RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Vertigo
Accession: DOID:9007736
browse the term
Definition: An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)
Synonyms: exact_synonym: Constant Vertigo; Essential Vertigo; Intermittant Vertigo; Paroxysmal Vertigo; Positional Vertigo; Spinning Sensation; Subjective Vertigo; vertigos
primary_id: MESH:D014717
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Slc25a4
solute carrier family 25 member 4
ISO
ClinVar Annotator: match by term: Vertigo
ClinVar
PMID:16155110 PMID:21549803 PMID:22497660 PMID:25741868 PMID:27693233 PMID:28823815 PMID:29654543 PMID:33923309 More...
NCBI chr16:46,072,935...46,076,730
Ensembl chr16:46,072,939...46,076,733
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Tnc
tenascin C
ISO
ClinVar Annotator: match by term: Vertigo
ClinVar
PMID:25741868
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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Acan
aggrecan
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25419514 PMID:25741868 PMID:28492532 PMID:29464738 PMID:34516402
NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
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Adgrv1
adhesion G protein-coupled receptor V1
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:24033266 PMID:25741868 PMID:26467025 PMID:28492532
NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688
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Agl
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 2:204,705,053...204,760,966
Ensembl chr 2:204,705,053...204,760,828
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Ank2
ankyrin 2
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
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Aqp4
aquaporin 4
susceptibility
ISO
protein:decreased expression:macula of utricle of membranous labyrinth: DNA:conservative mutation:cds:c.105G>C(human)
RGD
PMID:20461409 PMID:21063116
RGD:8696022 , RGD:8696023
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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Arhgef28
Rho guanine nucleotide exchange factor 28
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868
NCBI chr 2:29,263,888...29,560,595
Ensembl chr 2:29,263,886...29,560,672
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C20h10orf105
similar to human chromosome 10 open reading frame 105
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:18429043 PMID:24033266 PMID:25741868 PMID:28492532
NCBI chr20:28,333,094...28,339,341
Ensembl chr20:28,336,101...28,336,487
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Cacna1d
calcium voltage-gated channel subunit alpha1 D
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
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Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:28492532
NCBI chr 6:25,292,133...25,315,078
Ensembl chr 6:25,292,133...25,319,861
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Cdh23
cadherin-related 23
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:18429043 PMID:24033266 PMID:25741868 PMID:28492532
NCBI chr20:28,240,643...28,622,490
Ensembl chr20:28,240,645...28,622,419
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Cenpj
centromere protein J
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:24402816 PMID:25741868 PMID:28492532
NCBI chr15:30,627,206...30,690,384
Ensembl chr15:30,627,224...30,686,791
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Clec16a
C-type lectin domain containing 16A
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
NCBI chr10:4,927,799...5,123,749
Ensembl chr10:4,928,030...5,123,578
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Col11a1
collagen type XI alpha 1 chain
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
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Col4a4
collagen type IV alpha 4 chain
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:9536098 PMID:17576681 PMID:24052634 PMID:25741868 PMID:28492532
NCBI chr 9:83,833,173...83,875,436
Ensembl chr 9:83,755,515...83,875,876
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Col9a2
collagen type IX alpha 2 chain
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868 PMID:28492532 PMID:30753492
NCBI chr 5:134,607,616...134,624,678
Ensembl chr 5:134,607,616...134,624,677
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Dtna
dystrobrevin, alpha
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25305078 PMID:25741868 PMID:28492532
NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261
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Epha2
Eph receptor A2
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:19649315 PMID:20625407 PMID:22645087 PMID:22829731 PMID:23447127 PMID:24705208 PMID:25741868 PMID:28492532 PMID:29267365 More...
NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117
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Eps8l2
EPS8-like 2
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:28492532
NCBI chr 1:196,446,260...196,471,544
Ensembl chr 1:196,446,287...196,471,541
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Fam136a
family with sequence similarity 136, member A
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25305078
NCBI chr 4:118,805,129...118,811,046
Ensembl chr 4:118,805,127...118,811,047
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Fscn2
fascin actin-bundling protein 2, retinal
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:28492532
NCBI chr10:105,634,783...105,641,322
Ensembl chr10:105,634,783...105,641,322
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Fto
FTO, alpha-ketoglutarate dependent dioxygenase
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:19833892 PMID:25741868 PMID:28492532
NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083
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Hspa1a
heat shock protein family A (Hsp70) member 1A
susceptibility
ISO
DNA:SNP: :190G>C(human)
RGD
PMID:19241595
RGD:7257654
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Kif1b
kinesin family member 1B
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868 PMID:28492532 PMID:32376792
NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778
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Lrba
LPS responsive beige-like anchor protein
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:28492532
NCBI chr 2:171,623,668...172,202,576
Ensembl chr 2:171,621,507...172,202,724
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Lrp4
LDL receptor related protein 4
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593
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Lyst
lysosomal trafficking regulator
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868 PMID:28492532 PMID:28748566
NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480
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Manba
mannosidase beta
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:18980795 PMID:19728872 PMID:25741868 PMID:28492532 PMID:30552791 PMID:31115173 More...
NCBI chr 2:223,910,432...224,002,988
Ensembl chr 2:223,910,432...224,002,983
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Mpdz
multiple PDZ domain crumbs cell polarity complex component
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 5:95,766,112...95,920,531
Ensembl chr 5:95,766,118...95,920,499
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Mthfr
methylenetetrahydrofolate reductase
susceptibility
ISO
DNA:SNPs: :677C>T(rs1801133),1298A>C(1801131)(human)
RGD
PMID:23484733
RGD:7387223
NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
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Mybbp1a
MYB binding protein 1a
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
NCBI chr10:57,056,897...57,067,258
Ensembl chr10:57,056,874...57,067,255
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Myh14
myosin heavy chain 14
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:24033266 PMID:25741868 PMID:26467025 PMID:27610647 PMID:28492532 PMID:34681017 More...
NCBI chr 1:95,096,266...95,158,861
Ensembl chr 1:95,096,266...95,158,836
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Myh3
myosin heavy chain 3
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:16642020 PMID:25741868 PMID:28492532 PMID:28779239
NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
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Myh9
myosin, heavy chain 9
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:11752022 PMID:18676005 PMID:22123909 PMID:22477015 PMID:22995991 PMID:24033266 PMID:24643058 PMID:25741868 PMID:26467025 PMID:28059092 PMID:28492532 PMID:29090586 PMID:30720677 More...
NCBI chr 7:109,343,718...109,424,457
Ensembl chr 7:109,343,706...109,424,457
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Myo1c
myosin 1C
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
NCBI chr10:60,498,372...60,520,752
Ensembl chr10:60,498,280...60,520,752
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Myo6
myosin VI
ISO
ClinVar Annotator: match by term: Meniere disease | ClinVar Annotator: match by term: Ménière's disease
ClinVar
PMID:24033266 PMID:28492532
NCBI chr 8:81,087,157...81,242,022
Ensembl chr 8:81,087,139...81,239,292
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Myo7a
myosin VIIA
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:15221449 PMID:16470552 PMID:20146813 PMID:21487335 PMID:22681893 PMID:23804846 PMID:24033266 PMID:25741868 PMID:26467025 PMID:28000701 PMID:28492532 PMID:30303587 PMID:30459346 PMID:33363762 More...
NCBI chr 1:152,342,611...152,414,171
Ensembl chr 1:152,344,448...152,414,157
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Otog
otogelin
ISO
ClinVar Annotator: match by term: Meniere disease | ClinVar Annotator: match by term: Ménière's disease
ClinVar
PMID:9536098 PMID:17576681 PMID:24033266 PMID:25741868 PMID:26467025 PMID:28492532 PMID:28945198 More...
