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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Experimental Autoimmune Myasthenia Gravis
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Accession:DOID:9008286 term browser browse the term
Definition:Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3)
Synonyms:exact_synonym: EAMG;   Experimental Myasthenia;   Experimental Myasthenia Gravis;   Experimental Myasthenias;   Passive Transfer Experimental Autoimmune Myasthenia Gravis
 primary_id: MESH:D020720
 alt_id: RDO:0007422


show annotations for term's descendants           Sort by:
Experimental Autoimmune Myasthenia Gravis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARPC5 actin related protein 2/3 complex subunit 5 treatment ISO RGD PMID:17997938 RGD:11049469 NCBI chr 7:16,976,392...16,986,015
Ensembl chr 7:16,977,555...16,985,943 		JBrowse link
G C3 complement C3 ISO RGD PMID:147324 PMID:17962462 RGD:11040804 RGD:7401263 NCBI chr20:53,566,226...53,598,365
Ensembl chr20:53,566,261...53,598,761 		JBrowse link
G C6 complement C6 susceptibility ISO RGD PMID:17034580 RGD:1600670 NCBI chr 4:68,223,626...68,318,773
Ensembl chr 4:68,253,255...68,318,252 		JBrowse link
G CD40LG CD40 ligand treatment ISO RGD PMID:11359850 RGD:8547800 NCBI chr  X:107,001,421...107,023,007
Ensembl chr  X:107,010,890...107,023,006 		JBrowse link
G CFB complement factor B treatment ISO RGD PMID:25355917 RGD:11041161 NCBI chr12:1,400,143...1,406,267 JBrowse link
G CHRNA1 cholinergic receptor nicotinic alpha 1 subunit treatment ISO RGD PMID:10606626 RGD:704386 NCBI chr36:18,726,243...18,742,505
Ensembl chr36:18,726,243...18,742,505 		JBrowse link
G CTSL3 cathepsin L family member 3 ISO mRNA:increased expression:quadriceps (rat) RGD PMID:16365386 RGD:2315588 NCBI chr 1:72,215,774...72,219,093 JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 ISO RGD PMID:15843529 PMID:19232748 RGD:1598501 RGD:2311364 NCBI chr32:598,406...599,925
Ensembl chr32:597,987...599,979 		JBrowse link
G CXCR3 C-X-C motif chemokine receptor 3 ISO RGD PMID:15843529 PMID:19232748 RGD:1598501 RGD:2311364 NCBI chr  X:55,882,433...55,884,582
Ensembl chr  X:55,882,433...55,884,582 		JBrowse link
G IL15 interleukin 15 ISO protein:increased expression:skeletal muscle RGD PMID:11585642 RGD:1626617 NCBI chr19:1,339,607...1,364,762
Ensembl chr19:1,339,967...1,364,762 		JBrowse link
G IL23R interleukin 23 receptor ISO mRNA:increased expression:lymph node RGD PMID:21193288 RGD:5108250 NCBI chr 5:43,307,422...43,369,806
Ensembl chr 5:43,308,982...43,368,474 		JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISO RGD PMID:18250419 RGD:2325986 NCBI chr 2:29,892,130...29,948,926
Ensembl chr 2:29,894,125...29,944,643 		JBrowse link
G IL4R interleukin 4 receptor ISO protein:increased expression:skeletal muscle RGD PMID:19395316 RGD:4889981 NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291 		JBrowse link
G MUSK muscle associated receptor tyrosine kinase ISO RGD PMID:17081697 RGD:2317084 NCBI chr11:65,552,320...65,642,165
Ensembl chr11:65,551,889...65,642,349 		JBrowse link
G MYOG myogenin ISO RGD PMID:1312030 RGD:9686077 NCBI chr 7:112,116...114,604
Ensembl chr 7:112,034...113,892 		JBrowse link
G RAPSN receptor associated protein of the synapse ISO protein:decreased expression:neuromuscular junction RGD PMID:19344765 RGD:8549750 NCBI chr18:42,199,160...42,210,668
Ensembl chr18:42,199,412...42,210,673 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17774
    Animal Diseases 1331
      Animal Disease Models 1284
        Experimental Nervous System Autoimmune Disease 188
          Experimental Autoimmune Myasthenia Gravis 16
Path 2
Term Annotations click to browse term
  disease 17774
    disease of anatomical entity 15146
      Immune & Inflammatory Diseases 5006
        immune system disease 4334
          primary immunodeficiency disease 3733
            autoimmune disease 1992
              autoimmune disease of the nervous system 558
                autoimmune disease of peripheral nervous system 55
                  myasthenia gravis 31
                    Experimental Autoimmune Myasthenia Gravis 16
paths to the root