004955472:1,444,316...1,446,490
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Ccr7
C-C motif chemokine receptor 7
ISO
associated with Neutropenia
RGD
PMID:19783686
RGD:5130908
NCBI chrNW_004955451:15,086,119...15,101,862
Ensembl chrNW_004955451:15,086,119...15,095,561
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Cftr
CF transmembrane conductance regulator
severity
ISO
RGD
PMID:22135344
RGD:35673332
NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382
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Clec1a
C-type lectin domain family 1 member A
susceptibility
ISO
ClinVar Annotator: match by term: Aspergillosis, susceptibility to
OMIM ClinVar
PMID:25741868 PMID:29489751
NCBI chrNW_004955413:7,742,753...7,783,299
Ensembl chrNW_004955413:7,752,111...7,782,452
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Il15
interleukin 15
ISO
DNA:polymorphism (human)
RGD
PMID:16893395
RGD:4981337
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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Mbl2
mannose binding lectin 2
susceptibility
ISO
RGD
PMID:20064561
RGD:8694071
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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S100b
S100 calcium binding protein B
ISO
DNA:SNP: :427C>T (human)
RGD
PMID:22114731
RGD:8695981
NCBI chrNW_004955407:42,972,584...42,980,510
Ensembl chrNW_004955407:42,972,584...42,980,510
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Tlr1
toll like receptor 1
susceptibility
ISO
DNA:SNPs: :p.R80T, p.N248S (human)
RGD
PMID:16461792
RGD:4889535
NCBI chrNW_004955443:8,442,419...8,450,318
Ensembl chrNW_004955443:8,447,956...8,450,382
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Tlr2
toll like receptor 2
ISO
mRNA:increased expression:lung
RGD
PMID:19781388
RGD:4145322
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr6
toll like receptor 6
susceptibility
ISO
DNA:SNP: :p.S249P (human)
RGD
PMID:16461792
RGD:4889535
NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942
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Edn1
endothelin 1
ISO
protein:increased secretion:plasma (rat)
RGD
PMID:19262391
RGD:4145069
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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Il1a
interleukin 1 alpha
ISO
protein:increased expression:Bronchoalveolar Lavage Fluid
RGD
PMID:18042282
RGD:4142854
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
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Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15607125
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Tnf
tumor necrosis factor
ISO
protein:increased expression:Bronchoalveolar Lavage Fluid
RGD
PMID:18042282
RGD:4142854
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Cxcl8
C-X-C motif chemokine ligand 8
severity
ISO
protein:increased expression:nasal mucus (human)
RGD
PMID:24211414
RGD:40925940
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
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Marco
macrophage receptor with collagenous structure
disease_progression
ISO
association with Cryptococcal neoformans infection.
RGD
PMID:28298522
RGD:41412191
NCBI chrNW_004955459:10,700,645...10,739,222
Ensembl chrNW_004955459:10,698,294...10,739,131
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Abcc1
ATP binding cassette subfamily C member 1 (ABCC1 blood group)
ISO
RGD
PMID:11238654
RGD:5128828
NCBI chrNW_004955442:729,322...858,826
Ensembl chrNW_004955442:729,316...860,290
G
Ace2
angiotensin converting enzyme 2
ISO
associated with Pseudomonas Infections;mRNA, protein:altered expression, altered activity:lung (mouse)
RGD
PMID:31645418
RGD:40818279
NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495
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Ager
advanced glycosylation end-product specific receptor
severity
ISO
RGD
PMID:21629785
RGD:6767559
NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
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C3
complement C3
ISO
RGD
PMID:16014897
RGD:5129508
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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C3ar1
complement C3a receptor 1
ISO
RGD
PMID:16461429
RGD:5129690
NCBI chrNW_004955413:6,707,003...6,715,689
Ensembl chrNW_004955413:6,707,689...6,715,689
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Cat
catalase
ISO
protein:decreased expression:lung, plasma
RGD
PMID:19842849
RGD:5130748
NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
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Ccl19
C-C motif chemokine ligand 19
ISO
mRNA, protein:increased expression:lung
RGD
PMID:20176793
RGD:5130918
NCBI chrNW_004955472:1,444,598...1,446,488
Ensembl chrNW_004955472:1,444,316...1,446,490
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Ccr2
C-C motif chemokine receptor 2
ISO
RGD
PMID:20042590
RGD:4891443
NCBI chrNW_004955420:25,641,184...25,664,413
Ensembl chrNW_004955420:25,640,367...25,664,518
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Ccr7
C-C motif chemokine receptor 7
ISO
RGD
PMID:20176793
RGD:5130918
NCBI chrNW_004955451:15,086,119...15,101,862
Ensembl chrNW_004955451:15,086,119...15,095,561
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Cd14
CD14 molecule
ISO
RGD
PMID:16210672
RGD:4144197
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd40
CD40 molecule
ISO
RGD
PMID:20102413
RGD:5132268
NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093
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Cd80
CD80 molecule
ISO
RGD
PMID:20949109
RGD:4892562
NCBI chrNW_004955427:19,237,251...19,274,001
Ensembl chrNW_004955427:19,236,445...19,261,517
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
ISO
RGD
PMID:18643924
RGD:5133701
NCBI chrNW_004955507:6,066,026...6,102,066
Ensembl chrNW_004955507:6,067,203...6,102,001
G
Csf3
colony stimulating factor 3
disease_progression treatment
ISO
associated with Peritonitis;
RGD
PMID:12352049 PMID:21373266
RGD:11039437 RGD:5133733
NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126
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Csf3r
colony stimulating factor 3 receptor
disease_progression
ISO
RGD
PMID:17185469
RGD:5133739
NCBI chrNW_004955452:14,409,484...14,425,818
Ensembl chrNW_004955452:14,411,708...14,422,187
G
Cxcl10
C-X-C motif chemokine ligand 10
severity
ISO
RGD
PMID:15618188 PMID:16299319
RGD:5135458 RGD:5135459
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
G
Cxcl11
C-X-C motif chemokine ligand 11
ISO
RGD
PMID:15618188
RGD:5135459
NCBI chrNW_004955433:769,449...771,137
Ensembl chrNW_004955433:766,272...771,231
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Cxcl9
C-X-C motif chemokine ligand 9
ISO
RGD
PMID:15618188
RGD:5135459
NCBI chrNW_004955433:724,566...731,945
Ensembl chrNW_004955433:724,515...732,192
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:15618188
RGD:5135459
NCBI chrNW_004955475:11,148,928...11,152,313
Ensembl chrNW_004955475:11,148,879...11,152,596
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F2
coagulation factor II, thrombin
ISO
protein:increased expression:lung
RGD
PMID:21897338
RGD:6893486
NCBI chrNW_004955422:1,356,675...1,367,788
Ensembl chrNW_004955422:1,356,769...1,367,517
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Foxp3
forkhead box P3
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606
G
Gp1ba
glycoprotein Ib platelet subunit alpha
exacerbates
ISO
associated with Escherichia Coli Infections
RGD
PMID:27845343
RGD:42722624
NCBI chrNW_004955467:10,333,537...10,347,488
Ensembl chrNW_004955467:10,333,575...10,346,989
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Grk2
G protein-coupled receptor kinase 2
ISO
mRNA:decreased expression:polymorphonuclear leukocyte
RGD
PMID:24465168
RGD:126848796
NCBI chrNW_004955422:18,173,438...18,192,357
Ensembl chrNW_004955422:18,170,616...18,192,412
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Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:lung (mouse)
RGD
PMID:19846873
RGD:4145490
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Ifnar1
interferon alpha and beta receptor subunit 1
severity
ISO
RGD
PMID:19487810
RGD:5490274
NCBI chrNW_004955407:32,730,973...32,755,404
Ensembl chrNW_004955407:32,730,953...32,754,651
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Ifng
interferon gamma
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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Il10
interleukin 10
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
G
Il15
interleukin 15
ISO
RGD
PMID:17911627
RGD:5000754
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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Il17a
interleukin 17A
severity
ISO
RGD
PMID:18802100 PMID:25398094
RGD:38501102 RGD:4889153
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
G
Il18
interleukin 18
ISO
RGD
PMID:17664259
RGD:4889913
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il1b
interleukin 1 beta
treatment severity
ISO
associated with Agranulocytosis
RGD
PMID:7546648 PMID:18596024 PMID:25398094
RGD:10755357 RGD:38501102 RGD:4143205
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rl1
interleukin 1 receptor like 1
treatment
ISO
associated with Acinetobacter infectious disease associated with Sepsis
RGD
PMID:20959556 PMID:29508184
RGD:40818077 RGD:5144223
NCBI chrNW_004955470:7,779,828...7,849,157
Ensembl chrNW_004955470:7,832,109...7,842,435
G
Il1rn
interleukin 1 receptor antagonist
ISO
RGD
PMID:18322242 PMID:18596024
RGD:4143205 RGD:4143206
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il6
interleukin 6
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chrNW_004955410:25,079,835...25,084,390
G
Irak3
interleukin 1 receptor associated kinase 3
ISO
RGD
PMID:20439918 PMID:28120642
RGD:34888234 RGD:36049799
NCBI chrNW_004955458:12,839,995...12,880,285
Ensembl chrNW_004955458:12,846,237...12,879,316
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Irf1
interferon regulatory factor 1
ISO
RGD
PMID:11854220
RGD:5128725
NCBI chrNW_004955408:3,882,282...3,887,965
Ensembl chrNW_004955408:3,880,155...3,887,973
G
Irf3
interferon regulatory factor 3
ISO
RGD
PMID:20720199
RGD:4891951
NCBI chrNW_004955559:1,223,986...1,228,671
Ensembl chrNW_004955559:1,224,874...1,228,624
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Itgb3
integrin subunit beta 3
ISO
protein:increased expression:lung, neutrophil
RGD
PMID:15114484
RGD:4993468
NCBI chrNW_004955478:9,788,192...9,830,254
Ensembl chrNW_004955478:9,788,149...9,823,746
G
Lep
leptin
ISO
RGD
PMID:11937559
RGD:5128871
NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472
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Mapk8
mitogen-activated protein kinase 8
severity
ISO
associated with Escherichia Coli Infections
RGD
PMID:22514650
RGD:150340681
NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784
G
Mbl2
mannose binding lectin 2
ISO
Legionella Pneumonia; DNA:mutations:5' utr, exon:multiple (human)
RGD
PMID:18641104
RGD:4889477
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Mmp9
matrix metallopeptidase 9
ISO
protein:increased expression:bronchoalveolar lavage fluid
RGD
PMID:17202364 PMID:19535150
RGD:5129533 RGD:5130727
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Mpo
myeloperoxidase
ISO
protein:increased activity:bronchoalveolar lavage Fluid:
RGD
PMID:11269653
RGD:5130992
NCBI chrNW_004955451:4,743,744...4,753,358
Ensembl chrNW_004955451:4,743,744...4,753,358
G
Nod1
nucleotide binding oligomerization domain containing 1
ISO
RGD
PMID:19360122
RGD:5131449
NCBI chrNW_004955410:31,681,191...31,725,173
Ensembl chrNW_004955410:31,681,077...31,725,173
G
Nod2
nucleotide binding oligomerization domain containing 2
ISO
RGD
PMID:19360122
RGD:5131449
NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
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Pdpn
podoplanin
ISO
protein:increased expression:lung
RGD
PMID:7864138
RGD:2292375
NCBI chrNW_004955527:4,183,639...4,215,200
Ensembl chrNW_004955527:4,182,220...4,215,531
G
Pecam1
platelet and endothelial cell adhesion molecule 1
ISO
protein:decreased expression:lung
RGD
PMID:12524254
RGD:724645
NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188
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Pgf
placental growth factor
ISO
protein:increased expression:plasma
RGD
PMID:16702604
RGD:6483601
NCBI chrNW_004955523:616,196...627,055
Ensembl chrNW_004955523:616,154...627,713
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Pten
phosphatase and tensin homolog
ameliorates
ISO
myeloid knockout
RGD
PMID:21527775
RGD:127285594
NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829
G
Ripk3
receptor interacting serine/threonine kinase 3
ameliorates
ISO
RGD
PMID:28387756
RGD:127229944
NCBI chrNW_004955409:35,961,604...35,965,477
Ensembl chrNW_004955409:35,937,880...35,965,712
G
Rorc
RAR related orphan receptor C
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chrNW_004955589:590,653...616,784
Ensembl chrNW_004955589:590,743...616,694
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Serpine1
serpin family E member 1
severity
ISO
RGD
PMID:17032919
RGD:4144840
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
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Sftpb
surfactant protein B
ISO
protein:increased expression:lung associated with Cystic Fibrosis;protein:increased expression:lung
RGD
PMID:12169586 PMID:15271694
RGD:4143403 RGD:4143464
NCBI chrNW_004955424:1,849,313...1,858,087
Ensembl chrNW_004955424:1,849,314...1,858,087
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Sftpc
surfactant protein C
ISO
RGD
PMID:12169586 PMID:18566429
RGD:4143464 RGD:4144114
NCBI chrNW_004955403:45,649,149...45,651,421
Ensembl chrNW_004955403:45,649,122...45,651,837
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Sftpd
surfactant protein D
ISO
associated with Cystic Fibrosis;protein:decreased expression:lung protein:increased expression:lung
RGD
PMID:12169586 PMID:15271694
RGD:4143403 RGD:4143464
NCBI chrNW_004955510:213,468...226,096
Ensembl chrNW_004955510:213,438...225,896
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Stat3
signal transducer and activator of transcription 3
ISO
RGD
PMID:18192501
RGD:6892945
NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687
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Tgfb1
transforming growth factor beta 1
severity
ISO
RGD
PMID:25398094
RGD:38501102
NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441
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Tlr2
toll like receptor 2
ISO
RGD
PMID:18768871 PMID:19844782
RGD:4145337 RGD:4889533
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
ISO
RGD
PMID:16210672 PMID:20650991
RGD:4144172 RGD:4144197
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tlr5
toll like receptor 5
ISO
RGD
PMID:19801452
RGD:5129503
NCBI chrNW_004955520:1,544,840...1,562,081
Ensembl chrNW_004955520:1,556,523...1,559,093
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Tlr6
toll like receptor 6
ISO
RGD
PMID:19844782
RGD:4889533
NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942
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Tlr9
toll like receptor 9
ISO
RGD
PMID:20360853
RGD:5130719
NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582
G
Tnf
tumor necrosis factor
treatment disease_progression severity
ISO
associated with Agranulocytosis
RGD
PMID:7546648 PMID:9310939 PMID:10650487 PMID:12958055
RGD:10449451 RGD:10450564 RGD:10755357 RGD:4143476
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
protein:increased expression:serum (mouse)
RGD
PMID:19842848
RGD:5131429
NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021
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Tnfrsf1b
TNF receptor superfamily member 1B
ISO
protein:increased expression:serum (mouse)
RGD
PMID:19842848
RGD:5131429
NCBI chrNW_004955486:1,790,531...1,817,986
Ensembl chrNW_004955486:1,792,115...1,818,362
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Zc3h12a
zinc finger CCCH-type containing 12A
ISO
associated with Pseudomonas Infections
RGD
PMID:29695841
RGD:39938967
NCBI chrNW_004955452:15,306,398...15,314,959
Ensembl chrNW_004955452:15,305,775...15,314,959
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Adrb2
adrenoceptor beta 2
ISO
RGD
PMID:17687719
RGD:4145098
NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980
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Cd40
CD40 molecule
ISO
RGD
PMID:19470255
RGD:5132271
NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093
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Cd86
CD86 molecule
ISO
protein:decreased expression:myeloid dendritic cell (mouse)
RGD
PMID:20046053
RGD:4892291
NCBI chrNW_004955427:21,375,820...21,436,767
Ensembl chrNW_004955427:21,375,794...21,435,874
G
Cysltr1
cysteinyl leukotriene receptor 1
ISO
associated with Pneumovirus Infections
RGD
PMID:16337014
RGD:4843953
NCBI chrNW_004955557:1,667,518...1,702,272
G
Il17a
interleukin 17A
susceptibility
ISO
DNA:SNP:promoter:rs2275913 (human)
RGD
PMID:20437253
RGD:4889139
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il1b
interleukin 1 beta
ISO
protein:increased expression:lung
RGD
PMID:8608647
RGD:4143192
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
G
Il1rn
interleukin 1 receptor antagonist
ISO
protein:increased expression:lung
RGD
PMID:8608647
RGD:4143192
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
G
Muc5b
mucin 5B, oligomeric mucus/gel-forming
ISO
DNA:polymorphisms:promoter:rs885454,rs17235353, rs7115457 (human)
RGD
PMID:15709052
RGD:7349353
NCBI chrNW_004955476:11,021,665...11,049,239
G
Adora2a
adenosine A2a receptor
ISO
RGD
PMID:19766783
RGD:4890362
NCBI chrNW_004955455:7,886,720...7,906,214
Ensembl chrNW_004955455:7,895,974...7,906,505
G
Ccl17
C-C motif chemokine ligand 17
ISO
RGD
PMID:18785972
RGD:4145604
NCBI chrNW_004955433:15,052,616...15,054,732
Ensembl chrNW_004955433:15,053,061...15,054,572
G
Ccl22
C-C motif chemokine ligand 22
ISO
RGD
PMID:20628341
RGD:4891471
NCBI chrNW_004955433:15,002,001...15,007,324
Ensembl chrNW_004955433:15,001,930...15,008,032
G
Ccl5
C-C motif chemokine ligand 5
ISO
mRNA:increased expression:lung (rat)
RGD
PMID:14611812 PMID:19840961
RGD:2307195 RGD:4889978
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
G
Ccr2
C-C motif chemokine receptor 2
ISO
mRNA:increased expression:trachea:
RGD
PMID:11518728
RGD:4145124
NCBI chrNW_004955420:25,641,184...25,664,413
Ensembl chrNW_004955420:25,640,367...25,664,518
G
Cd86
CD86 molecule
ISO
RGD
PMID:11266944
RGD:2307206
NCBI chrNW_004955427:21,375,820...21,436,767
Ensembl chrNW_004955427:21,375,794...21,435,874
G
Csf2
colony stimulating factor 2
ISO
associated with Respiratory Aspiration;protein:increased expression:serum
RGD
PMID:18557728
RGD:2317286
NCBI chrNW_004955408:3,452,009...3,454,255
Ensembl chrNW_004955408:3,451,965...3,454,312
G
Cxcl10
C-X-C motif chemokine ligand 10
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:12097412 PMID:16709871
RGD:5135441 RGD:5135451
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
G
Cxcl11
C-X-C motif chemokine ligand 11
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:12097412
RGD:5135451
NCBI chrNW_004955433:769,449...771,137
Ensembl chrNW_004955433:766,272...771,231
G
Cxcl9
C-X-C motif chemokine ligand 9
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:12097412 PMID:16709871
RGD:5135441 RGD:5135451
NCBI chrNW_004955433:724,566...731,945
Ensembl chrNW_004955433:724,515...732,192
G
Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:12097412 PMID:16709871
RGD:5135441 RGD:5135451
NCBI chrNW_004955475:11,148,928...11,152,313
Ensembl chrNW_004955475:11,148,879...11,152,596
G
Edn1
endothelin 1
ISO
human gene in a rat model
RGD
PMID:9595474
RGD:8662402
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
G
Foxp3
forkhead box P3
ISO
mRNA:increased expression:lung
RGD
PMID:19840961
RGD:4889978
NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606
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Hmox1
heme oxygenase 1
ISO
RGD
PMID:12973103
RGD:4145412
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
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Ifng
interferon gamma
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:16137903
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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Il13
interleukin 13
ISO
protein:increased expression:bronchoalveolar lavage fluid
RGD
PMID:17182591
RGD:4146242
NCBI chrNW_004955408:4,046,406...4,049,795
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Il13ra1
interleukin 13 receptor subunit alpha 1
ISO
RGD
PMID:17182591
RGD:4146242
NCBI chrNW_004955534:1,157,758...1,205,158
Ensembl chrNW_004955534:1,160,340...1,204,911
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Il13ra2
interleukin 13 receptor subunit alpha 2
ISO
RGD
PMID:17182591
RGD:4146242
NCBI chrNW_004955490:708,144...758,195
Ensembl chrNW_004955490:709,446...758,272
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Il17a
interleukin 17A
ISO
mRNA:increased expression:trachea
RGD
PMID:20393404
RGD:4143277
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il1rn
interleukin 1 receptor antagonist
ISO
protein:increased expression:lung
RGD
PMID:11889437
RGD:4143176
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il4
interleukin 4
ISO
protein:increased expression:serum
RGD
PMID:18557728
RGD:2317286
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
G
Il6
interleukin 6
ISO
RGD
PMID:20393404
RGD:4143277
NCBI chrNW_004955410:25,079,835...25,084,390
G
Mbl2
mannose binding lectin 2
resistance
ISO
DNA:transversion:5' utr:-290C>G rs7096206 (human)
RGD
PMID:19104434
RGD:4889456
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Mmp9
matrix metallopeptidase 9
ISO
protein:increased expression, increased activity:bronchoalveolar lavage fluid
RGD
PMID:20417130
RGD:5130759
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Muc1
mucin 1, cell surface associated
ISO
protein:increased expression:serum
RGD
PMID:16969297
RGD:5131273
NCBI chrNW_004955545:1,657,728...1,662,112
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Nod2
nucleotide binding oligomerization domain containing 2
ISO
RGD
PMID:18158963
RGD:5131450
NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
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Nos2
nitric oxide synthase 2
ISO
associated with lung transplantation; protein:increased expression:lung
RGD
PMID:11112135
RGD:4892082
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Nos3
nitric oxide synthase 3
ISO
protein:increased expression:lung
RGD
PMID:15136885
RGD:4892068
NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
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Scgb1a1
secretoglobin family 1A member 1
ISO
associated with lung transplantation; protein:decreased expression:serum,bronchoalveolar lavage
RGD
PMID:11981419
RGD:5147386
NCBI chrNW_004955599:688,414...690,644
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Sftpd
surfactant protein D
ISO
RGD
PMID:18347569
RGD:4143500
NCBI chrNW_004955510:213,468...226,096
Ensembl chrNW_004955510:213,438...225,896
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Tlr9
toll like receptor 9
ISO
DNA:SNPs:promoter, 3' utr:g.-1485C>T (rs187084), rs352162 (human)
RGD
PMID:20227302
RGD:5130722
NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582
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Egr1
early growth response 1
ISO
RGD
PMID:17384085
RGD:5132266
NCBI chrNW_004955418:2,001,509...2,005,269
Ensembl chrNW_004955418:2,002,699...2,005,007
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Hdac2
histone deacetylase 2
treatment
ISO
RGD
PMID:22708526
RGD:9590258
NCBI chrNW_004955526:2,739,099...2,759,640
Ensembl chrNW_004955526:2,728,377...2,759,707
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Ifng
interferon gamma
resistance
ISO
RGD
PMID:20953328
RGD:4145525
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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LOC102010850
cytochrome P450 1A1
ISO
DNA:polymorphism (human)
RGD
PMID:14593914
RGD:4889126
NCBI chrNW_004955450:3,183,958...3,189,488
Ensembl chrNW_004955450:3,183,750...3,189,488
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Ccl5
C-C motif chemokine ligand 5
ISO
protein:increased secretion:serum (human)
RGD
PMID:20350425
RGD:4892019
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Mbl2
mannose binding lectin 2
ISO
associated with Down Syndrome; protein:decreased secretion:serum (human)
RGD
PMID:19804807
RGD:4889483
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Cd274
CD274 molecule
ISO
mRNA:increased expression:lung
RGD
PMID:26378990
RGD:41412180
NCBI chrNW_004955434:9,487,309...9,508,366
Ensembl chrNW_004955434:9,487,315...9,505,904
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Pdcd1
programmed cell death 1
ISO
mRNA:increased expression:lung
RGD
PMID:26378990
RGD:41412180
NCBI chrNW_004955542:49,290...57,747
Ensembl chrNW_004955542:49,259...58,823
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Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
severity
ISO
RGD
PMID:29893841
RGD:40890270
NCBI chrNW_004955486:3,813,923...3,837,563
Ensembl chrNW_004955486:3,813,923...3,838,119
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Cftr
CF transmembrane conductance regulator
susceptibility
ISO
DNA:deletion: :F508del(human) associated with pulmonary disease chronic obstructive; DNA:missense mutation:exon:p.R75Q(human)
RGD
PMID:10767489 PMID:15463907
RGD:4140475 RGD:4140484
NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382
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Ctla4
cytotoxic T-lymphocyte associated protein 4
ISO
DNA:SNPs: :multiple (human)
RGD
PMID:19386687
RGD:4891509
NCBI chrNW_004955457:11,028,707...11,034,898
Ensembl chrNW_004955457:11,028,698...11,073,460
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Edn1
endothelin 1
ISO
Chronic Allergic Airway Inflammation; protein:increased secretion:bronchoalveolar lavage (mouse)
