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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Ductal, Lobular, and Medullary Neoplasms
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Accession:DOID:9008490 term browser browse the term
Definition:Neoplasms, usually carcinoma, located within the center of an organ or within small lobes, and in the case of the breast, intraductally. The emphasis of the name is on the location of the neoplastic tissue rather than on its histological type. Most cancers of this type are located in the breast.
Synonyms:primary_id: MESH:D018299
For additional species annotation, visit the Alliance of Genome Resources.


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breast ductal carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Amfr autocrine motility factor receptor ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr19:11,473,538...11,509,500
Ensembl chr19:11,473,541...11,508,102
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member ISO RGD PMID:11605729 RGD:1579979 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Brca1 BRCA1, DNA repair associated ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar PMID:9063749, PMID:10196379, PMID:11400546, PMID:14555511, PMID:15235020, PMID:16014699, PMID:17341484, PMID:17585057, PMID:19661094, PMID:20104584, PMID:21232165, PMID:21702907, PMID:21708019, PMID:21965345, PMID:21990134, PMID:22136207, PMID:22703879, PMID:23192404, PMID:23249957, PMID:23469205, PMID:24033266, PMID:24728327, PMID:25741868, PMID:28492532 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brca2 BRCA2, DNA repair associated ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar PMID:11062481, PMID:11927503, PMID:14555511, PMID:15235023, PMID:17767707, PMID:20135345, PMID:22703879, PMID:24033266, PMID:24323938, PMID:24728327, PMID:25741868, PMID:28492532 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Bsg basigin (Ok blood group) ISO mRNA:increased expression:breast RGD PMID:9154157 RGD:2289059 NCBI chr 7:12,875,536...12,882,753
Ensembl chr 7:12,875,537...12,882,753
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar PMID:26467025, PMID:27148582, PMID:28492532 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Ccdc180 coiled-coil domain containing 180 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 5:61,467,799...61,542,675
Ensembl chr 5:61,474,000...61,542,653
JBrowse link
G Ccdc71l coiled-coil domain containing 71-like ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 6:51,659,498...51,666,145
Ensembl chr 6:51,662,224...51,662,874
JBrowse link
G Cd44 CD44 molecule (Indian blood group) disease_progression ISO mRNA, protein:splice variant, increased expression:breast RGD PMID:16425351 RGD:2289356 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cnnm1 cyclin and CBS domain divalent metal cation transport mediator 1 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 1:263,184,361...263,243,912
Ensembl chr 1:263,186,235...263,242,468
JBrowse link
G Coro6 coronin 6 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr10:62,691,952...62,700,658
Ensembl chr10:62,691,953...62,699,723
JBrowse link
G Cpxm2 carboxypeptidase X (M14 family), member 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 1:204,048,785...204,161,090
Ensembl chr 1:204,048,785...204,087,001
JBrowse link
G Creb3 cAMP responsive element binding protein 3 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 5:59,063,532...59,068,196
Ensembl chr 5:59,063,531...59,068,188
JBrowse link
G Ebag9 estrogen receptor binding site associated, antigen, 9 severity ISO protein:increased expression:breast RGD PMID:12054692 RGD:2298489 NCBI chr 7:83,564,563...83,582,516
Ensembl chr 7:83,564,563...83,582,508
JBrowse link
G Fubp1 far upstream element binding protein 1 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 2:257,425,676...257,452,745
Ensembl chr 2:257,425,679...257,449,568
JBrowse link
G Htra2 HtrA serine peptidase 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 4:113,883,671...113,886,833
Ensembl chr 4:113,883,670...113,886,994
JBrowse link
G Kndc1 kinase non-catalytic C-lobe domain containing 1 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 1:212,229,751...212,279,254
Ensembl chr 1:212,230,259...212,277,694
JBrowse link
G Lrat lecithin retinol acyltransferase ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 2:181,896,304...181,905,366
Ensembl chr 2:181,896,305...181,905,300
JBrowse link
G Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 1:177,048,607...177,173,729
Ensembl chr 1:177,048,655...177,173,995
JBrowse link
G Mug2 murinoglobulin 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 4:154,215,262...154,282,608
Ensembl chr 4:154,215,250...154,282,608
JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Nts neurotensin ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Phf24 PHD finger protein 24 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 5:58,359,744...58,387,446
Ensembl chr 5:58,359,498...58,383,070
JBrowse link
G Plk4 polo-like kinase 4 ISO protein:increased expression:breast RGD PMID:26439168 RGD:11075990 NCBI chr 2:127,686,911...127,705,518
Ensembl chr 2:127,686,925...127,705,518
JBrowse link
G Pml PML nuclear body scaffold ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Rad54l RAD54 like ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar PMID:10362365 NCBI chr 5:134,948,511...134,978,125
Ensembl chr 5:134,948,512...134,978,125
JBrowse link
G Rnf212 ring finger protein 212 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr14:1,959,148...1,998,077
Ensembl chr14:1,959,610...1,998,102
JBrowse link
G Rp1 RP1, axonemal microtubule associated ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 5:15,005,028...15,060,508
Ensembl chr 5:15,043,955...15,060,508
JBrowse link
G Rrp1 ribosomal RNA processing 1 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr20:10,982,016...10,993,260
Ensembl chr20:10,981,998...10,993,280
JBrowse link
G Slitrk6 SLIT and NTRK-like family, member 6 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr15:95,507,632...95,514,259
Ensembl chr15:95,507,640...95,514,259
JBrowse link
G Spen spen family transcriptional repressor ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 5:160,015,573...160,070,915
Ensembl chr 5:160,015,454...160,070,965
JBrowse link
G Syt6 synaptotagmin 6 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 2:206,064,181...206,119,034
Ensembl chr 2:206,064,179...206,127,907
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b ISO mRNA:decreased expression:breast RGD PMID:17011986 RGD:2290492 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tp73 tumor protein p73 ISO mRNA:decreased expression:breast RGD PMID:17011986 RGD:2290492 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Tspan8 tetraspanin 8 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 7:58,814,805...58,847,564
Ensembl chr 7:58,814,805...58,847,563
JBrowse link
G Tspear thrombospondin-type laminin G domain and EAR repeats ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr20:11,501,510...11,529,210
