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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Seasonal Allergic Rhinitis
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Accession:DOID:9008103 term browser browse the term
Definition:Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.
Synonyms:exact_synonym: hay fever;   hayfever;   pollinoses;   pollinosis;   seasonal allergic rhinitides
 primary_id: MESH:D006255
 xref: EFO:0003956


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Seasonal Allergic Rhinitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase IEP RGD PMID:16677242 RGD:5147463 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G APOA4 apolipoprotein A4 resistance IEP protein:increased expression:blood serum (human) RGD PMID:20810159 RGD:5685642 NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304 		JBrowse link
G BDNF brain derived neurotrophic factor severity IEP protein:increased expression:blood, nasal cavity epithelium RGD PMID:18266897 RGD:5144117 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 IEP protein:increased expression:inferior turbinate, epithelium (human) RGD PMID:20459697 RGD:4891379 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CMA1 chymase 1 IEP protein:increased expression:nasal mucosa, mast cell (human) RGD PMID:11549546 RGD:5128839 NCBI chr14:24,505,353...24,508,265
Ensembl chr14:24,505,353...24,508,265 		JBrowse link
G CST1 cystatin SN EXP CTD Direct Evidence: marker/mechanism CTD PMID:23950865 NCBI chr20:23,747,562...23,750,935
Ensembl chr20:23,747,562...23,751,268 		JBrowse link
G FGA fibrinogen alpha chain IDA RGD PMID:21887273 RGD:5688767 NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,126...154,590,742 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 IEP protein:decreased expression;T lymphocyte: RGD PMID:21410266 RGD:5491008 NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459 		JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility IAGP DNA:polymorphism:cds:HLA-DQB1*05 (human)
DNA:polymorphisms, haplotype:cds:HLA-DQB1*0301, HLA-DQB1*0501 (human)		 RGD PMID:22032123 PMID:9641569 RGD:7421561, RGD:7421576 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 IEP protein:increased secretion:nasopharynx, secretion (human) RGD PMID:20128420 RGD:4145459 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNGR1 interferon gamma receptor 1 IAGP DNA: SNP: Leu467Pro RGD PMID:12851715 RGD:6480431 NCBI chr 6:137,197,484...137,219,385
Ensembl chr 6:137,197,483...137,219,449 		JBrowse link
G IL10 interleukin 10 treatment IEP RGD PMID:19505388 RGD:7365025 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL18 interleukin 18 susceptibility
no_association		 IAGP DNA:SNPs:promoters, exon:multiple
DNA:SNPs:promoters:multiple		 RGD PMID:12532106 PMID:12532106 RGD:8655871, RGD:8655871 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL4 interleukin 4 IEP protein:increased expression:serum
mRNA:increased expression:nose:		 RGD PMID:9237816 PMID:7551298 RGD:7829817, RGD:8662960 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G KDR kinase insert domain receptor IEP protein:increased expression:nasal cavity of mucosa: RGD PMID:17651148 RGD:8551771 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G MC1R melanocortin 1 receptor no_association ISO RGD PMID:20357480 RGD:5687317 NCBI chr16:89,918,862...89,920,972
Ensembl chr16:89,912,119...89,920,973 		JBrowse link
G MMP9 matrix metallopeptidase 9 IAGP DNA:SNPs:promoter, intron, cds:-1590C>T, 2127G>T, p.R668Q (rs3918242, rs2274755, rs17577) (human) RGD PMID:22237587 RGD:8547819 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 susceptibility IAGP DNA:SNP: :rs2075817 (human) RGD PMID:16918516 RGD:5131519 NCBI chr 7:30,424,527...30,478,784
Ensembl chr 7:30,424,527...30,478,784 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 susceptibility IAGP DNA:polymorphisms:5'UTR/exon, exon:rs5743266, rs2066842 (human) RGD PMID:16008671 RGD:5131477 NCBI chr16:50,693,606...50,733,075
Ensembl chr16:50,693,588...50,733,077 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 IEP protein:increased expression:respiratory system epithelium RGD PMID:19364335 RGD:5147461 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 IEP mRNA, protein:decreased expression:nasal lavage fluid RGD PMID:15836756 RGD:5144234 NCBI chr11:62,419,033...62,423,195
Ensembl chr11:62,405,103...62,423,195 		JBrowse link
G TLR3 toll like receptor 3 IEP protein:decreased expression:bone marrow, blood, eosinophil (human) RGD PMID:19752565 RGD:5129130 NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,068,911...186,088,073 		JBrowse link
G TLR4 toll like receptor 4 susceptibility IAGP DNA:polymorphisms:cds:p.D299G, T399I (human) RGD PMID:18517079 RGD:4144192 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G VEGFA vascular endothelial growth factor A IEP mRNA,protein:increased expression:nasal biopsies,nasal lavage fluid: RGD PMID:12633568 RGD:7483595 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 97557
    disease of anatomical entity 91096
      respiratory system disease 10490
        respiratory allergy 1237
          allergic rhinitis 479
            Seasonal Allergic Rhinitis 71
              pollen allergy + 0
Path 2
Term Annotations click to browse term
  disease 97557
    Pathological Conditions, Signs and Symptoms 53684
      Signs and Symptoms 35181
        Neurologic Manifestations 31832
          sensory system disease 20899
            Otorhinolaryngologic Diseases 3878
              nose disease 743
                nasal cavity disease 632
                  rhinitis 596
                    allergic rhinitis 479
                      Seasonal Allergic Rhinitis 71
                        pollen allergy + 0
paths to the root