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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Mononegavirales Infections
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Accession:DOID:9007829 term browser browse the term
Definition:Infections with viruses of the order MONONEGAVIRALES. The concept includes FILOVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; and RHABDOVIRIDAE INFECTIONS.
Synonyms:exact_synonym: Mononegavirales Infection
 primary_id: MESH:D018701;   RDO:0005036
For additional species annotation, visit the Alliance of Genome Resources.

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borna disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldoc aldolase, fructose-bisphosphate C ISO mRNA, protein:decreased expression:cerebellum, Purkinje cell RGD PMID:17182680 RGD:2301132 NCBI chrNW_004936538:4,798,991...4,802,700 JBrowse link
G Atf4 activating transcription factor 4 ISO protein:increased expression:cerebellum RGD PMID:16912310 RGD:32733622 NCBI chrNW_004936492:2,114,478...2,115,969 JBrowse link
G Atf6 activating transcription factor 6 ISO protein:increased expression:cerebellum, hippocampus RGD PMID:16912310 RGD:32733622 NCBI chrNW_004937131:170,649...183,942 JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO RGD PMID:16612977 RGD:2289373 NCBI chrNW_004936533:2,949,026...3,033,166 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:12053272 RGD:4891998 NCBI chrNW_004936475:9,443,851...9,454,715 JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO mRNA:increased expression:brain RGD PMID:12053272 RGD:4891998 NCBI chrNW_004936473:28,508,726...28,535,640 JBrowse link
G Ddit3 DNA damage inducible transcript 3 ISO mRNA,protein:increased expression:cerebellum, hippocampus RGD PMID:16912310 RGD:32733622 NCBI chrNW_004936646:1,665,019...1,669,212 JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO protein:increased expression:cerebellum,hippocampus RGD PMID:16912310 RGD:32733622 NCBI chrNW_004936758:960,305...992,152 JBrowse link
G Gja1 gap junction protein alpha 1 ISO RGD PMID:18538309 RGD:7364785 NCBI chrNW_004936658:3,920,043...3,932,987 JBrowse link
G Gjb6 gap junction protein beta 6 ISO RGD PMID:18538309 RGD:7364785 NCBI chrNW_004936720:1,485,895...1,494,673 JBrowse link
G Il16 interleukin 16 ISO protein:increased expression:brain RGD PMID:14698845 RGD:1354526 NCBI chrNW_004936483:19,417,580...19,512,654 JBrowse link
G Mif macrophage migration inhibitory factor ISO protein:increased expression:astrocyte RGD PMID:11870869 RGD:1642006 NCBI chrNW_004936619:1,207,058...1,208,010 JBrowse link
G Mt3 metallothionein 3 ISO RGD PMID:16612977 RGD:2289373 NCBI chrNW_004936475:8,864,512...8,866,516 JBrowse link
G Parg poly(ADP-ribose) glycohydrolase ISO mRNA:decreased expression:hippocampus RGD PMID:18057239 RGD:2316738 NCBI chrNW_004936728:428,028...538,413 JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 ISO mRNA,protein:increased expression,increased activity:neuron, glial cell: RGD PMID:18057239 RGD:2316738 NCBI chrNW_004936526:3,102,468...3,147,601 JBrowse link
G Slc6a4 solute carrier family 6 member 4 ISO protein:increased expression:brain (rat) RGD PMID:12106671 RGD:38549588 NCBI chrNW_004936538:6,205,268...6,239,062 JBrowse link
G Xbp1 X-box binding protein 1 ISO mRNA,protein:altered expression:cerebellum,hippocampus RGD PMID:16912310 RGD:32733622 NCBI chrNW_004936657:2,891,171...2,895,409 JBrowse link
Ebola hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il3 interleukin 3 ISO protein: reduced expression: plasma RGD PMID:20957152 RGD:5686879 NCBI chrNW_004936647:3,102,922...3,104,758 JBrowse link
measles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2-microglobulin ISO protein:increased expression:plasma RGD PMID:1402029 RGD:6482707 NCBI chrNW_004936471:7,646,504...7,655,656 JBrowse link
G Cd46 CD46 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:8402913 NCBI chrNW_004936557:5,136,784...5,175,543 JBrowse link
G Muc1 mucin 1, cell surface associated severity ISO protein:increased expression:serum RGD PMID:11802251 RGD:5131281 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