Ensembl chr20:11,501,925...11,528,332
JBrowse link
G Xiap X-linked inhibitor of apoptosis severity ISO RGD PMID:17350670 RGD:2315853 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Yeats2 YEATS domain containing 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr11:84,330,064...84,595,296
Ensembl chr11:84,330,064...84,583,542
JBrowse link
G Zdbf2 zinc finger, DBF-type containing 2 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 9:70,052,088...70,090,847
Ensembl chr 9:70,059,683...70,089,778
JBrowse link
G Zfp420 zinc finger protein 420 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 1:88,531,975...88,564,480
Ensembl chr 1:88,542,035...88,544,156
JBrowse link
G Zfp473 zinc finger protein 473 ISO ClinVar Annotator: match by term: Ductal breast carcinoma ClinVar NCBI chr 1:100,736,319...100,755,498
Ensembl chr 1:100,736,243...100,746,021
JBrowse link
cutaneous Paget's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha severity ISO DNA:mutations:multiple: RGD PMID:22522847 RGD:14402410 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
Ductal Carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a ISO CTD Direct Evidence: marker/mechanism CTD PMID:8389152 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member ISO CTD Direct Evidence: marker/mechanism CTD PMID:29295717 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Ca9 carbonic anhydrase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20526721 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Cdh1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29295717 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Foxa1 forkhead box A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29295717 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20526721 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 IDA RGD PMID:19322027 RGD:5686847 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:29295717 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Pten phosphatase and tensin homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:29295717 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20526721 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Spop speckle type BTB/POZ protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:29295717 NCBI chr10:83,231,187...83,311,987
Ensembl chr10:83,231,238...83,311,592
JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO CTD Direct Evidence: marker/mechanism CTD PMID:15609129 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29295717 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
ductal carcinoma in situ term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 ISO protein:increased expression:myoepithelial cells: RGD PMID:16735089 RGD:10053629 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Ang angiogenin ISO protein:increased expression:breast RGD PMID:15776477 RGD:2325702 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Anxa1 annexin A1 ISO protein:decreased expression:mammary gland RGD PMID:22323911 RGD:7421537 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Ar androgen receptor ISO RGD PMID:17543076 RGD:1643341 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin ISO protein:increased expression:breast RGD PMID:8543395 RGD:2292664 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Bcl2 BCL2, apoptosis regulator disease_progression ISO RGD PMID:12628841 RGD:2289659 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 disease_progression ISO protein:increased expression:breast RGD PMID:16421596 RGD:2293106 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO RGD PMID:14648660 RGD:7483575 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Brca2 BRCA2, DNA repair associated onset ISO DNA:missense mutation: :5972C>T RGD PMID:16280055 RGD:2289048 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Ca9 carbonic anhydrase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20526721 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Casp6 caspase 6 ISO protein:increased expression:breast RGD PMID:10574243 RGD:2301339 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Ccnd1 cyclin D1 ISO protein:decreased expression:breast RGD PMID:14612904 RGD:2289132 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 ISO DNA:hypermethylation:promoter, breast RGD PMID:14601057 RGD:2289156 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A disease_progression ISO protein:increased expression:breast RGD PMID:12628841 RGD:2289659 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO protein:increased expression:breast RGD PMID:15788662, PMID:17119686 RGD:2289981, RGD:2289931 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:9470844 RGD:2289952 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO RGD PMID:15788662 RGD:2289981 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO associated with Carcinoma, Ductal, Breast RGD PMID:15841074 RGD:2289965 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit ISO mRNA, protein:increased expression:breast RGD PMID:17254320 RGD:2293756 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:altered localization:nucleus
CTD Direct Evidence: marker/mechanism
CTD PMID:20526721, PMID:16080559 RGD:2306227 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hoxb13 homeo box B13 ISO DNA:hypermethylation RGD PMID:19250546 RGD:2314726 NCBI chr10:84,031,955...84,034,228
Ensembl chr10:84,031,955...84,034,228
JBrowse link
G Klk10 kallikrein related-peptidase 10 disease_progression ISO mRNA:decreased expression:breast RGD PMID:12788170 RGD:2314849 NCBI chr 1:99,718,275...99,722,743
Ensembl chr 1:99,718,907...99,722,284
JBrowse link
G Ldhb lactate dehydrogenase B ISO CTD Direct Evidence: marker/mechanism CTD PMID:23437403 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:breast RGD PMID:17642161 RGD:2290392 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:breast RGD PMID:14744773 RGD:2290436 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Notch4 notch receptor 4 ISO RGD PMID:17440163 RGD:2299156 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 ISO RGD PMID:22886747 RGD:7775026 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
JBrowse link
G Pgr progesterone receptor disease_progression ISO RGD PMID:12628841 RGD:2289659 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Prkca protein kinase C, alpha ISO protein:decreased expression:breast RGD PMID:15454252 RGD:2292458 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptges prostaglandin E synthase ISO protein:increased expression:breast RGD PMID:16353170 RGD:2300083 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 disease_progression ISO mRNA, protein:decreased expression:breast RGD PMID:18199541, PMID:18237383 RGD:2300203, RGD:2300199 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO protein:increased expression:breast RGD PMID:15564794 RGD:2292561 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO mRNA, protein:decreased expression:breast RGD PMID:15312366 RGD:2299890 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO DNA:amplification RGD PMID:17375183 RGD:2298754 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc2a1 solute carrier family 2 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20526721 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs2 suppressor of cytokine signaling 2 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase severity ISO protein:increased activity:breast RGD PMID:17060931 RGD:2315078 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G St14 ST14 transmembrane serine protease matriptase ISO protein:increased expression:breast RGD PMID:17163404 RGD:2315089 NCBI chr 8:32,240,113...32,280,813