RGD
PMID:18631350
RGD:4145074
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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Gc
GC vitamin D binding protein
susceptibility
ISO
RGD
PMID:12096683
RGD:5129516
NCBI chrNW_004955447:1,361,698...1,400,633
Ensembl chrNW_004955447:1,361,566...1,402,491
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Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:bronchial epithelium (rat)
RGD
PMID:19507274
RGD:2308951
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Il10
interleukin 10
ISO
protein:decreased expression:lung
RGD
PMID:19507274
RGD:2308951
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il13
interleukin 13
ISO
protein:increased expression:Respiratory Mucosa
RGD
PMID:14582911
RGD:4759835
NCBI chrNW_004955408:4,046,406...4,049,795
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Il15
interleukin 15
ISO
mRNA, protein:increased expression:lung
RGD
PMID:11742275
RGD:4990461
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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LOC102010850
cytochrome P450 1A1
susceptibility
ISO
DNA:polymorphism (human)
RGD
PMID:15928955
RGD:4142512
NCBI chrNW_004955450:3,183,958...3,189,488
Ensembl chrNW_004955450:3,183,750...3,189,488
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LOC102026028
cytochrome P450 2E1
ISO
DNA:polymorphism (human)
RGD
PMID:14593914
RGD:4889126
NCBI chrNW_004955507:6,293,162...6,303,255
Ensembl chrNW_004955507:6,289,576...6,304,193
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Mpo
myeloperoxidase
ISO
protein:increased expression:lung
RGD
PMID:11798689
RGD:5130990
NCBI chrNW_004955451:4,743,744...4,753,358
Ensembl chrNW_004955451:4,743,744...4,753,358
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Nos2
nitric oxide synthase 2
ISO
RGD
PMID:19938219
RGD:4891494
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Npy
neuropeptide Y
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9731035
NCBI chrNW_004955410:26,348,388...26,355,232
Ensembl chrNW_004955410:26,348,504...26,355,297
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Vegfa
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19263519
NCBI chrNW_004955437:9,527,445...9,541,908
Ensembl chrNW_004955437:9,531,362...9,542,664
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Edn1
endothelin 1
ISO
protein:increased expression:inferior turbinate, nasal gland, inflammatory cell (human)
RGD
PMID:8845175
RGD:8661738
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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Cd8a
CD8 subunit alpha
ameliorates
ISO
protein:decreased expression:blood, T cell (human)
RGD
PMID:24639246
RGD:124715444
NCBI chrNW_004955424:952,595...979,159
Ensembl chrNW_004955424:952,502...978,636
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Il17a
interleukin 17A
ISO
protein:increased expression:uncinate process, nasal mucosa (human)
RGD
PMID:23613503
RGD:8696039
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il1rn
interleukin 1 receptor antagonist
susceptibility
ISO
DNA:repeats:intron:IVS2+914_1000dup I/II alleles (human)
RGD
PMID:16549749
RGD:8549791
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Mbl2
mannose binding lectin 2
ISO
protein:decreased activity:serum:
RGD
PMID:23144819
RGD:8693716
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Alox5
arachidonate 5-lipoxygenase
ISO
protein:increased expression:bronchus
RGD
PMID:11865407
RGD:4890421
NCBI chrNW_004955546:2,495,226...2,550,909
Ensembl chrNW_004955546:2,494,819...2,550,909
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Alox5ap
arachidonate 5-lipoxygenase activating protein
ISO
protein:increased expression:bronchus
RGD
PMID:11865407
RGD:4890421
NCBI chrNW_004955431:15,071,535...15,097,496
Ensembl chrNW_004955431:15,069,089...15,097,580
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Cx3cl1
C-X3-C motif chemokine ligand 1
ISO
RGD
PMID:20696083
RGD:4140458
NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:15764644
RGD:5135489
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
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Cxcl8
C-X-C motif chemokine ligand 8
treatment
ISO
RGD
PMID:28343401
RGD:150521550
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
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Il10
interleukin 10
ISO
RGD
PMID:20696083
RGD:4140458
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il1a
interleukin 1 alpha
ISO
protein:increased expression:nasal mucus
RGD
PMID:10358201
RGD:4143183
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
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Il1b
interleukin 1 beta
ISO
protein:increased expression:nasal mucus
RGD
PMID:7734976
RGD:7401200
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rn
interleukin 1 receptor antagonist
ISO
protein:increased expression:nasal mucus
RGD
PMID:10358201 PMID:18279051
RGD:4143183 RGD:4143207
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il33
interleukin 33
ISO
protein:increased expression:nasal mucus
RGD
PMID:28471975
RGD:38596342
NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
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Il4
interleukin 4
ISO
associated with Asthma;mRNA, protein:increased expression:alveolar macrophage, respiratory system fluid/secretion
RGD
PMID:20644177
RGD:4140459
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
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Prdx5
peroxiredoxin 5
ISO
associated with asthma;protein:increased expression:sputum (human)
RGD
PMID:18219526
RGD:41404684
NCBI chrNW_004955422:20,763,822...20,766,976
Ensembl chrNW_004955422:20,761,495...20,766,976
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Tslp
thymic stromal lymphopoietin
ISO
protein:increased expression:nasal mucus (human)
RGD
PMID:28471975
RGD:38596342
NCBI chrNW_004955418:4,041,529...4,045,534
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
protein:increased expression:lung, macrophage (human)
RGD
PMID:21144722
RGD:5131112
NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021
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Tnfrsf1b
TNF receptor superfamily member 1B
ISO
protein:increased expression:lung, lymphocyte (human)
RGD
PMID:21144722
RGD:5131112
NCBI chrNW_004955486:1,790,531...1,817,986
Ensembl chrNW_004955486:1,792,115...1,818,362
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Sftpc
surfactant protein C
ISO
OMIM:263000
MouseDO
NCBI chrNW_004955403:45,649,149...45,651,421
Ensembl chrNW_004955403:45,649,122...45,651,837
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Mbl2
mannose binding lectin 2
susceptibility
ISO
DNA:SNP:exon:p.G54D(rs1800450)(human)
RGD
PMID:15249448
RGD:8693755
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
ISO
protein:decreased expression:bronchiole epithelium
RGD
PMID:15364771
RGD:7364741
NCBI chrNW_004955476:11,061,405...11,084,294
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Muc5b
mucin 5B, oligomeric mucus/gel-forming
ISO
DNA:insertion/deletion
RGD
PMID:15709052
RGD:7349353
NCBI chrNW_004955476:11,021,665...11,049,239
G
Mucl3
mucin like 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22152429
NCBI chrNW_004955583:880,011...882,770
G
Tap2
transporter 2, ATP binding cassette subfamily B member
susceptibility
ISO
DNA:polymorphisms:exon:
RGD
PMID:10323341
RGD:5147847
NCBI chrNW_004955437:1,480,217...1,499,032
Ensembl chrNW_004955437:1,477,341...1,498,575
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Gata2
GATA binding protein 2
ISO
associated with Pneumocystis Infections
RGD
PMID:16774119
RGD:9587813
NCBI chrNW_004955429:15,326,551...15,334,774
Ensembl chrNW_004955429:15,327,113...15,336,460
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Il13
interleukin 13
ISO
protein:increased expression:lung
RGD
PMID:16544260 PMID:19752036
RGD:4145474 RGD:4145506
NCBI chrNW_004955408:4,046,406...4,049,795
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Il33
interleukin 33
ISO
protein:increased expression:lung
RGD
PMID:25746970
RGD:39938968
NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
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Nos2
nitric oxide synthase 2
ISO
protein:decreased expression:lung
RGD
PMID:10639453
RGD:4891455
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Sftpd
surfactant protein D
susceptibility
ISO
RGD
PMID:20413160
RGD:4143489
NCBI chrNW_004955510:213,468...226,096
Ensembl chrNW_004955510:213,438...225,896
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Tnf
tumor necrosis factor
ISO
protein:increased expression:lung
RGD
PMID:16544260
RGD:4145506
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Atf3
activating transcription factor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955406:4,875,672...4,889,173
Ensembl chrNW_004955406:4,875,613...4,889,242
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C3
complement C3
ISO
RGD
PMID:21408070
RGD:5129492
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Cat
catalase
ISO
RGD
PMID:16804020 PMID:19959187 PMID:20653246
RGD:5130201 RGD:5130744 RGD:5130864
NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
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Ccl28
C-C motif chemokine ligand 28
resistance
ISO
RGD
PMID:19847203
RGD:4892196
NCBI chrNW_004955446:18,902,465...18,925,178
Ensembl chrNW_004955446:18,902,636...18,925,561
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Ccl5
C-C motif chemokine ligand 5
susceptibility
ISO
protein:increased expression:lung (mouse)
RGD
PMID:16208318 PMID:20656925
RGD:4145452 RGD:4892131
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Cd14
CD14 molecule
ISO
RGD
PMID:17825924
RGD:4144809
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd28
CD28 molecule
ISO
RGD
PMID:21389258
RGD:5131611
NCBI chrNW_004955457:11,159,769...11,253,099
Ensembl chrNW_004955457:11,162,282...11,192,991
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Cd40
CD40 molecule
ISO
RGD
PMID:19922665
RGD:5132270
NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093
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Cd80
CD80 molecule
ISO
RGD
PMID:10604996 PMID:19922665
RGD:5132270 RGD:5132623
NCBI chrNW_004955427:19,237,251...19,274,001
Ensembl chrNW_004955427:19,236,445...19,261,517
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Cd86
CD86 molecule
ISO
protein:increased expression:mediastinal lymph node, B cell (mouse)
RGD
PMID:19933871
RGD:4892570
NCBI chrNW_004955427:21,375,820...21,436,767
Ensembl chrNW_004955427:21,375,794...21,435,874
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Csf2
colony stimulating factor 2
ISO
RGD
PMID:20427198 PMID:21474645
RGD:5131470 RGD:5131472
NCBI chrNW_004955408:3,452,009...3,454,255
Ensembl chrNW_004955408:3,451,965...3,454,312
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
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Ddx60
DExD/H-box helicase 60
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955403:37,679,939...37,765,074
Ensembl chrNW_004955403:37,679,730...37,765,886
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Egr1
early growth response 1
ISO
mRNA:increased expression:frontal cortex (mouse)
RGD
PMID:21289196
RGD:5131660
NCBI chrNW_004955418:2,001,509...2,005,269
Ensembl chrNW_004955418:2,002,699...2,005,007
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Eif2ak2
eukaryotic translation initiation factor 2 alpha kinase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955441:4,908,318...4,944,343
Ensembl chrNW_004955441:4,908,286...4,948,113
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Foxp2
forkhead box P2
ISO
RGD
PMID:18248790
RGD:11536002
NCBI chrNW_004955432:20,205,369...20,589,608
Ensembl chrNW_004955432:20,334,237...20,589,352
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Herc5
HECT and RLD domain containing E3 ubiquitin protein ligase 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955474:11,954,915...11,991,849
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Ifi35
interferon induced protein 35
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955451:16,790,998...16,798,993
Ensembl chrNW_004955451:16,790,383...16,802,664
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Ifih1
interferon induced with helicase C domain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955449:11,538,869...11,596,502
Ensembl chrNW_004955449:11,538,889...11,593,349
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Ifit1
interferon induced protein with tetratricopeptide repeats 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955425:3,581,705...3,588,528
Ensembl chrNW_004955425:3,581,608...3,588,639
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Ifit2
interferon induced protein with tetratricopeptide repeats 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955425:3,685,626...3,692,482
Ensembl chrNW_004955425:3,682,327...3,692,397
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Ifit3
interferon induced protein with tetratricopeptide repeats 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955425:3,671,303...3,692,478
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Ifit5
interferon induced protein with tetratricopeptide repeats 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955425:3,569,448...3,575,043
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Il10
interleukin 10
susceptibility
ISO
RGD
PMID:20200252
RGD:4140426
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il12b
interleukin 12B
ISO
RGD
PMID:16389596
RGD:4145426
NCBI chrNW_004955408:13,302,506...13,316,300
Ensembl chrNW_004955408:13,304,219...13,312,620
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Il13
interleukin 13
ISO
protein:increased expression:serum
RGD
PMID:20003352
RGD:4888530
NCBI chrNW_004955408:4,046,406...4,049,795
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Il15
interleukin 15
ISO
mRNA, protein:increased expression:lung
RGD
PMID:19234203 PMID:20212069 PMID:21098221
RGD:4994196 RGD:4996471 RGD:4996472
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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Il15ra
interleukin 15 receptor subunit alpha
ISO
RGD
PMID:21098221
RGD:4994196
NCBI chrNW_004955421:22,590,168...22,612,835
Ensembl chrNW_004955421:22,586,012...22,620,788
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Il17a
interleukin 17A
ISO
mRNA, protein:increased expression:lung
RGD
PMID:19265125 PMID:19783685
RGD:4889102 RGD:4889150
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il17ra
interleukin 17 receptor A
ISO
RGD
PMID:19783685
RGD:4889102
NCBI chrNW_004955454:5,230,384...5,252,769
Ensembl chrNW_004955454:5,230,522...5,254,394
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Il18
interleukin 18
ISO
RGD
PMID:15606801
RGD:4889964
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il1a
interleukin 1 alpha
ISO
protein:increased expression:lung
RGD
PMID:11535264
RGD:4142860
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
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Il1b
interleukin 1 beta
ISO
RGD
PMID:20438620
RGD:4142822
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rn
interleukin 1 receptor antagonist
disease_progression
ISO
protein:increased expression:serum
RGD
PMID:9439800 PMID:20840779
RGD:4143203 RGD:4143228
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il2
interleukin 2
ISO
protein:increased expression:serum
RGD
PMID:21603856
RGD:5147905
NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
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Il4
interleukin 4
ISO
RGD
PMID:21092162
RGD:5128546
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
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Il6
interleukin 6
ISO
RGD
PMID:20731583
RGD:4143268
NCBI chrNW_004955410:25,079,835...25,084,390
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Irf7
interferon regulatory factor 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955476:11,442,781...11,445,706
Ensembl chrNW_004955476:11,443,272...11,445,657
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Isg15
ISG15 ubiquitin like modifier
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955486:9,706,878...9,707,876
Ensembl chrNW_004955486:9,706,703...9,707,949
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Lamp3
lysosomal associated membrane protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955420:24,155,793...24,185,366
Ensembl chrNW_004955420:24,155,890...24,187,466
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LOC106146232
protein SCO2 homolog, mitochondrial
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955413:33,503,882...33,505,417
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Lyst
lysosomal trafficking regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26597256
NCBI chrNW_004955492:4,161,976...4,371,637
Ensembl chrNW_004955492:4,209,749...4,369,762
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Mmp9
matrix metallopeptidase 9
ISO
protein:increased activity:lung, heart, brain
RGD
PMID:20299740
RGD:5130855
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Nos1
nitric oxide synthase 1
ISO
protein:increased expression:hippocampus
RGD
PMID:9552178
RGD:5132870
NCBI chrNW_004955455:13,797,557...13,978,402
Ensembl chrNW_004955455:13,797,545...13,972,566
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Nos2
nitric oxide synthase 2
ISO
mRNA:increased expression:olfactory epithelium mRNA,protein:increased expression:brain
RGD
PMID:17030871 PMID:17674769 PMID:18080188
RGD:4891919 RGD:4891937 RGD:4891952
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Oas2
2'-5'-oligoadenylate synthetase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955482:9,365,400...9,386,314
Ensembl chrNW_004955482:9,364,516...9,386,852
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Oas3
2'-5'-oligoadenylate synthetase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955482:9,339,174...9,359,266
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Oasl
2'-5'-oligoadenylate synthetase like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955455:10,658,080...10,682,493
Ensembl chrNW_004955455:10,657,440...10,682,546
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Parp12
poly(ADP-ribose) polymerase family member 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955494:3,126,451...3,158,550
Ensembl chrNW_004955494:3,126,454...3,157,904
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Plscr1
phospholipid scramblase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955474:10,953,381...10,989,100
Ensembl chrNW_004955474:10,953,033...10,990,712
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Prf1
perforin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26597256
NCBI chrNW_004955437:20,700,912...20,705,076
Ensembl chrNW_004955437:20,700,718...20,706,929
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
RGD
PMID:16272346
RGD:5143925
NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171
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Rigi
RNA sensor RIG-I
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955472:3,093,895...3,135,524
Ensembl chrNW_004955472:3,093,939...3,133,987
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Rsad2
radical S-adenosyl methionine domain containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955487:1,988,226...2,001,731
Ensembl chrNW_004955487:1,987,405...2,001,731
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Rtp4
receptor transporter protein 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955420:20,435,924...20,459,440
G
Samd9
sterile alpha motif domain containing 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955432:9,957,521...9,972,622
Ensembl chrNW_004955432:9,957,677...9,962,389
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Serping1
serpin family G member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955511:2,545,337...2,557,850
Ensembl chrNW_004955511:2,545,285...2,557,982
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Sftpd
surfactant protein D
ISO
RGD
PMID:16787926
RGD:4143518
NCBI chrNW_004955510:213,468...226,096
Ensembl chrNW_004955510:213,438...225,896
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Siglec1
sialic acid binding Ig like lectin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955415:14,539,284...14,560,614
Ensembl chrNW_004955415:14,536,266...14,560,632
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Slc22a8
solute carrier family 22 member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23129053
NCBI chrNW_004955599:284,038...299,603
Ensembl chrNW_004955599:283,929...300,796
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Stat1
signal transducer and activator of transcription 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955403:8,156,660...8,192,018
Ensembl chrNW_004955403:8,156,660...8,194,762
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Tdrd7
tudor domain containing 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955419:27,919,664...27,983,426
Ensembl chrNW_004955419:27,916,011...27,976,163
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Tlr2
toll like receptor 2
ISO
protein:increased expression:monocyte
RGD
PMID:18657324
RGD:4145339
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr3
toll like receptor 3
ISO
mRNA:increased expression:lung (mouse)
RGD
PMID:16789835 PMID:18654661
RGD:5129136 RGD:5129219
NCBI chrNW_004955403:22,977,882...23,001,392
Ensembl chrNW_004955403:22,979,120...23,001,467
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Tmprss4
transmembrane serine protease 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26889029
NCBI chrNW_004955412:19,258,955...19,292,766
Ensembl chrNW_004955412:19,258,949...19,292,829
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Tnf
tumor necrosis factor
ISO
protein:increased expression:serum
RGD
PMID:21062445
RGD:5128683
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tnfaip6
TNF alpha induced protein 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955440:16,915,952...16,944,375
Ensembl chrNW_004955440:16,916,055...16,944,190
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
protein:increased expression:serum (human)
RGD
PMID:17182684 PMID:19497758
RGD:5131157 RGD:5131432
NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021
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Tnfsf10
TNF superfamily member 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955420:2,550,392...2,566,448
Ensembl chrNW_004955420:2,549,142...2,566,564
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Tor1b
torsin family 1 member B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955513:23,118...29,401
Ensembl chrNW_004955513:23,118...29,401
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Trex1
three prime repair exonuclease 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955532:533,877...535,767
Ensembl chrNW_004955532:533,877...535,767
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Ube2l6
ubiquitin conjugating enzyme E2 L6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955511:2,522,850...2,528,926
Ensembl chrNW_004955511:2,522,850...2,528,926
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Ugcg
UDP-glucose ceramide glucosyltransferase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33639165
NCBI chrNW_004955419:15,417,468...15,451,936
Ensembl chrNW_004955419:15,416,796...15,451,936
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Xaf1
XIAP associated factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955467:12,240,075...12,257,595
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Zcchc2
zinc finger CCHC-type containing 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23326326
NCBI chrNW_004955402:46,426,432...46,466,064
Ensembl chrNW_004955402:46,426,432...46,464,063
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Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:lung, alveolar macrophage (human)
RGD
PMID:19218648
RGD:4145518
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Il6
interleukin 6
ISO
protein:increased expression:bronchoalveolar lavage (rat)
RGD
PMID:10988147
RGD:11062092
NCBI chrNW_004955410:25,079,835...25,084,390
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Keap1
kelch like ECH associated protein 1
ISO
protein:increased expression:hyperplastic lung epithelium, alveolus (human)
RGD
PMID:20718723
RGD:6893300
NCBI chrNW_004955495:1,704,695...1,711,339
Ensembl chrNW_004955495:1,704,695...1,711,290
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Mtor
mechanistic target of rapamycin kinase
ISO
RGD
PMID:21444868
RGD:7245946
NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694
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Scgb1a1
secretoglobin family 1A member 1
ISO
protein:increased expression:serum
RGD
PMID:15467329
RGD:5144148
NCBI chrNW_004955599:688,414...690,644
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Tert
telomerase reverse transcriptase
ISO
ClinVar Annotator: match by term: idiopathic fibrosing alveolitis
ClinVar
PMID:9536098 PMID:15814878 PMID:15885610 PMID:16247010 PMID:16627250 PMID:16990594 PMID:17460043 PMID:17576681 PMID:18042801 PMID:18460650 PMID:18635888 PMID:18931339 PMID:19561322 PMID:19674077 PMID:19760749 PMID:20301779 PMID:20502709 PMID:20858879 PMID:21436073 PMID:21483807 PMID:21520174 PMID:21602826 PMID:22424236 PMID:22853774 PMID:23538340 PMID:23716176 PMID:23901009 PMID:24033266 PMID:24763404 PMID:24833766 PMID:24983628 PMID:25346280 PMID:25365545 PMID:25562321 PMID:25741868 PMID:25785092 PMID:26024875 PMID:26136524 PMID:26329388 PMID:26365799 PMID:26580448 PMID:26859482 PMID:26887940 PMID:27192671 PMID:27418648 PMID:27540018 PMID:27848944 PMID:28104920 PMID:28154186 PMID:28492532 PMID:28813500 PMID:29036293 PMID:29483670 PMID:30426156 PMID:30523342 PMID:30791107 PMID:31268371 PMID:33709208 PMID:33850299 PMID:34019641 PMID:34482403 PMID:34565437 PMID:34890115 PMID:35078193 PMID:35106810 PMID:35776903 PMID:35927969 PMID:36622818 PMID:37096215 PMID:37944684 More...
