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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Seasonal Allergic Rhinitis
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Accession:DOID:9008103 term browser browse the term
Definition:Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.
Synonyms:exact_synonym: hay fever;   hayfever;   pollinoses;   pollinosis;   seasonal allergic rhinitides
 primary_id: MESH:D006255
 xref: EFO:0003956


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Seasonal Allergic Rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:16677242 RGD:5147463 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Apoa4 apolipoprotein A-IV resistance ISO protein:increased expression:blood serum (human) RGD PMID:20810159 RGD:5685642 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757 		JBrowse link
G Bdnf brain derived neurotrophic factor severity ISO protein:increased expression:blood, nasal cavity epithelium RGD PMID:18266897 RGD:5144117 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:inferior turbinate, epithelium (human) RGD PMID:20459697 RGD:4891379 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Cma1 chymase 1, mast cell ISO protein:increased expression:nasal mucosa, mast cell (human) RGD PMID:11549546 RGD:5128839 NCBI chr14:56,178,908...56,182,132
Ensembl chr14:56,178,908...56,182,132 		JBrowse link
G Fga fibrinogen alpha chain ISO RGD PMID:21887273 RGD:5688767 NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO protein:decreased expression;T lymphocyte: RGD PMID:21410266 RGD:5491008 NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*05 (human)
DNA:polymorphisms, haplotype:cds:HLA-DQB1*0301, HLA-DQB1*0501 (human)		 RGD PMID:22032123 PMID:9641569 RGD:7421561, RGD:7421576 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased secretion:nasopharynx, secretion (human) RGD PMID:20128420 RGD:4145459 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifngr1 interferon gamma receptor 1 ISO DNA: SNP: Leu467Pro RGD PMID:12851715 RGD:6480431 NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:19505388 RGD:7365025 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il18 interleukin 18 susceptibility
no_association		 ISO DNA:SNPs:promoters, exon:multiple
DNA:SNPs:promoters:multiple		 RGD PMID:12532106 PMID:12532106 RGD:8655871, RGD:8655871 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il4 interleukin 4 ISO protein:increased expression:serum
mRNA:increased expression:nose:		 RGD PMID:9237816 PMID:7551298 RGD:7829817, RGD:8662960 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Kdr kinase insert domain protein receptor ISO protein:increased expression:nasal cavity of mucosa: RGD PMID:17651148 RGD:8551771 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Mc1r melanocortin 1 receptor no_association IEP RGD PMID:20357480 RGD:5687317 NCBI chr 8:124,133,839...124,137,483
Ensembl chr 8:124,133,846...124,137,483 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO DNA:SNPs:promoter, intron, cds:-1590C>T, 2127G>T, p.R668Q (rs3918242, rs2274755, rs17577) (human) RGD PMID:22237587 RGD:8547819 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 susceptibility ISO DNA:SNP: :rs2075817 (human) RGD PMID:16918516 RGD:5131519 NCBI chr 6:54,900,927...54,949,655
Ensembl chr 6:54,900,934...54,949,597 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 susceptibility ISO DNA:polymorphisms:5'UTR/exon, exon:rs5743266, rs2066842 (human) RGD PMID:16008671 RGD:5131477 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:respiratory system epithelium RGD PMID:19364335 RGD:5147461 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Scgb1a1 secretoglobin, family 1A, member 1 ISO mRNA, protein:decreased expression:nasal lavage fluid RGD PMID:15836756 RGD:5144234 NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322 		JBrowse link
G Tlr3 toll-like receptor 3 ISO protein:decreased expression:bone marrow, blood, eosinophil (human) RGD PMID:19752565 RGD:5129130 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:polymorphisms:cds:p.D299G, T399I (human) RGD PMID:18517079 RGD:4144192 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA,protein:increased expression:nasal biopsies,nasal lavage fluid: RGD PMID:12633568 RGD:7483595 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16193
    disease of anatomical entity 15759
      respiratory system disease 3556
        respiratory allergy 388
          allergic rhinitis 83
            Seasonal Allergic Rhinitis 23
              pollen allergy + 0
Path 2
Term Annotations click to browse term
  disease 16193
    Pathological Conditions, Signs and Symptoms 12529
      Signs and Symptoms 10387
        Neurologic Manifestations 10062
          sensory system disease 7036
            Otorhinolaryngologic Diseases 1782
              nose disease 234
                nasal cavity disease 187
                  rhinitis 155
                    allergic rhinitis 83
                      Seasonal Allergic Rhinitis 23
                        pollen allergy + 0
paths to the root