Ensembl chr 8:32,240,133...32,280,869
JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO protein:altered localization:nucleus
CTD Direct Evidence: marker/mechanism
protein:decreased expression:breast
CTD PMID:15609129, PMID:15609129, PMID:16133357 RGD:2291932, RGD:2291930 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Tert telomerase reverse transcriptase ISO mRNA:decreased expression:breast RGD PMID:15010825 RGD:2291992 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tff1 trefoil factor 1 ISO RGD PMID:15375487 RGD:2292005 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 ISO protein:increased expression:breast RGD PMID:14744773 RGD:2290436 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 ISO protein:increased expression:breast RGD PMID:14744773 RGD:2290436 NCBI chr 4:147,156,948...147,163,467
Ensembl chr 4:147,156,948...147,163,467
JBrowse link
G Top2a DNA topoisomerase II alpha severity ISO protein:increased expression:breast RGD PMID:11070118 RGD:2315133 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Tp53 tumor protein p53 ISO protein:increased expression:breast RGD PMID:17119686 RGD:2289931 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tymp thymidine phosphorylase ISO RGD PMID:9306962 RGD:2293726 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:breast RGD PMID:19623180 RGD:2315458 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
familial medullary thyroid carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insrr insulin receptor-related receptor ISO ClinVar Annotator: match by term: Familial medullary thyroid carcinoma ClinVar NCBI chr 2:187,161,817...187,181,400
Ensembl chr 2:187,162,017...187,181,395
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 ISO ClinVar Annotator: match by term: Familial medullary thyroid carcinoma ClinVar PMID:10330344, PMID:10443680, PMID:11139246, PMID:11159935, PMID:11719521, PMID:25741868, PMID:26467025, PMID:28492532 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Prlr prolactin receptor ISS OMIM:155240 MouseDO NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Ret ret proto-oncogene ISO ClinVar Annotator: match by term: Familial medullary thyroid carcinoma
ClinVar Annotator: match by term: MEN2A and FMTC
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by null
OMIM
ClinVar
CTD
PMID:3078962, PMID:3697657, PMID:7633441, PMID:7647787, PMID:7784092, PMID:7824936, PMID:7845675, PMID:7849720, PMID:7874109, PMID:7881414, PMID:7907913, PMID:7911697, PMID:7915165, PMID:8099202, PMID:8103403, PMID:8114940, PMID:8557249, PMID:8625130, PMID:8675603, PMID:8797874, PMID:8807338, PMID:8855832, PMID:8918855, PMID:9003111, PMID:9090527, PMID:9111992, PMID:9146685, PMID:9174404, PMID:9230192, PMID:9242375, PMID:9259198, PMID:9263528, PMID:9384613, PMID:9398735, PMID:9452077, PMID:9498388, PMID:9506724, PMID:9681851, PMID:9681852, PMID:9727738, PMID:9745455, PMID:9760196, PMID:9839497, PMID:9879991, PMID:10024437, PMID:10076558, PMID:10235148, PMID:10323403, PMID:10445857, PMID:10462620, PMID:10490816, PMID:10549772, PMID:10646792, PMID:10777380, PMID:10876191, PMID:10982477, PMID:11114642, PMID:11230481, PMID:11454140, PMID:11524247, PMID:11562352, PMID:11589684, PMID:11739416, PMID:11900218, PMID:11932300, PMID:11935126, PMID:12000816, PMID:12116277, PMID:12193298, PMID:12205548, PMID:12409662, PMID:12490841, PMID:12566528, PMID:12604374, PMID:12686527, PMID:12694233, PMID:12864791, PMID:14517954, PMID:14561794, PMID:14566559, PMID:14602786, PMID:14633923, PMID:14715928, PMID:14718397, PMID:15164440, PMID:15184865, PMID:15240641, PMID:15277225, PMID:15292360, PMID:15452453, PMID:15531714, PMID:15699703, PMID:15741265, PMID:15753368, PMID:15771139, PMID:15855933, PMID:15858153, PMID:15870131, PMID:16118333, PMID:16314641, PMID:16343097, PMID:16388093, PMID:16441254, PMID:16469774, PMID:16507829, PMID:16532227, PMID:16649977, PMID:16705552, PMID:16707008, PMID:16712668, PMID:16715139, PMID:16736292, PMID:16813623, PMID:16865646, PMID:16865647, PMID:16868135, PMID:16928683, PMID:17021738, PMID:17047083, PMID:17097365, PMID:17102091, PMID:17178962, PMID:17188172, PMID:17209045, PMID:17483988, PMID:17610518, PMID:17704047, PMID:17895320, PMID:18058472, PMID:18062802, PMID:18063059, PMID:18805915, PMID:19138318, PMID:19469690, PMID:19472011, PMID:19826964, PMID:19906784, PMID:20080836, PMID:20087666, PMID:20103606, PMID:20497437, PMID:20516206, PMID:20554711, PMID:20739875, PMID:20833330, PMID:20979234, PMID:20981092, PMID:21254918, PMID:21311890, PMID:21422799, PMID:21626080, PMID:21655256, PMID:21678021, PMID:21688339, PMID:21690267, PMID:21765987, PMID:21810974, PMID:21834681, PMID:21986619, PMID:21995290, PMID:22068382, PMID:22403753, PMID:22584710, PMID:22676047, PMID:22703879, PMID:22729463, PMID:22837065, PMID:22965292, PMID:22995991, PMID:23084198, PMID:23210566, PMID:23295303, PMID:23461807, PMID:23527089, PMID:23723040, PMID:23745650, PMID:23756355, PMID:24033266, PMID:24064755, PMID:24152999, PMID:24361808, PMID:24375508, PMID:24449023, PMID:24569963, PMID:24616773, PMID:24617864, PMID:24684035, PMID:24716929, PMID:24728327, PMID:24805091, PMID:24845513, PMID:25157968, PMID:25319874, PMID:25374962, PMID:25425582, PMID:25440022, PMID:25628771, PMID:25629635, PMID:25637381, PMID:25694125, PMID:25741868, PMID:25767701, PMID:25810047, PMID:25887804, PMID:25950813, PMID:26046350, PMID:26247112, PMID:26269449, PMID:26356818, PMID:26467025, PMID:27153395, PMID:27673361, PMID:27809725, PMID:27884173, PMID:27994876, PMID:28323957, PMID:28492532, PMID:28647780, PMID:28946813, PMID:28951487, PMID:29097883, PMID:29408964, PMID:29656518, PMID:29684080, PMID:30311386, PMID:30644554, PMID:30927507, PMID:31510104 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
invasive ductal carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A disease_progression ISO RGD PMID:19879256 RGD:2315549 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adgrb1 adhesion G protein-coupled receptor B1 disease_progression ISO RGD PMID:25376607 RGD:13831358 NCBI chr 7:115,766,484...115,828,514 JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO protein:increased expression:breast RGD PMID:22366088 RGD:8695990 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO DNA:missense mutation:p.E17K (human) RGD PMID:18392055 RGD:13209138 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Anxa1 annexin A1 treatment ISO RGD PMID:18776816, PMID:19171478 RGD:7421535, RGD:7421560 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 treatment ISO RGD PMID:19171478 RGD:7421560 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Ar androgen receptor severity ISO RGD PMID:16075292 RGD:1643344 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin ISO RGD PMID:11523048 RGD:2292660 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 ISO protein:increased expression:breast (human) RGD PMID:21136934 RGD:11049179 NCBI chr 9:81,518,163...81,548,871
