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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Insulin Resistance
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Accession:DOID:9007692 term browser browse the term
Definition:Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Synonyms:exact_synonym: Insulin Sensitivity
 narrow_synonym: Insulin Resistance Syndrome, Type A
 related_synonym: FATTY ACID-BINDING PROTEIN, INTESTINAL, POLYMORPHISM OF;   Insulin Resistance, Susceptibility To;   Serum hdl cholesterol level, modifier of
 primary_id: MESH:D007333;   RDO:0003504
 xref: EFO:0002614

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Insulin Resistance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha treatment ISO RGD PMID:16485039 PMID:26394137 RGD:1625727 RGD:329955565 NCBI chrNW_004624871:4,103,014...4,364,690
Ensembl chrNW_004624871:4,105,067...4,412,325 		JBrowse link
G Acacb acetyl-CoA carboxylase beta treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16485039 PMID:22658938 PMID:26394137 RGD:1625727 RGD:329955565 NCBI chrNW_004624747:12,287,817...12,426,340
Ensembl chrNW_004624747:12,307,541...12,424,897 		JBrowse link
G Acp1 acid phosphatase 1 ISO associated with Obesity RGD PMID:17353188 RGD:2313180 NCBI chrNW_004624846:1,735,944...1,748,495
Ensembl chrNW_004624846:1,736,038...1,747,009 		JBrowse link
G Acsl1 acyl-CoA synthetase long chain family member 1 ISO mRNA:decreased expression:subcutaneous adipose tissue RGD PMID:16788709 RGD:1625735 NCBI chrNW_004624769:15,503,757...15,584,741
Ensembl chrNW_004624769:15,503,757...15,584,777 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing treatment ISO associated with Hypertension
CTD Direct Evidence: therapeutic 		RGD
CTD		 PMID:16041833 PMID:18931039 PMID:21484566 PMID:21872431 PMID:23089228 RGD:1599150 RGD:8695928 RGD:8695951 NCBI chrNW_004624730:69,941,963...69,959,266
Ensembl chrNW_004624730:69,941,001...69,957,012 		JBrowse link
G Adipor1 adiponectin receptor 1 resistance ISO associated with Diabetes Mellitus, Type 2;DNA:SNP: :-3881T>C RGD PMID:17285539 RGD:1625762 NCBI chrNW_004624807:7,896,508...7,912,088 JBrowse link
G Adipor2 adiponectin receptor 2 treatment ISO RGD PMID:24797033 PMID:30225267 RGD:21406435 RGD:25824940 NCBI chrNW_004624735:11,103,082...11,174,277
Ensembl chrNW_004624735:11,103,076...11,174,337 		JBrowse link
G Adm adrenomedullin ISO CTD Direct Evidence: therapeutic CTD PMID:33491863 NCBI chrNW_004624766:2,402,152...2,404,343
Ensembl chrNW_004624766:2,401,769...2,404,446 		JBrowse link
G Adora1 adenosine A1 receptor treatment ISO associated with Obesity RGD PMID:11703426 PMID:15220221 RGD:1625243 RGD:2313807 NCBI chrNW_004624807:7,674,164...7,705,736
Ensembl chrNW_004624807:7,674,927...7,705,051 		JBrowse link
G Adra1b adrenoceptor alpha 1B susceptibility ISO RGD PMID:14581480 RGD:1625772 NCBI chrNW_004624733:29,545,870...29,661,954
Ensembl chrNW_004624733:29,545,789...29,662,028 		JBrowse link
G Adrb2 adrenoceptor beta 2 ISO DNA:polymorphisms: :p.R16G
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:11510954 PMID:15699455 PMID:19034036 RGD:1598757 RGD:1601125 NCBI chrNW_004624774:8,211,723...8,215,962
Ensembl chrNW_004624774:8,211,984...8,213,240 		JBrowse link
G Adrb3 adrenoceptor beta 3 no_association ISO DNA:missense mutation:cds:p.W64R rs4994 (human)
associated with Obesity;DNA:polymorphism: :p.W64R (human) 		RGD PMID:10421225 PMID:10582543 PMID:17299491 RGD:1559326 RGD:2313158 RGD:5684421 NCBI chrNW_004624780:5,653,499...5,656,138 JBrowse link
G Agtr2 angiotensin II receptor type 2 ISO protein:increased expression:dorsal root ganglion, neuron RGD PMID:22357959 RGD:6903873 NCBI chrNW_004624967:327,627...332,000
Ensembl chrNW_004624967:329,284...330,372 		JBrowse link
