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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chronic Relapsing Experimental Autoimmune Encephalomyelitis
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Accession:DOID:9007752 term browser browse the term
Definition:A chronic relapsing-remitting version of EAE, an experimental animal model for central nervous system demyelinating disease in which demyelination is extensive.
Synonyms:exact_synonym: CR-EAE;   CREAE;   chronic relapsing EAE;   chronic relapsing experimental allergic encephalomyelitis;   chronic relapsing-remitting EAE
 primary_id: RDO:9000096


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Chronic Relapsing Experimental Autoimmune Encephalomyelitis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO mRNA:increased expression:spinal cord (rat) RGD PMID:12098510 RGD:8655962 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G NEFH neurofilament heavy chain ISO protein:decreased expression:spinal cord: RGD PMID:12742652 RGD:27226817 NCBI chr26:22,726,523...22,735,129
Ensembl chr26:22,726,526...22,735,125 		JBrowse link
G PLP1 proteolipid protein 1 ISO human sequence peptide in a mouse model; associated with Herpesviridae infections RGD PMID:12811845 RGD:30296670 NCBI chr  X:77,191,112...77,207,772
Ensembl chr  X:77,191,150...77,205,964 		JBrowse link
G SERPINE1 serpin family E member 1 ISO RGD PMID:17983428 RGD:13208507 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17773
    Animal Diseases 1331
      Animal Disease Models 1284
        Experimental Nervous System Autoimmune Disease 188
          Experimental Autoimmune Encephalomyelitis 161
            Chronic Relapsing Experimental Autoimmune Encephalomyelitis 4
Path 2
Term Annotations click to browse term
  disease 17773
    disease of anatomical entity 15145
      Immune & Inflammatory Diseases 5008
        immune system disease 4336
          primary immunodeficiency disease 3735
            autoimmune disease 1994
              autoimmune disease of the nervous system 558
                autoimmune disease of central nervous system 300
                  Demyelinating Autoimmune Diseases, CNS 293
                    Experimental Autoimmune Encephalomyelitis 161
                      Chronic Relapsing Experimental Autoimmune Encephalomyelitis 4
paths to the root