NCBI chr 1:96,746,336...96,815,416
Ensembl chr 1:96,746,336...96,815,415
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Otogl
otogelin-like
ISO
ClinVar Annotator: match by term: Meniere disease | ClinVar Annotator: match by term: Ménière's disease
ClinVar
PMID:25741868
NCBI chr 7:43,065,800...43,211,400
Ensembl chr 7:43,067,644...43,223,592
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Pcdh15
protocadherin related 15
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719
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Ptpn13
protein tyrosine phosphatase, non-receptor type 13
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563
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Ptpn22
protein tyrosine phosphatase, non-receptor type 22
ISO
DNA:missense mutation:cds:p.R620W (c.1858C>T) (rs2476601) (human)
RGD
PMID:19780033
RGD:7829747
NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
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Rabl6
RAB, member RAS oncogene family-like 6
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
NCBI chr 3:8,402,666...8,428,588
Ensembl chr 3:8,402,672...8,428,611
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Rnf17
ring finger protein 17
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:24402816 PMID:25741868 PMID:28492532
NCBI chr15:30,487,899...30,626,024
Ensembl chr15:30,487,883...30,626,024
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RT1-CE13
RT1 class I, locus CE13
ISO
DNA:polymorphisms:cds:HLA-B44 (human, South Korean)
RGD
PMID:12542204
RGD:7364921
NCBI chr20:3,314,830...3,318,106
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RT1-Db1
RT1 class II, locus Db1
susceptibility
ISO
DNA:polymorphism: : HLA-DRB1*15(human)
RGD
PMID:12542204
RGD:7364921
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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Shroom2
shroom family member 2
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868
NCBI chr X:21,812,469...21,983,724
Ensembl chr X:21,812,469...21,984,153
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Spag17
sperm associated antigen 17
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
NCBI chr 2:187,264,004...187,511,061
Ensembl chr 2:187,264,009...187,510,501
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Synj2
synaptojanin 2
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
NCBI chr 1:46,518,594...46,621,919
Ensembl chr 1:46,518,709...46,633,687
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Tecta
tectorin alpha
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:24033266 PMID:25741868 PMID:28492532
NCBI chr 8:42,707,962...42,779,726
Ensembl chr 8:42,707,962...42,779,707
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Tenm3
teneurin transmembrane protein 3
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
NCBI chr16:41,251,909...43,978,594
Ensembl chr16:41,252,182...43,978,594
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Thada
THADA, armadillo repeat containing
ISO
ClinVar Annotator: match by term: Meniere disease | ClinVar Annotator: match by term: Ménière's disease
ClinVar
PMID:25741868
NCBI chr 6:10,183,942...10,488,007
Ensembl chr 6:10,183,982...10,487,159
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Tnc
tenascin C
ISO
ClinVar Annotator: match by term: Meniere disease | ClinVar Annotator: match by term: Ménière's disease
ClinVar
PMID:25741868
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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Tnni3k
TNNI3 interacting kinase
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 2:243,737,346...244,005,319
Ensembl chr 2:243,710,950...244,005,268
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Triobp
TRIO and F-actin binding protein
ISO
ClinVar Annotator: match by term: Meniere disease | ClinVar Annotator: match by term: Ménière's disease
ClinVar
PMID:16385457 PMID:16385458 PMID:20510926 PMID:24033266 PMID:25741868 PMID:26467025 PMID:28000701 PMID:28089734 PMID:28492532 PMID:29197352 PMID:30311386 More...
NCBI chr 7:110,505,916...110,569,301
Ensembl chr 7:110,506,248...110,562,474
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Ush1c
USH1 protein network component harmonin
ISO
ClinVar Annotator: match by term: Meniere disease
ClinVar
PMID:12136232 PMID:16963483 PMID:24033266 PMID:24875298 PMID:25741868 PMID:28492532 PMID:29739340 More...
NCBI chr 1:96,695,303...96,743,671
Ensembl chr 1:96,695,307...96,743,671
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Wfs1
wolframin ER transmembrane glycoprotein
ISO
ClinVar Annotator: match by term: Meniere disease | ClinVar Annotator: match by term: Ménière's disease
ClinVar
PMID:9856492 PMID:11244483 PMID:12107816 PMID:12955714 PMID:17603484 PMID:18040659 PMID:20028947 PMID:24033266 PMID:24890733 PMID:25133958 PMID:25497598 PMID:25714468 PMID:25741868 PMID:25842391 PMID:26435059 PMID:26467025 PMID:26969326 PMID:27167055 PMID:28492532 PMID:29563951 PMID:30245029 PMID:31264968 PMID:31521625 PMID:31980526 PMID:34356170 PMID:34556497 PMID:34789499 PMID:35206658 PMID:36208030 More...
NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
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