NCBI chrNW_004955504:649,248...669,796
Ensembl chrNW_004955504:651,779...670,589
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Atm
ATM serine/threonine kinase
exacerbates
ISO
RGD
PMID:31509427
RGD:126779564
NCBI chrNW_004955412:10,422,753...10,531,406
Ensembl chrNW_004955412:10,426,135...10,530,545
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Btk
Bruton tyrosine kinase
ameliorates
ISO
Associated with Acute Lung Injury
RGD
PMID:29516781
RGD:124713566
NCBI chrNW_004955503:7,483,819...7,515,085
Ensembl chrNW_004955503:7,482,793...7,515,120
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Duox1
dual oxidase 1
ISO
protein:decreased expression:blood plasma (human)
RGD
PMID:24888898
RGD:40903071
NCBI chrNW_004955409:8,228,754...8,256,575
Ensembl chrNW_004955409:8,229,199...8,255,003
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Duox2
dual oxidase 2
severity
ISO
RGD
PMID:25751630 PMID:28936773 PMID:29556357
RGD:40924644 RGD:40925921 RGD:40925925
NCBI chrNW_004955409:8,270,657...8,288,201
Ensembl chrNW_004955409:8,271,164...8,287,096
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Ifih1
interferon induced with helicase C domain 1
ISO
mRNA:increased expression:nasal cavity mucosa (mouse)
RGD
PMID:25751630
RGD:40925925
NCBI chrNW_004955449:11,538,869...11,596,502
Ensembl chrNW_004955449:11,538,889...11,593,349
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Il21
interleukin 21
ISO
RGD
PMID:25251568
RGD:127285548
NCBI chrNW_004955428:18,057,096...18,065,492
Ensembl chrNW_004955428:18,057,096...18,065,492
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Il27
interleukin 27
ISO
protein:increased expression:blood serum (human)
RGD
PMID:22343630
RGD:126790513
NCBI chrNW_004955493:6,712,005...6,717,417
Ensembl chrNW_004955493:6,712,005...6,717,417
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Map3k8
mitogen-activated protein kinase kinase kinase 8
exacerbates
ISO
RGD
PMID:26241898
RGD:11055126
NCBI chrNW_004955429:21,717,153...21,739,349
Ensembl chrNW_004955429:21,716,958...21,741,585
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Mapk8
mitogen-activated protein kinase 8
ameliorates
ISO
RGD
PMID:22514650
RGD:150340681
NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784
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Marco
macrophage receptor with collagenous structure
ameliorates
ISO
RGD
PMID:21562316
RGD:41412197
NCBI chrNW_004955459:10,700,645...10,739,222
Ensembl chrNW_004955459:10,698,294...10,739,131
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Mavs
mitochondrial antiviral signaling protein
disease_progression
ISO
RGD
PMID:27438481
RGD:40903047
NCBI chrNW_004955415:14,691,918...14,704,782
Ensembl chrNW_004955415:14,695,438...14,703,672
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Plac8
placenta associated 8
ISO
RGD
PMID:32639988
RGD:40925929
NCBI chrNW_004955474:6,518,459...6,533,251
Ensembl chrNW_004955474:6,522,204...6,534,312
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Ppia
peptidylprolyl isomerase A
ameliorates
ISO
human gene in a mouse model
RGD
PMID:27354005
RGD:150429624
NCBI chrNW_004955456:7,381,923...7,383,203
Ensembl chrNW_004955456:7,379,586...7,383,236
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Rigi
RNA sensor RIG-I
ISO
mRNA:increased expression:nasal cavity mucosa (mouse)
RGD
PMID:25751630
RGD:40925925
NCBI chrNW_004955472:3,093,895...3,135,524
Ensembl chrNW_004955472:3,093,939...3,133,987
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Ripk3
receptor interacting serine/threonine kinase 3
susceptibility exacerbates
ISO
RGD
PMID:27321907 PMID:28410401 PMID:32200799
RGD:127229911 RGD:127229918 RGD:127229922
NCBI chrNW_004955409:35,961,604...35,965,477
Ensembl chrNW_004955409:35,937,880...35,965,712
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Stat2
signal transducer and activator of transcription 2
exacerbates
ISO
RGD
PMID:30337919
RGD:41789626
NCBI chrNW_004955458:3,953,019...3,973,151
Ensembl chrNW_004955458:3,952,738...3,970,668
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Ager
advanced glycosylation end-product specific receptor
ISO
RGD
PMID:21423669
RGD:5508765
NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479
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Ccl20
C-C motif chemokine ligand 20
ISO
protein:increased expression:lung
RGD
PMID:20926800
RGD:7483599
NCBI chrNW_004955453:6,846,625...6,850,007
Ensembl chrNW_004955453:6,846,549...6,850,031
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Ccr6
C-C motif chemokine receptor 6
disease_progression
ISO
RGD
PMID:17379855
RGD:7483617
NCBI chrNW_004955439:14,921,524...14,949,493
Ensembl chrNW_004955439:14,920,601...14,924,191
G
Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:17298426
RGD:5135501
NCBI chrNW_004955475:11,148,928...11,152,313
Ensembl chrNW_004955475:11,148,879...11,152,596
G
Cybb
cytochrome b-245 beta chain
ISO
RGD
PMID:24054721
RGD:10450528
NCBI chrNW_004955587:781,533...818,149
Ensembl chrNW_004955587:781,388...819,912
G
Il17a
interleukin 17A
severity
ISO
RGD
PMID:21807912
RGD:8698654
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
G
LOC102018844
neutrophil elastase
ISO
RGD
PMID:24054721
RGD:10450528
NCBI chrNW_004955495:6,964,577...6,967,208
Ensembl chrNW_004955495:6,964,667...6,967,106
G
Mbl2
mannose binding lectin 2
ISO
DNA:SNP:exon:rs5030737(human)
RGD
PMID:17311505
RGD:8693758
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Ptx3
pentraxin 3
severity
ISO
protein:increased expression:bronchoalveolar lavage fluid (human) DNA:SNPs, missense mutation:intron, cds:rs2305619, rs1840680, rs3816527
RGD
PMID:28487045 PMID:30275011
RGD:38501097 RGD:38508892
NCBI chrNW_004955448:8,366,795...8,373,010
Ensembl chrNW_004955448:8,366,925...8,372,411
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S100b
S100 calcium binding protein B
ISO
RGD
PMID:21423669
RGD:5508765
NCBI chrNW_004955407:42,972,584...42,980,510
Ensembl chrNW_004955407:42,972,584...42,980,510
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Tlr2
toll like receptor 2
ISO
RGD
PMID:16113258
RGD:8553022
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
susceptibility
ISO
DNA:polymorphism:exon:p.D299G(human)
RGD
PMID:18275280
RGD:5130863
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
G
Fgf2
fibroblast growth factor 2
treatment
ISO
RGD
PMID:23303813
RGD:8655596
NCBI chrNW_004955428:17,840,554...17,894,779
Ensembl chrNW_004955428:17,840,628...17,894,773
G
Il1a
interleukin 1 alpha
ISO
DNA:polymorphism, haplotype:promoter:-889C>T (human)
RGD
PMID:18484169
RGD:4142867
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
G
Il1b
interleukin 1 beta
ISO
DNA:polymorphism, haplotype: :-511C>T (human)
RGD
PMID:18484169
RGD:4142867
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
G
Itih4
inter-alpha-trypsin inhibitor heavy chain 4
ISO
protein:increased expression:respiratory system fluid/secretion, serum
RGD
PMID:24360996
RGD:40903005
NCBI chrNW_004955430:2,772,064...2,787,912
Ensembl chrNW_004955430:2,770,373...2,789,131
G
Mbl2
mannose binding lectin 2
treatment
ISO
RGD
PMID:17335555
RGD:8693746
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
G
Ptx3
pentraxin 3
susceptibility no_association
ISO
DNA:SNP:intron:rs1840680 (human) protein:increased expression:plasma DNA:SNP, missense mutation:intron, cds:rs2305619, rs3816527 protein:increased expression:bronchoalveolar lavage fluid, plasma (human)
RGD
PMID:29020397 PMID:29964232
RGD:38501098 RGD:38508894
NCBI chrNW_004955448:8,366,795...8,373,010
Ensembl chrNW_004955448:8,366,925...8,372,411
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Vegfa
vascular endothelial growth factor A
treatment
ISO
RGD
PMID:23303813
RGD:8655596
NCBI chrNW_004955437:9,527,445...9,541,908
Ensembl chrNW_004955437:9,531,362...9,542,664
G
Cxcl8
C-X-C motif chemokine ligand 8
ISO
RGD
PMID:11207292
RGD:38549344
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
G
Il23a
interleukin 23 subunit alpha
severity
ISO
RGD
PMID:16157683
RGD:39457940
NCBI chrNW_004955458:3,946,964...3,949,180
Ensembl chrNW_004955458:3,947,803...3,949,312
G
Irak3
interleukin 1 receptor associated kinase 3
severity
ISO
mRNA:increased expression:lung (mouse)
RGD
PMID:20864681 PMID:22729155
RGD:35316077 RGD:36049798
NCBI chrNW_004955458:12,839,995...12,880,285
Ensembl chrNW_004955458:12,846,237...12,879,316
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Plac8
placenta associated 8
severity
ISO
RGD
PMID:17404296
RGD:40924563
NCBI chrNW_004955474:6,518,459...6,533,251
Ensembl chrNW_004955474:6,522,204...6,534,312
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Ada
adenosine deaminase
ISO
protein:increased expression:serum
RGD
PMID:9255891
RGD:5128857
NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
G
Cx3cl1
C-X3-C motif chemokine ligand 1
ISO
RGD
PMID:16113250
RGD:4891897
NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711
G
Ifng
interferon gamma
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11349020
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
G
Il18
interleukin 18
ISO
RGD
PMID:11083766
RGD:4889865
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
G
Mbl2
mannose binding lectin 2
susceptibility
ISO
RGD
PMID:19073229
RGD:12910934
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
G
Nod1
nucleotide binding oligomerization domain containing 1
ISO
RGD
PMID:20685341
RGD:5131443
NCBI chrNW_004955410:31,681,191...31,725,173
Ensembl chrNW_004955410:31,681,077...31,725,173
G
Nod2
nucleotide binding oligomerization domain containing 2
ISO
RGD
PMID:20685341
RGD:5131443
NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
G
Tlr5
toll like receptor 5
ISO
ClinVar Annotator: match by term: Legionnaire disease, susceptibility to
OMIM ClinVar
PMID:14623910 PMID:16027372 PMID:23447684
NCBI chrNW_004955520:1,544,840...1,562,081
Ensembl chrNW_004955520:1,556,523...1,559,093
G
Tlr9
toll like receptor 9
ISO
RGD
PMID:18426877
RGD:5130707
NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582
G
Tnfrsf1a
TNF receptor superfamily member 1A
ISO
RGD
PMID:18838275
RGD:5131445
NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021
G
Tnfrsf1b
TNF receptor superfamily member 1B
ISO
RGD
PMID:18838275
RGD:5131445
NCBI chrNW_004955486:1,790,531...1,817,986
Ensembl chrNW_004955486:1,792,115...1,818,362
G
Ada
adenosine deaminase
ISO
protein:increased expression:serum
RGD
PMID:9255891
RGD:5128857
NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
G
Atp1b2
ATPase Na+/K+ transporting subunit beta 2
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955467:9,261,775...9,268,743
Ensembl chrNW_004955467:9,261,775...9,268,743
G
Ccl5
C-C motif chemokine ligand 5
ISO
protein:increased secretion:lung, secretion (mouse)
RGD
PMID:18717637
RGD:4891914
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Clec5a
C-type lectin domain containing 5A
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955494:1,683,926...1,694,914
Ensembl chrNW_004955494:1,683,956...1,693,348
G
Col3a1
collagen type III alpha 1 chain
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955403:9,720,831...9,758,019
Ensembl chrNW_004955403:9,721,114...9,757,887
G
Col6a1
collagen type VI alpha 1 chain
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955407:42,461,837...42,479,048
Ensembl chrNW_004955407:42,461,952...42,478,261
G
Col6a2
collagen type VI alpha 2 chain
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955407:42,575,677...42,600,967
Ensembl chrNW_004955407:42,575,170...42,600,495
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Dnase1l3
deoxyribonuclease 1L3
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955430:7,867,172...7,892,079
Ensembl chrNW_004955430:7,867,109...7,892,079
G
Fcer2
Fc fragment of IgE receptor II
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955563:1,587,471...1,596,707
Ensembl chrNW_004955563:1,587,396...1,596,063
G
Flt1
fms related receptor tyrosine kinase 1
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955497:7,653,309...7,831,737
Ensembl chrNW_004955497:7,653,248...7,831,472
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Galc
galactosylceramidase
ISO
associated with Guillain-Barre syndrome; protein:increased expression:serum (human) protein:increased expression:serum (mouse) associated with Guillain-Barre syndrome; protein:increased expression:Cerebrospinal fluid, serum (human)
RGD
PMID:12225900 PMID:27490360 PMID:29301655 PMID:30396892
RGD:38599168 RGD:38599169 RGD:38599171 RGD:38599172
NCBI chrNW_004955438:10,667,807...10,704,386
Ensembl chrNW_004955438:10,667,807...10,704,384
G
Hdc
histidine decarboxylase
ISO
RGD
PMID:17158962
RGD:5143920
NCBI chrNW_004955409:4,051,574...4,072,641
Ensembl chrNW_004955409:4,051,271...4,072,642
G
Htra3
HtrA serine peptidase 3
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955514:2,716,448...2,740,590
Ensembl chrNW_004955514:2,717,290...2,737,288
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Ifng
interferon gamma
ISO
mRNA:increased expression:lung:
RGD
PMID:7935058
RGD:10755754
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
G
Il13
interleukin 13
ISO
protein:increased expression:serum
RGD
PMID:20416219
RGD:4145765
NCBI chrNW_004955408:4,046,406...4,049,795
G
Il22ra2
interleukin 22 receptor subunit alpha 2
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955436:22,208,267...22,219,667
Ensembl chrNW_004955436:22,211,175...22,220,566
G
Inhba
inhibin subunit beta A
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955460:2,054,879...2,066,628
Ensembl chrNW_004955460:2,046,588...2,066,609
G
Ms4a1
membrane spanning 4-domains A1
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955511:5,252,934...5,263,961
Ensembl chrNW_004955511:5,258,341...5,267,113
G
Pld4
phospholipase D family member 4
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955538:3,296,581...3,303,187
Ensembl chrNW_004955538:3,295,937...3,303,802
G
Spib
Spi-B transcription factor
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955559:705,809...711,407
Ensembl chrNW_004955559:705,809...711,407
G
Tcf7
transcription factor 7
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955408:5,362,423...5,388,684
Ensembl chrNW_004955408:5,362,084...5,388,527
G
Tcl1a
TCL1 family AKT coactivator A
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955438:16,934,650...16,952,926
G
Tnf
tumor necrosis factor
ISO
protein:increased expression:serum
RGD
PMID:20416219
RGD:4145765
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
G
Tnfrsf13c
TNF receptor superfamily member 13C
severity
ISO
RGD
PMID:28302172
RGD:32716376
NCBI chrNW_004955413:27,341,977...27,344,009
G
Ptch1
patched 1
ISO
mRNA:decreased expression:epithelium of nasopharynx
RGD
PMID:23001130
RGD:150523839
NCBI chrNW_004955422:22,362,330...22,418,062
Ensembl chrNW_004955422:22,362,221...22,427,622
G
Adipoq
adiponectin, C1Q and collagen domain containing
ISO
protein:decreased expression:serum
RGD
PMID:19725899
RGD:5686851
NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
G
Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19389874
NCBI chrNW_004955447:9,327...21,212
G
Alox5ap
arachidonate 5-lipoxygenase activating protein
ISO
protein:increased expression:nasal turbinate
RGD
PMID:19364335
RGD:5147461
NCBI chrNW_004955431:15,071,535...15,097,496
Ensembl chrNW_004955431:15,069,089...15,097,580
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Cat
catalase
ISO
protein:decreased expression:plasma
RGD
PMID:20493834
RGD:5130771
NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
G
Ccr2
C-C motif chemokine receptor 2
ISO
mRNA:increased expression:Nasal Mucosa
RGD
PMID:17982926
RGD:4145109
NCBI chrNW_004955420:25,641,184...25,664,413
Ensembl chrNW_004955420:25,640,367...25,664,518
G
Cd40
CD40 molecule
ISO
RGD
PMID:20226305
RGD:5132269
NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093
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Cd86
CD86 molecule
ISO
protein:increased expression:nasal mucosa, dendritic cell (human)
RGD
PMID:17088138
RGD:4892343
NCBI chrNW_004955427:21,375,820...21,436,767
Ensembl chrNW_004955427:21,375,794...21,435,874
G
Egr1
early growth response 1
ISO
DNA:snp:5' utr:g.-4071A>G rs7729723 (human)
RGD
PMID:19833116
RGD:5131984
NCBI chrNW_004955418:2,001,509...2,005,269
Ensembl chrNW_004955418:2,002,699...2,005,007
G
F2rl1
F2R like trypsin receptor 1
ISO
RGD
PMID:17727088
RGD:4892590
NCBI chrNW_004955425:24,050,901...24,054,039
G
Gstp1
glutathione S-transferase pi 1
susceptibility
ISO
DNA:polymorphism:exon:p.I105V (rs1695) (human)
RGD
PMID:17181111
RGD:4142523
NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428
G
Hmox1
heme oxygenase 1
ISO
mRNA, protein:increased expression: nasal mucosa
RGD
PMID:16540907
RGD:4145406
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
G
Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:lung, endothelium (mouse) protein:increased secretion:nasopharynx (human)
RGD
PMID:19047814 PMID:19968652
RGD:4145464 RGD:4145520
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
G
Ifngr1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715
RGD:6480431
NCBI chrNW_004955436:22,183,318...22,199,013
Ensembl chrNW_004955436:22,183,311...22,198,291
G
Il13
interleukin 13
ISO
mRNA, protein:increased expression:nasal mucosa
RGD
PMID:8520776
RGD:4782826
NCBI chrNW_004955408:4,046,406...4,049,795
G
Il17a
interleukin 17A
severity
ISO
protein:increased expression:serum
RGD
PMID:19226302
RGD:4889151
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
G
Il18
interleukin 18
susceptibility
ISO
DNA:SNP:promoter:c. -607A>C (rs1946518) (human)
RGD
PMID:16406079
RGD:4889924
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
G
Il1a
interleukin 1 alpha
ISO
DNA:polymorphism:exon:c.4845G>T (human)
RGD
PMID:14533660
RGD:4142859
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
G
Il1r1
interleukin 1 receptor type 1
ISO
RGD
PMID:18637763
RGD:5037238
NCBI chrNW_004955470:7,685,498...7,703,374
G
Il2
interleukin 2
ISO
protein:decreased expression:serum:
RGD
PMID:17608155
RGD:8662959
NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
G
Il4
interleukin 4
treatment
ISO
protein:increased expression:serum
RGD
PMID:9237816 PMID:15329007 PMID:21171297
RGD:5128559 RGD:7829804 RGD:7829817
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
G
Il5
interleukin 5
ISO
protein: increased levels: sputum
RGD
PMID:22186238
RGD:5687140
NCBI chrNW_004955408:3,937,128...3,951,784
Ensembl chrNW_004955408:3,937,894...3,939,358
G
Mmp2
matrix metallopeptidase 2
ISO
protein:increased expression:nasal mucosa:
RGD
PMID:19786210
RGD:5130872
NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775
G
Mmp9
matrix metallopeptidase 9
ISO
protein:increased expression:nasal mucosa:
RGD
PMID:19786210
RGD:5130872
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
G
Nos2
nitric oxide synthase 2
ISO
protein:increased expression:nasal mucosa
RGD
PMID:14587983
RGD:4892078
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
G
Nos3
nitric oxide synthase 3
ISO
DNA:snp:promoter:g.-786T>C (human)
RGD
PMID:18086269
RGD:4892054
NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814
G
Nr3c1
nuclear receptor subfamily 3 group C member 1
ISO
protein:altered expression:nasal mucosa
RGD
PMID:20185258
RGD:4892593
NCBI chrNW_004955415:10,494,704...10,585,778
Ensembl chrNW_004955415:10,494,640...10,586,221
G
Pparg
peroxisome proliferator activated receptor gamma
ISO
mRNA, protein:increased expression:nasal mucosa (human)
RGD
PMID:17116814
RGD:8552811
NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387
G
Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:respiratory system epithelium
RGD
PMID:19364335
RGD:5147461
NCBI chrNW_004955419:5,678,750...5,699,305
Ensembl chrNW_004955419:5,678,694...5,699,305
G
Tbxa2r
thromboxane A2 receptor
treatment
ISO
RGD
PMID:15247523
RGD:11059532
NCBI chrNW_004955495:5,539,382...5,557,441
Ensembl chrNW_004955495:5,539,889...5,557,441
G
Plau
plasminogen activator, urokinase
ISO
Gene product used in treatment of disease
RGD
PMID:20304453
RGD:4891955
NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
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Tnc
tenascin C
ISO
protein:increased expression:pleura
RGD
PMID:10950882
RGD:4889594
NCBI chrNW_004955419:12,569,620...12,662,897
Ensembl chrNW_004955419:12,569,547...12,662,958
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Ada
adenosine deaminase
ISO
protein:increased activity:pleural fluid: protein:increased activity:serum: protein:increased expression:serum:
RGD
PMID:1689629 PMID:1818842 PMID:18357489 PMID:21860532
RGD:152995280 RGD:152995288 RGD:152995292 RGD:152998934
NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
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Ada2
adenosine deaminase 2
treatment
ISO
RGD
PMID:8656037
RGD:152995258
NCBI chrNW_004955454:5,341,822...5,355,383
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Ccl22
C-C motif chemokine ligand 22
ISO
RGD
PMID:20337996
RGD:4891473
NCBI chrNW_004955433:15,002,001...15,007,324
Ensembl chrNW_004955433:15,001,930...15,008,032
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Ccr2
C-C motif chemokine receptor 2
ISO
RGD
PMID:19159432
RGD:4145106
NCBI chrNW_004955420:25,641,184...25,664,413
Ensembl chrNW_004955420:25,640,367...25,664,518
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Foxp3
forkhead box P3
disease_progression
ISO
associated with human immunodeficiency virus infectious disease;
RGD
PMID:21303360
RGD:36947878
NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606
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Il1b
interleukin 1 beta
ISO
DNA:polymorphism: :3953T>C (human)
RGD
PMID:10377182
RGD:4143226
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rn
interleukin 1 receptor antagonist
ISO
DNA:repeat (human)
RGD
PMID:10377182
RGD:4143226
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il27
interleukin 27
exacerbates
ISO
protein:increased expression:alveolar system (human) associated with Pleural Effusion;protein:increased expression:pleural fluid (human)
RGD
PMID:23962500 PMID:25753767 PMID:28844060 PMID:31819557
RGD:126790505 RGD:126790517 RGD:126790523 RGD:126790549
NCBI chrNW_004955493:6,712,005...6,717,417
Ensembl chrNW_004955493:6,712,005...6,717,417
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Il33
interleukin 33
ISO
protein:increased expression:pleural fluid:
RGD
PMID:23301222
RGD:39939042
NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
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Mmp9
matrix metallopeptidase 9
ISO
protein:increased expression:pleura:
RGD
PMID:18715875
RGD:5129700
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Tlr4
toll like receptor 4
ISO
RGD
PMID:18295348
RGD:4144193
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tnc
tenascin C
ISO
protein:increased expression:pleura
RGD
PMID:10950882
RGD:4889594
NCBI chrNW_004955419:12,569,620...12,662,897
Ensembl chrNW_004955419:12,569,547...12,662,958
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Ada
adenosine deaminase
ISO
RGD
PMID:16860713
RGD:5128847
NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
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Alox5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:9109363
RGD:4890429
NCBI chrNW_004955546:2,495,226...2,550,909
Ensembl chrNW_004955546:2,494,819...2,550,909
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Anxa1
annexin A1
ISO
RGD
PMID:15784654
RGD:2306907
NCBI chrNW_004955512:5,686,508...5,703,645
Ensembl chrNW_004955512:5,685,856...5,703,817
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Bdkrb1
bradykinin receptor B1
ISO
RGD
PMID:11853231
RGD:5129218
NCBI chrNW_004955438:16,500,219...16,505,394
Ensembl chrNW_004955438:16,500,633...16,501,691
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Bdkrb2
bradykinin receptor B2
ISO
RGD
PMID:9208140 PMID:15316088
RGD:4891029 RGD:4891041
NCBI chrNW_004955438:16,514,300...16,537,160
Ensembl chrNW_004955438:16,511,759...16,537,172
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C3
complement C3
ISO
protein:increased activity:pleural cavity
RGD
PMID:18256172
RGD:5129520
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Cat
catalase
ISO
RGD
PMID:19778612
RGD:5130749
NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
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Ccl25
C-C motif chemokine ligand 25
ISO
protein:increased expression:pleural fluid
RGD
PMID:18056919
RGD:5130924
NCBI chrNW_004955563:1,249,098...1,255,469
Ensembl chrNW_004955563:1,251,526...1,256,650
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Ccl5
C-C motif chemokine ligand 5
ISO
protein:increased secretion:lung (mouse)
RGD
PMID:18672096
RGD:4890016
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Ccr3
C-C motif chemokine receptor 3
ISO
associated with Mycobacterium Infections
RGD
PMID:17158890
RGD:4145643
NCBI chrNW_004955420:25,702,917...25,723,269
Ensembl chrNW_004955420:25,701,407...25,723,353
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Csf3
colony stimulating factor 3
ISO
RGD
PMID:8841835
RGD:11039424
NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
RGD
PMID:14527170
RGD:5135449
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
