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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Bacterial Lung Diseases
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Accession:DOID:9008559 term browser browse the term
Definition:Pulmonary diseases caused by bacterial infections.
Synonyms:primary_id: RDO:9002453
For additional species annotation, visit the Alliance of Genome Resources.



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Bacterial Lung Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Marco macrophage receptor with collagenous structure disease_progression ISO association with Cryptococcal neoformans infection. RGD PMID:28298522 RGD:41412191 NCBI chr13:31,616,278...31,648,521
Ensembl chr13:31,616,278...31,648,521
JBrowse link
aspiration pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO associated with Cerebrovascular Accident RGD PMID:14990394 RGD:4140926 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP RGD PMID:19515386 RGD:4891456 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 IEP RGD PMID:19515386 RGD:4891456 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Edn1 endothelin 1 IEP protein:increased secretion:plasma (rat) RGD PMID:19262391 RGD:4145069 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Il1a interleukin 1 alpha IEP protein:increased expression:Bronchoalveolar Lavage Fluid RGD PMID:18042282 RGD:4142854 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15607125 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Tnf tumor necrosis factor IEP protein:increased expression:Bronchoalveolar Lavage Fluid RGD PMID:18042282 RGD:4142854 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
bacterial pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 ISO RGD PMID:11238654 RGD:5128828 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Ace2 angiotensin I converting enzyme 2 ISO associated with Pseudomonas Infections;mRNA, protein:altered expression, altered activity:lung (mouse) RGD PMID:31645418 RGD:40818279 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ager advanced glycosylation end product-specific receptor severity ISO RGD PMID:21629785 RGD:6767559 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G C3 complement C3 ISO RGD PMID:16014897 RGD:5129508 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C3ar1 complement C3a receptor 1 ISO RGD PMID:16461429 RGD:5129690 NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
JBrowse link
G C5 complement C5 ISO RGD PMID:17975174 RGD:5129707 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Cat catalase IDA protein:decreased expression:lung, plasma RGD PMID:19842849 RGD:5130748 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 ISO mRNA, protein:increased expression:lung RGD PMID:20176793 RGD:5130918 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO RGD PMID:20042590 RGD:4891443 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO RGD PMID:20483921 RGD:5130905 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO RGD PMID:20042590 RGD:4891443 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 ISO RGD PMID:20176793 RGD:5130918 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd14 CD14 molecule ISO RGD PMID:16210672 RGD:4144197 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd40 CD40 molecule ISO RGD PMID:20102413 RGD:5132268 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd80 Cd80 molecule ISO RGD PMID:20949109 RGD:4892562 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO RGD PMID:18643924 RGD:5133701 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Csf3 colony stimulating factor 3 disease_progression
treatment
ISO associated with Peritonitis; RGD PMID:21373266 PMID:12352049 RGD:5133733, RGD:11039437 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Csf3r colony stimulating factor 3 receptor disease_progression ISO RGD PMID:17185469 RGD:5133739 NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO
IEP
RGD PMID:21723409 PMID:11052817 RGD:5135062, RGD:5135234 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 severity ISO RGD PMID:16299319 PMID:15618188 RGD:5135458, RGD:5135459 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO RGD PMID:15618188 RGD:5135459 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 severity ISO
IEP
RGD PMID:19239431 PMID:11052817 PMID:21723409 RGD:5135065, RGD:5135234, RGD:5135062 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 IEP RGD PMID:11052817 RGD:5135234 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 ISO RGD PMID:19846873 RGD:4145490 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO RGD PMID:15618188 RGD:5135459 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:15618188 RGD:5135459 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 IEP protein:decreased expression:lung RGD PMID:14766666 RGD:1625385 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Defb4 defensin beta 4 ISO protein:increased expression:plasma RGD PMID:10213993 RGD:4892266 NCBI chr16:70,650,472...70,653,665
Ensembl chr16:70,650,472...70,653,665
JBrowse link