Metapneumovirus infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mavs mitochondrial antiviral signaling protein severity ISO RGD PMID:25953917 RGD:40903044 NCBI chrNW_004936485:14,842,778...14,859,163 JBrowse link
Nasu-Hakola disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101962495 transmembrane immune signaling adaptor TYROBP ISO ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 OMIM
ClinVar		 PMID:10888890 PMID:11109371 PMID:12370476 PMID:15883308 PMID:17125796 More... NCBI chrNW_004936570:457,993...460,735 JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 ClinVar PMID:12080485 PMID:12754369 PMID:12925681 PMID:15883308 PMID:18546367 More... NCBI chrNW_004936476:18,659,725...18,665,406 JBrowse link
Paramyxoviridae Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased expression:nasal mucus (human) RGD PMID:20182399 RGD:4891406 NCBI chrNW_004936490:253,279...259,947 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO RGD PMID:20053825 RGD:4891886 NCBI chrNW_004936475:9,443,851...9,454,715 JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:nasal mucus RGD PMID:20182399 RGD:4891406 NCBI chrNW_004936676:33,580...40,323 JBrowse link
Pneumovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il21 interleukin 21 ISO mRNA:increased expression:lung (mouse) RGD PMID:22238461 RGD:6892925 NCBI chrNW_004936662:1,689,879...1,696,883 JBrowse link
G Il21r interleukin 21 receptor ISO RGD PMID:22238461 RGD:6892925 NCBI chrNW_004936501:11,100,170...11,112,112 JBrowse link
G Pdcd1 programmed cell death 1 treatment ISO associated with reinfection RGD PMID:25339663 RGD:40822811 NCBI chrNW_004936745:152,571...163,712 JBrowse link
rabies term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2n1 calcium/calmodulin dependent protein kinase II inhibitor 1 ISO RGD PMID:17010311 RGD:18337278 NCBI chrNW_004936474:6,463,691...6,466,641 JBrowse link
G Cd274 CD274 molecule ISO RGD PMID:18490751 RGD:41410795 NCBI chrNW_004936539:132,870...145,288 JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO RGD PMID:9696812 RGD:40907065 NCBI chrNW_004936612:1,262,557...1,556,281 JBrowse link
G Nefh neurofilament heavy chain ISO protein:increased expression:spinal cord: RGD PMID:29509660 RGD:27226884 NCBI chrNW_004936657:3,443,406...3,453,096 JBrowse link
respiratory syncytial virus infectious disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 treatment
severity		 ISO human protein in a mouse model RGD PMID:26813885 RGD:32716392 NCBI chrNW_004936470:4,964,526...5,011,808 JBrowse link
G Aicda activation induced cytidine deaminase treatment ISO RGD PMID:27721128 RGD:127285642 NCBI chrNW_004936870:25,039...34,601 JBrowse link
G Ccl1 C-C motif chemokine ligand 1 ISO mRNA:increased expression:lung RGD PMID:11134301 RGD:4891417 NCBI chrNW_004936538:781,687...784,199 JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO mRNA:increased expression:lung RGD PMID:17641031 RGD:4145495 NCBI chrNW_004936475:9,475,013...9,476,326 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:altered expression:lung, T cell (mouse) RGD PMID:19124761 RGD:4891880 NCBI chrNW_004936490:253,279...259,947 JBrowse link
G Cd274 CD274 molecule severity ISO protein:increased expression: lung RGD PMID:25465101 RGD:11056952 NCBI chrNW_004936539:132,870...145,288 JBrowse link
G Cd28 CD28 molecule ISO RGD PMID:18056387 RGD:5131621 NCBI chrNW_004936631:335,411...363,407 JBrowse link
G Cftr CF transmembrane conductance regulator ISO DNA:mutation: : RGD PMID:20015999 RGD:4140389 NCBI chrNW_004936589:1,565,933...1,719,208 JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 severity ISO RGD PMID:12941892 PMID:16424189 RGD:4892016 RGD:4892018 NCBI chrNW_004936473:28,508,726...28,535,640 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:18624292 RGD:5135483 NCBI chrNW_004936676:60,869...63,028 JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:15916706 RGD:5135444 NCBI chrNW_004936676:33,580...40,323 JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:18624292 RGD:5135483 NCBI chrNW_004936762:66,636...69,694 JBrowse link
G Dnase1 deoxyribonuclease 1 ISO CTD Direct Evidence: therapeutic CTD PMID:28780505 NCBI chrNW_004936694:704,948...715,846 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism
protein:increased secretion:nasopharynx		 CTD