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Cxcl9
C-X-C motif chemokine ligand 9
ISO
RGD
PMID:14527170
RGD:5135449
NCBI chrNW_004955433:724,566...731,945
Ensembl chrNW_004955433:724,515...732,192
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Ednra
endothelin receptor type A
ISO
RGD
PMID:15107459
RGD:4892325
NCBI chrNW_004955428:3,062,303...3,114,761
Ensembl chrNW_004955428:3,062,303...3,114,761
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Esr1
estrogen receptor 1
ISO
RGD
PMID:17035596
RGD:4892303
NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353
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Icam1
intercellular adhesion molecule 1
ISO
associated with Tuberculosis; protein:increased expression:pleural fluid, natural killer cell (human) CTD Direct Evidence: marker/mechanism protein:increased expression:bronchial epithelium (mouse)
RGD CTD
PMID:11181422 PMID:19056932 PMID:19714575
RGD:4145510 RGD:4145519
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Il10
interleukin 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11181422
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il15
interleukin 15
ISO
RGD
PMID:10823416
RGD:4990464
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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Il17a
interleukin 17A
treatment
ISO
RGD
PMID:21898269
RGD:7175307
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il1b
interleukin 1 beta
ISO
protein:increased expression:lung protein:increased expression:pleural cavity, exudate (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11181422 PMID:20141620 PMID:20175894 PMID:21898269
RGD:4142808 RGD:4142826 RGD:7175307
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rn
interleukin 1 receptor antagonist
ISO
RGD
PMID:8491511
RGD:4143233
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11181422
NCBI chrNW_004955410:25,079,835...25,084,390
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LOC102018844
neutrophil elastase
ISO
RGD
PMID:20860667
RGD:10450565
NCBI chrNW_004955495:6,964,577...6,967,208
Ensembl chrNW_004955495:6,964,667...6,967,106
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Mpo
myeloperoxidase
ISO
protein:increased activity:lung
RGD
PMID:11577999
RGD:5130991
NCBI chrNW_004955451:4,743,744...4,753,358
Ensembl chrNW_004955451:4,743,744...4,753,358
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Nfe2l2
NFE2 like bZIP transcription factor 2
ISO
RGD
PMID:14673141
RGD:6893408
NCBI chrNW_004955403:19,510,122...19,536,428
Ensembl chrNW_004955403:19,532,103...19,535,944
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Nos2
nitric oxide synthase 2
ISO
protein:increased expression:pleural cavity (rat)
RGD
PMID:20141620 PMID:21898269
RGD:4142808 RGD:7175307
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Pla2g6
phospholipase A2 group VI
ISO
RGD
PMID:15003994
RGD:6482741
NCBI chrNW_004955413:24,431,592...24,482,229
Ensembl chrNW_004955413:24,429,589...24,482,537
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Ptafr
platelet activating factor receptor
treatment
ISO
RGD
PMID:8395390
RGD:10043147
NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929
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Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
RGD
PMID:15740981 PMID:20141620
RGD:4142808 RGD:5143929
NCBI chrNW_004955406:25,077,988...25,086,259
Ensembl chrNW_004955406:25,079,945...25,086,171
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Selp
selectin P
ISO
protein:increased expression:lung CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11181422 PMID:21147071
RGD:6219005
NCBI chrNW_004955462:7,658,371...7,692,870
Ensembl chrNW_004955462:7,652,437...7,693,994
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Serpine1
serpin family E member 1
susceptibility
ISO
associated with Familial Mediterranean Fever;DNA: DNA:polymorphism:promoter:rs1799768 (human):
RGD
PMID:23052617
RGD:13207414
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11161459 PMID:11181422 PMID:20141620
RGD:4142808 RGD:4143474
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Alox5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:12773506
RGD:4890419
NCBI chrNW_004955546:2,495,226...2,550,909
Ensembl chrNW_004955546:2,494,819...2,550,909
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Alox5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:20231413
RGD:4890435
NCBI chrNW_004955546:2,495,226...2,550,909
Ensembl chrNW_004955546:2,494,819...2,550,909
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Btk
Bruton tyrosine kinase
ameliorates
ISO
RGD
PMID:30646846
RGD:124715470
NCBI chrNW_004955503:7,483,819...7,515,085
Ensembl chrNW_004955503:7,482,793...7,515,120
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C3
complement C3
disease_progression
ISO
associated with Liver Cirrhosis, Experimental;protein:decreased expression:respiratory system fluid/secretion protein:decreased expression:serum
RGD
PMID:20405 PMID:15972516 PMID:17956621
RGD:5129509 RGD:5129523 RGD:5130163
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Ccl5
C-C motif chemokine ligand 5
susceptibility
ISO
RGD
PMID:16455992
RGD:4892130
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Cd14
CD14 molecule
ISO
RGD
PMID:17185649
RGD:4144788
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Chi3l1
chitinase 3 like 1
ISO
protein:increased secretion:serum (human)
RGD
PMID:10515841
RGD:4892626
NCBI chrNW_004955406:39,195,101...39,201,808
Ensembl chrNW_004955406:39,191,073...39,202,020
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Crhr1
corticotropin releasing hormone receptor 1
ISO
RGD
PMID:21774994
RGD:5147472
NCBI chrNW_004955478:10,380,185...10,390,838
Ensembl chrNW_004955478:10,379,287...10,404,825
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Crhr2
corticotropin releasing hormone receptor 2
ISO
RGD
PMID:21774994
RGD:5147472
NCBI chrNW_004955410:31,830,333...31,874,384
Ensembl chrNW_004955410:31,828,506...31,875,100
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Cxcl8
C-X-C motif chemokine ligand 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24894820
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
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Cxcl9
C-X-C motif chemokine ligand 9
ISO
protein:increased expression:lung
RGD
PMID:20381636
RGD:5135285
NCBI chrNW_004955433:724,566...731,945
Ensembl chrNW_004955433:724,515...732,192
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Hmox1
heme oxygenase 1
ISO
associated with influenza;protein:increased expression:lung
RGD
PMID:17348295
RGD:4145366
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
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Il15
interleukin 15
ISO
protein:increased expression:alveolar macrophage, bronchial epithelial cell
RGD
PMID:17611121
RGD:5000755
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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Il15ra
interleukin 15 receptor subunit alpha
ISO
RGD
PMID:17611121
RGD:5000755
NCBI chrNW_004955421:22,590,168...22,612,835
Ensembl chrNW_004955421:22,586,012...22,620,788
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Il17a
interleukin 17A
ISO
RGD
PMID:19995896
RGD:4888531
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il18
interleukin 18
ISO
RGD
PMID:15770015
RGD:4889960
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il6
interleukin 6
ISO
RGD
PMID:20643849
RGD:4143255
NCBI chrNW_004955410:25,079,835...25,084,390
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Lep
leptin
ISO
RGD
PMID:17822444
RGD:5128869
NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472
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Lepr
leptin receptor
ISO
RGD
PMID:21148797
RGD:5128846
NCBI chrNW_004955423:25,108,897...25,185,315
Ensembl chrNW_004955423:25,111,266...25,185,407
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Mapk1
mitogen-activated protein kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24894820
NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020
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Mapk3
mitogen-activated protein kinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24894820
NCBI chrNW_004955493:6,870,699...6,876,836
Ensembl chrNW_004955493:6,869,668...6,879,152
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Masp2
MBL associated serine protease 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12904520
NCBI chrNW_004955486:2,641,730...2,655,125
Ensembl chrNW_004955486:2,641,837...2,643,828
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Mbl2
mannose binding lectin 2
no_association
ISO
DNA:polymorphisms:5' utr, exon:multiple (human) DNA:mutations:5' utr, exon:multiple (human)
RGD
PMID:12047967 PMID:18641104
RGD:4889477 RGD:4889478
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Nos2
nitric oxide synthase 2
ISO
RGD
PMID:17056580
RGD:4891950
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Pten
phosphatase and tensin homolog
ameliorates
ISO
myeloid knockout
RGD
PMID:20505137
RGD:127285597
NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829
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Sftpd
surfactant protein D
severity
ISO
RGD
PMID:16255775
RGD:4143519
NCBI chrNW_004955510:213,468...226,096
Ensembl chrNW_004955510:213,438...225,896
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Sirt1
sirtuin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24894820
NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663
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Sting1
stimulator of interferon response cGAMP interactor 1
ISO
RGD
PMID:29263110
RGD:39128230
NCBI chrNW_004955418:1,091,022...1,097,064
Ensembl chrNW_004955418:1,083,613...1,100,448
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Tlr2
toll like receptor 2
ISO
RGD
PMID:19956717
RGD:4145321
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tnf
tumor necrosis factor
ISO
associated with influenza;protein:increased expression:lung
RGD
PMID:9032201 PMID:17348295
RGD:4143479 RGD:4145366
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Azin1
antizyme inhibitor 1
ISO
mRNA:increased expression:alveolar macrophage
RGD
PMID:19158080
RGD:14700806
NCBI chrNW_004955417:27,231,695...27,259,564
Ensembl chrNW_004955417:27,231,696...27,259,564
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C3
complement C3
ISO
RGD
PMID:17169032
RGD:5129525
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Cd40
CD40 molecule
treatment
ISO
RGD
PMID:10968950
RGD:8547797
NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093
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Csf2
colony stimulating factor 2
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:19487471
RGD:5131475
NCBI chrNW_004955408:3,452,009...3,454,255
Ensembl chrNW_004955408:3,451,965...3,454,312
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Il23a
interleukin 23 subunit alpha
ISO
RGD
PMID:17403873
RGD:39458043
NCBI chrNW_004955458:3,946,964...3,949,180
Ensembl chrNW_004955458:3,947,803...3,949,312
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Il33
interleukin 33
treatment
ISO
RGD
PMID:21220696
RGD:40400892
NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
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Muc1
mucin 1, cell surface associated
ISO
protein:increased expression:serum
RGD
PMID:9617869
RGD:5131424
NCBI chrNW_004955545:1,657,728...1,662,112
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Nos2
nitric oxide synthase 2
ISO
protein:decreased dimerization:alveolar macrophage mRNA:increased expression:alveolar macrophage
RGD
PMID:20377877 PMID:20558778
RGD:4144112 RGD:4891486
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Sftpb
surfactant protein B
ISO
protein:decreased expression:lung
RGD
PMID:11385364
RGD:4143431
NCBI chrNW_004955424:1,849,313...1,858,087
Ensembl chrNW_004955424:1,849,314...1,858,087
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Sftpc
surfactant protein C
ISO
protein:decreased expression:lung
RGD
PMID:11385364
RGD:4143431
NCBI chrNW_004955403:45,649,149...45,651,421
Ensembl chrNW_004955403:45,649,122...45,651,837
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Sftpd
surfactant protein D
ISO
protein:increased expression:lung
RGD
PMID:11385364
RGD:4143431
NCBI chrNW_004955510:213,468...226,096
Ensembl chrNW_004955510:213,438...225,896
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Tlr2
toll like receptor 2
ISO
RGD
PMID:18400546
RGD:4145341
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Abcf1
ATP binding cassette subfamily F member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955583:600,381...607,211
Ensembl chrNW_004955583:600,398...606,820
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Adora1
adenosine A1 receptor
ISO
RGD
PMID:15630442
RGD:5129098
NCBI chrNW_004955406:39,148,811...39,183,577
Ensembl chrNW_004955406:39,149,689...39,187,688
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Adora2a
adenosine A2a receptor
ISO
associated with Lung Injury associated with Anemia, Sickle Cell
RGD
PMID:17601796 PMID:18703794 PMID:20798237
RGD:4890358 RGD:4890364 RGD:4890376
NCBI chrNW_004955455:7,886,720...7,906,214
Ensembl chrNW_004955455:7,895,974...7,906,505
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Adrb2
adrenoceptor beta 2
ISO
RGD
PMID:19925785
RGD:4145041
NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980
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Agt
angiotensinogen
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:28960804
NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357
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Ahr
aryl hydrocarbon receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23337360
NCBI chrNW_004955410:20,428,531...20,459,482
Ensembl chrNW_004955410:20,428,546...20,456,836
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Alb
albumin
disease_progression
ISO
RGD
PMID:23286966
RGD:11035283
NCBI chrNW_004955447:9,327...21,212
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Bdkrb2
bradykinin receptor B2
ISO
RGD
PMID:15021973
RGD:4891030
NCBI chrNW_004955438:16,514,300...16,537,160
Ensembl chrNW_004955438:16,511,759...16,537,172
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C3
complement C3
ISO
RGD
PMID:10886251
RGD:5129562
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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C3ar1
complement C3a receptor 1
ISO
associated with Respiratory Syncytial Virus Infections
RGD
PMID:17079327
RGD:5129688
NCBI chrNW_004955413:6,707,003...6,715,689
Ensembl chrNW_004955413:6,707,689...6,715,689
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Ccl17
C-C motif chemokine ligand 17
ISO
mRNA:increased expression:lung CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15993846 PMID:21625544
RGD:2306304
NCBI chrNW_004955433:15,052,616...15,054,732
Ensembl chrNW_004955433:15,053,061...15,054,572
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Ccl19
C-C motif chemokine ligand 19
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955472:1,444,598...1,446,488
Ensembl chrNW_004955472:1,444,316...1,446,490
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Ccl20
C-C motif chemokine ligand 20
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955453:6,846,625...6,850,007
Ensembl chrNW_004955453:6,846,549...6,850,031
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Ccl22
C-C motif chemokine ligand 22
ISO
mRNA:increased expression:lung
RGD
PMID:15993846
RGD:2306304
NCBI chrNW_004955433:15,002,001...15,007,324
Ensembl chrNW_004955433:15,001,930...15,008,032
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Ccl24
C-C motif chemokine ligand 24
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955456:14,582,812...14,588,574
Ensembl chrNW_004955456:14,583,610...14,585,169
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Ccr2
C-C motif chemokine receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14615370 PMID:17284325 PMID:21625544
RGD:4145068 RGD:8661704
NCBI chrNW_004955420:25,641,184...25,664,413
Ensembl chrNW_004955420:25,640,367...25,664,518
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Ccr3
C-C motif chemokine receptor 3
ISO
mRNA:increased expression:lung
RGD
PMID:19762220
RGD:4145622
NCBI chrNW_004955420:25,702,917...25,723,269
Ensembl chrNW_004955420:25,701,407...25,723,353
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Ccr6
C-C motif chemokine receptor 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955439:14,921,524...14,949,493
Ensembl chrNW_004955439:14,920,601...14,924,191
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Ccr7
C-C motif chemokine receptor 7
ISO
mRNA, protein:increased expression:lung
RGD
PMID:16394278
RGD:5130919
NCBI chrNW_004955451:15,086,119...15,101,862
Ensembl chrNW_004955451:15,086,119...15,095,561
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Ccr9
C-C motif chemokine receptor 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955420:26,083,445...26,093,740
Ensembl chrNW_004955420:26,083,040...26,093,775
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Cd14
CD14 molecule
ISO
protein:increased expression:multiple
RGD
PMID:20302606
RGD:4144794
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd40lg
CD40 ligand
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955489:8,465,571...8,477,714
Ensembl chrNW_004955489:8,465,164...8,477,746
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Coq6
coenzyme Q6, monooxygenase
ISO
ClinVar Annotator: match by term: increased susceptibility to pneumonia
ClinVar
NCBI chrNW_004955523:1,444,675...1,458,769
Ensembl chrNW_004955523:1,444,901...1,458,718
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Crhr2
corticotropin releasing hormone receptor 2
ISO
RGD
PMID:16855006
RGD:5130933
NCBI chrNW_004955410:31,830,333...31,874,384
Ensembl chrNW_004955410:31,828,506...31,875,100
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Csf2
colony stimulating factor 2
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11732872 PMID:19633061
RGD:4142837
NCBI chrNW_004955408:3,452,009...3,454,255
Ensembl chrNW_004955408:3,451,965...3,454,312
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Csf3r
colony stimulating factor 3 receptor
ISO
mRNA:increased expression:bronchoalveolar lavage (human)
RGD
PMID:32407669
RGD:30296672
NCBI chrNW_004955452:14,409,484...14,425,818
Ensembl chrNW_004955452:14,411,708...14,422,187
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Csk
C-terminal Src kinase
ISO
RGD
PMID:14975240
RGD:5134363
NCBI chrNW_004955450:3,127,561...3,144,550
Ensembl chrNW_004955450:3,127,561...3,144,550
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Cx3cl1
C-X3-C motif chemokine ligand 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
associated with Lupus Erythematosus, Systemic;mRNA:increased expression:lung
RGD
PMID:14979941 PMID:15265940
RGD:5135445 RGD:5135491
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
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Cxcl8
C-X-C motif chemokine ligand 8
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:bronchoalveolar lavage (human)
CTD RGD
PMID:21625544 PMID:32407669
RGD:30296672
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
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Cxcl9
C-X-C motif chemokine ligand 9
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:serum
CTD RGD
PMID:15265940 PMID:17052299 PMID:21625544
RGD:5135440 RGD:5135445
NCBI chrNW_004955433:724,566...731,945
Ensembl chrNW_004955433:724,515...732,192
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
associated with Lupus Erythematosus, Systemic;mRNA:increased expression:lung CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:14979941 PMID:15265940 PMID:21625544
RGD:5135445 RGD:5135491
NCBI chrNW_004955475:11,148,928...11,152,313
Ensembl chrNW_004955475:11,148,879...11,152,596
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Edn1
endothelin 1
severity
ISO
protein:increased secretion:plasma (human)
RGD
PMID:20529344
RGD:4144879
NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753
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Egf
epidermal growth factor
resistance
ISO
RGD
PMID:21701422
RGD:6906904
NCBI chrNW_004955496:325,954...401,430
Ensembl chrNW_004955496:328,075...401,569
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Egr1
early growth response 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:29787794
NCBI chrNW_004955418:2,001,509...2,005,269
Ensembl chrNW_004955418:2,002,699...2,005,007
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Entpd5
ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
ISO
ClinVar Annotator: match by term: increased susceptibility to pneumonia
ClinVar
NCBI chrNW_004955523:1,407,812...1,441,829
Ensembl chrNW_004955523:1,421,749...1,441,829
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Grp
gastrin releasing peptide
ISO
protein:increased expression:serum (human)
RGD
PMID:30146822
RGD:401700396
NCBI chrNW_004955402:43,382,608...43,393,452
Ensembl chrNW_004955402:43,382,552...43,393,463
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Hdc
histidine decarboxylase
ISO
RGD
PMID:14556983
RGD:5143922
NCBI chrNW_004955409:4,051,574...4,072,641
Ensembl chrNW_004955409:4,051,271...4,072,642
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Hmox1
heme oxygenase 1
susceptibility
ISO
DNA:allele:promoter:L allele of the (GT)n repeat (>30 repeats) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16582079
RGD:1601608
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
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Icam1
intercellular adhesion molecule 1
treatment
ISO
associated with Reperfusion Injury
RGD
PMID:22882462
RGD:8547727
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Ifnar1
interferon alpha and beta receptor subunit 1
resistance
ISO
Cryptococcus (yeast) pneumonia
RGD
PMID:18566423
RGD:5490275
NCBI chrNW_004955407:32,730,973...32,755,404
Ensembl chrNW_004955407:32,730,953...32,754,651
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Ifng
interferon gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20080200 PMID:31095431
RGD:7495767
NCBI chrNW_004955536:611,965...658,647
Ensembl chrNW_004955536:612,774...658,647
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Il10
interleukin 10
disease_progression
ISO
protein:increased expression:blood
RGD
PMID:20595152
RGD:4140400
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il13
interleukin 13
ISO
associated with Respiratory Distress Syndrome, Newborn; protein:increased expression:bronchoalveolar lavage fluid CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19695190 PMID:21625544
RGD:4145774
NCBI chrNW_004955408:4,046,406...4,049,795
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Il13ra2
interleukin 13 receptor subunit alpha 2
ISO
mRNA:increased expression:lung, fibroblast
RGD
PMID:15161635
RGD:4890021
NCBI chrNW_004955490:708,144...758,195
Ensembl chrNW_004955490:709,446...758,272
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Il17a
interleukin 17A
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20498020 PMID:21625544 PMID:22848348
RGD:4888524 RGD:9068417
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il18
interleukin 18
ISO
associated with reperfusion injury CTD Direct Evidence: marker/mechanism mRNA, protein:increased expression:lung,bronchoalveolar fluid protein:increased expression:serum
RGD CTD
PMID:11739527 PMID:15955140 PMID:16052682 PMID:17400729 PMID:21625544
RGD:4889590 RGD:4889825 RGD:4889836 RGD:729357
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il1a
interleukin 1 alpha
ISO
mRNA:increased expression:lung
RGD
PMID:8806881
RGD:7794765
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
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Il1b
interleukin 1 beta
ISO
mRNA:increased expression:lung mRNA:increased expression:bronchoalveolar lavage (human) CTD Direct Evidence: marker/mechanism protein:increased expression:lung mRNA, protein:increased expression:lung
RGD CTD
PMID:19825784 PMID:19901996 PMID:20007584 PMID:20155581 PMID:20476872 PMID:21625544 PMID:32407669 More...
RGD:30296672 RGD:4142536 RGD:4142812 RGD:4142827 RGD:4142831 RGD:4143211
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1r1
interleukin 1 receptor type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955470:7,685,498...7,703,374
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Il1r2
interleukin 1 receptor type 2
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:bronchoalveolar lavage (human)
CTD RGD
PMID:21625544 PMID:32407669
RGD:30296672
NCBI chrNW_004955470:7,518,565...7,562,219
Ensembl chrNW_004955470:7,518,663...7,559,470
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Il1rn
interleukin 1 receptor antagonist
no_association disease_progression
ISO
DNA:polymorphism (human) mRNA:increased expression:bronchoalveolar lavage (human) DNA:polymorphism:intron (human) mRNA:increased expression:bronchioalveolar lavage fluid, neutrophil (rat) mRNA:increased expression:lung
RGD
PMID:1385928 PMID:16369129 PMID:17569781 PMID:18838927 PMID:19900796 PMID:32407669 More...
