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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Experimental Autoimmune Myasthenia Gravis
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Accession:DOID:9008286 term browser browse the term
Definition:Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Synonyms:exact_synonym: EAMG;   Experimental Myasthenia;   Experimental Myasthenia Gravis;   Experimental Myasthenias;   Passive Transfer Experimental Autoimmune Myasthenia Gravis
 primary_id: MESH:D020720
 alt_id: RDO:0007422

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Experimental Autoimmune Myasthenia Gravis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc5 actin related protein 2/3 complex subunit 5 treatment ISO RGD PMID:17997938 RGD:11049469 NCBI chrNW_004936481:6,267,133...6,276,173
Ensembl chrNW_004936481:6,267,091...6,278,170 		JBrowse link
G C3 complement C3 ISO RGD PMID:147324 PMID:17962462 RGD:11040804 RGD:7401263 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G C6 complement C6 susceptibility ISO RGD PMID:17034580 RGD:1600670 NCBI chrNW_004936518:1,471,116...1,532,733
Ensembl chrNW_004936518:1,471,355...1,532,439 		JBrowse link
G Cd40lg CD40 ligand treatment ISO RGD PMID:11359850 RGD:8547800 NCBI chrNW_004936513:10,607,617...10,620,403
Ensembl chrNW_004936513:10,607,617...10,620,403 		JBrowse link
G Cfb complement factor B treatment ISO RGD PMID:25355917 RGD:11041161 NCBI chrNW_004936727:1,595,872...1,602,274
Ensembl chrNW_004936727:1,595,499...1,602,215 		JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit treatment ISO RGD PMID:10606626 RGD:704386 NCBI chrNW_004936509:4,452,382...4,470,658
Ensembl chrNW_004936509:4,452,616...4,470,658 		JBrowse link
G Ctsl cathepsin L ISO mRNA:increased expression:quadriceps (rat) RGD PMID:16365386 RGD:2315588 NCBI chrNW_004936680:3,047,355...3,050,640 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:15843529 PMID:19232748 RGD:1598501 RGD:2311364 NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO RGD PMID:15843529 RGD:1598501 NCBI chrNW_004936676:33,580...40,323
Ensembl chrNW_004936676:32,128...40,329 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:15843529 PMID:19232748 RGD:1598501 RGD:2311364 NCBI chrNW_004936762:66,636...69,694
Ensembl chrNW_004936762:66,636...69,373 		JBrowse link
G Il15 interleukin 15 ISO protein:increased expression:skeletal muscle RGD PMID:11585642 RGD:1626617 NCBI chrNW_004936535:6,344,348...6,358,803
Ensembl chrNW_004936535:6,344,395...6,350,197 		JBrowse link
G Il23r interleukin 23 receptor ISO mRNA:increased expression:lymph node RGD PMID:21193288 RGD:5108250 NCBI chrNW_004936591:4,365,598...4,425,053
Ensembl chrNW_004936591:4,365,762...4,425,005 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha ISO RGD PMID:18250419 RGD:2325986 NCBI chrNW_004936484:8,514,333...8,555,392
Ensembl chrNW_004936484:8,544,062...8,555,332 		JBrowse link
G Il4r interleukin 4 receptor ISO protein:increased expression:skeletal muscle RGD PMID:19395316 RGD:4889981 NCBI chrNW_004936501:11,025,590...11,058,807
Ensembl chrNW_004936501:11,025,567...11,058,818 		JBrowse link
G Musk muscle associated receptor tyrosine kinase ISO RGD PMID:17081697 RGD:2317084 NCBI chrNW_004936559:2,387,019...2,486,685
Ensembl chrNW_004936559:2,387,027...2,486,552 		JBrowse link
G Myog myogenin ISO RGD PMID:1312030 RGD:9686077 NCBI chrNW_004936567:1,507,042...1,509,814
Ensembl chrNW_004936567:1,507,042...1,509,815 		JBrowse link
G Rapsn receptor associated protein of the synapse ISO protein:decreased expression:neuromuscular junction RGD PMID:19344765 RGD:8549750 NCBI chrNW_004936562:1,796,087...1,804,153
Ensembl chrNW_004936562:1,795,905...1,804,181 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14569
    Animal Diseases 1218
      Animal Disease Models 1180
        Experimental Nervous System Autoimmune Disease 175
          Experimental Autoimmune Myasthenia Gravis 17
Path 2
Term Annotations click to browse term
  disease 14569
    disease of anatomical entity 14271
      Immune & Inflammatory Diseases 4892
        immune system disease 4261
          primary immunodeficiency disease 3697
            autoimmune disease 1941
              autoimmune disease of the nervous system 561
                autoimmune disease of peripheral nervous system 49
                  myasthenia gravis 30
                    Experimental Autoimmune Myasthenia Gravis 17
paths to the root