G F2 coagulation factor II IEP protein:increased expression:lung RGD PMID:21897338 RGD:6893486 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Fcgr2a Fc gamma receptor IIa ISO RGD PMID:17975174 RGD:5129707 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
JBrowse link
G Foxp3 forkhead box P3 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha exacerbates ISO associated with Escherichia Coli Infections RGD PMID:27845343 RGD:42722624 NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO mRNA:decreased expression:polymorphonuclear leukocyte RGD PMID:24465168 RGD:126848796 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:lung (mouse) RGD PMID:19846873 RGD:4145490 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 severity ISO RGD PMID:19487810 PMID:19487810 RGD:5490274, RGD:5490274 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979
JBrowse link
G Ifng interferon gamma severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il15 interleukin 15 ISO RGD PMID:17911627 RGD:5000754 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il17a interleukin 17A severity ISO RGD PMID:18802100 PMID:25398094 RGD:4889153, RGD:38501102 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 ISO RGD PMID:17664259 RGD:4889913 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta severity
treatment
ISO associated with Agranulocytosis RGD PMID:18596024 PMID:25398094 PMID:7546648 RGD:4143205, RGD:38501102, RGD:10755357 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 treatment ISO
IEP
associated with Sepsis
associated with Acinetobacter infectious disease
RGD PMID:20959556 PMID:29508184 RGD:5144223, RGD:40818077 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO RGD PMID:18596024 PMID:18322242 RGD:4143205, RGD:4143206 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il22 interleukin 22 ISO RGD PMID:21178015 RGD:5147404 NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186
JBrowse link
G Il6 interleukin 6 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO RGD PMID:28120642 PMID:20439918 RGD:34888234, RGD:36049799 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Irf1 interferon regulatory factor 1 ISO RGD PMID:11854220 RGD:5128725 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Irf3 interferon regulatory factor 3 ISO RGD PMID:20720199 RGD:4891951 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Itgb3 integrin subunit beta 3 IEP protein:increased expression:lung, neutrophil RGD PMID:15114484 RGD:4993468 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Lep leptin ISO RGD PMID:11937559 RGD:5128871 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 severity ISO associated with Escherichia Coli Infections RGD PMID:22514650 RGD:150340681 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mbl2 mannose binding lectin 2 ISO Legionella Pneumonia; DNA:mutations:5' utr, exon:multiple (human) RGD PMID:18641104 RGD:4889477 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mc1r melanocortin 1 receptor ISO RGD PMID:18304533 RGD:5687324 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:bronchoalveolar lavage fluid RGD PMID:17202364 PMID:19535150 RGD:5130727, RGD:5129533 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:bronchoalveolar lavage Fluid: RGD PMID:11269653 RGD:5130992 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 ISO RGD PMID:19360122 RGD:5131449 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO RGD PMID:19360122 RGD:5131449 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Pdpn podoplanin IEP protein:increased expression:lung RGD PMID:7864138 RGD:2292375 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 IEP protein:decreased expression:lung RGD PMID:12524254 RGD:724645 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pgf placental growth factor ISO protein:increased expression:plasma RGD PMID:16702604 RGD:6483601 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
JBrowse link
G Pten phosphatase and tensin homolog ameliorates ISO myeloid knockout RGD PMID:21527775 RGD:127285594 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 ameliorates ISO RGD PMID:28387756 RGD:127229944 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Rorc RAR-related orphan receptor C severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Serpine1 serpin family E member 1 severity ISO RGD PMID:17032919 RGD:4144840 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sftpa1 surfactant protein A1 IEP protein:increased expression:lung RGD PMID:12169586 RGD:4143464 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
JBrowse link
G Sftpb surfactant protein B ISO
IEP
associated with Cystic Fibrosis;protein:increased expression:lung RGD PMID:15271694 PMID:12169586 RGD:4143403, RGD:4143464 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
JBrowse link
G Sftpc surfactant protein C ISO
IEP
RGD PMID:18566429 PMID:12169586 RGD:4144114, RGD:4143464 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
JBrowse link
G Sftpd surfactant protein D ISO
IEP
associated with Cystic Fibrosis;protein:decreased expression:lung
protein:increased expression:lung
RGD PMID:15271694 PMID:12169586 RGD:4143403, RGD:4143464 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:18192501 RGD:6892945 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 severity ISO RGD PMID:25398094 RGD:38501102 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr2 toll-like receptor 2 ISO
