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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Experimental Autoimmune Myasthenia Gravis
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Accession:DOID:9008286 term browser browse the term
Definition:Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Synonyms:exact_synonym: EAMG;   Experimental Myasthenia;   Experimental Myasthenia Gravis;   Experimental Myasthenias;   Passive Transfer Experimental Autoimmune Myasthenia Gravis
 primary_id: MESH:D020720
 alt_id: RDO:0007422


show annotations for term's descendants           Sort by:
Experimental Autoimmune Myasthenia Gravis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc5 actin related protein 2/3 complex, subunit 5 treatment ISO RGD PMID:17997938 RGD:11049469 NCBI chr 1:152,642,293...152,651,331
Ensembl chr 1:152,642,293...152,651,348 		JBrowse link
G C3 complement component 3 IEP
ISO		 RGD PMID:17962462 PMID:147324 RGD:7401263, RGD:11040804 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G C6 complement component 6 susceptibility ISO RGD PMID:17034580 RGD:1600670 NCBI chr15:4,756,550...4,833,527
Ensembl chr15:4,756,657...4,844,449 		JBrowse link
G Cd40lg CD40 ligand treatment ISO RGD PMID:11359850 RGD:8547800 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cfb complement factor B treatment ISO RGD PMID:25355917 RGD:11041161 NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494 		JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit treatment ISO RGD PMID:10606626 RGD:704386 NCBI chr 2:73,393,625...73,410,682
Ensembl chr 2:73,393,559...73,410,682 		JBrowse link
G Ctsl cathepsin L ISO mRNA:increased expression:quadriceps (rat) RGD PMID:16365386 RGD:2315588 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:19232748 PMID:15843529 RGD:2311364, RGD:1598501 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO RGD PMID:15843529 RGD:1598501 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:19232748 RGD:2311364 NCBI chr  X:100,775,141...100,777,753
Ensembl chr  X:100,775,141...100,777,875 		JBrowse link
G Il15 interleukin 15 ISO protein:increased expression:skeletal muscle RGD PMID:11585642 RGD:1626617 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851 		JBrowse link
G Il23r interleukin 23 receptor ISO mRNA:increased expression:lymph node RGD PMID:21193288 RGD:5108250 NCBI chr 6:67,399,906...67,468,838
Ensembl chr 6:67,399,916...67,468,839 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain ISO RGD PMID:18250419 RGD:2325986 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Il4ra interleukin 4 receptor, alpha ISO protein:increased expression:skeletal muscle RGD PMID:19395316 RGD:4889981 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646 		JBrowse link
G Musk muscle, skeletal, receptor tyrosine kinase ISO RGD PMID:17081697 RGD:2317084 NCBI chr 4:58,285,742...58,377,848
Ensembl chr 4:58,285,962...58,374,303 		JBrowse link
G Myog myogenin ISO RGD PMID:1312030 RGD:9686077 NCBI chr 1:134,217,742...134,220,286
Ensembl chr 1:134,217,727...134,220,286 		JBrowse link
G Rapsn receptor-associated protein of the synapse ISO protein:decreased expression:neuromuscular junction RGD PMID:19344765 RGD:8549750 NCBI chr 2:90,864,594...90,876,074
Ensembl chr 2:90,865,965...90,876,074 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16178
    Animal Diseases 1400
      Animal Disease Models 1350
        Experimental Nervous System Autoimmune Disease 192
          Experimental Autoimmune Myasthenia Gravis 17
Path 2
Term Annotations click to browse term
  disease 16178
    disease of anatomical entity 15792
      Immune & Inflammatory Diseases 5354
        immune system disease 4628
          primary immunodeficiency disease 4023
            autoimmune disease 2111
              autoimmune disease of the nervous system 608
                autoimmune disease of peripheral nervous system 57
                  myasthenia gravis 34
                    Experimental Autoimmune Myasthenia Gravis 17
paths to the root