RGD:30296672 RGD:4142865 RGD:4142871 RGD:4143204 RGD:4143213 RGD:8551846
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il27
interleukin 27
ISO
RGD
PMID:19124731
RGD:5128483
NCBI chrNW_004955493:6,712,005...6,717,417
Ensembl chrNW_004955493:6,712,005...6,717,417
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Il2rb
interleukin 2 receptor subunit beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955413:23,623,567...23,640,245
Ensembl chrNW_004955413:23,623,154...23,640,259
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Il33
interleukin 33
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24453940
NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
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Il4
interleukin 4
ISO
CTD Direct Evidence: marker/mechanism mRNA:increased expression:bronchoalveolar lavage (human)
CTD RGD
PMID:21625544 PMID:32407669
RGD:30296672
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
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Il4r
interleukin 4 receptor
ISO
mRNA:decreased expression:bronchoalveolar lavage (human)
RGD
PMID:32407669
RGD:30296672
NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422
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Il5ra
interleukin 5 receptor subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955421:10,211,594...10,259,760
Ensembl chrNW_004955421:10,221,694...10,259,885
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Il6
interleukin 6
disease_progression
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:blood
CTD RGD
PMID:20595152 PMID:21625544
RGD:4140400
NCBI chrNW_004955410:25,079,835...25,084,390
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Il6st
interleukin 6 cytokine family signal transducer
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955446:11,790,636...11,837,734
Ensembl chrNW_004955446:11,790,444...11,835,001
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Itga2
integrin subunit alpha 2
treatment
ISO
RGD
PMID:11207307
RGD:8693217
NCBI chrNW_004955446:14,309,516...14,421,991
Ensembl chrNW_004955446:14,309,349...14,422,170
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Itga4
integrin subunit alpha 4
treatment
ISO
RGD
PMID:8703473
RGD:9698424
NCBI chrNW_004955403:15,726,296...15,807,055
Ensembl chrNW_004955403:15,723,785...15,807,111
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Itgb2
integrin subunit beta 2
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:10030843 PMID:21625544
RGD:6482228
NCBI chrNW_004955407:41,779,849...41,805,637
Ensembl chrNW_004955407:41,777,777...41,800,201
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Itgb3
integrin subunit beta 3
disease_progression
ISO
RGD
PMID:12746502
RGD:5100478
NCBI chrNW_004955478:9,788,192...9,830,254
Ensembl chrNW_004955478:9,788,149...9,823,746
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Lias
lipoic acid synthetase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:32017981
NCBI chrNW_004955443:7,889,274...7,907,560
Ensembl chrNW_004955443:7,889,467...7,907,437
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LOC102004444
beta-defensin 1-like
ISO
protein:increased expression:serum
RGD
PMID:17000097
RGD:4892262
NCBI chrNW_004955403:53,643,328...53,644,361
Ensembl chrNW_004955403:53,643,300...53,644,505
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LOC102010850
cytochrome P450 1A1
susceptibility
ISO
DNA:polymorphism (human)
RGD
PMID:15928955
RGD:4142512
NCBI chrNW_004955450:3,183,958...3,189,488
Ensembl chrNW_004955450:3,183,750...3,189,488
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LOC102026028
cytochrome P450 2E1
ISO
DNA:polymorphism (human) protein:increased expression:alveolus, epithelial cell
RGD
PMID:14698565 PMID:15928955
RGD:4142512 RGD:4892223
NCBI chrNW_004955507:6,293,162...6,303,255
Ensembl chrNW_004955507:6,289,576...6,304,193
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Mbl2
mannose binding lectin 2
ISO
protein:increased secretion:lung (human) protein:increased expression:Bronchoalveolar lavage:
RGD
PMID:15249448 PMID:18988662
RGD:4889459 RGD:8693755
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Mif
macrophage migration inhibitory factor
severity
ISO
DNA:repeats:promoter
RGD
PMID:19346297
RGD:4891058
NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460
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Mmp9
matrix metallopeptidase 9
ISO
RGD
PMID:18007984
RGD:5130157
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Muc1
mucin 1, cell surface associated
ISO
protein:increased expression:serum
RGD
PMID:11802251
RGD:5131281
NCBI chrNW_004955545:1,657,728...1,662,112
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Muc2
mucin 2, oligomeric mucus/gel-forming
treatment
ISO
RGD
PMID:23590300
RGD:7349359
NCBI chrNW_004955476:11,108,826...11,135,697
Ensembl chrNW_004955476:11,108,826...11,135,697
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Myd88
MYD88 innate immune signal transduction adaptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26882889
NCBI chrNW_004955427:25,553,589...25,557,654
Ensembl chrNW_004955427:25,553,589...25,559,138
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Mylk
myosin light chain kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15863634
NCBI chrNW_004955427:22,760,432...23,008,432
Ensembl chrNW_004955427:22,762,221...22,970,508
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Nfkbia
NFKB inhibitor alpha
susceptibility
ISO
associated with combined immunodeficiency;DNA:missense mutation:CDS:c.106T>G (p.S36A) (human)
RGD
PMID:31683054
RGD:126925985
NCBI chrNW_004955409:25,691,673...25,695,151
Ensembl chrNW_004955409:25,691,534...25,697,520
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Nrp1
neuropilin 1
treatment
ISO
RGD
PMID:36373992
RGD:401901166
NCBI chrNW_004955462:4,101,997...4,241,012
Ensembl chrNW_004955462:4,101,999...4,241,012
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Parp1
poly(ADP-ribose) polymerase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20561897
NCBI chrNW_004955489:520,875...557,609
Ensembl chrNW_004955489:520,875...557,615
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Pomc
proopiomelanocortin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:6254450
NCBI chrNW_004955469:7,217,233...7,220,401
Ensembl chrNW_004955469:7,217,363...7,220,386
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Serpine1
serpin family E member 1
disease_progression
ISO
DNA:polymorphism:promoter: Pneumonia, Ventilator-Associated; protein:increased expression:Bronchoalveolar Lavage Fluid
RGD
PMID:19387177 PMID:20473240
RGD:4143511 RGD:4143525
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
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Sftpb
surfactant protein B
ISO
RGD
PMID:12594064 PMID:15967375 PMID:16024721
RGD:4143393 RGD:4143394 RGD:4143412
NCBI chrNW_004955424:1,849,313...1,858,087
Ensembl chrNW_004955424:1,849,314...1,858,087
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Sftpc
surfactant protein C
ISO
RGD
PMID:15967375
RGD:4143394
NCBI chrNW_004955403:45,649,149...45,651,421
Ensembl chrNW_004955403:45,649,122...45,651,837
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Sftpd
surfactant protein D
ISO
associated with Bronchitis;protein:decreased expression:lung
RGD
PMID:15967375 PMID:17925426 PMID:18266831
RGD:4143394 RGD:4143504 RGD:4143517
NCBI chrNW_004955510:213,468...226,096
Ensembl chrNW_004955510:213,438...225,896
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Sirt1
sirtuin 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:24633890
NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663
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Sod3
superoxide dismutase 3
ISO
RGD
PMID:16842247
RGD:1581268
NCBI chrNW_004955480:257,716...263,149
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Spp1
secreted phosphoprotein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955474:1,914,477...1,922,025
Ensembl chrNW_004955474:1,913,829...1,922,016
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Tgfb1
transforming growth factor beta 1
severity
ISO
protein:increased expression:lung CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19181604 PMID:19965809 PMID:21625544
RGD:4145120 RGD:4145141
NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441
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Tlr2
toll like receptor 2
susceptibility
ISO
RGD
PMID:19011150
RGD:4145330
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:20357263 PMID:26882889
RGD:4142858
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tnc
tenascin C
ISO
protein:increased expression:serum, respiratory system fluid/secretion
RGD
PMID:19721293
RGD:4889573
NCBI chrNW_004955419:12,569,620...12,662,897
Ensembl chrNW_004955419:12,569,547...12,662,958
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:21625544 PMID:28917655 PMID:34390737
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tnfrsf1a
TNF receptor superfamily member 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21625544
NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021
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Tnfrsf1b
TNF receptor superfamily member 1B
susceptibility
ISO
CTD Direct Evidence: marker/mechanism associated with Carcinoma, Non-Small-Cell Lung; DNA:snp:cds:p.M196R rs1061622 (human) Idiopathic Pneumonia Syndrome
CTD RGD
PMID:18664626 PMID:20811626 PMID:21625544
RGD:5131286 RGD:5131448
NCBI chrNW_004955486:1,790,531...1,817,986
Ensembl chrNW_004955486:1,792,115...1,818,362
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Vdr
vitamin D receptor
susceptibility
ISO
DNA:SNP: :rs2239185(human)
RGD
PMID:17224129 PMID:25367052
RGD:11074745 RGD:4889851
NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
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Gc
GC vitamin D binding protein
ISO
protein:increased expression:bronchoalveolar fluid:
RGD
PMID:21136918
RGD:5509873
NCBI chrNW_004955447:1,361,698...1,400,633
Ensembl chrNW_004955447:1,361,566...1,402,491
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Ido1
indoleamine 2,3-dioxygenase 1
ISO
RGD
PMID:20385761
RGD:39938865
NCBI chrNW_004955536:2,944,770...2,955,829
Ensembl chrNW_004955536:2,943,611...2,955,829
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Ptx3
pentraxin 3
ISO
protein:increased expression:bronchoalveolar lavage fluid, plasma (human)
RGD
PMID:29964232
RGD:38508894
NCBI chrNW_004955448:8,366,795...8,373,010
Ensembl chrNW_004955448:8,366,925...8,372,411
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Abcb1
ATP binding cassette subfamily B member 1
treatment
ISO
DNA:SNP: :2677G>A (human)
RGD
PMID:26067842
RGD:11098541
NCBI chrNW_004955432:4,911,774...5,085,349
Ensembl chrNW_004955432:4,912,184...5,007,188
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Ada
adenosine deaminase
ISO
protein:increased expression:plasma, respiratory system fluid/secretion protein:increased activity:sputum: protein:increased activity:blood, pulmonary alveolar duct
RGD
PMID:2212911 PMID:12194640 PMID:19460251
RGD:152995271 RGD:152995390 RGD:5128854
NCBI chrNW_004955445:12,696,096...12,717,488
Ensembl chrNW_004955445:12,696,096...12,717,488
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Ada2
adenosine deaminase 2
ISO
protein:increased activity:sputum:
RGD
PMID:19460251
RGD:152995271
NCBI chrNW_004955454:5,341,822...5,355,383
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Adipoq
adiponectin, C1Q and collagen domain containing
ISO
protein:increased expression:plasma
RGD
PMID:22022605
RGD:5686405
NCBI chrNW_004955420:20,911,181...20,922,992
Ensembl chrNW_004955420:20,912,348...20,914,402
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Akt1
AKT serine/threonine kinase 1
susceptibility
ISO
DNA:SNP,haplotype:intron: IVS3+18 C/C (human)
RGD
PMID:20141546
RGD:38676498
NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
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Alox5
arachidonate 5-lipoxygenase
susceptibility
ISO
DNA:polymorphism, repeat:promoter, exon:g.760G>A (human)
RGD
PMID:18174194
RGD:4890411
NCBI chrNW_004955546:2,495,226...2,550,909
Ensembl chrNW_004955546:2,494,819...2,550,909
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Asap1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25774636
NCBI chrNW_004955461:4,813,228...5,083,548
Ensembl chrNW_004955461:4,811,069...5,133,257
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Atf3
activating transcription factor 3
ISO
mRNA,protein:increased expression:lung
RGD
PMID:20856677
RGD:34888225
NCBI chrNW_004955406:4,875,672...4,889,173
Ensembl chrNW_004955406:4,875,613...4,889,242
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C3
complement C3
ISO
RGD
PMID:19472039
RGD:5129500
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Ccl1
C-C motif chemokine ligand 1
susceptibility
ISO
mRNA:increased expression:lung, dendritic cell DNA:SNP: :multiple (human)
RGD
PMID:18703681 PMID:19057661
RGD:4891408 RGD:4891409
NCBI chrNW_004955481:9,085,943...9,089,147
Ensembl chrNW_004955481:9,085,935...9,088,753
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Ccl19
C-C motif chemokine ligand 19
ISO
mRNA:increased expression:lung
RGD
PMID:19933855
RGD:5130906
NCBI chrNW_004955472:1,444,598...1,446,488
Ensembl chrNW_004955472:1,444,316...1,446,490
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Ccl5
C-C motif chemokine ligand 5
susceptibility
ISO
DNA:snps:5' utr:g.-403G>A rs2280788, g.-28C>G rs2107538 (human) mRNA:increased expression:lung (human)
RGD
PMID:15128813 PMID:19335954
RGD:4891879 RGD:4892112
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Ccr2
C-C motif chemokine receptor 2
disease_progression
ISO
RGD
PMID:11438742
RGD:734715
NCBI chrNW_004955420:25,641,184...25,664,413
Ensembl chrNW_004955420:25,640,367...25,664,518
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Cd14
CD14 molecule
susceptibility
ISO
protein:increased expression:monocyte, serum DNA:polymorphism:promoter:c. -159C>T (human)
RGD
PMID:18008256
RGD:4144205
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd274
CD274 molecule
ISO
protein:increased expression:Tcell, B cell, monocyte
RGD
PMID:23661793
RGD:40818418
NCBI chrNW_004955434:9,487,309...9,508,366
Ensembl chrNW_004955434:9,487,315...9,505,904
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Cd36
CD36 molecule (CD36 blood group)
susceptibility
ISO
DNA:SNPs: :rs1194182, rs10499859(human)
RGD
PMID:28693442
RGD:41412192
NCBI chrNW_004955410:5,003,720...5,120,903
Ensembl chrNW_004955410:5,003,668...5,075,313
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Cd86
CD86 molecule
ISO
protein:decreased expression:sputum, macrophage (human)
RGD
PMID:17713660
RGD:4892339
NCBI chrNW_004955427:21,375,820...21,436,767
Ensembl chrNW_004955427:21,375,794...21,435,874
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Cxcl10
C-X-C motif chemokine ligand 10
treatment
ISO
RGD
PMID:29843631
RGD:27095956
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
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Cxcl8
C-X-C motif chemokine ligand 8
exacerbates
ISO
protein:increased expression:serum (human) RNA:increased expression:blood plasma (human)
RGD
PMID:16001981 PMID:27434276
RGD:150523784 RGD:39939055
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
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Ddit3
DNA damage inducible transcript 3
ISO
mRNA,protein:increased expression:lung
RGD
PMID:20856677
RGD:34888225
NCBI chrNW_004955458:5,232,979...5,238,513
Ensembl chrNW_004955458:5,232,979...5,238,513
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Egfr
epidermal growth factor receptor
disease_progression
ISO
associated with lung adenocarcinoma;
RGD
PMID:22173705 PMID:29621876
RGD:38599162 RGD:38599176
NCBI chrNW_004955456:321,222...456,431
Ensembl chrNW_004955456:321,222...371,701
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Ereg
epiregulin
susceptibility
ISO
DNA:SNP:exon 4: (rs2367707) (human)
RGD
PMID:30634928
RGD:39457687
NCBI chrNW_004955474:612,440...627,606
Ensembl chrNW_004955474:612,440...627,606
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Foxp3
forkhead box P3
susceptibility
ISO
DNA:polymorphism:promoter:-924A>G(human)
RGD
PMID:29020928
RGD:38501101
NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606
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Gbe1
1,4-alpha-glucan branching enzyme 1
ISO
DNA:SNP:intron:rs2307058 (human)
RGD
PMID:28355295
RGD:18337291
NCBI chrNW_004955407:10,692,082...10,959,236
Ensembl chrNW_004955407:10,692,303...10,963,489
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Havcr2
hepatitis A virus cellular receptor 2
ISO
RGD
PMID:21382414
RGD:5135524
NCBI chrNW_004955408:11,289,920...11,311,216
Ensembl chrNW_004955408:11,291,937...11,311,320
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Ido1
indoleamine 2,3-dioxygenase 1
treatment
ISO
RGD
PMID:32369456
RGD:39939073
NCBI chrNW_004955536:2,944,770...2,955,829
Ensembl chrNW_004955536:2,943,611...2,955,829
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Il13
interleukin 13
ISO
mRNA:increased expression:Leukocytes, Mononuclear
RGD
PMID:10608794
RGD:4145649
NCBI chrNW_004955408:4,046,406...4,049,795
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Il15
interleukin 15
ISO
mRNA, protein:increased expression:lung
RGD
PMID:11742275
RGD:4990461
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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Il18
interleukin 18
ISO
protein:increased expression:serum
RGD
PMID:15955140
RGD:4889836
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il1a
interleukin 1 alpha
ISO
RGD
PMID:9176116
RGD:4142835
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
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Il1b
interleukin 1 beta
susceptibility severity
ISO
DNA:polymorphism: :3953T>C (human) protein:increased expression:lung protein:increased expression:bronchioalveolar lavage fluid (human)
RGD
PMID:10543265 PMID:10631206 PMID:16634865
RGD:4143179 RGD:4143180 RGD:5147843
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rl1
interleukin 1 receptor like 1
ISO
RGD
PMID:28128217
RGD:39938965
NCBI chrNW_004955470:7,779,828...7,849,157
Ensembl chrNW_004955470:7,832,109...7,842,435
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Il1rn
interleukin 1 receptor antagonist
severity
ISO
protein:increased expression:lung, serum
RGD
PMID:10543265 PMID:10631206 PMID:14619382
RGD:4143174 RGD:4143179 RGD:4143180
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il23a
interleukin 23 subunit alpha
ISO
mRNA:increased expression:lung (mouse)
RGD
PMID:11801672 PMID:16002675 PMID:20624887 PMID:21156751
RGD:39457949 RGD:39457953 RGD:39458036 RGD:39458038
NCBI chrNW_004955458:3,946,964...3,949,180
Ensembl chrNW_004955458:3,947,803...3,949,312
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Il27
interleukin 27
exacerbates
ISO
DNA:SNPs:promoter, exon:-964A>G, 2905T>G (human) DNA:SNPs:promoter,exons:-964A>G, 2905T>G, 4730T>C (rs153109, rs17855750, rs181206) (human)
RGD
PMID:30948177 PMID:31949807
RGD:126790508 RGD:39456132
NCBI chrNW_004955493:6,712,005...6,717,417
Ensembl chrNW_004955493:6,712,005...6,717,417
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Il27ra
interleukin 27 receptor subunit alpha
ISO
RGD
PMID:15749890
RGD:5128486
NCBI chrNW_004955415:32,749,682...32,762,532
Ensembl chrNW_004955415:32,749,094...32,761,882
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Il33
interleukin 33
ISO
RGD
PMID:28128217
RGD:39938965
NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
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Il4
interleukin 4
severity
ISO
RGD
PMID:20832364
RGD:5128550
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
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Il4r
interleukin 4 receptor
ISO
protein:decreased expression:serum
RGD
PMID:21251883
RGD:5128510
NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422
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Il6
interleukin 6
ISO
RGD
PMID:20624776
RGD:4143257
NCBI chrNW_004955410:25,079,835...25,084,390
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Il6r
interleukin 6 receptor
ISO
protein:decreased expression:T cell
RGD
PMID:20019339
RGD:5128632
NCBI chrNW_004955545:932,814...979,359
Ensembl chrNW_004955545:950,765...981,762
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Irf1
interferon regulatory factor 1
ISO
RGD
PMID:11083808
RGD:5128719
NCBI chrNW_004955408:3,882,282...3,887,965
Ensembl chrNW_004955408:3,880,155...3,887,973
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Itih4
inter-alpha-trypsin inhibitor heavy chain 4
ISO
protein:increased expression:urine
RGD
PMID:29636444
RGD:40903003
NCBI chrNW_004955430:2,772,064...2,787,912
Ensembl chrNW_004955430:2,770,373...2,789,131
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
protein:decreased phosphorylation:macrophage, nucleus
RGD
PMID:19737230
RGD:4889999
NCBI chrNW_004955464:1,107,598...1,110,326
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LOC102004641
cytochrome b-245 light chain
no_association
ISO
DNA:SNPs:exons:214C>T (rs4673), 521C>T (rs17845095) (human)
RGD
PMID:16608528
RGD:4780358
NCBI chrNW_004955541:2,570,843...2,573,822
Ensembl chrNW_004955541:2,569,727...2,574,118
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LOC102026469
HLA class II histocompatibility antigen, DP beta 1 chain
ISO
RGD
PMID:18652916
RGD:5144001
NCBI chrNW_004955437:1,655,092...1,666,552
Ensembl chrNW_004955437:1,635,538...1,669,042
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Lta
lymphotoxin alpha
susceptibility
ISO
DNA:polymorphism:intron:252G>A (human)
RGD
PMID:20180006
RGD:4143234
NCBI chrNW_004955437:114,216...116,003
Ensembl chrNW_004955437:114,640...115,529
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Marco
macrophage receptor with collagenous structure
susceptibility
ISO
DNA:SNP: :rs12998782(human) DNA:SNPs:introns:rs4491733,rs12998782,rs13389814,rs7559955 (human) DNA:SNPs: :rs2278589, rs6751745,rs6748401 (human)
RGD
PMID:23617307 PMID:27853145 PMID:28693442
RGD:41412192 RGD:41412194 RGD:41412195
NCBI chrNW_004955459:10,700,645...10,739,222
Ensembl chrNW_004955459:10,698,294...10,739,131
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Mbl2
mannose binding lectin 2
ISO
DNA:polymorphisms:5' utr, exon:multiple (human)
RGD
PMID:19199550
RGD:4889452
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Mif
macrophage migration inhibitory factor
susceptibility
ISO
DNA:SNP: :rs755622 (human)
RGD
PMID:20439102
RGD:4891004
NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460
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Mmp7
matrix metallopeptidase 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24890593
NCBI chrNW_004955412:5,780,772...5,792,485
Ensembl chrNW_004955412:5,778,502...5,792,445
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Mmp8
matrix metallopeptidase 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24890593
NCBI chrNW_004955412:5,928,997...5,939,012
Ensembl chrNW_004955412:5,928,997...5,939,012
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Mmp9
matrix metallopeptidase 9
ISO
RGD
PMID:16982845
RGD:5130746
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Nfkbia
NFKB inhibitor alpha
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:9379002
RGD:126908014
NCBI chrNW_004955409:25,691,673...25,695,151
Ensembl chrNW_004955409:25,691,534...25,697,520
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Nod2
nucleotide binding oligomerization domain containing 2
susceptibility
ISO
DNA:SNPs:CDs:p.P268S, R702W, A725G (human)
RGD
PMID:18419343
RGD:5131510
NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
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Nos2
nitric oxide synthase 2
ISO
DNA:SNPs:multiple (human)
RGD
PMID:19575238
RGD:4144122
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Pdcd1
programmed cell death 1
treatment
ISO
protein:increased expression:Tcell, B cell, monocyte
RGD
PMID:23661793
RGD:40818418
NCBI chrNW_004955542:49,290...57,747
Ensembl chrNW_004955542:49,259...58,823
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Pdcd1lg2
programmed cell death 1 ligand 2
ISO
protein:increased expression:Tcell, B cell, monocyte
RGD
PMID:23661793
RGD:40818418
NCBI chrNW_004955434:9,540,047...9,559,335
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Plaur
plasminogen activator, urokinase receptor
severity
ISO
RGD
PMID:18359089
RGD:6483832
NCBI chrNW_004955555:1,378,505...1,393,395
Ensembl chrNW_004955555:1,378,793...1,393,324
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Ptpn22
protein tyrosine phosphatase non-receptor type 22
ISO
DNA:SNPs:cds:788G>A, 1858C>T (human)
RGD
PMID:19563523
RGD:6484723
NCBI chrNW_004955435:17,082,762...17,139,067
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Slc11a1
solute carrier family 11 member 1
susceptibility
ISO
DNA:polymorphism:intron (human) DNA:deletion:3'UTR:
RGD
PMID:21169917 PMID:24024195
RGD:36049753 RGD:5684974
NCBI chrNW_004955453:14,980,562...14,995,118
Ensembl chrNW_004955453:14,980,562...14,995,608
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Tap1
transporter 1, ATP binding cassette subfamily B member
ISO
associated with HIV Infections;
RGD
PMID:21843574
RGD:6482248
NCBI chrNW_004955437:1,504,549...1,511,110
Ensembl chrNW_004955437:1,504,947...1,511,097
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Tap2
transporter 2, ATP binding cassette subfamily B member
susceptibility
ISO
DNA:polymorphism: :
RGD
PMID:9062973
RGD:5147851
NCBI chrNW_004955437:1,480,217...1,499,032
Ensembl chrNW_004955437:1,477,341...1,498,575
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Tlr1
toll like receptor 1
ISO
mRNA:increased expression:blood
RGD
PMID:16493059
RGD:4889525
NCBI chrNW_004955443:8,442,419...8,450,318
Ensembl chrNW_004955443:8,447,956...8,450,382
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Tlr2
toll like receptor 2
susceptibility
ISO
DNA:polymorphism:intron (human) DNA:SNP: :rs1816702 (human) DNA:polymorphisms: :multiple (human) mRNA, protein:increased expression:blood, T cell
RGD
PMID:19552525 PMID:19723394 PMID:20113509 PMID:20298136
RGD:4145304 RGD:4145320 RGD:4145323 RGD:4145355
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
severity susceptibility
ISO
DNA:polymorphisms:cds: p. D299F, T399I (human) protein:increased expression:monocyte DNA:SNP:intron: rs5030729 (human)
RGD
PMID:18008256 PMID:19575238 PMID:20403143
RGD:4144106 RGD:4144122 RGD:4144205
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tlr9
toll like receptor 9
ISO
DNA:snps:multiple (human)
RGD
PMID:19771452
RGD:5130704
NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582
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Tnf
tumor necrosis factor
disease_progression susceptibility
ISO
DNA:polymorphisms::c.-857 C>T, c. -863 A>C (human)
RGD
PMID:9176116 PMID:18212516 PMID:20650298
RGD:4142835 RGD:4143388 RGD:4143395
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Vdr
vitamin D receptor
susceptibility
ISO
DNA:SNPs (human) DNA:SNPs:promoter, 3' UTR (human) DNA:SNP (human) DNA:SNPs:5' UTR (human)
RGD
PMID:15295697 PMID:17236578 PMID:18231846 PMID:18397302 PMID:20231985
RGD:4889830 RGD:4889842 RGD:4889845 RGD:4889849 RGD:4889853
NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
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Cd274
CD274 molecule
ISO
protein:increased expression: larynx
RGD
PMID:22322668
RGD:40822813
NCBI chrNW_004955434:9,487,309...9,508,366
Ensembl chrNW_004955434:9,487,315...9,505,904
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Foxp3
forkhead box P3
susceptibility
ISO
DNA:SNPs:promoter:rs5902434,rs2232365 (human)
RGD
PMID:28298239
RGD:38549360
NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606
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Pdcd1
programmed cell death 1
ISO
RGD
PMID:22322668
RGD:40822813
NCBI chrNW_004955542:49,290...57,747
Ensembl chrNW_004955542:49,259...58,823
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Tap1
transporter 1, ATP binding cassette subfamily B member
severity
ISO
DNA:polymorphism:cds:p.D637G(human)
RGD
PMID:14976605
RGD:5147844
NCBI chrNW_004955437:1,504,549...1,511,110