IDA
RGD PMID:18768871 PMID:19844782 RGD:4145337, RGD:4889533 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:20650991 PMID:16210672 RGD:4144172, RGD:4144197 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr5 toll-like receptor 5 ISO RGD PMID:19801452 RGD:5129503 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
JBrowse link
G Tlr6 toll-like receptor 6 IDA RGD PMID:19844782 RGD:4889533 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
G Tlr9 toll-like receptor 9 ISO RGD PMID:20360853 RGD:5130719 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tnf tumor necrosis factor disease_progression
treatment
severity
ISO associated with Agranulocytosis RGD PMID:10650487 PMID:7546648 PMID:9310939 PMID:12958055 RGD:4143476, RGD:10755357, RGD:10450564, RGD:10449451 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO protein:increased expression:serum (mouse) RGD PMID:19842848 RGD:5131429 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO protein:increased expression:serum (mouse) RGD PMID:19842848 RGD:5131429 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 severity
ameliorates
ISO
IDA
RGD PMID:24465168 PMID:16960786 PMID:22996209 RGD:126848796, RGD:127229902, RGD:126925987 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A ISO associated with Pseudomonas Infections RGD PMID:29695841 RGD:39938967 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351
JBrowse link
Chlamydia pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd274 CD274 molecule ISO mRNA:increased expression:lung RGD PMID:26378990 RGD:41412180 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Pdcd1 programmed cell death 1 ISO mRNA:increased expression:lung RGD PMID:26378990 RGD:41412180 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta severity ISO RGD PMID:29893841 RGD:40890270 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
Klebsiella pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha severity ISO RGD PMID:16157683 RGD:39457940 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 severity ISO mRNA:increased expression:lung (mouse) RGD PMID:22729155 PMID:20864681 RGD:35316077, RGD:36049798 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Lcn2 lipocalin 2 exacerbates
ameliorates
ISO protein:increased expression:lung
protein:increased expression:serum
RGD PMID:29633303 PMID:19342674 PMID:19342674 PMID:19342674 PMID:25234944 More... RGD:126725082, RGD:126725085, RGD:126725085, RGD:126725085, RGD:126725084, RGD:126725084 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Plac8 placenta associated 8 severity ISO RGD PMID:17404296 RGD:40924563 NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 disease_progression ISO RGD PMID:24396044 RGD:126925976 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
JBrowse link
Mycoplasma pneumoniae pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO protein:increased expression:serum RGD PMID:9255891 RGD:5128857 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr10:54,318,698...54,324,933
Ensembl chr10:54,318,701...54,324,933
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO RGD PMID:16988274 RGD:4892091 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:lung, secretion (mouse) RGD PMID:18717637 RGD:4891914 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO protein:increased expression:lung, T-helper cell (mouse) RGD PMID:16988274 RGD:4892091 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Clec5a C-type lectin domain containing 5A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859
JBrowse link
G Col3a1 collagen type III alpha 1 chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col6a1 collagen type VI alpha 1 chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Col6a2 collagen type VI alpha 2 chain severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564
JBrowse link
G Crp C-reactive protein ISO RGD PMID:21426633 RGD:5131292 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317
JBrowse link
G Fcer2 Fc epsilon receptor II severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Galc galactosylceramidase ISO associated with Guillain-Barre syndrome; protein:increased expression:serum (human)
associated with Guillain-Barre syndrome; protein:increased expression:Cerebrospinal fluid, serum (human)
protein:increased expression:serum (mouse)
RGD PMID:27490360 PMID:29301655 PMID:30396892 PMID:30396892 PMID:12225900 RGD:38599168, RGD:38599172, RGD:38599171, RGD:38599171, RGD:38599169 NCBI chr 6:117,452,888...117,522,281
Ensembl chr 6:117,452,895...117,515,830
JBrowse link
G Hdc histidine decarboxylase ISO RGD PMID:17158962 RGD:5143920 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Htra3 HtrA serine peptidase 3 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr14:75,068,917...75,097,315
Ensembl chr14:75,068,917...75,097,315
JBrowse link
G Ifng interferon gamma ISO mRNA:increased expression:lung: RGD PMID:7935058 RGD:10755754 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:serum RGD PMID:20416219 RGD:4145765 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 1:14,353,736...14,377,844
