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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Sleep Deprivation
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Accession:DOID:9007980 term browser browse the term
Definition:The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.
Synonyms:exact_synonym: Insufficient Sleep Syndrome;   Insufficient Sleep Syndromes;   REM Sleep Deprivation;   REM Sleep Deprivations;   Sleep Deprivations;   Sleep Fragmentation;   Sleep Fragmentations
 primary_id: MESH:D012892
 alt_id: RDO:0006585
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
Sleep Deprivation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BACE1 beta-secretase 1 ISO protein:increased expression:brain: RGD PMID:28455102 RGD:13782059 NCBI chr 5:16,308,953...16,319,100
Ensembl chr 5:16,308,944...16,319,100
JBrowse link
G BDNF brain derived neurotrophic factor treatment ISO RGD PMID:25450575 RGD:10059355 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480
JBrowse link
G CTSH cathepsin H ISO RGD PMID:17027151 RGD:2306498 NCBI chr 3:58,103,284...58,113,958
Ensembl chr 3:58,103,291...58,113,718
JBrowse link
G DLAT dihydrolipoamide S-acetyltransferase ISO mRNA:decreased expression:cerebral cortex RGD PMID:16923172 RGD:2313667 NCBI chr 5:21,062,833...21,094,235
Ensembl chr 5:21,064,026...21,094,153
JBrowse link
G DRD1 dopamine receptor D1 ISO protein:increased expression:hypothalamus RGD PMID:25433096 RGD:13506946 NCBI chr 4:37,550,454...37,554,641
Ensembl chr 4:37,549,708...37,553,287
JBrowse link
G EEF2 eukaryotic translation elongation factor 2 ISO protein:hyperphosphorylation:prefrontal cortex, dentate gyrus; RGD PMID:22917528 RGD:10401259 NCBI chr20:55,577,413...55,586,422
Ensembl chr20:55,522,213...55,586,126
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B ISO protein:decreased expression:hippocampus (rat) RGD PMID:20237303 RGD:4107020 NCBI chr27:32,470,889...32,883,606
Ensembl chr27:32,471,153...32,877,680
JBrowse link
G GSR glutathione-disulfide reductase ISO protein:increased expression:hippocampus, cortex, amygdala: RGD PMID:21621560 RGD:11059509 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
G JPH3 junctophilin 3 ISO mRNA:increased expression:brain RGD PMID:18077435 RGD:6480426 NCBI chr 5:65,445,329...65,530,288
Ensembl chr 5:65,451,050...65,530,294
JBrowse link
G LOC607874 cystatin-C-like ISO RGD PMID:17027151 RGD:2306498 NCBI chr23:49,562...53,618 JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 ISO mRNA, protein:decreased expression:mandible condylar process RGD PMID:23859770 RGD:7495827 NCBI chr 5:36,142,610...36,243,673
Ensembl chr 5:36,118,388...36,241,296
JBrowse link
G MIR223 microRNA mir-223 ISO RGD PMID:30225174 RGD:25824951 NCBI chr  X:50,838,131...50,838,233
Ensembl chr  X:50,838,131...50,838,233
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase ISO RNA:increased expression:liver: RGD PMID:28860003 RGD:13781877 NCBI chr18:14,110,045...14,211,268
Ensembl chr18:13,993,022...14,208,657
JBrowse link
G NGB neuroglobin ISO protein:decreased expression:brain RGD PMID:23262504 RGD:9743966 NCBI chr 8:50,081,960...50,086,071
Ensembl chr 8:50,081,960...50,085,435
JBrowse link
G NRGN neurogranin ISO RGD PMID:7583240 RGD:9835425 NCBI chr 5:9,673,107...9,679,819
Ensembl chr 5:9,673,809...9,679,799
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16343605 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO mRNA:increased expression:brain RGD PMID:18077435 RGD:6480426 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14860
    disease of anatomical entity 14527
      nervous system disease 12337
        Neurologic Manifestations 6006
          sleep disorder 141
            Dyssomnias 116
              Sleep Deprivation 17
Path 2
Term Annotations click to browse term
  disease 14860
    disease of anatomical entity 14527
      nervous system disease 12337
        central nervous system disease 10809
          brain disease 10149
            disease of mental health 7320
              sleep disorder 141
                Dyssomnias 116
                  Sleep Deprivation 17
paths to the root