RGD		 PMID:17425601 PMID:20209309 RGD:4140425 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Ifng interferon gamma ISO associated with Otitis media;protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19352211 PMID:21937650 RGD:8142352 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il10 interleukin 10 severity ISO RGD PMID:20209309 RGD:4140425 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il13 interleukin 13 ISO RGD PMID:18250447 RGD:4145641 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il17a interleukin 17A severity ISO protein:increased expression:plasma RGD PMID:19738511 RGD:4889103 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il18 interleukin 18 ISO DNA:polymorphism:intron:rs360721 (human) RGD PMID:18043444 PMID:20130064 RGD:4889550 RGD:4889584 NCBI chrNW_004936612:2,306,963...2,325,086 JBrowse link
G Il1rl1 interleukin 1 receptor like 1 ISO RGD PMID:11283151 RGD:5144238 NCBI chrNW_004936713:1,020,969...1,035,012 JBrowse link
G Il27 interleukin 27 ameliorates ISO RGD PMID:22301139 RGD:126790525 NCBI chrNW_004936501:11,972,715...11,978,152 JBrowse link
G Il2ra interleukin 2 receptor subunit alpha ISO RGD PMID:20639494 RGD:5147443 NCBI chrNW_004936484:8,514,333...8,555,392 JBrowse link
G Il33 interleukin 33 ISO RGD PMID:26044350 PMID:28771101 RGD:11342984 RGD:39939029 NCBI chrNW_004936539:763,755...791,461 JBrowse link
G Il5 interleukin 5 severity ISO RGD PMID:25410867 RGD:11354937 NCBI chrNW_004936647:2,647,982...2,651,477 JBrowse link
G Il5ra interleukin 5 receptor subunit alpha ISO protein:decreased expression:blood, eosinophil RGD PMID:16734609 RGD:5128618 NCBI chrNW_004936577:2,776,608...2,797,303 JBrowse link
G Il6 interleukin 6 severity ISO protein:increased expression:nasal mucus
associated with Otitis media;protein:increased expression:serum:		 RGD PMID:19352211 PMID:20622030 RGD:4143259 RGD:8142352 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Il9 interleukin 9 susceptibility ISO DNA:SNPs: :rs2069885, rs1799962 (human) RGD PMID:19915054 PMID:20503287 RGD:5128684 RGD:5128685 NCBI chrNW_004936597:2,983,953...2,986,975 JBrowse link
G Irf1 interferon regulatory factor 1 ISO protein:increased expression:dorsal root ganglion RGD PMID:20045913 RGD:5128775 NCBI chrNW_004936647:2,686,247...2,693,633 JBrowse link
G LOC101958191 thymic stromal lymphopoietin sexual_dimorphism ISO mRNA:increased expression:lung (mouse)
protein:increased expression:nasal mucus (human)		 RGD PMID:27156176 PMID:28471975 PMID:31076663 RGD:38549376 RGD:38596342 RGD:38596346 NCBI chrNW_004936531:5,495,872...5,500,462 JBrowse link
G LOC101964975 interleukin-8 ISO protein:increased expression:nasopharynx(human) RGD PMID:29325581 RGD:150521551 NCBI chrNW_004936598:1,779,471...1,781,353 JBrowse link
G LOC101968920 eotaxin ISO RGD PMID:10955955 RGD:4145447 NCBI chrNW_004936538:835,436...848,907 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:17254480 RGD:5130726 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO associated with Respiratory Hypersensitivity; protein:increased expression:lung RGD PMID:15130904 RGD:5131205 NCBI chrNW_004936816:129,926...159,396 JBrowse link
G Ngf nerve growth factor ISO RGD PMID:19824047 RGD:4891065 NCBI chrNW_004936627:635,784...641,290 JBrowse link
G Ngfr nerve growth factor receptor ISO RGD PMID:19824047 RGD:4891065 NCBI chrNW_004936490:12,038,500...12,057,257 JBrowse link
G Pdcd1 programmed cell death 1 ISO protein:increased expression:CD4 Tcell, CD8 Tcell from lung:
protein:increased expression: CD8 Tcell from nasal wash:		 RGD PMID:25465101 RGD:11056952 NCBI chrNW_004936745:152,571...163,712 JBrowse link
G Pde12 phosphodiesterase 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26055709 NCBI chrNW_004936473:7,894,026...7,897,844 JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:33303545 RGD:127229923 NCBI chrNW_004936722:209,019...212,817 JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 treatment ISO RGD PMID:23018837 RGD:11554170 NCBI chrNW_004936532:3,921,824...3,936,027 JBrowse link
G Sarm1 sterile alpha and TIR motif containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chrNW_004936538:4,526,713...4,546,861 JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO RGD PMID:12847279 RGD:5144208 NCBI chrNW_004936581:798,738...801,614 JBrowse link