Ensembl chrNW_004955437:1,504,947...1,511,097
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Agr2
anterior gradient 2, protein disulphide isomerase family member
ISO
ClinVar Annotator: match by term: Respiratory infections, recurrent, and failure to thrive with or without diarrhea
OMIM ClinVar
PMID:25741868 PMID:34952832
NCBI chrNW_004955410:19,984,768...19,995,446
Ensembl chrNW_004955410:19,984,768...19,995,733
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Adam33
ADAM metallopeptidase domain 33
susceptibility
ISO
DNA:SNPs: :multiple (human)
RGD
PMID:15298558 PMID:18778489
RGD:4145378 RGD:4145383
NCBI chrNW_004955415:14,523,517...14,535,701
Ensembl chrNW_004955415:14,524,354...14,533,700
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Bdkrb1
bradykinin receptor B1
ISO
RGD
PMID:12165532
RGD:5129220
NCBI chrNW_004955438:16,500,219...16,505,394
Ensembl chrNW_004955438:16,500,633...16,501,691
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Bdkrb2
bradykinin receptor B2
ISO
RGD
PMID:1890650 PMID:11149999
RGD:4891033 RGD:4891044
NCBI chrNW_004955438:16,514,300...16,537,160
Ensembl chrNW_004955438:16,511,759...16,537,172
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Bdnf
brain derived neurotrophic factor
susceptibility
ISO
mRNA:increased expression:nasal cavity epithelium DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human)
RGD
PMID:20464992 PMID:21723144
RGD:4891116 RGD:8655967
NCBI chrNW_004955476:6,773,244...6,822,201
Ensembl chrNW_004955476:6,772,088...6,822,588
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C3
complement C3
ISO
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:17345707 PMID:20109314
RGD:5129524 RGD:5129539
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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C3ar1
complement C3a receptor 1
severity
ISO
protein:increased expression:nasal cavity
RGD
PMID:18538384
RGD:5129559
NCBI chrNW_004955413:6,707,003...6,715,689
Ensembl chrNW_004955413:6,707,689...6,715,689
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C5ar1
complement C5a receptor 1
ISO
RGD
PMID:18538384
RGD:5129559
NCBI chrNW_004955574:1,221,942...1,229,634
Ensembl chrNW_004955574:1,221,187...1,231,655
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Cat
catalase
treatment
ISO
protein:increased activity:blood,nasal cavity mucosa:
RGD
PMID:21541033
RGD:9479054
NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
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Ccl1
C-C motif chemokine ligand 1
ISO
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:17982926
RGD:4145109
NCBI chrNW_004955481:9,085,943...9,089,147
Ensembl chrNW_004955481:9,085,935...9,088,753
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Ccl17
C-C motif chemokine ligand 17
ISO
protein:increased expression:blood, mononuclear cell
RGD
PMID:17517104
RGD:4145498
NCBI chrNW_004955433:15,052,616...15,054,732
Ensembl chrNW_004955433:15,053,061...15,054,572
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Ccl19
C-C motif chemokine ligand 19
ISO
RGD
PMID:17947663
RGD:5130909
NCBI chrNW_004955472:1,444,598...1,446,488
Ensembl chrNW_004955472:1,444,316...1,446,490
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Ccl22
C-C motif chemokine ligand 22
ISO
protein:increased expression:blood, mononuclear cell
RGD
PMID:17517104
RGD:4145498
NCBI chrNW_004955433:15,002,001...15,007,324
Ensembl chrNW_004955433:15,001,930...15,008,032
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Ccl24
C-C motif chemokine ligand 24
ISO
DNA:SNPs: :179T>C, 275C>T (human) mRNA:increased expression:nasal cavity epithelium
RGD
PMID:15580493 PMID:17982926
RGD:4145109 RGD:4891493
NCBI chrNW_004955456:14,582,812...14,588,574
Ensembl chrNW_004955456:14,583,610...14,585,169
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Ccl26
C-C motif chemokine ligand 26
ISO
DNA:polymorphism: :2497T>G (human) associated with Eosinophilia;protein:increased expression:oronasal secretion (human)
RGD
PMID:15580493 PMID:24989688
RGD:11531119 RGD:4891493
NCBI chrNW_004955456:14,554,583...14,558,967
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Ccr2
C-C motif chemokine receptor 2
susceptibility
ISO
Rhinitis, Allergic, Seasonal; DNA:SNP:cds:p.V64I (human)
RGD
PMID:17135764
RGD:4145111
NCBI chrNW_004955420:25,641,184...25,664,413
Ensembl chrNW_004955420:25,640,367...25,664,518
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Ccr3
C-C motif chemokine receptor 3
ISO
mRNA:increased expression:nose DNA:SNP:exon:51T>C (human) protein:increased expression:blood, T cell
RGD
PMID:17135764 PMID:17156343 PMID:20696593
RGD:4145111 RGD:4145454 RGD:4145645
NCBI chrNW_004955420:25,702,917...25,723,269
Ensembl chrNW_004955420:25,701,407...25,723,353
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Cd14
CD14 molecule
susceptibility resistance
ISO
DNA:polymorphism:promoter:c. -159c>T (human)
RGD
PMID:16950285 PMID:20109306
RGD:4144795 RGD:4144810
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd28
CD28 molecule
ISO
RGD
PMID:21356099
RGD:5131612
NCBI chrNW_004955457:11,159,769...11,253,099
Ensembl chrNW_004955457:11,162,282...11,192,991
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Cd80
CD80 molecule
ISO
RGD
PMID:21108691
RGD:5132622
NCBI chrNW_004955427:19,237,251...19,274,001
Ensembl chrNW_004955427:19,236,445...19,261,517
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Cdc42
cell division cycle 42
ISO
mRNA:increased expression:nasal turbinate
RGD
PMID:19432938
RGD:5688273
NCBI chrNW_004955452:2,255,940...2,299,042
Ensembl chrNW_004955452:2,255,117...2,299,042
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Cftr
CF transmembrane conductance regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16083808
NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382
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Crhr1
corticotropin releasing hormone receptor 1
ISO
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:17597629
RGD:5130940
NCBI chrNW_004955478:10,380,185...10,390,838
Ensembl chrNW_004955478:10,379,287...10,404,825
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Crhr2
corticotropin releasing hormone receptor 2
ISO
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:17597629
RGD:5130940
NCBI chrNW_004955410:31,830,333...31,874,384
Ensembl chrNW_004955410:31,828,506...31,875,100
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Ctla4
cytotoxic T-lymphocyte associated protein 4
ISO
protein:increased expression:T cell
RGD
PMID:17625281
RGD:4891512
NCBI chrNW_004955457:11,028,707...11,034,898
Ensembl chrNW_004955457:11,028,698...11,073,460
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Cx3cl1
C-X3-C motif chemokine ligand 1
ISO
protein:increased expression:plasma
RGD
PMID:14657873
RGD:4891906
NCBI chrNW_004955433:15,023,272...15,034,650
Ensembl chrNW_004955433:15,023,050...15,034,711
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Cysltr1
cysteinyl leukotriene receptor 1
ISO
associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium
RGD
PMID:15379985 PMID:16689996 PMID:17627772 PMID:18946234
RGD:4781451 RGD:4783198 RGD:4847512 RGD:4888516
NCBI chrNW_004955557:1,667,518...1,702,272
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Cysltr2
cysteinyl leukotriene receptor 2
ISO
associated with Sinusitis;mRNA:increased expression:nasal cavity epithelium
RGD
PMID:16689996
RGD:4783198
NCBI chrNW_004955431:2,203,342...2,282,635
Ensembl chrNW_004955431:2,263,698...2,282,635
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Fcer1a
Fc fragment of IgE receptor Ia
ISO
RGD
PMID:20650300
RGD:5128714
NCBI chrNW_004955468:11,094,792...11,101,191
Ensembl chrNW_004955468:11,094,788...11,101,173
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Fis1
fission, mitochondrial 1
ISO
mRNA, protein:increased expression:nasal cavity mucosa (rat)
RGD
PMID:28146064
RGD:13204839
NCBI chrNW_004955456:16,057,158...16,060,623
Ensembl chrNW_004955456:16,038,221...16,060,623
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Hdc
histidine decarboxylase
ISO
DNA:SNP: :p.E644D (rs2073440) (human)
RGD
PMID:15054596 PMID:20608921
RGD:5128884 RGD:5143921
NCBI chrNW_004955409:4,051,574...4,072,641
Ensembl chrNW_004955409:4,051,271...4,072,642
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Hnmt
histamine N-methyltransferase
no_association
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:17651147
RGD:5128885
NCBI chrNW_004955440:5,084,198...5,137,577
Ensembl chrNW_004955440:5,084,081...5,139,348
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Hrh1
histamine receptor H1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12167471
NCBI chrNW_004955429:14,022,332...14,069,931
Ensembl chrNW_004955429:14,067,405...14,068,853
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Il13
interleukin 13
susceptibility disease_progression
ISO
associated with asthma; DNA:polymorphisms:promoter:c. -1510A>C, -1055C>T (human) DNA:polymorphism: :rs1800925 (human) mRNA:increased expression:nose
RGD
PMID:16120094 PMID:17088137 PMID:20358028 PMID:20484924 PMID:20696593
RGD:4145454 RGD:4145534 RGD:4145767 RGD:4159171 RGD:4206706
NCBI chrNW_004955408:4,046,406...4,049,795
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Il13ra2
interleukin 13 receptor subunit alpha 2
ISO
RGD
PMID:17088137
RGD:4159171
NCBI chrNW_004955490:708,144...758,195
Ensembl chrNW_004955490:709,446...758,272
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Il15
interleukin 15
ISO
RGD
PMID:16750998
RGD:5000756
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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Il16
interleukin 16
ISO
protein:increased expression:serum protein:increased expression:nasal cavity epithelium, serum
RGD
PMID:18254318 PMID:19295235
RGD:5024931 RGD:5024932
NCBI chrNW_004955416:11,876,317...11,987,548
Ensembl chrNW_004955416:11,893,801...11,987,548 Ensembl chrNW_004955416:11,893,801...11,987,548
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Il17a
interleukin 17A
ISO
protein:increased expression:nasal mucosa
RGD
PMID:19927541 PMID:20506642
RGD:4889137 RGD:4889144
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il18
interleukin 18
disease_progression
ISO
protein:increased expression:nasal lavage fluid, bronchoalveolar lavage fluid rhinitis allergic, seasonal; protein:increased expression:plasma protein:increased expression:serum
RGD
PMID:15934281 PMID:17305282 PMID:17323858
RGD:4889916 RGD:4889917 RGD:4889927
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il1b
interleukin 1 beta
susceptibility
ISO
associated with Hypersensitivity;protein:increased expression:nasal mucus associated with Hypersensitivity;DNA:polymorphism: :-511C>T (human) mRNA:increased expression:nasal cavity epithelium
RGD
PMID:10224452 PMID:14533660 PMID:20490816
RGD:4142821 RGD:4142859 RGD:4143227
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rl1
interleukin 1 receptor like 1
severity
ISO
associated with Sinusitis;DNA:SNPs: :multiple (human)
RGD
PMID:19671251
RGD:5144228
NCBI chrNW_004955470:7,779,828...7,849,157
Ensembl chrNW_004955470:7,832,109...7,842,435
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Il1rn
interleukin 1 receptor antagonist
susceptibility
ISO
associated with Hypersensitivity associated with Hypersensitivity;DNA:repeat:intron (human)
RGD
PMID:10224452 PMID:14533660 PMID:15178892
RGD:4142859 RGD:4143215 RGD:4143227
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il2
interleukin 2
susceptibility
ISO
DNA:SNP:promoter:rs2069762(human)
RGD
PMID:16333313
RGD:8663473
NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
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Il21
interleukin 21
ISO
RGD
PMID:17982108
RGD:5147397
NCBI chrNW_004955428:18,057,096...18,065,492
Ensembl chrNW_004955428:18,057,096...18,065,492
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Il22
interleukin 22
severity
ISO
mRNA:increased expression:blood, mononuclear cell
RGD
PMID:21535180
RGD:5147409
NCBI chrNW_004955458:14,747,339...14,755,602
Ensembl chrNW_004955458:14,747,084...14,752,553
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Il23r
interleukin 23 receptor
susceptibility
ISO
DNA:SNP,haplotype: :rs7517847(human)
RGD
PMID:23696856
RGD:8549605
NCBI chrNW_004955423:23,841,342...23,885,191
Ensembl chrNW_004955423:23,842,475...23,884,904
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Il27ra
interleukin 27 receptor subunit alpha
ISO
RGD
PMID:19354069
RGD:5128480
NCBI chrNW_004955415:32,749,682...32,762,532
Ensembl chrNW_004955415:32,749,094...32,761,882
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Il4
interleukin 4
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:serum mRNA:increased expression:nasal cavity epithelium
CTD RGD
PMID:18826099 PMID:19672097 PMID:21208219
RGD:2317285 RGD:5128558
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
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Il4r
interleukin 4 receptor
ISO
DNA:polymorphism: :c.1432T>C (human)
RGD
PMID:15564773
RGD:4890394
NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422
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Il5
interleukin 5
ISO
RGD
PMID:11884474
RGD:5128622
NCBI chrNW_004955408:3,937,128...3,951,784
Ensembl chrNW_004955408:3,937,894...3,939,358
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Il9
interleukin 9
ISO
RGD
PMID:20525149
RGD:5128687
NCBI chrNW_004955408:30,950,816...30,953,571
Ensembl chrNW_004955408:30,950,816...30,953,571
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Lep
leptin
ISO
RGD
PMID:19860581
RGD:5128850
NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472
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Mbl2
mannose binding lectin 2
susceptibility
ISO
DNA:polymorphism: :
RGD
PMID:18831943
RGD:8693717
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Mfn1
mitofusin 1
ISO
mRNA, protein:increased expression:nasal cavity mucosa (rat)
RGD
PMID:28146064
RGD:13204839
NCBI chrNW_004955420:8,541,547...8,596,494
Ensembl chrNW_004955420:8,541,936...8,594,437
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Mif
macrophage migration inhibitory factor
severity
ISO
protein:increased expression:serum, nasal mucosa
RGD
PMID:15053202 PMID:15922619
RGD:4891045 RGD:4891056
NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460
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Ms4a2
membrane spanning 4-domains A2
ISO
RGD
PMID:15480314
RGD:5131152
NCBI chrNW_004955511:4,377,894...4,400,797
Ensembl chrNW_004955511:4,380,502...4,400,852
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
ISO
mRNA:increased expression:nose
RGD
PMID:15715404 PMID:20696593
RGD:4145454 RGD:7364740
NCBI chrNW_004955476:11,061,405...11,084,294
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Ngf
nerve growth factor
ISO
associated with Sinusitis;protein:increased expression:respiratory system mucosa protein:increased expression:respiratory system fluid/secretion
RGD
PMID:10224365 PMID:19958603
RGD:4891064 RGD:4891115
NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059
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Ngfr
nerve growth factor receptor
ISO
protein:increased expression:blood, eosinophil
RGD
PMID:18647313
RGD:5144116
NCBI chrNW_004955451:12,030,303...12,047,305
Ensembl chrNW_004955451:12,030,252...12,047,305
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Nod1
nucleotide binding oligomerization domain containing 1
ISO
mRNA:decreased expression:nose
RGD
PMID:20384614
RGD:5131446
NCBI chrNW_004955410:31,681,191...31,725,173
Ensembl chrNW_004955410:31,681,077...31,725,173
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Nod2
nucleotide binding oligomerization domain containing 2
susceptibility
ISO
DNA:polymorphisms:cds:2104C>T,2722G>C (human)
RGD
PMID:12704363
RGD:5131484
NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
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Nos2
nitric oxide synthase 2
ISO
protein:increased expression:nasal mucosa
RGD
PMID:18254476
RGD:4891910
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Npy
neuropeptide Y
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12746121
NCBI chrNW_004955410:26,348,388...26,355,232
Ensembl chrNW_004955410:26,348,504...26,355,297
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Ntrk1
neurotrophic receptor tyrosine kinase 1
ISO
protein:increased expression:eosinophil
RGD
PMID:18647313
RGD:5144116
NCBI chrNW_004955545:2,929,704...2,947,579
Ensembl chrNW_004955545:2,929,704...2,947,579
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Opa1
OPA1 mitochondrial dynamin like GTPase
ISO
mRNA, protein:increased expression:nasal cavity mucosa (rat)
RGD
PMID:28146064
RGD:13204839
NCBI chrNW_004955420:14,927,490...15,007,082
Ensembl chrNW_004955420:14,923,575...15,007,081
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Plau
plasminogen activator, urokinase
ISO
mRNA:increased expression:nasal cavity epithelium
RGD
PMID:21339035
RGD:8547809
NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
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Ptgdr2
prostaglandin D2 receptor 2
ISO
RGD
PMID:19230460 PMID:19608418
RGD:5135017 RGD:5135021
NCBI chrNW_004955511:5,536,602...5,539,944
Ensembl chrNW_004955511:5,536,642...5,537,926
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Scgb3a2
secretoglobin family 3A member 2
ISO
mRNA,protein:decreased expression:nasal mucosa protein:increased expression:sputum
RGD
PMID:17218572 PMID:21385388
RGD:5144232 RGD:5147389
NCBI chrNW_004955415:6,332,121...6,335,474
Ensembl chrNW_004955415:6,331,535...6,335,462
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Serpine1
serpin family E member 1
susceptibility
ISO
DNA:polymorphism:promoter:rs1799768 (human)
RGD
PMID:19063817
RGD:4144832
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
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Sftpd
surfactant protein D
susceptibility
ISO
associated with Hypersensitivity;DNA:polymorphism: :p.M11T (human)
RGD
PMID:19493231
RGD:4143494
NCBI chrNW_004955510:213,468...226,096
Ensembl chrNW_004955510:213,438...225,896
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Tap1
transporter 1, ATP binding cassette subfamily B member
no_association susceptibility
ISO
DNA:SNPs: :
RGD
PMID:12018331 PMID:17982230
RGD:6482262 RGD:6482274
NCBI chrNW_004955437:1,504,549...1,511,110
Ensembl chrNW_004955437:1,504,947...1,511,097
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Tbxa2r
thromboxane A2 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12167471
NCBI chrNW_004955495:5,539,382...5,557,441
Ensembl chrNW_004955495:5,539,889...5,557,441
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Tgfb1
transforming growth factor beta 1
ISO
associated with Sinusitis
RGD
PMID:18423831
RGD:4145277
NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441
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Tlr2
toll like receptor 2
no_association susceptibility
ISO
mRNA:decreased expression:nasal mucosa: associated with Sinusitis;DNA:SNPs: :multiple (human) DNA:SNPs: :597T>C, 1350T>C (human)
RGD
PMID:18219831 PMID:19128592 PMID:19763595
RGD:4145354 RGD:4145356 RGD:7800742
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr6
toll like receptor 6
ISO
associated with Asthma;DNA:SNP: :rs2381289 (human)
RGD
PMID:20815312
RGD:4145352
NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942
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Tnf
tumor necrosis factor
ISO
mRNA:increased expression:nose
RGD
PMID:15120189 PMID:20696593
RGD:4143470 RGD:4145454
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Vegfa
vascular endothelial growth factor A
ISO
protein:increased expression:sputum
RGD
PMID:19178538
RGD:6892723
NCBI chrNW_004955437:9,527,445...9,541,908
Ensembl chrNW_004955437:9,531,362...9,542,664
G
Vip
vasoactive intestinal peptide
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12746121 PMID:14680090
NCBI chrNW_004955439:9,021,923...9,031,783
Ensembl chrNW_004955439:9,021,904...9,031,792
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Anxa1
annexin A1
ISO
associated with Nasal Polyps
RGD
PMID:22279949
RGD:7421555
NCBI chrNW_004955512:5,686,508...5,703,645
Ensembl chrNW_004955512:5,685,856...5,703,817
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C3
complement C3
ISO
protein:increased expression:serum
RGD
PMID:19593977
RGD:4889484
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Ccl20
C-C motif chemokine ligand 20
ISO
RGD
PMID:16702571
RGD:7483585
NCBI chrNW_004955453:6,846,625...6,850,007
Ensembl chrNW_004955453:6,846,549...6,850,031
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Hgf
hepatocyte growth factor
susceptibility
ISO
DNA:haplotype::rs38850,rs38855,rs38857(human)
RGD
PMID:20416453
RGD:8548615
NCBI chrNW_004955410:4,114,280...4,181,953
Ensembl chrNW_004955410:4,114,778...4,182,058
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Igf1
insulin like growth factor 1
ISO
mRNA:increased expression:nose:
RGD
PMID:20713758
RGD:8548883
NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152
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Il10
interleukin 10
ISO
protein:decreased expression:blood, mononuclear cell
RGD
PMID:23168151
RGD:7364820
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il17a
interleukin 17A
ISO
associated with Asthma;mRNA, protein:increased expression:nasal polyps (human)
RGD
PMID:19672092
RGD:4889146
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il1b
interleukin 1 beta
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:11197112
RGD:7401169
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il22ra1
interleukin 22 receptor subunit alpha 1
susceptibility
ISO
DNA:SNPs:5' utr, intron: (rs4292900, rs16829225, rs4648936) (human)
RGD
PMID:19393422
RGD:5147411
NCBI chrNW_004955452:3,975,597...3,992,809
Ensembl chrNW_004955452:3,972,946...3,992,815
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Il4
interleukin 4
treatment
ISO
associated with Asthma
RGD
PMID:12787306
RGD:7829803
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
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Mmp9
matrix metallopeptidase 9
ISO
RGD
PMID:23401274
RGD:8547880
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
treatment
ISO
RGD
PMID:19389874 PMID:23131200
RGD:7349403 RGD:7364734
NCBI chrNW_004955476:11,061,405...11,084,294
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Prkra
protein activator of interferon induced protein kinase EIF2AK2
severity
ISO
associated with Nasal Polyps
RGD
PMID:22961479
RGD:7777146
NCBI chrNW_004955403:18,394,609...18,410,381
Ensembl chrNW_004955403:18,373,375...18,410,627
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Serpine1
serpin family E member 1
ISO
protein:increased expression:nasal mucosa (human)
RGD
PMID:21711960
RGD:6483796
NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
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Tlr2
toll like receptor 2
susceptibility
ISO
mRNA,protein:increased expression:paranasal sinus DNA:polymorphisms:: rs3804099,rs3804100(human)
RGD
PMID:21493395 PMID:22182736
RGD:7800733 RGD:8552975
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
ISO
mRNA,protein:increased expression:paranasal sinus
RGD
PMID:22182736
RGD:7800733
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tnf
tumor necrosis factor
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:11197112 PMID:20147558
RGD:7401169 RGD:7401236
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Alox5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:16677242
RGD:5147463
NCBI chrNW_004955546:2,495,226...2,550,909
Ensembl chrNW_004955546:2,494,819...2,550,909
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Apoa4
apolipoprotein A4
resistance
ISO
protein:increased expression:blood serum (human)
RGD
PMID:20810159
RGD:5685642
NCBI chrNW_004955412:18,158,095...18,160,636
Ensembl chrNW_004955412:18,155,801...18,160,701
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Bdnf
brain derived neurotrophic factor
severity
ISO
protein:increased expression:blood, nasal cavity epithelium
RGD
PMID:18266897
RGD:5144117
NCBI chrNW_004955476:6,773,244...6,822,201
Ensembl chrNW_004955476:6,772,088...6,822,588
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Ccl5
C-C motif chemokine ligand 5
ISO
protein:increased expression:inferior turbinate, epithelium (human)
RGD
PMID:20459697
RGD:4891379
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Fga
fibrinogen alpha chain
ISO
RGD
PMID:21887273
RGD:5688767
NCBI chrNW_004955471:8,806,964...8,814,671
Ensembl chrNW_004955471:8,806,650...8,816,791
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Icam1
intercellular adhesion molecule 1
ISO
protein:increased secretion:nasopharynx, secretion (human)
RGD
PMID:20128420
RGD:4145459
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Ifngr1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715
RGD:6480431
NCBI chrNW_004955436:22,183,318...22,199,013
Ensembl chrNW_004955436:22,183,311...22,198,291
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Il10
interleukin 10
treatment
ISO
RGD
PMID:19505388
RGD:7365025
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il18
interleukin 18
susceptibility no_association
ISO
DNA:SNPs:promoters, exon:multiple DNA:SNPs:promoters:multiple
RGD
PMID:12532106
RGD:8655871
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il4
interleukin 4
ISO
mRNA:increased expression:nose: protein:increased expression:serum
RGD
PMID:7551298 PMID:9237816
RGD:7829817 RGD:8662960
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
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Kdr
kinase insert domain receptor
ISO
protein:increased expression:nasal cavity of mucosa:
RGD
PMID:17651148
RGD:8551771
NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583
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Mmp9
matrix metallopeptidase 9
ISO
DNA:SNPs:promoter, intron, cds:-1590C>T, 2127G>T, p.R668Q (rs3918242, rs2274755, rs17577) (human)
RGD
PMID:22237587
RGD:8547819
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Nod1
nucleotide binding oligomerization domain containing 1
susceptibility
ISO
DNA:SNP: :rs2075817 (human)
RGD
PMID:16918516
RGD:5131519
NCBI chrNW_004955410:31,681,191...31,725,173
Ensembl chrNW_004955410:31,681,077...31,725,173
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Nod2
nucleotide binding oligomerization domain containing 2
susceptibility
ISO
DNA:polymorphisms:5'UTR/exon, exon:rs5743266, rs2066842 (human)
RGD
PMID:16008671
RGD:5131477
NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
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Ptgs1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:respiratory system epithelium
RGD
PMID:19364335
RGD:5147461
NCBI chrNW_004955419:5,678,750...5,699,305
Ensembl chrNW_004955419:5,678,694...5,699,305
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Scgb1a1
secretoglobin family 1A member 1
ISO
mRNA, protein:decreased expression:nasal lavage fluid
RGD
PMID:15836756
RGD:5144234
NCBI chrNW_004955599:688,414...690,644
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Tlr3
toll like receptor 3
ISO
protein:decreased expression:bone marrow, blood, eosinophil (human)
RGD
PMID:19752565
RGD:5129130
NCBI chrNW_004955403:22,977,882...23,001,392
Ensembl chrNW_004955403:22,979,120...23,001,467
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Tlr4
toll like receptor 4
susceptibility
ISO
DNA:polymorphisms:cds:p.D299G, T399I (human)
RGD
PMID:18517079
RGD:4144192
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Vegfa
vascular endothelial growth factor A
ISO
mRNA,protein:increased expression:nasal biopsies,nasal lavage fluid:
RGD
PMID:12633568
RGD:7483595
NCBI chrNW_004955437:9,527,445...9,541,908
Ensembl chrNW_004955437:9,531,362...9,542,664
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Ace2
angiotensin converting enzyme 2
treatment severity susceptibility
ISO
mRNA, protein:decreased expression:heart (mouse) human gene in a mouse model mRNA:decreased expression:lung (mouse) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:14647384 PMID:16007097 PMID:16166518 PMID:16339146 PMID:17974127 PMID:19453650 PMID:19625462 PMID:23678171 PMID:24172901 PMID:24227843 PMID:26801988 PMID:31996437 PMID:32092392 PMID:32201080 PMID:32339157 PMID:32553273 More...