Ensembl chr 1:14,364,489...14,377,844
JBrowse link
G Inhba inhibin subunit beta A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Klrb1 killer cell lectin like receptor B1 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 4:162,456,294...162,474,989
Ensembl chr 4:162,456,294...162,474,989
JBrowse link
G Ms4a1 membrane spanning 4-domains A1 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512
JBrowse link
G Pld4 phospholipase D family, member 4 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 6:131,818,860...131,827,457
Ensembl chr 6:131,818,860...131,826,376
JBrowse link
G Spib Spi-B transcription factor severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 1:95,018,939...95,024,804
Ensembl chr 1:95,018,947...95,024,780
JBrowse link
G Tcf7 transcription factor 7 severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
JBrowse link
G Tcl1a Tcl1 family Akt coactivator A severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 6:124,125,032...124,131,025
Ensembl chr 6:124,125,032...124,131,025
JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:serum RGD PMID:20416219 RGD:4145765 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf13c TNF receptor superfamily member 13C severity ISO RGD PMID:28302172 RGD:32716376 NCBI chr 7:113,736,046...113,738,523
Ensembl chr 7:113,736,055...113,738,517
JBrowse link
Pneumococcal Pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase ISO RGD PMID:26456931 RGD:11098923 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972
JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:20231413 RGD:4890435 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Btk Bruton tyrosine kinase ameliorates ISO RGD PMID:30646846 RGD:124715470 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853
JBrowse link
G C3 complement C3 disease_progression ISO
IEP
protein:decreased expression:serum
associated with Liver Cirrhosis, Experimental;protein:decreased expression:respiratory system fluid/secretion
RGD PMID:20405 PMID:17956621 PMID:15972516 RGD:5130163, RGD:5129523, RGD:5129509 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C5 complement C5 severity ISO RGD PMID:7814608 RGD:5130159 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 susceptibility ISO RGD PMID:16455992 RGD:4892130 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd14 CD14 molecule ISO RGD PMID:17185649 RGD:4144788 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Chi3l1 chitinase 3 like 1 ISO protein:increased secretion:serum (human) RGD PMID:10515841 RGD:4892626 NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:21774994 RGD:5147472 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:21774994 RGD:5147472 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
JBrowse link
G Crp C-reactive protein disease_progression ISO RGD PMID:21281676 RGD:5131293 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:20958976 RGD:5134957 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:lung RGD PMID:20381636 RGD:5135285 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Defb4 defensin beta 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr16:70,650,472...70,653,665
Ensembl chr16:70,650,472...70,653,665
JBrowse link
G Hmox1 heme oxygenase 1 ISO associated with influenza;protein:increased expression:lung RGD PMID:17348295 RGD:4145366 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hp haptoglobin ISO RGD PMID:19396720 RGD:5147385 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Il15 interleukin 15 ISO protein:increased expression:alveolar macrophage, bronchial epithelial cell RGD PMID:17611121 RGD:5000755 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il15ra interleukin 15 receptor subunit alpha ISO RGD PMID:17611121 RGD:5000755 NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278
JBrowse link
G Il17a interleukin 17A ISO RGD PMID:19995896 RGD:4888531 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 ISO RGD PMID:15770015 RGD:4889960 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il6 interleukin 6 ISO RGD PMID:20643849 RGD:4143255 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lep leptin ISO RGD PMID:17822444 RGD:5128869 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor ISO RGD PMID:21148797 RGD:5128846 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Masp2 MBL associated serine protease 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12904520 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580
JBrowse link
G Mbl2 mannose binding lectin 2 no_association ISO DNA:mutations:5' utr, exon:multiple (human)
DNA:polymorphisms:5' utr, exon:multiple (human)
RGD PMID:18641104 PMID:12047967 RGD:4889477, RGD:4889478 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Nos2 nitric oxide synthase 2 ISO RGD PMID:17056580 RGD:4891950 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pten phosphatase and tensin homolog ameliorates ISO myeloid knockout RGD PMID:20505137 RGD:127285597 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Sftpd surfactant protein D severity ISO RGD PMID:16255775 RGD:4143519 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894820 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 ISO RGD PMID:29263110 RGD:39128230 NCBI chr18:27,332,119...27,338,371