Ensembl chr 9:81,518,176...81,548,871
JBrowse link
G Atf4 activating transcription factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14604972 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Aurka aurora kinase A ISO protein:altered expression RGD PMID:14693746 RGD:1643348 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Bag1 BAG cochaperone 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19066611 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Brca1 BRCA1, DNA repair associated ISO ClinVar Annotator: match by term: Infiltrating duct carcinoma of breast
ClinVar Annotator: match by term: Invasive Ductal Carcinoma, Not Otherwise Specified
ClinVar PMID:7493024, PMID:11179017, PMID:11956590, PMID:12698193, PMID:12955716, PMID:14517958, PMID:14760071, PMID:15145354, PMID:16455195, PMID:17645508, PMID:20727672, PMID:22711857, PMID:22798144, PMID:23469205, PMID:23479189, PMID:23633455, PMID:24884479, PMID:25256238, PMID:25741868, PMID:25863477, PMID:26026974, PMID:26295337, PMID:26467025, PMID:28492532, PMID:29446198 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brca2 BRCA2, DNA repair associated ISO ClinVar Annotator: match by term: Infiltrating duct carcinoma of breast
ClinVar Annotator: match by term: Invasive Ductal Carcinoma, Not Otherwise Specified
ClinVar PMID:14973102, PMID:15145354, PMID:17899372, PMID:18627636, PMID:18779604, PMID:19043619, PMID:19499246, PMID:21218378, PMID:22126563, PMID:22476429, PMID:24470074, PMID:24728327, PMID:25741868, PMID:25782689, PMID:25980754, PMID:26221963, PMID:26402875, PMID:26467025, PMID:26530882, PMID:26757417, PMID:27157322, PMID:27257965, PMID:27658390, PMID:27701467, PMID:28111427, PMID:28222693, PMID:28277317, PMID:28283652, PMID:28351343, PMID:28419251, PMID:28492532, PMID:28993434, PMID:29192238, PMID:29240602, PMID:29394989, PMID:29681614, PMID:29752822, PMID:29988080, PMID:30287823, PMID:30415210 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Brms1 BRMS1, transcriptional repressor and anoikis regulator disease_progression ISO RGD PMID:15592684 RGD:2289400 NCBI chr 1:220,325,352...220,334,616 JBrowse link
G Cav1 caveolin 1 no_association ISO DNA:missense mutation: :p.P132L (human) RGD PMID:21909981 RGD:8661779 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:breast, ductal carcinoma (human) RGD PMID:18790652 RGD:4891911 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd3 cyclin D3 severity ISO protein:increased expression:breast RGD PMID:11329139 RGD:2316016 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cd44 CD44 molecule (Indian blood group) disease_progression ISO protein:increased expression:breast RGD PMID:17059779 RGD:2289352 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8557030, PMID:17660459 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO DNA:hypermethylation:promoter:breast, serum RGD PMID:17383681 RGD:2289677 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2a_v1 cyclin-dependent kinase inhibitor 2A, variant 1 ISO DNA:hypermethylation:promoter:breast, serum RGD PMID:17383681 RGD:2289677
G Cdkn2a_v2 cyclin-dependent kinase inhibitor 2A, variant 2 ISO DNA:hypermethylation:promoter:breast, serum RGD PMID:17383681 RGD:2289677
G Cldn4 claudin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19142967 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Clu clusterin ISO RGD PMID:10934144 RGD:8699513 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein disease_progression ISO protein:increased expression:breast RGD PMID:23686806 RGD:7488897 NCBI chr11:87,338,606...87,356,644
Ensembl chr11:87,778,312...87,815,043
JBrowse link
G Csnk1e casein kinase 1, epsilon ISO DNA:mutation:CDS:multiple nonsynonymous mutations (human) RGD PMID:14871824 RGD:2306813 NCBI chr 7:120,651,976...120,675,559
Ensembl chr 7:120,651,881...120,672,359
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 ISO DNA:mutation:CDS:multiple nonsynonymous mutations (human) RGD PMID:14871824 RGD:2306813 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Ebag9 estrogen receptor binding site associated, antigen, 9 ISO mRNA, protein:increased expression:breast RGD PMID:11742495 RGD:2289858 NCBI chr 7:83,564,563...83,582,516
Ensembl chr 7:83,564,563...83,582,508
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28235801 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:14532106 RGD:9588325 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Fgd1 FYVE, RhoGEF and PH domain containing 1 ISO protein:increased expression:breast (human) RGD PMID:19141649 RGD:11554027 NCBI chr  X:20,100,942...20,143,871
Ensembl chr  X:20,216,587...20,225,955
Ensembl chr  X:20,216,587...20,225,955
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase ISO RGD PMID:12231533 RGD:2289894 NCBI chr15:15,697,292...16,862,873 JBrowse link
G Foxc1 forkhead box C1 disease_progression ISO RGD PMID:21424368 RGD:8662363 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO protein:altered localization:nucleus RGD PMID:16080559 RGD:2306227 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hoxb7 homeo box B7 ISO mRNA:increased expression:breast epithelium (human) RGD PMID:17018609 RGD:10402178 NCBI chr10:84,135,224...84,138,642
Ensembl chr10:84,135,116...84,138,637
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 severity ISO protein:decreased expression:ductal breast carcinoma (human) RGD PMID:10682658 RGD:4890946 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:breast RGD PMID:22135852 RGD:8549515 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:breast RGD PMID:21263407 RGD:8655888 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Inha inhibin subunit alpha ISO RGD PMID:15583806 RGD:2290390 NCBI chr 9:82,700,482...82,703,383
Ensembl chr 9:82,700,468...82,703,400
JBrowse link
G Jup junction plakoglobin disease_progression ISO RGD PMID:16610682 RGD:2291882 NCBI chr10:88,280,517...88,307,451
Ensembl chr10:88,279,632...88,307,412
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor disease_progression ISO RGD PMID:15592684 RGD:2289400 NCBI chr13:50,529,506...50,537,603
Ensembl chr13:50,529,510...50,535,389
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase severity ISO RGD PMID:16721362 RGD:2292426 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 disease_progression ISO RGD PMID:15592684 RGD:2289400 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase severity ISO protein:increased expression:tumor (human) RGD PMID:10590366 RGD:2317607 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mmp13 matrix metallopeptidase 13 disease_progression ISO RGD PMID:11585740 RGD:2293606 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 ISO protein:decreased expression:breast RGD PMID:11561770 RGD:2293536 NCBI chr16:8,302,950...8,323,294