G Sftpb surfactant protein B severity ISO DNA:SNPs:promoter, cds, intron:-32G>T (rs2077079), p.T131I (rs1130866), 5781A>C (rs2040349) (human)
protein:decreased expression:lung		 RGD PMID:10194154 PMID:17498296 RGD:4143382 RGD:4143439 NCBI chrNW_004936712:1,614,979...1,621,207 JBrowse link
G Sftpc surfactant protein C ISO DNA:polymorphism: :138A>C, 186A>G (human) RGD PMID:17121584 PMID:19304906 RGD:4144065 RGD:4144116 NCBI chrNW_004936555:5,966,610...5,982,083 JBrowse link
G Sftpd surfactant protein D susceptibility ISO DNA:polymorphisms: :p.M11T, p.A160T (human
protein:decreased expression:lung		 RGD PMID:10194154 PMID:19287351 RGD:4143439 RGD:4143495 NCBI chrNW_004936716:60,754...73,010 JBrowse link
G Tac1 tachykinin precursor 1 ISO mRNA,protein:increased expression:lung RGD PMID:10516226 RGD:5147822 NCBI chrNW_004936585:2,932,783...2,941,141 JBrowse link
G Tacr1 tachykinin receptor 1 treatment ISO RGD PMID:10516226 RGD:5147822 NCBI chrNW_004936556:1,266,621...1,421,271 JBrowse link
G Ticam1 toll like receptor adaptor molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24478430 NCBI chrNW_004936588:2,818,909...2,827,797 JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:19019963 RGD:4889534 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr3 toll like receptor 3 ISO RGD PMID:16424225 RGD:5129224 NCBI chrNW_004936554:3,370,766...3,388,125 JBrowse link
G Tlr4 toll like receptor 4 susceptibility
no_association		 ISO DNA:polymorphisms:cds:p.D259G, T359I (human)
DNA:SNPs:cds:p.D299G, T399I (human)
DNA:SNP:cds:p.D299G (human)		 RGD PMID:17264400 PMID:17449325 PMID:17709532 PMID:19019963 RGD:4144161 RGD:4144164 RGD:4144167 RGD:4889534 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
G Tlr6 toll like receptor 6 ISO RGD PMID:19019963 RGD:4889534 NCBI chrNW_004936482:6,607,723...6,610,161 JBrowse link
G Tlr7 toll like receptor 7 ISO associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chrNW_004936470:2,593,544...2,610,972 JBrowse link
G Tlr8 toll like receptor 8 ISO associated with Bronchiolitis; mRNA:increased expression:nasopharynx (human) RGD PMID:19386802 RGD:5129471 NCBI chrNW_004936470:2,638,020...2,642,201 JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:Bronchoalveolar lavage fluid RGD PMID:15791294 RGD:4145715 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
Respirovirus Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl28 C-C motif chemokine ligand 28 ISO mRNA:increased expression:lung (mouse) RGD PMID:17954569 RGD:4892194 NCBI chrNW_004936480:18,819,012...18,824,981 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA, protein:increased expression, increased activity:lung RGD PMID:16816895 RGD:5130923 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Ppia peptidylprolyl isomerase A exacerbates ISO RGD PMID:28594325 RGD:150429629 NCBI chrNW_004936478:19,669,727...19,673,355 JBrowse link
Rhabdoviridae Infections term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ameliorates ISO RGD PMID:25692705 RGD:126790565 NCBI chrNW_004936551:359,134...534,672 JBrowse link
subacute sclerosing panencephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101968921 angiotensin-converting enzyme ISO DNA:insertion/deletion: RGD PMID:16741935 RGD:40400901 NCBI chrNW_004936541:4,157,847...4,178,156 JBrowse link
Vesicular Stomatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ehmt2 euchromatic histone lysine methyltransferase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:26418342 NCBI chrNW_004936727:1,648,451...1,663,294 JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 ameliorates ISO RGD PMID:25326752 RGD:127229916 NCBI chrNW_004936722:209,019...212,817 JBrowse link
G Stat2 signal transducer and activator of transcription 2 exacerbates ISO RGD PMID:32759968 RGD:41789624 NCBI chrNW_004936646:747,178...763,449 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13689
    disease by infectious agent 1891
      viral infectious disease 1493
        RNA Virus Infections 1249
          Mononegavirales Infections 89
            Filoviridae Infections + 1
            Paramyxoviridae Infections + 67
            Rhabdoviridae Infections + 8
            borna disease 17
paths to the root