Ensembl chr18:27,332,119...27,338,335
JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:19956717 RGD:4145321 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tnf tumor necrosis factor ISO associated with influenza;protein:increased expression:lung RGD PMID:9032201 PMID:17348295 RGD:4143479, RGD:4145366 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ameliorates ISO RGD PMID:24752755 PMID:19596984 RGD:126928121, RGD:127229903 NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
JBrowse link
pneumonic tularemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ido1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:20385761 RGD:39938865 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
Staphylococcal Pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 treatment ISO RGD PMID:23613163 RGD:38676477 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Cd86 CD86 molecule ISO protein:decreased expression:spleen, plasmacytoid dendritic cell (mouse) RGD PMID:20949109 RGD:4892562 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cftr CF transmembrane conductance regulator ISO RGD PMID:28289144 RGD:36049750 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:10228098 RGD:11039478 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Fn1 fibronectin 1 IDA RGD PMID:12065530 RGD:7205474 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 susceptibility ISO RGD PMID:19603548 PMID:19603548 RGD:5490273, RGD:5490273 NCBI chr11:30,725,774...30,752,227
Ensembl chr11:30,725,790...30,749,979
JBrowse link
G Il10 interleukin 10 ISO mRNA, protein:increased expression:lung RGD PMID:22940620 RGD:7364825 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il15 interleukin 15 ISO RGD PMID:18390740 RGD:4996474 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:20065029 RGD:4142828 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il33 interleukin 33 ISO mRNA:increased expression:lung: RGD PMID:28401938 RGD:40400699 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO RGD PMID:20493961 RGD:5131444 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO protein:increased expression:lung (mouse) RGD PMID:28663335 RGD:13432209 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 severity ISO mRNA:increased expression:lung
associated with influenza
RGD PMID:31782850 PMID:31782850 RGD:39131288, RGD:39131288 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 treatment ISO RGD PMID:25445964 RGD:127229910 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
Streptococcus pneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase exacerbates ISO RGD PMID:27421701 RGD:126779562 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Btk Bruton tyrosine kinase ISO RGD PMID:30873567 RGD:124715473 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853
JBrowse link
G Clec4m C-type lectin domain family 4 member M severity ISO RGD PMID:16134084 RGD:39938986 NCBI chr12:1,915,902...1,924,529
Ensembl chr12:1,915,919...1,924,539
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO mRNA:increased expression:lung (mouse) RGD PMID:20385761 RGD:39938865 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Ifng interferon gamma ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 severity ISO RGD PMID:22492852 RGD:35316076 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Itgb2 integrin subunit beta 2 susceptibility ISO RGD PMID:11390487 RGD:127345090 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 ISO protein:increased expression:lung, natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Marco macrophage receptor with collagenous structure exacerbates ISO RGD PMID:15263032 RGD:41412189 NCBI chr13:31,616,278...31,648,521
Ensembl chr13:31,616,278...31,648,521
JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 severity ISO RGD PMID:21887255 RGD:40818252 NCBI chr 1:69,614,744...69,622,570 JBrowse link
G Pdcd1 programmed cell death 1 treatment ISO RGD PMID:25624454 RGD:40818422 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta treatment ISO associated with immunodeficiency 14 RGD PMID:30093657 RGD:40890269 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma severity ISO RGD PMID:17322108 RGD:38599154 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 exacerbates ISO RGD PMID:33625952 RGD:127229925 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:lung,natural killer cell (mouse) RGD PMID:21887255 RGD:40818252 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17427
    disease by infectious agent 1931
      Bacterial Infections and Mycoses 797
        bacterial infectious disease 631
          Bacterial Lung Diseases 145
            bacterial pneumonia + 145
            pneumonic tularemia 1
Path 2
Term Annotations click to browse term
  disease 17427
    disease of anatomical entity 16758
      respiratory system disease 2932
        lower respiratory tract disease 1818
          lung disease 1775
            Bacterial Lung Diseases 145
              bacterial pneumonia + 145
              pneumonic tularemia 1
paths to the root