Ensembl chr16:8,302,950...8,323,293
JBrowse link
G Nefl neurofilament light ISO DNA:loss of heterozygosity RGD PMID:8814452 RGD:2298999 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Pcna proliferating cell nuclear antigen severity ISO RGD PMID:8102204 RGD:2315014 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Prkci protein kinase C, iota disease_progression ISO protein:increased expression, altered localization:breast, cytoplasm RGD PMID:18538170 RGD:2314932 NCBI chr 2:115,941,998...116,002,550
Ensembl chr 2:115,941,993...116,002,561
JBrowse link
G Ptger1 prostaglandin E receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11751431 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21153458 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rad50 RAD50 double strand break repair protein ISO RGD PMID:14511253 RGD:2300250 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Runx3 RUNX family transcription factor 3 disease_progression ISO DNA, protein:hypermethylation, altered localization:promoter RGD PMID:18256927 RGD:2302557 NCBI chr 5:153,507,093...153,531,137
Ensembl chr 5:153,507,093...153,531,137
JBrowse link
G Serpinb5 serpin family B member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19944674 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28235801 NCBI chr10:103,713,045...103,730,145
Ensembl chr10:103,713,045...103,730,145
JBrowse link
G Smad4 SMAD family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20565773 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs2 suppressor of cytokine signaling 2 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO mRNA:increased expression:breast RGD PMID:12888825 RGD:2298909 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23964924 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 disease_progression IEP RGD PMID:17054309 RGD:2291958 NCBI chr 7:141,039,433...141,070,269
Ensembl chr 7:141,034,982...141,069,989
JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 ISO DNA:mutation:CDS:multiple nonsynonymous mutations RGD PMID:14871824 RGD:2306813 NCBI chr 7:76,789,110...76,835,517
NCBI chr 7:76,839,661...76,907,441
Ensembl chr 7:76,789,531...76,853,840
JBrowse link
G Vegfc vascular endothelial growth factor C disease_progression ISO RGD PMID:19885590 RGD:2315471 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Wif1 Wnt inhibitory factor 1 ISO protein:decreased expression:breast RGD PMID:14517837 RGD:727214 NCBI chr 7:63,094,955...63,165,158
Ensembl chr 7:63,094,911...63,165,159
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:polymorphism: :p.R399Q RGD PMID:18752184 RGD:2302569 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
invasive lobular carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a ISO CTD Direct Evidence: marker/mechanism CTD PMID:8389152 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8389152 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Ccnd1 cyclin D1 ISO protein:increased expression:breast
DNA:amplification:cds (human)
RGD PMID:12203362, PMID:12448002 RGD:2289133, RGD:11353788 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 ISO DNA:hypermethylation:promoter, breast RGD PMID:14601057 RGD:2289156 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO mRNA, protein:splice variants, altered localization:breast RGD PMID:11245336 RGD:2289362 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 ISO DNA:nonsense mutation: :517insA (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:8557030, PMID:17660459, PMID:17660459, PMID:18213475 RGD:2289492, RGD:2289450 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Ctnna1 catenin alpha 1 ISO protein:decreased expression:breast RGD PMID:12047765 RGD:2289795 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
JBrowse link
G Ctnnb1 catenin beta 1 ISO protein:decreased expression:breast RGD PMID:17721269 RGD:2289814 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 severity ISO RGD PMID:16761510 RGD:2289935 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Faslg Fas ligand ISO protein:increased expression:breast RGD PMID:10640988 RGD:2290134 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Myh9 myosin, heavy chain 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28650484 NCBI chr 7:118,740,005...118,792,507
Ensembl chr 7:118,741,110...118,792,625
JBrowse link
G Ppp1r12b protein phosphatase 1, regulatory subunit 12B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28650484 NCBI chr13:51,583,603...51,784,641
Ensembl chr13:51,584,299...51,784,639
JBrowse link
G Stat5a signal transducer and activator of transcription 5A ISO protein:altered localization:nucleus
CTD Direct Evidence: marker/mechanism
CTD PMID:15609129, PMID:15609129 RGD:2291932 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Tp53bp2 tumor protein p53 binding protein, 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28650484 NCBI chr13:100,817,206...100,873,837
Ensembl chr13:100,817,359...100,873,890
JBrowse link
mammary Paget's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO DNA:amplification RGD PMID:16932067 RGD:2289933 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
Medullary Carcinomas term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpgd 15-hydroxyprostaglandin dehydrogenase ISO CTD Direct Evidence: therapeutic CTD PMID:11352223 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Ret ret proto-oncogene ISO CTD Direct Evidence: marker/mechanism CTD PMID:7915165 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
pancreatic ductal adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO protein:increased expression:pancreas RGD PMID:19714807 RGD:2325658 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 ISO protein:increased expression:pancreas RGD PMID:19077459 RGD:2325696 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Ccnd1 cyclin D1 severity ISO DNA:snp:exon:c.870G>A (human)
protein:increased expression:pancreas (human)
RGD PMID:25470788, PMID:22939953 RGD:13462050, RGD:13462062 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk4 cyclin-dependent kinase 4 severity ISO protein:increased expression:pancreas, islet of Langerhans (human) RGD PMID:29735403 RGD:13781899 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G E2f1 E2F transcription factor 1 severity ISO protein:increased expression:pancreatic ductal cell, nucleus (human)
DNA:amplification: : (human)
RGD PMID:12650514, PMID:17233815, PMID:27573434 RGD:13838735, RGD:13838739, RGD:13838738 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 treatment ISO human cells in a mouse model RGD PMID:23535601 RGD:13504844 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta susceptibility ISO RGD PMID:22264792 RGD:13838741 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Jak1 Janus kinase 1 ISO mRNA:decreased expression:pancreatic ductal cell (human) RGD PMID:28677798 RGD:13838745 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 severity
disease_progression
