Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Experimental Autoimmune Myasthenia Gravis
go back to main search page
Accession:DOID:9008286 term browser browse the term
Definition:Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Synonyms:exact_synonym: EAMG;   Experimental Myasthenia;   Experimental Myasthenia Gravis;   Experimental Myasthenias;   Passive Transfer Experimental Autoimmune Myasthenia Gravis
 primary_id: MESH:D020720
 alt_id: RDO:0007422


show annotations for term's descendants           Sort by:
Experimental Autoimmune Myasthenia Gravis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARPC5 actin related protein 2/3 complex subunit 5 treatment ISO RGD PMID:17997938 RGD:11049469 NCBI chr 9:124,839,062...124,847,906
Ensembl chr 9:124,837,765...124,848,105 		JBrowse link
G C3 complement C3 ISO RGD PMID:147324 PMID:17962462 RGD:11040804 RGD:7401263 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G C6 complement C6 susceptibility ISO RGD PMID:17034580 RGD:1600670 NCBI chr16:26,023,646...26,089,518
Ensembl chr16:26,020,628...26,084,652 		JBrowse link
G CD40LG CD40 ligand treatment ISO RGD PMID:11359850 RGD:8547800 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,709 		JBrowse link
G CFB complement factor B treatment ISO RGD PMID:25355917 RGD:11041161 NCBI chr 7:24,034,077...24,040,523
Ensembl chr 7:24,033,740...24,041,179 		JBrowse link
G CHRNA1 cholinergic receptor nicotinic alpha 1 subunit treatment ISO RGD PMID:10606626 RGD:704386 NCBI chr15:80,673,072...80,692,256
Ensembl chr15:80,673,067...80,692,208 		JBrowse link
G CTSL cathepsin L ISO mRNA:increased expression:quadriceps (rat) RGD PMID:16365386 RGD:2315588 NCBI chr10:27,668,523...27,674,705
Ensembl chr10:27,668,264...27,674,618 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:15843529 PMID:19232748 RGD:1598501 RGD:2311364 NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 ISO RGD PMID:15843529 RGD:1598501 NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:15843529 PMID:19232748 RGD:1598501 RGD:2311364 NCBI chr  X:57,592,032...57,595,706
Ensembl chr  X:57,592,038...57,595,692 		JBrowse link
G IL15 interleukin 15 ISO protein:increased expression:skeletal muscle RGD PMID:11585642 RGD:1626617 NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461 		JBrowse link
G IL23R interleukin 23 receptor ISO mRNA:increased expression:lymph node RGD PMID:21193288 RGD:5108250 NCBI chr 6:145,337,765...145,401,909
Ensembl chr 6:145,335,741...145,401,510 		JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISO RGD PMID:18250419 RGD:2325986 NCBI chr10:64,948,149...65,001,320
Ensembl chr10:64,948,563...65,001,142 		JBrowse link
G IL4R interleukin 4 receptor ISO protein:increased expression:skeletal muscle RGD PMID:19395316 RGD:4889981 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G MUSK muscle associated receptor tyrosine kinase ISO RGD PMID:17081697 RGD:2317084 NCBI chr 1:251,650,151...251,758,538
Ensembl chr 1:251,650,710...251,756,608 		JBrowse link
G MYOG myogenin ISO RGD PMID:1312030 RGD:9686077 NCBI chr 9:113,783,233...113,785,312
Ensembl chr 9:113,782,284...113,787,340 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15346
    Animal Diseases 1302
      Animal Disease Models 1256
        Experimental Nervous System Autoimmune Disease 184
          Experimental Autoimmune Myasthenia Gravis 16
Path 2
Term Annotations click to browse term
  disease 15346
    disease of anatomical entity 15037
      Immune & Inflammatory Diseases 5129
        immune system disease 4447
          primary immunodeficiency disease 3862
            autoimmune disease 2016
              autoimmune disease of the nervous system 586
                autoimmune disease of peripheral nervous system 52
                  myasthenia gravis 29
                    Experimental Autoimmune Myasthenia Gravis 16
paths to the root