RGD:30309202 RGD:30309965 RGD:30310237 RGD:32716426 RGD:40818405
NCBI chrNW_004955519:2,591,229...2,643,705
Ensembl chrNW_004955519:2,591,248...2,633,495
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Anpep
alanyl aminopeptidase, membrane
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955416:15,415,981...15,442,032
Ensembl chrNW_004955416:15,424,932...15,444,075
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Bpi
bactericidal permeability increasing protein
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955445:18,393,854...18,433,948
Ensembl chrNW_004955445:18,391,215...18,427,980
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C1qb
complement C1q B chain
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955452:2,765,844...2,771,695
Ensembl chrNW_004955452:2,769,752...2,772,534
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C5ar1
complement C5a receptor 1
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955574:1,221,942...1,229,634
Ensembl chrNW_004955574:1,221,187...1,231,655
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Casp3
caspase 3
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955403:24,315,712...24,326,271
Ensembl chrNW_004955403:24,315,727...24,324,732
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Casp9
caspase 9
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955527:2,613,691...2,630,217
Ensembl chrNW_004955527:2,613,683...2,629,738
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Ccl1
C-C motif chemokine ligand 1
ISO
mRNA: increased expression:lung (mouse)
RGD
PMID:15356152
RGD:30309221
NCBI chrNW_004955481:9,085,943...9,089,147
Ensembl chrNW_004955481:9,085,935...9,088,753
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Ccl5
C-C motif chemokine ligand 5
treatment severity
ISO
mRNA:increased expression:lung (mouse) protein:increased expression:bronchoalveolar lavage (human) Severe Acute Respiratory Syndrome; DNA:transversion:5' utr:-28C>G (human) protein:increased expression:plasma (human) mRNA, protein: increased expression, altered expression:lung, brain (mouse)
RGD
PMID:15356152 PMID:15781938 PMID:15865221 PMID:15888207 PMID:16195357 PMID:19258635 PMID:32364527 PMID:32365944 PMID:32553273 More...
RGD:27226699 RGD:30309207 RGD:30309218 RGD:30309220 RGD:30309221 RGD:32716426 RGD:33769580 RGD:34201108 RGD:4891448
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Ccr3
C-C motif chemokine receptor 3
ISO
mRNA:altered expression:lung (mouse)
RGD
PMID:15356152
RGD:30309221
NCBI chrNW_004955420:25,702,917...25,723,269
Ensembl chrNW_004955420:25,701,407...25,723,353
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Cd14
CD14 molecule
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd3e
CD3e molecule
ISO
protein:increased expression:Tcell, testis (human)
RGD
PMID:16237152
RGD:27372876
NCBI chrNW_004955412:19,464,666...19,476,425
Ensembl chrNW_004955412:19,464,613...19,478,990
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Cd4
CD4 molecule
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955413:4,400,326...4,422,110
Ensembl chrNW_004955413:4,408,390...4,421,535
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Cd68
CD68 molecule
disease_progression
ISO
protein:increased expression:macrophage, testis (human) mRNA, protein:increased expression:lung (human)
RGD
PMID:16237152 PMID:19635508
RGD:27372876 RGD:5490168
NCBI chrNW_004955467:9,340,490...9,343,912
Ensembl chrNW_004955467:9,341,364...9,343,836
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Cd9
CD9 molecule
disease_progression
ISO
mRNA, protein:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955413:3,891,874...3,924,065
Ensembl chrNW_004955413:3,891,874...3,928,119
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Clcf1
cardiotrophin like cytokine factor 1
disease_progression
ISO
mRNA:decreased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955422:18,097,779...18,108,628
Ensembl chrNW_004955422:18,097,779...18,108,628
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Cxcl10
C-X-C motif chemokine ligand 10
treatment severity disease_progression
ISO
protein:increased expression:serum protein:increased expression:serum (human) mRNA:increased expression:lung (mouse) protein:increased expression:lung (mouse) mRNA, protein:increased expression:serum, lung (human) mRNA, protein:increased expression:plasma, lung (human) protein:increased expression:lung (human) mRNA, protein: increased expression, altered expression:lung (mouse) mRNA:decreased expression:lung (human)
RGD
PMID:15356152 PMID:15602737 PMID:15657466 PMID:15781938 PMID:15865221 PMID:16195357 PMID:17052299 PMID:17129463 PMID:19635508 PMID:20231782 PMID:32364527 PMID:32365944 PMID:32553273 More...
RGD:27226699 RGD:30309207 RGD:30309216 RGD:30309217 RGD:30309218 RGD:30309219 RGD:30309220 RGD:30309221 RGD:32716399 RGD:32716426 RGD:33769580 RGD:5135440 RGD:5490168
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
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Cxcl11
C-X-C motif chemokine ligand 11
treatment
ISO
RGD
PMID:32553273
RGD:32716426
NCBI chrNW_004955433:769,449...771,137
Ensembl chrNW_004955433:766,272...771,231
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Cxcl8
C-X-C motif chemokine ligand 8
disease_progression treatment severity
ISO
mRNA:increased expression:lung (human) protein:increased expression:bronchoalveolar lavage (human) protein:increased expression:blood (human) protein:increased expression:serum (human) protein:increased expression:plasma (human)
RGD
PMID:14514395 PMID:15271897 PMID:15472864 PMID:15657466 PMID:15865221 PMID:15888207 PMID:16195357 PMID:19635508 More...
RGD:30309218 RGD:30309219 RGD:30309961 RGD:32716401 RGD:33769580 RGD:34201108 RGD:34888224 RGD:5490168
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
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Cxcl9
C-X-C motif chemokine ligand 9
severity treatment
ISO
mRNA, protein:increased expression:lung protein:increased expression:serum (human) protein:increased expression:plasma (human) protein:increased expression:bronchoalveolar lavage (human) mRNA, protein: increased expression, altered expression:lung (mouse)
RGD
PMID:15356152 PMID:15602737 PMID:15781938 PMID:15888207 PMID:16195357 PMID:19906920 More...
RGD:30309218 RGD:30309220 RGD:30309221 RGD:32716399 RGD:34201108 RGD:4891446
NCBI chrNW_004955433:724,566...731,945
Ensembl chrNW_004955433:724,515...732,192
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
mRNA:altered expression:lung (mouse)
RGD
PMID:15356152
RGD:30309221
NCBI chrNW_004955475:11,148,928...11,152,313
Ensembl chrNW_004955475:11,148,879...11,152,596
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Egfr
epidermal growth factor receptor
severity
ISO
RGD
PMID:28404843
RGD:38599178
NCBI chrNW_004955456:321,222...456,431
Ensembl chrNW_004955456:321,222...371,701
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Fgb
fibrinogen beta chain
ISO
protein:increased expression:lung (mouse)
RGD
PMID:23919993
RGD:30310231
NCBI chrNW_004955471:8,824,901...8,832,836
Ensembl chrNW_004955471:8,822,965...8,832,884
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Fgf7
fibroblast growth factor 7
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955409:4,633,542...4,686,768
Ensembl chrNW_004955409:4,632,858...4,686,860
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Fgg
fibrinogen gamma chain
ISO
protein:increased expression:lung (mouse)
RGD
PMID:23919993
RGD:30310231
NCBI chrNW_004955471:8,786,910...8,794,947
Ensembl chrNW_004955471:8,786,910...8,795,013
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Fn1
fibronectin 1
ISO
protein:increased expression:lung (mouse)
RGD
PMID:23919993
RGD:30310231
NCBI chrNW_004955457:629,599...694,948
Ensembl chrNW_004955457:629,518...696,975
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Fshb
follicle stimulating hormone subunit beta
ISO
protein:increased expression:adenohypophysis (human)
RGD
PMID:20651845
RGD:28711759
NCBI chrNW_004955476:8,795,354...8,797,244
Ensembl chrNW_004955476:8,795,351...8,797,244
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Ifnb1
interferon beta 1
treatment
ISO
CTD Direct Evidence: marker/mechanism|therapeutic mRNA:increased expression:lung (mouse)
CTD RGD
PMID:15200845 PMID:26861016 PMID:32364527 PMID:32553273
RGD:27226699 RGD:32716426
NCBI chrNW_004955434:23,301,623...23,302,304
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Ifng
interferon gamma
treatment susceptibility
ISO
protein:increased expression:serum (human) protein:increased expression:peripheral blood mononuclear cells (human) DNA:SNP:intron:+874A>T (rs2430561)(human) DNA:polymorphism:cds:+874A>T(human)
RGD
PMID:15602737 PMID:15865221 PMID:16672072 PMID:16781892 PMID:17872527 PMID:19258635 PMID:19526193 More...
RGD:32716396 RGD:32716397 RGD:32716398 RGD:32716399 RGD:32716400 RGD:33769580 RGD:4891448
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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Igf1
insulin like growth factor 1
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152
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Il10
interleukin 10
treatment
ISO
mRNA:increased expression:lung (mouse) protein:increased expression:serum, bronchoalveolar Lavage fluid (rat)
RGD
PMID:15865221 PMID:16409721 PMID:32364527
RGD:27226699 RGD:32726073 RGD:33769580
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il18
interleukin 18
ISO
protein:increased expression:serum (human)
RGD
PMID:15602737
RGD:32716399
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il1a
interleukin 1 alpha
ISO
mRNA:altered expression:lung (mouse)
RGD
PMID:32364527
RGD:27226699
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
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Il1b
interleukin 1 beta
severity
ISO
mRNA:altered expression:lung (mouse) mRNA, protein:increased expression:lung, bronchoalveolar lavage (mouse)
RGD
PMID:32364527 PMID:32365944
RGD:27226699 RGD:30309207
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1r1
interleukin 1 receptor type 1
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955470:7,685,498...7,703,374
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Il23a
interleukin 23 subunit alpha
ISO
mRNA:decreased expression:lung (mouse)
RGD
PMID:32364527
RGD:27226699
NCBI chrNW_004955458:3,946,964...3,949,180
Ensembl chrNW_004955458:3,947,803...3,949,312
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Il6
interleukin 6
treatment disease_progression severity
ISO
mRNA:increased expression:lung (mouse) protein:increased expression:serum (human) protein:increased expression:bronchoalveolar lavage (human) protein:increased expression:blood (human) protein:increased expression:serum, Bronchoalveolar Lavage fluid (rat)
RGD
PMID:15271897 PMID:15472864 PMID:15657466 PMID:15865221 PMID:15888207 PMID:16409721 PMID:32364527 PMID:32553273 More...
RGD:27226699 RGD:30309219 RGD:32716401 RGD:32716426 RGD:32726073 RGD:33769580 RGD:34201108 RGD:34888224
NCBI chrNW_004955410:25,079,835...25,084,390
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Il7
interleukin 7
ISO
mRNA:decreased expression:lung (mouse)
RGD
PMID:32364527
RGD:27226699
NCBI chrNW_004955444:2,365,077...2,400,953
Ensembl chrNW_004955444:2,361,170...2,399,142
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Irf3
interferon regulatory factor 3
disease_progression
ISO
mRNA:increased expression:lung (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19635508 PMID:26861016
RGD:5490168
NCBI chrNW_004955559:1,223,986...1,228,671
Ensembl chrNW_004955559:1,224,874...1,228,624
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Itga2b
integrin subunit alpha 2b
disease_progression
ISO
mRNA:decreased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955451:17,381,323...17,392,122
Ensembl chrNW_004955451:17,382,779...17,391,859
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Krt7
keratin 7
ISO
protein:increased expression:lung (mouse)
RGD
PMID:23919993
RGD:30310231
NCBI chrNW_004955547:2,584,425...2,598,770
Ensembl chrNW_004955547:2,533,377...2,598,833
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Lhb
luteinizing hormone subunit beta
ISO
protein:increased expression:adenohypophysis (human)
RGD
PMID:20651845
RGD:28711759
NCBI chrNW_004955559:1,656,106...1,657,192
Ensembl chrNW_004955559:1,656,291...1,657,151
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LOC102019320
mamu class II histocompatibility antigen, DR alpha chain
disease_progression
ISO
mRNA:increased expression:lung
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955437:1,109,735...1,114,742
Ensembl chrNW_004955437:1,109,713...1,114,802
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Mapk1
mitogen-activated protein kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20484496
NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020
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Mapk3
mitogen-activated protein kinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20484496
NCBI chrNW_004955493:6,870,699...6,876,836
Ensembl chrNW_004955493:6,869,668...6,879,152
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Msr1
macrophage scavenger receptor 1
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955463:1,197,086...1,263,943
Ensembl chrNW_004955463:1,197,022...1,264,765
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Myd88
MYD88 innate immune signal transduction adaptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26861016
NCBI chrNW_004955427:25,553,589...25,557,654
Ensembl chrNW_004955427:25,553,589...25,559,138
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Nfil3
nuclear factor, interleukin 3 regulated
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955515:908,313...910,159
Ensembl chrNW_004955515:908,477...909,868
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Nlrp3
NLR family pyrin domain containing 3
ISO
RGD
PMID:32365944
RGD:30309207
NCBI chrNW_004955581:597,952...616,903
Ensembl chrNW_004955581:597,667...617,410
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Pecam1
platelet and endothelial cell adhesion molecule 1
disease_progression
ISO
mRNA, protein:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188
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Pi4kb
phosphatidylinositol 4-kinase beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22253445
NCBI chrNW_004955588:648,180...679,374
Ensembl chrNW_004955588:648,180...679,374
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Plat
plasminogen activator, tissue type
ISO
protein:increased expression:plasma (human)
RGD
PMID:16274108
RGD:30309949
NCBI chrNW_004955536:730,962...754,333
Ensembl chrNW_004955536:730,981...756,394
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Plg
plasminogen
ISO
protein:increased expression:lung (mouse)
RGD
PMID:23919993
RGD:30310231
NCBI chrNW_004955439:20,317,814...20,366,724
Ensembl chrNW_004955439:20,317,552...20,366,475
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Pomc
proopiomelanocortin
ISO
protein:decreased expression:adenohypophysis (human)
RGD
PMID:20651845
RGD:28711759
NCBI chrNW_004955469:7,217,233...7,220,401
Ensembl chrNW_004955469:7,217,363...7,220,386
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Prl
prolactin
ISO
protein:increased expression:adenohypophysis (human)
RGD
PMID:20651845
RGD:28711759
NCBI chrNW_004955483:4,495,257...4,503,377
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Rab31
RAB31, member RAS oncogene family
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955402:2,354,399...2,446,537
Ensembl chrNW_004955402:2,354,646...2,446,453
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Rela
RELA proto-oncogene, NF-kB subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26861016
NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516
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Serpina3
serpin family A member 3
ISO
protein:increased expression:plasma
RGD
PMID:16649161
RGD:5147434
NCBI chrNW_004955438:17,758,763...17,766,113
Ensembl chrNW_004955438:17,758,718...17,766,180
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Stat1
signal transducer and activator of transcription 1
ISO
MouseDO
NCBI chrNW_004955403:8,156,660...8,192,018
Ensembl chrNW_004955403:8,156,660...8,194,762
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Tbk1
TANK binding kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26861016
NCBI chrNW_004955458:11,210,120...11,263,632
Ensembl chrNW_004955458:11,211,398...11,263,867
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Tgfb1
transforming growth factor beta 1
ISO
protein:increased expression:serum (human) protein:increased expression:serum, bronchoalveolar Lavage fluid (rat)
RGD
PMID:15271897 PMID:16409721
RGD:32716401 RGD:32726073
NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441
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Thbd
thrombomodulin
ISO
protein:increased expression:plasma (human)
RGD
PMID:16274108
RGD:30309949
NCBI chrNW_004955415:30,222,830...30,226,406
G
Ticam2
toll like receptor adaptor molecule 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26861016
NCBI chrNW_004955411:31,010,373...31,042,321
G
Tirap
TIR domain containing adaptor protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26861016
NCBI chrNW_004955412:27,303,548...27,315,031
Ensembl chrNW_004955412:27,312,489...27,315,031
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Tlr2
toll like receptor 2
disease_progression
ISO
mRNA:increased expression:lung (human)
RGD
PMID:19635508
RGD:5490168
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tmprss2
transmembrane serine protease 2
severity
ISO
RGD
PMID:30626688
RGD:30309210
NCBI chrNW_004955407:40,958,562...40,985,415
Ensembl chrNW_004955407:40,957,122...40,976,644
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Tnf
tumor necrosis factor
ISO
protein:increased expression:plasma (human) protein:increased expression:bronchoalveolar lavage (human)
RGD
PMID:14514395 PMID:15888207
RGD:30309961 RGD:34201108
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tshb
thyroid stimulating hormone subunit beta
ISO
protein:decreased expression:adenohypophysis (human)
RGD
PMID:20651845
RGD:28711759
NCBI chrNW_004955435:18,316,585...18,339,935
Ensembl chrNW_004955435:18,316,585...18,339,935
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Vim
vimentin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:26801988
NCBI chrNW_004955429:10,708,852...10,716,743
Ensembl chrNW_004955429:10,707,719...10,717,554
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Vwf
von Willebrand factor
ISO
protein:increased expression:lung (mouse)
RGD
PMID:23919993
RGD:30310231
NCBI chrNW_004955413:3,672,470...3,825,588
Ensembl chrNW_004955413:3,672,470...3,819,571
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Xcl1
X-C motif chemokine ligand 1
ISO
mRNA:increased expression:lung (mouse)
RGD
PMID:15356152
RGD:30309221
NCBI chrNW_004955462:8,594,416...8,598,101
Ensembl chrNW_004955462:8,594,326...8,598,221
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Sting1
stimulator of interferon response cGAMP interactor 1
severity
ISO
RGD
PMID:31141689
RGD:39128194
NCBI chrNW_004955418:1,091,022...1,097,064
Ensembl chrNW_004955418:1,083,613...1,100,448
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Azgp1
alpha-2-glycoprotein 1, zinc-binding
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18391768
NCBI chrNW_004955573:902,153...910,481
Ensembl chrNW_004955573:899,798...912,272
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Cfb
complement factor B
ISO
protein:decreased expression:serum
RGD
PMID:14510109
RGD:7411729
NCBI chrNW_004955437:461,235...466,908
Ensembl chrNW_004955437:461,235...470,464
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Cftr
CF transmembrane conductance regulator
susceptibility
ISO
DNA:mutations: : CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11773581 PMID:16083808
RGD:4140477
NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382
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Il13
interleukin 13
susceptibility
ISO
CTD Direct Evidence: marker/mechanism associated with asthma; DNA:polymorphisms:promoter:c. -1510A>C, -1055C>T (human)
CTD RGD
PMID:20358028
RGD:4145767
NCBI chrNW_004955408:4,046,406...4,049,795
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Il1b
interleukin 1 beta
ISO
associated with Hypersensitivity
RGD
PMID:16358839
RGD:4143214
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il2
interleukin 2
ISO
RGD
PMID:11758471
RGD:8662964
NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
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Lta
lymphotoxin alpha
susceptibility
ISO
DNA:polymorphism: :
RGD
PMID:11037831
RGD:4143260
NCBI chrNW_004955437:114,216...116,003
Ensembl chrNW_004955437:114,640...115,529
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Met
MET proto-oncogene, receptor tyrosine kinase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18391768
NCBI chrNW_004955432:22,440,671...22,519,592
Ensembl chrNW_004955432:22,440,637...22,517,647
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Mmp9
matrix metallopeptidase 9
ISO
protein:increased expression: :
RGD
PMID:20392482
RGD:5130763
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Muc5b
mucin 5B, oligomeric mucus/gel-forming
ISO
protein:increased secretion:sinus mucus
RGD
PMID:17063754
RGD:5131192
NCBI chrNW_004955476:11,021,665...11,049,239
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Nr3c1
nuclear receptor subfamily 3 group C member 1
ISO
RGD
PMID:18396779
RGD:4892328
NCBI chrNW_004955415:10,494,704...10,585,778
Ensembl chrNW_004955415:10,494,640...10,586,221
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Pdgfb
platelet derived growth factor subunit B
ISO
protein: increased expression: nasal cavity epithelium
RGD
PMID:21255638
RGD:6483060
NCBI chrNW_004955413:25,150,702...25,166,987
Ensembl chrNW_004955413:25,148,062...25,166,987
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Plau
plasminogen activator, urokinase
ISO
RGD