ISO protein:increased phosphorylation:pancreas (mouse) RGD PMID:28837246, PMID:23237571 RGD:14348974, RGD:14348975 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mir155 microRNA 155 disease_progression ISO RGD PMID:28198398 RGD:25314300 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Pgf placental growth factor severity ISO associated with obesity RGD PMID:26861455 RGD:14349030 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO mRNA, protein:increased expression:pancreas (human) RGD PMID:20876794 RGD:14390130 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 severity ISO human cells in a mouse model RGD PMID:15591514 RGD:14390084 NCBI chr16:20,415,109...20,424,982
Ensembl chr16:20,416,432...20,424,980
JBrowse link
G Pld1 phospholipase D1 severity ISO protein:increased expression:pancreas (human) RGD PMID:27713167 RGD:14392801 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Rac1 Rac family small GTPase 1 ISO mRNA:increased expression:pancreas (human)
mRNA, protein:increased expression:pancreas (mouse)
RGD PMID:23334332, PMID:21684285 RGD:14392806, RGD:14392816 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rala RAS like proto-oncogene A ISO mRNA:increased expression:pancreas (human) RGD PMID:29113235 RGD:14394418 NCBI chr17:49,676,073...49,729,133
Ensembl chr17:49,714,294...49,727,664
JBrowse link
G Smad2 SMAD family member 2 severity ISO RGD PMID:26908446 RGD:14394493 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
pancreatic ductal carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO mRNA, protein:increased expression:pancreas RGD PMID:17481528 RGD:2325211 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 ISO protein:decreased expression:pancreas RGD PMID:19212105 RGD:2325210 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 disease_progression ISO mRNA:increased expression:pancreas RGD PMID:17979891 RGD:2325243 NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 disease_progression ISO protein:altered localization:cytoplasm RGD PMID:14997207 RGD:2325249 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO mRNA:increased expression:pancreas RGD PMID:19609859 RGD:2325659 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO CTD Direct Evidence: marker/mechanism CTD PMID:17481528 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Alb albumin disease_progression ISO RGD PMID:19011933 RGD:2325677 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Anxa2 annexin A2 disease_progression ISO mRNA, protein:increased expression, altered localization:pancreas, plasma membrane RGD PMID:19260470, PMID:16450333 RGD:2317307, RGD:2325731 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa5 annexin A5 ISO protein:increased expression:pancreas RGD PMID:19488907 RGD:2317538 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Anxa8 annexin A8 ISO mRNA:increased expression:pancreas RGD PMID:18223320 RGD:2325735 NCBI chr16:10,417,174...10,432,388
Ensembl chr16:10,417,185...10,432,393
JBrowse link
G Apoc1 apolipoprotein C1 ISO RGD PMID:15876873 RGD:2325793 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921
JBrowse link
G Arg2 arginase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23424623 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger ISO protein:increased expression:pancreas
protein:increased expression:exocrine pancreas:
RGD PMID:19585519, PMID:19585519 RGD:9491843, RGD:9491843 NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
JBrowse link
G Calr calreticulin ISO protein:increased expression:pancreatic duct RGD PMID:15289361 RGD:2326165 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Cbx7 chromobox 7 disease_progression ISO protein:decreased expression:pancreas RGD PMID:20185297 RGD:9587360 NCBI chr 7:121,136,067...121,153,503
Ensembl chr 7:121,136,058...121,153,383
JBrowse link
G Cckar cholecystokinin A receptor ISO mRNA:increased expression:pancreatic duct
protein:decreased expression:pancreas
RGD PMID:9239407, PMID:12851875 RGD:4110818, RGD:4110816 NCBI chr14:59,610,939...59,619,786
Ensembl chr14:59,611,434...59,619,783
JBrowse link
G Cckbr cholecystokinin B receptor ISO protein:decreased expression:pancreas RGD PMID:12851875 RGD:4110816 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Ccnd1 cyclin D1 severity ISO protein:increased expression:pancreas (human) RGD PMID:17420962 RGD:13462063 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd40 CD40 molecule treatment ISO protein:increased expression:dendritic cell RGD PMID:21436454, PMID:23983255, PMID:20976171 RGD:5490301, RGD:11522743, RGD:5490524 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cdk6 cyclin-dependent kinase 6 treatment ISO human cells in a mouse model RGD PMID:24389175 RGD:13782187 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A disease_progression ISO RGD PMID:17671118 RGD:8662851 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24986516 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cldn4 claudin 4 ISO RGD PMID:15693851 RGD:2317592 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Dnmt1 DNA methyltransferase 1 disease_progression ISO protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism
CTD PMID:29844410, PMID:19424621 RGD:9588974 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta disease_progression ISO RGD PMID:22919364 RGD:9589121 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dtx1 deltex E3 ubiquitin ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr12:41,383,885...41,415,783
Ensembl chr12:41,385,241...41,414,754
JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 1:228,729,842...228,759,783
Ensembl chr 1:228,732,985...228,755,866
JBrowse link
G Egf epidermal growth factor disease_progression ISO protein:increased expression: : RGD PMID:18505086 RGD:2317644 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Faslg Fas ligand ISO protein:increased expression:pancreas, liver RGD PMID:10547193, PMID:15375495 RGD:2317747, RGD:2317741 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf2 fibroblast growth factor 2 disease_progression ISO RGD PMID:12717266, PMID:18704599 RGD:2317758, RGD:2317756 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fscn1 fascin actin-bundling protein 1 disease_progression ISO protein:increased expression:pancreas RGD PMID:12109856 RGD:2317790 NCBI chr12:13,655,459...13,668,595
Ensembl chr12:13,656,554...13,668,515
JBrowse link
G Gpnmb glycoprotein nmb ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gstp1 glutathione S-transferase pi 1 resistance ISO DNA:methylation: :
mRNA, protein:increased expression:pancreas
RGD PMID:16537562, PMID:17265526, PMID:12488200 RGD:2317809, RGD:2317806, RGD:2317811 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac1 histone deacetylase 1 disease_progression ISO protein:increased expression:pancreas RGD PMID:19424621 RGD:9588974 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Heatr1 HEAT repeat containing 1 treatment ISO RGD PMID:26676747 RGD:10761108 NCBI chr17:66,446,135...66,488,303
Ensembl chr17:66,446,162...66,619,250
JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17234771 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:17234771 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Igf1 insulin-like growth factor 1 ISO RGD PMID:20098680 RGD:2317639 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor ISO protein:increased expression:pancreas RGD PMID:14627343, PMID:14506643 RGD:2317649, RGD:2317652 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il4 interleukin 4 ISO RGD PMID:17942922 RGD:2317264 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor ISO protein:increased expression:pancreas RGD PMID:17942922 RGD:2317264 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Ins2 insulin 2 ISO Glucagon/insulin RGD PMID:19571666 RGD:2317248 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jag2 jagged canonical Notch ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 6:137,711,144...137,733,331
Ensembl chr 6:137,711,155...137,733,026
JBrowse link
G Kdm2b lysine demethylase 2B severity ISO mRNA, protein:increased expression:pancreas (human) RGD PMID:23321669 RGD:9588253 NCBI chr12:39,021,924...39,161,954
Ensembl chr12:39,078,119...39,161,956
JBrowse link
G Kitlg KIT ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25347530, PMID:30654191 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt7 keratin 7 disease_progression ISO RGD PMID:19260470 RGD:2317307 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
JBrowse link
G L1cam L1 cell adhesion molecule severity ISO protein:increased expression:pancreas (human) RGD PMID:20162456 RGD:6483447 NCBI chr  X:156,901,244...156,928,064
Ensembl chr  X:156,909,913...156,928,057
JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment ISO human cells in mouse model RGD PMID:20179210 RGD:14348973 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 ISO mRNA, protein:increased expression:pancreatic duct RGD PMID:15548371 RGD:2317697 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mdm2 MDM2 proto-oncogene onset
severity
ISO DNA:snp:promoter, intron:IVS1+309T>G (human)
protein:increased expression:pancreas (human)
RGD PMID:19752772, PMID:15810085 RGD:2317414, RGD:2317416 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Men1 menin 1 ISO protein:decreased expression:pancreas RGD PMID:19170121 RGD:2317294 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:pancreatic duct (human) RGD PMID:7866999 RGD:2317530 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase susceptibility ISO DNA:missense mutation:cds:p.L84F rs12917 (human)
protein:increased activity, increased expression:ductal adenocarcinoma (human)
RGD PMID:16844323, PMID:9393761 RGD:2317648, RGD:2317664 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir142 microRNA 142 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29844410 NCBI chr10:75,050,839...75,050,925
Ensembl chr10:75,050,832...75,050,942
JBrowse link
G Mir873 microRNA 873 ISO CTD Direct Evidence: therapeutic CTD PMID:30654191 NCBI chr 5:52,481,076...52,481,152
Ensembl chr 5:52,481,076...52,481,152
JBrowse link
G Mmp2 matrix metallopeptidase 2 severity ISO protein:increased expression:pancreas RGD PMID:17377415 RGD:2325746 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:pancreas, serum
protein:increased expression:blood
RGD PMID:18706098, PMID:20332475 RGD:2325844, RGD:2325830 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Msln mesothelin disease_progression ISO protein:increased secretion:serum
CTD Direct Evidence: marker/mechanism
DNA:hypomethylation:5'UTR
CTD PMID:14576474, PMID:21775916, PMID:25347530, PMID:19818733, PMID:12874021 RGD:2326055, RGD:2326065 NCBI chr10:15,119,700...15,129,129
Ensembl chr10:15,119,663...15,125,408
JBrowse link
G Muc1 mucin 1, cell surface associated disease_progression ISO protein:increased expression, altered localization:pancreas RGD PMID:14681945, PMID:19109152, PMID:18713982 RGD:2317983, RGD:2324616, RGD:2324633 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Muc3 mucin 3, intestinal disease_progression ISO mRNA:increased expression:pancreas RGD PMID:12657964 RGD:2324946 NCBI chr12:22,535,663...22,584,775 JBrowse link
G Muc4 mucin 4, cell surface associated disease_progression ISO mRNA:increased expression:pancreas
protein:increased expression:pancreas
RGD PMID:12657964, PMID:16049287 RGD:2324946, RGD:2324942 NCBI chr11:71,242,973...71,285,217
Ensembl chr11:71,243,334...71,284,939
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming disease_progression ISO mRNA:increased expression:pancreas RGD PMID:7657125, PMID:10227724 RGD:2324986, RGD:2324907 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:pancreas RGD PMID:7657125 RGD:2324986 NCBI chr 1:214,778,459...214,811,237
Ensembl chr 1:214,778,496...214,810,720
JBrowse link
G Ndrg1 N-myc downstream regulated 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16778198 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21489257 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO protein:increased expression:pancreas (human) RGD PMID:17492507 RGD:5132867 NCBI chr10:81,657,152...81,666,542
Ensembl chr10:81,657,153...81,666,523
JBrowse link
G Nos2 nitric oxide synthase 2 ISO RGD PMID:12660813 RGD:2325254 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch1 notch receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345, PMID:20484026, PMID:19028876 RGD:2325323, RGD:2325324 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch3 notch receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Notch4 notch receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 disease_progression ISO protein:increased expression:pancreas RGD PMID:11295066, PMID:10209957 RGD:2325660, RGD:2325663 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Osm oncostatin M ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Palld palladin, cytoskeletal associated protein ISO protein:increased expression, alternative form:pancreas, fibroblast RGD PMID:17404500 RGD:2325781 NCBI chr16:31,865,712...31,948,168 JBrowse link
G Pax6 paired box 6 ISO protein:increased expression:pancreatic duct (human) RGD PMID:17849422 RGD:8552381 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component ISO protein:increased expression:pancreatic duct RGD PMID:15856462 RGD:2324870 NCBI chr 9:53,120,656...53,206,520
Ensembl chr 9:53,120,656...53,206,516
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma disease_progression ISO RGD PMID:19396032 RGD:2317461 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:18670639 RGD:2317185 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rnf2 ring finger protein 2 ISO protein:increased expression:pancreas RGD PMID:19585519 RGD:9491843 NCBI chr13:68,829,714...68,859,920
Ensembl chr13:68,830,620...68,858,809
JBrowse link
G Rxra retinoid X receptor alpha severity ISO RGD PMID:19396032 RGD:2317461 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Serpina1 serpin family A member 1 ISO mRNA, protein:increased expression:pancreas RGD PMID:12488200 RGD:2317811 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
JBrowse link
G Slc2a2 solute carrier family 2 member 2 ISO protein:increased expression:pancreatic duct RGD PMID:19252908 RGD:2324975 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Smad4 SMAD family member 4 disease_progression ISO RGD PMID:15173084 RGD:21066334 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Smo smoothened, frizzled class receptor ISO RGD PMID:16826192 RGD:2324981 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Stk11 serine/threonine kinase 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26887594 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Tgfb1 transforming growth factor, beta 1 disease_progression ISO RGD PMID:16101174 RGD:2325019 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 disease_progression ISO mRNA:increased expresssion:pancreas RGD PMID:17114585, PMID:10547197 RGD:2317498, RGD:2317500 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Thbs1 thrombospondin 1 disease_progression ISO DNA:hypermethylation:promoter (human) RGD PMID:12429967, PMID:19065635 RGD:2325025, RGD:2325022 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tmprss3 transmembrane serine protease 3 ISO RGD PMID:14695172 RGD:2325152 NCBI chr20:9,910,522...9,929,705
Ensembl chr20:9,910,522...9,929,705
JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29844410 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tsc2 TSC complex subunit 2 severity ISO RGD PMID:16213898 RGD:11568674 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Tymp thymidine phosphorylase disease_progression ISO RGD PMID:19760965 RGD:2325155 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17481528 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO DNA:hypermethylation:promoter (human) RGD PMID:19065635 RGD:2325022 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
thyroid gland medullary carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Medullary Thyroid Cancer ClinVar PMID:12460918, PMID:15696205, PMID:16361624, PMID:16618717, PMID:17062680, PMID:17384584, PMID:18316791, PMID:18794081, PMID:19114683, PMID:19255327, PMID:19679400, PMID:19773371, PMID:20921462, PMID:20921465, PMID:21228335, PMID:23406027, PMID:24033266, PMID:25157968 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Men1 menin 1 ISO ClinVar Annotator: match by term: Medullary thyroid cancer (MTC) ClinVar PMID:25741868, PMID:30311386 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Ret ret proto-oncogene ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Medullary thyroid carcinoma
ClinVar Annotator: match by term: Medullary thyroid cancer
CTD
ClinVar
PMID:2008030, PMID:2660074, PMID:2904651, PMID:3078962, PMID:7491519, PMID:7536460, PMID:7595171, PMID:7608256, PMID:7633441, PMID:7784092, PMID:7824936, PMID:7835899, PMID:7845675, PMID:7849700, PMID:7849720, PMID:7860065, PMID:7874109, PMID:7881414, PMID:7906417, PMID:7906866, PMID:7907913, PMID:7911697, PMID:7914213, PMID:7915165, PMID:7915822, PMID:7977365, PMID:8099202, PMID:8103403, PMID:8114940, PMID:8570194, PMID:8595427, PMID:8675603, PMID:8757765, PMID:8765374, PMID:8782503, PMID:8797874, PMID:8807338, PMID:8855832, PMID:8880581, PMID:8909322, PMID:8918855, PMID:9012462, PMID:9067749, PMID:9090527, PMID:9111992, PMID:9146685, PMID:9174404, PMID:9223675, PMID:9230192, PMID:9242375, PMID:9259198, PMID:9263528, PMID:9384613, PMID:9398735, PMID:9498388, PMID:9506724, PMID:9620546, PMID:9681850, PMID:9681851, PMID:9699127, PMID:9820617, PMID:9839497, PMID:9879991, PMID:9950371, PMID:10024437, PMID:10076558, PMID:10235148, PMID:10369718, PMID:10445857, PMID:10462620, PMID:10490816, PMID:10522989, PMID:10679286, PMID:11114642, PMID:11230481, PMID:11351254, PMID:11389085, PMID:11524247, PMID:11562352, PMID:11739416, PMID:11900218, PMID:11935126, PMID:11939755, PMID:11987030, PMID:12000816, PMID:12116277, PMID:12205548, PMID:12466368, PMID:12566528, PMID:12604374, PMID:12686527, PMID:12711285, PMID:12746565, PMID:12788868, PMID:12864791, PMID:14561794, PMID:14715928, PMID:14718397, PMID:15184865, PMID:15277225, PMID:15281979, PMID:15292360, PMID:15472167, PMID:15523405, PMID:15531714, PMID:15588376, PMID:15699703, PMID:15741265, PMID:15753368, PMID:15855933, PMID:15858153, PMID:15870131, PMID:16053382, PMID:16099853, PMID:16118333, PMID:16314641, PMID:16322339, PMID:16343097, PMID:16388093, PMID:16419493, PMID:16469774, PMID:16525712, PMID:16705552, PMID:16707008, PMID:16712668, PMID:16715139, PMID:16736292, PMID:16778204, PMID:16817830, PMID:16849421, PMID:16865647, PMID:16868135, PMID:17021738, PMID:17047083, PMID:17065770, PMID:17097365, PMID:17102080, PMID:17102083, PMID:17102091, PMID:17108110, PMID:17178962, PMID:17209045, PMID:17270543, PMID:17316110, PMID:17483988, PMID:17527003, PMID:17573899, PMID:17605401, PMID:17610518, PMID:17639058, PMID:17848262, PMID:17895320, PMID:17898100, PMID:18058472, PMID:18062802, PMID:18063059, PMID:18073307, PMID:18206480, PMID:18209889, PMID:18252215, PMID:18541894, PMID:18794325, PMID:18976013, PMID:19015274, PMID:19041016, PMID:19062722, PMID:19240193, PMID:19255327, PMID:19336503, PMID:19469690, PMID:19472011, PMID:19825962, PMID:19826964, PMID:19906784, PMID:20065189, PMID:20080836, PMID:20103606, PMID:20368568, PMID:20516206, PMID:20554711, PMID:20847059, PMID:20943719, PMID:20979234, PMID:21054478, PMID:21253810, PMID:21254918, PMID:21311890, PMID:21422799, PMID:21422803, PMID:21449769, PMID:21455200, PMID:21470995, PMID:21479187, PMID:21551259, PMID:21655256, PMID:21690267, PMID:21765987, PMID:21810974, PMID:21986619, PMID:22025146, PMID:22068382, PMID:22199277, PMID:22233172, PMID:22359510, PMID:22584710, PMID:22676344, PMID:22703879, PMID:22900816, PMID:22992277, PMID:23056499, PMID:23295303, PMID:23404858, PMID:23416954, PMID:23617071, PMID:23723040, PMID:23861463, PMID:24033266, PMID:24055113, PMID:24064755, PMID:24152999, PMID:24331334, PMID:24336963, PMID:24375508, PMID:24449023, PMID:24561444, PMID:24617864, PMID:24716929, PMID:24784869, PMID:24805091, PMID:24845513, PMID:25027091, PMID:25157968, PMID:25374962, PMID:25425582, PMID:25440022, PMID:25515555, PMID:25628771, PMID:25637381, PMID:25694125, PMID:25741868, PMID:25810047, PMID:25887804, PMID:25950813, PMID:26046350, PMID:26084817, PMID:26269449, PMID:26332594, PMID:26356818, PMID:26467025, PMID:26556299, PMID:26732158, PMID:27153395, PMID:27406704, PMID:27539324, PMID:27673361, PMID:27698838, PMID:27807060, PMID:27994876, PMID:28099363, PMID:28323957, PMID:28469506, PMID:28492532, PMID:28647780, PMID:28946813, PMID:28951487, PMID:29097883, PMID:29133048, PMID:29197744, PMID:29656518, PMID:30311386, PMID:30644554, PMID:30927507, PMID:31510104 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16108
    disease of cellular proliferation 5913
      Neoplasms by Histologic Type 3722
        Glandular and Epithelial Neoplasms 2309
          Ductal, Lobular, and Medullary Neoplasms 261
            Ductal Carcinoma + 221
            Medullary Carcinomas + 7
            breast lobular carcinoma + 14
            cutaneous Paget's disease + 1
            ductal carcinoma in situ + 49
            intraductal breast benign neoplasm + 0
            intraductal papilloma 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.