PMID:21711960
RGD:6483796
NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
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Plaur
plasminogen activator, urokinase receptor
ISO
RGD
PMID:21711960
RGD:6483796
NCBI chrNW_004955555:1,378,505...1,393,395
Ensembl chrNW_004955555:1,378,793...1,393,324
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Ppp1r9b
protein phosphatase 1 regulatory subunit 9B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18391768
NCBI chrNW_004955451:11,516,548...11,530,263
Ensembl chrNW_004955451:11,516,548...11,530,830
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Scgb3a2
secretoglobin family 3A member 2
ISO
mRNA,protein:decreased expression:nasal mucosa
RGD
PMID:21385388
RGD:5147389
NCBI chrNW_004955415:6,332,121...6,335,474
Ensembl chrNW_004955415:6,331,535...6,335,462
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Sftpd
surfactant protein D
ISO
associated with Cystic Fibrosis;mRNA:increased expression:respiratory system mucosa
RGD
PMID:17599561
RGD:4143506
NCBI chrNW_004955510:213,468...226,096
Ensembl chrNW_004955510:213,438...225,896
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Tlr2
toll like receptor 2
ISO
mRNA:increased expression:nasal cavity epithelium:
RGD
PMID:14743629
RGD:8552991
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
ISO
mRNA:increased expression:nasal cavity epithelium: associated with Pneumococal Infections;
RGD
PMID:14743629 PMID:16301373
RGD:7800729 RGD:8552991
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tlr9
toll like receptor 9
ISO
Chronic Sinusitis; protein:decreased expression:nasal mucosa, epithelial cell (human) Acute Sinusitis; protein:decreased expression:nasal mucosa, epithelial cell (human)
RGD
PMID:17283572 PMID:18416964
RGD:5130708 RGD:5130870
NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582
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Akt1
AKT serine/threonine kinase 1
treatment
ISO
RGD
PMID:23613163
RGD:38676477
NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904
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Cd86
CD86 molecule
ISO
protein:decreased expression:spleen, plasmacytoid dendritic cell (mouse)
RGD
PMID:20949109
RGD:4892562
NCBI chrNW_004955427:21,375,820...21,436,767
Ensembl chrNW_004955427:21,375,794...21,435,874
G
Cftr
CF transmembrane conductance regulator
ISO
RGD
PMID:28289144
RGD:36049750
NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382
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Csf3
colony stimulating factor 3
treatment
ISO
RGD
PMID:10228098
RGD:11039478
NCBI chrNW_004955451:14,688,181...14,690,126
Ensembl chrNW_004955451:14,688,181...14,690,126
G
Fn1
fibronectin 1
ISO
RGD
PMID:12065530
RGD:7205474
NCBI chrNW_004955457:629,599...694,948
Ensembl chrNW_004955457:629,518...696,975
G
Ifnar1
interferon alpha and beta receptor subunit 1
susceptibility
ISO
RGD
PMID:19603548
RGD:5490273
NCBI chrNW_004955407:32,730,973...32,755,404
Ensembl chrNW_004955407:32,730,953...32,754,651
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Il10
interleukin 10
ISO
mRNA, protein:increased expression:lung
RGD
PMID:22940620
RGD:7364825
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
G
Il15
interleukin 15
ISO
RGD
PMID:18390740
RGD:4996474
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
G
Il1b
interleukin 1 beta
ISO
RGD
PMID:20065029
RGD:4142828
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
G
Il33
interleukin 33
ISO
mRNA:increased expression:lung:
RGD
PMID:28401938
RGD:40400699
NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
G
Nod2
nucleotide binding oligomerization domain containing 2
ISO
RGD
PMID:20493961
RGD:5131444
NCBI chrNW_004955433:8,746,213...8,780,119
Ensembl chrNW_004955433:8,746,004...8,782,710
G
Prkn
parkin RBR E3 ubiquitin protein ligase
ISO
protein:increased expression:lung (mouse)
RGD
PMID:28663335
RGD:13432209
NCBI chrNW_004955439:18,664,230...19,953,358
Ensembl chrNW_004955439:18,664,379...19,951,152
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Ptpn11
protein tyrosine phosphatase non-receptor type 11
severity
ISO
associated with influenza mRNA:increased expression:lung
RGD
PMID:31782850
RGD:39131288
NCBI chrNW_004955482:8,934,734...9,031,230
Ensembl chrNW_004955482:8,934,306...9,035,203
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Ripk3
receptor interacting serine/threonine kinase 3
treatment
ISO
RGD
PMID:25445964
RGD:127229910
NCBI chrNW_004955409:35,961,604...35,965,477
Ensembl chrNW_004955409:35,937,880...35,965,712
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Sftpb
surfactant protein B
ameliorates
ISO
RGD
PMID:20007532
RGD:151667448
NCBI chrNW_004955424:1,849,313...1,858,087
Ensembl chrNW_004955424:1,849,314...1,858,087
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Atm
ATM serine/threonine kinase
exacerbates
ISO
RGD
PMID:27421701
RGD:126779562
NCBI chrNW_004955412:10,422,753...10,531,406
Ensembl chrNW_004955412:10,426,135...10,530,545
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Btk
Bruton tyrosine kinase
ISO
RGD
PMID:30873567
RGD:124715473
NCBI chrNW_004955503:7,483,819...7,515,085
Ensembl chrNW_004955503:7,482,793...7,515,120
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Ido1
indoleamine 2,3-dioxygenase 1
ISO
mRNA:increased expression:lung (mouse)
RGD
PMID:20385761
RGD:39938865
NCBI chrNW_004955536:2,944,770...2,955,829
Ensembl chrNW_004955536:2,943,611...2,955,829
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Ifng
interferon gamma
ISO
protein:increased expression:lung,natural killer cell (mouse)
RGD
PMID:21887255
RGD:40818252
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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Il6
interleukin 6
ISO
protein:increased expression:lung,natural killer cell (mouse)
RGD
PMID:21887255
RGD:40818252
NCBI chrNW_004955410:25,079,835...25,084,390
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Irak3
interleukin 1 receptor associated kinase 3
severity
ISO
RGD
PMID:22492852
RGD:35316076
NCBI chrNW_004955458:12,839,995...12,880,285
Ensembl chrNW_004955458:12,846,237...12,879,316
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Itgb2
integrin subunit beta 2
susceptibility
ISO
RGD
PMID:11390487
RGD:127345090
NCBI chrNW_004955407:41,779,849...41,805,637
Ensembl chrNW_004955407:41,777,777...41,800,201
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Lamp1
lysosomal associated membrane protein 1
ISO
protein:increased expression:lung, natural killer cell (mouse)
RGD
PMID:21887255
RGD:40818252
NCBI chrNW_004955404:557,090...573,532
Ensembl chrNW_004955404:557,862...573,379
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Marco
macrophage receptor with collagenous structure
exacerbates
ISO
RGD
PMID:15263032
RGD:41412189
NCBI chrNW_004955459:10,700,645...10,739,222
Ensembl chrNW_004955459:10,698,294...10,739,131
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Pdcd1
programmed cell death 1
treatment
ISO
RGD
PMID:25624454
RGD:40818422
NCBI chrNW_004955542:49,290...57,747
Ensembl chrNW_004955542:49,259...58,823
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Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
treatment
ISO
associated with immunodeficiency 14
RGD
PMID:30093657
RGD:40890269
NCBI chrNW_004955486:3,813,923...3,837,563
Ensembl chrNW_004955486:3,813,923...3,838,119
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
severity
ISO
RGD
PMID:17322108
RGD:38599154
NCBI chrNW_004955410:11,402,476...11,433,335
Ensembl chrNW_004955410:11,402,520...11,437,422
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Ripk3
receptor interacting serine/threonine kinase 3
exacerbates
ISO
RGD
PMID:33625952
RGD:127229925
NCBI chrNW_004955409:35,961,604...35,965,477
Ensembl chrNW_004955409:35,937,880...35,965,712
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Tnf
tumor necrosis factor
ISO
protein:increased expression:lung,natural killer cell (mouse)
RGD
PMID:21887255
RGD:40818252
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Il18
interleukin 18
treatment
ISO
RGD
PMID:16129701
RGD:8655932
NCBI chrNW_004955412:13,807,361...13,826,007
Ensembl chrNW_004955412:13,806,553...13,825,634
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Il5
interleukin 5
severity
ISO
RGD
PMID:9824515
RGD:11354934
NCBI chrNW_004955408:3,937,128...3,951,784
Ensembl chrNW_004955408:3,937,894...3,939,358
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Igfbp3
insulin like growth factor binding protein 3
treatment
ISO
RGD
PMID:27738609
RGD:12743605
NCBI chrNW_004955456:6,795,560...6,802,147
Ensembl chrNW_004955456:6,795,604...6,800,845
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Adam33
ADAM metallopeptidase domain 33
susceptibility
ISO
DNA:SNP: :rs2787094 c.2891G>C (human)
RGD
PMID:19258923
RGD:4142862
NCBI chrNW_004955415:14,523,517...14,535,701
Ensembl chrNW_004955415:14,524,354...14,533,700
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Bcl2
BCL2 apoptosis regulator
severity
ISO
protein:increased expression:natural killer cell, T cell (human)
RGD
PMID:26541527
RGD:40902860
NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485
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Bcl2l1
BCL2 like 1
severity
ISO
protein:increased expression:natural killer cell,t cell (human)
RGD
PMID:26541527
RGD:40902860
NCBI chrNW_004955422:29,254,440...29,307,104
Ensembl chrNW_004955422:29,254,216...29,308,174
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C3
complement C3
resistance
ISO
RGD
PMID:12235218 PMID:19258923
RGD:4142862 RGD:5129513
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Cat
catalase
ISO
protein:decreased expression:lung protein:decreased expression:nasal mucus
RGD
PMID:21471094
RGD:5130770
NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
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Ccl5
C-C motif chemokine ligand 5
susceptibility
ISO
protein:increased secretion:serum (human) DNA:snp:5' utr:g.-28C>G (human)
RGD
PMID:19005677 PMID:19099677
RGD:4891881 RGD:4891884
NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
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Cd14
CD14 molecule
ISO
DNA:polymorphism:promoter:c.-550C>T (human)
RGD
PMID:17471431
RGD:4144210
NCBI chrNW_004955418:73,736...75,345
Ensembl chrNW_004955418:73,897...75,224
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Cd274
CD274 molecule
treatment
ISO
mRNA:increased expression:lung
RGD
PMID:22797302
RGD:40818270
NCBI chrNW_004955434:9,487,309...9,508,366
Ensembl chrNW_004955434:9,487,315...9,505,904
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Csf2
colony stimulating factor 2
ISO
protein:increased expression:nasal mucus
RGD
PMID:20088864
RGD:4143440
NCBI chrNW_004955408:3,452,009...3,454,255
Ensembl chrNW_004955408:3,451,965...3,454,312
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Cx3cr1
C-X3-C motif chemokine receptor 1
ISO
DNA:SNP: :p.T280M (human)
RGD
PMID:16645504 PMID:18257903
RGD:4891891 RGD:4891905
NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
mRNA:increased expression:lung protein:increased expression:plasma
RGD
PMID:12909590 PMID:20561238
RGD:2311388 RGD:5135493
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:20561238
RGD:5135493
NCBI chrNW_004955475:11,148,928...11,152,313
Ensembl chrNW_004955475:11,148,879...11,152,596
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Fas
Fas cell surface death receptor
severity
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:26541527
RGD:40902860
NCBI chrNW_004955425:3,961,671...3,987,513
Ensembl chrNW_004955425:3,961,013...3,987,455
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Flt3
fms related receptor tyrosine kinase 3
severity
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:26541527
RGD:40902860
NCBI chrNW_004955497:7,357,533...7,441,215
Ensembl chrNW_004955497:7,357,212...7,461,439
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Gapdh
glyceraldehyde-3-phosphate dehydrogenase
severity
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:26541527
RGD:40902860
NCBI chrNW_004955413:4,162,467...4,166,783
Ensembl chrNW_004955413:4,162,467...4,166,783
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Il15
interleukin 15
severity
ISO
mRNA,protein:increased expression:peripheral blood mononuclear cell,serum,dendritic cell (human)
RGD
PMID:26541527
RGD:40902860
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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Il17a
interleukin 17A
susceptibility
ISO
DNA:SNP: :rs7747909(human)
RGD
PMID:17703412
RGD:4889847
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il1rn
interleukin 1 receptor antagonist
susceptibility
ISO
DNA:SNP: :c.390T>C (rs315952) (human)
RGD
PMID:19258923
RGD:4142862
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il33
interleukin 33
ISO
protein:increased expression:nasal mucus
RGD
PMID:28471975
RGD:38596342
NCBI chrNW_004955434:10,145,449...10,187,595
Ensembl chrNW_004955434:10,171,812...10,188,948
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Il4r
interleukin 4 receptor
susceptibility
ISO
associated with respiratory syncystial virus infection; DNA:polymorphism:cds:p. Q551R (human) DNA:SNPs: :rs1805011,rs2057768 (human)
RGD
PMID:12508140 PMID:17703412 PMID:20404812
RGD:4889847 RGD:4889996 RGD:4890022
NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422
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Il6
interleukin 6
ISO
mRNA, protein:increased expression:respiratory system fluid/secretion
RGD
PMID:14738241
RGD:5128668
NCBI chrNW_004955410:25,079,835...25,084,390
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Il9
interleukin 9
ISO
RGD
PMID:15051283
RGD:5128692
NCBI chrNW_004955408:30,950,816...30,953,571
Ensembl chrNW_004955408:30,950,816...30,953,571
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Jak3
Janus kinase 3
severity
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:26541527
RGD:40902860
NCBI chrNW_004955524:3,399,895...3,412,018
Ensembl chrNW_004955524:3,401,642...3,411,643
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Mpo
myeloperoxidase
ISO
RGD
PMID:7841728
RGD:5130995
NCBI chrNW_004955451:4,743,744...4,753,358
Ensembl chrNW_004955451:4,743,744...4,753,358
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Muc1
mucin 1, cell surface associated
severity
ISO
protein:increased expression:serum
RGD
PMID:19856476
RGD:5131164
NCBI chrNW_004955545:1,657,728...1,662,112
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Nfkb1
nuclear factor kappa B subunit 1
severity
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:26541527
RGD:40902860
NCBI chrNW_004955496:5,842,734...5,950,995
Ensembl chrNW_004955496:5,842,600...5,927,885
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Nfkbia
NFKB inhibitor alpha
susceptibility
ISO
associated with respiratory syncytial virus infectious disease;DNA:SNP:promoter: (rs2233406) (human)
RGD
PMID:23487427
RGD:40902982
NCBI chrNW_004955409:25,691,673...25,695,151
Ensembl chrNW_004955409:25,691,534...25,697,520
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Nos2
nitric oxide synthase 2
susceptibility
ISO
DNA:SNP: :rs1060826(human)
RGD
PMID:17703412
RGD:4889847
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Pdcd1
programmed cell death 1
ISO
protein:increased expression:CD8 T cell
RGD
PMID:22797302
RGD:40818270
NCBI chrNW_004955542:49,290...57,747
Ensembl chrNW_004955542:49,259...58,823
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Postn
periostin
ISO
mRNA,protein:increased expression:nasal mucus
RGD
PMID:28471975
RGD:38596342
NCBI chrNW_004955431:8,510,646...8,544,901
Ensembl chrNW_004955431:8,510,624...8,544,971
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Stat5a
signal transducer and activator of transcription 5A
severity
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human)
RGD
PMID:26541527
RGD:40902860
NCBI chrNW_004955451:16,305,363...16,319,219
Ensembl chrNW_004955451:16,305,363...16,318,534
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Tlr4
toll like receptor 4
ISO
protein:increased expression:monocyte protein:decreased expression:neutrophil
RGD
PMID:14738455 PMID:19497921
RGD:4144183 RGD:4144819
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tlr5
toll like receptor 5
susceptibility
ISO
DNA:snp:cds:p.F616L rs5744174 (human)
RGD
PMID:19258923
RGD:4142862
NCBI chrNW_004955520:1,544,840...1,562,081
Ensembl chrNW_004955520:1,556,523...1,559,093
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Tnf
tumor necrosis factor
susceptibility
ISO
DNA:SNP: :rs1799724(human) DNA:polymorphism:promoter: c. -308A>G (human) protein:increased expression:nasal lavage fluid
RGD
PMID:17703412 PMID:19849941 PMID:20088864
RGD:4143440 RGD:4143441 RGD:4889847
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tslp
thymic stromal lymphopoietin
severity
ISO
mRNA, protein:increased expression:nasal mucus (human)
RGD
PMID:28471975
RGD:38596342
NCBI chrNW_004955418:4,041,529...4,045,534
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Vdr
vitamin D receptor
susceptibility
ISO
DNA:SNP (human) DNA:SNP: :rs10735810 (human)
RGD
PMID:17703412 PMID:18266602
RGD:4889843 RGD:4889847
NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
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Cd68
CD68 molecule
ISO
mRNA:increased expression:lung,trachea (mouse)
RGD
PMID:12581500
RGD:40925942
NCBI chrNW_004955467:9,340,490...9,343,912
Ensembl chrNW_004955467:9,341,364...9,343,836
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
RGD
PMID:17655904
RGD:5135437
NCBI chrNW_004955433:748,392...750,890
Ensembl chrNW_004955433:748,284...750,927
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Cxcl16
C-X-C motif chemokine ligand 16
ISO
mRNA:decreased expression:bronchoalveolar lavage (human)
RGD
PMID:32407669
RGD:30296672
NCBI chrNW_004955467:10,132,461...10,136,649
Ensembl chrNW_004955467:10,132,544...10,136,239
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Cxcl8
C-X-C motif chemokine ligand 8
ISO
mRNA:increased expression:bronchoalveolar lavage (human)
RGD
PMID:32407669
RGD:30296672
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
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Cxcl9
C-X-C motif chemokine ligand 9
ISO
RGD
PMID:17655904
RGD:5135437
NCBI chrNW_004955433:724,566...731,945
Ensembl chrNW_004955433:724,515...732,192
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Fgf10
fibroblast growth factor 10
treatment
ISO
protein:increased expression:epithelial stem/progenitor cells (mouse)
RGD
PMID:27322618
RGD:127284849
NCBI chrNW_004955446:18,163,117...18,244,840
Ensembl chrNW_004955446:18,163,117...18,245,199
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Fgfr2
fibroblast growth factor receptor 2
ISO
RGD
PMID:27322618
RGD:127284849
NCBI chrNW_004955551:2,321,190...2,427,000
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Hmox1
heme oxygenase 1
ISO
mRNA:increased expression:lung
RGD
PMID:8843786
RGD:4145417
NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
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Ifnar1
interferon alpha and beta receptor subunit 1
disease_progression
ISO
RGD
PMID:21383977
RGD:5490272
NCBI chrNW_004955407:32,730,973...32,755,404
Ensembl chrNW_004955407:32,730,953...32,754,651
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Il10
interleukin 10
treatment
ISO
RGD
PMID:25219125
RGD:10450576
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il15
interleukin 15
ISO
RGD
PMID:20335267
RGD:4892670
NCBI chrNW_004955471:1,496,352...1,583,919
Ensembl chrNW_004955471:1,497,483...1,511,469
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Il17ra
interleukin 17 receptor A
ISO
mRNA:decreased expression:bronchoalveolar lavage (human)
RGD
PMID:32407669
RGD:30296672
NCBI chrNW_004955454:5,230,384...5,252,769
Ensembl chrNW_004955454:5,230,522...5,254,394
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Il1b
interleukin 1 beta
ISO
mRNA:increased expression:bronchoalveolar lavage (human)
RGD
PMID:32407669
RGD:30296672
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il1rn
interleukin 1 receptor antagonist
ISO
mRNA:increased expression:bronchoalveolar lavage (human)
RGD
PMID:32407669
RGD:30296672
NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
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Il4r
interleukin 4 receptor
ISO
mRNA:decreased expression:bronchoalveolar lavage (human)
RGD
PMID:32407669
RGD:30296672
NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422
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Mif
macrophage migration inhibitory factor
ISO
RGD
PMID:19941385
RGD:4891005
NCBI chrNW_004955455:8,367,566...8,368,460
Ensembl chrNW_004955455:8,367,566...8,368,460
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Tlr9
toll like receptor 9
ISO
DNA:SNP:promoter:g.-1237T>C rs5743836 (human)
RGD
PMID:19539691
RGD:5130766
NCBI chrNW_004955532:3,828,645...3,832,699
Ensembl chrNW_004955532:3,828,775...3,832,582
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Tnf
tumor necrosis factor
treatment
ISO
RGD
PMID:25219125
RGD:10450576
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Rpgr
retinitis pigmentosa GTPase regulator
ISO
ClinVar Annotator: match by term: RETINITIS PIGMENTOSA, SINORESPIRATORY INFECTIONS, AND DEAFNESS | ClinVar Annotator: match by term: Retinitis pigmentosa, X-linked, and sinorespiratory infections, with or without deafness
OMIM ClinVar
PMID:1733835 PMID:8673101 PMID:10094550 PMID:14627685 PMID:16055928 PMID:25741868 PMID:28492532 More...
NCBI chrNW_004955601:398,772...453,271
Ensembl chrNW_004955601:400,633...453,313
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Cfap221
cilia and flagella associated protein 221
ISO
OMIM
NCBI chrNW_004955459:10,070,827...10,192,411
Ensembl chrNW_004955459:10,086,111...10,192,821
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Pgk1
phosphoglycerate kinase 1
ISO
ClinVar Annotator: match by term: Male infertility due to obstructive azoospermia
ClinVar
NCBI chrNW_004955557:1,566,534...1,584,799
Ensembl chrNW_004955557:1,566,214...1,584,799
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all