G Ahr aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25734695 NCBI chrNW_004624739:12,939,183...12,987,574
Ensembl chrNW_004624739:12,942,165...12,987,973 		JBrowse link
G Ahsg alpha 2-HS glycoprotein susceptibility ISO protein:increased expression:plasma RGD PMID:16567827 PMID:17011519 RGD:1625793 RGD:1625794 NCBI chrNW_004624730:70,149,461...70,156,058
Ensembl chrNW_004624730:70,149,850...70,156,039 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 no_association ISO DNA:SNPs RGD PMID:17327441 RGD:1601155 NCBI chrNW_004624925:262,590...322,440
Ensembl chrNW_004624925:273,881...326,984 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member treatment ISO protein:altered expression, altered activity:liver (rat) RGD PMID:28688179 RGD:14981582 NCBI chrNW_004624747:20,407,190...20,438,605
Ensembl chrNW_004624747:20,403,717...20,438,690 		JBrowse link
G Apln apelin ISO mRNA:increased expression:subcutaneous adipose tissue RGD PMID:17594060 RGD:1626170 NCBI chrNW_004624797:8,857,490...8,866,157
Ensembl chrNW_004624797:8,857,070...8,866,329 		JBrowse link
G Apoa2 apolipoprotein A2 ISO RGD PMID:11246886 RGD:2313957 NCBI chrNW_004624794:164,351...165,676
Ensembl chrNW_004624794:164,370...166,248 		JBrowse link
G Apoc1 apolipoprotein C1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:11723061 RGD:2313951 NCBI chrNW_004624907:1,758,671...1,760,611
Ensembl chrNW_004624907:1,758,696...1,760,611 		JBrowse link
G Apoc3 apolipoprotein C3 treatment
susceptibility 		ISO RGD PMID:15007394 PMID:15734841 RGD:1580750 RGD:1601226 NCBI chrNW_004624784:12,244,565...12,246,790
Ensembl chrNW_004624784:12,244,646...12,246,790 		JBrowse link
G Ar androgen receptor ISO CTD Direct Evidence: marker/mechanism
associated with Polycystic Ovary Syndrome;DNA:repeat: :CAG 		CTD
RGD		 PMID:16793958 PMID:17332526 PMID:21444647 RGD:1601244 RGD:2306773 NCBI chrNW_004624891:3,135,824...3,330,487
Ensembl chrNW_004624891:3,138,848...3,329,459 		JBrowse link
G Arg1 arginase 1 ISO protein:decreased activity:liver (rat) RGD PMID:20593143 RGD:4142796 NCBI chrNW_004624753:5,737,720...5,749,313
Ensembl chrNW_004624753:5,737,237...5,752,966 		JBrowse link
G Atm ATM serine/threonine kinase treatment ISO protein:decreased expression:muscle:
Associated with human immunodeficiency virus infectious disease, hepatitis C;DNA:SNP:intron: (rs11212617) (human) 		RGD PMID:18534819 PMID:23171036 RGD:126781688 RGD:8693659 NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216 		JBrowse link
G Bad BCL2 associated agonist of cell death ISO protein:decreased phosphorylation, increased dimerization, increased glycosylation:heart RGD PMID:21385329 RGD:10053645 NCBI chrNW_004624767:22,025,721...22,037,283
Ensembl chrNW_004624767:22,026,133...22,037,277 		JBrowse link
G Bche butyrylcholinesterase ISO RGD PMID:17917325 RGD:2306776 NCBI chrNW_004624730:43,793,550...43,849,169
Ensembl chrNW_004624730:43,793,040...43,843,519 		JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:17618300 PMID:17988733 RGD:5129214 RGD:5129217 NCBI chrNW_004624734:8,545,707...8,549,846
Ensembl chrNW_004624734:8,548,356...8,549,414 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin ISO RGD PMID:25934999 RGD:11085488 NCBI chrNW_004624926:1,189,990...1,197,220
Ensembl chrNW_004624926:1,190,072...1,196,076 		JBrowse link
G C1r complement C1r ISO protein:increased expression:adipocyte RGD PMID:17244723 RGD:1600551 NCBI chrNW_004624860:3,675,926...3,684,598
Ensembl chrNW_004624860:3,676,252...3,684,406 		JBrowse link
G C3 complement C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18615583 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
G Capn10 calpain 10 ISO DNA:SNP:intron:rs3792267 (human) RGD PMID:11018080 RGD:7247736 NCBI chrNW_004624847:4,911,052...4,922,549
Ensembl chrNW_004624847:4,911,737...4,922,192 		JBrowse link
G Casp8 caspase 8 ISO RGD PMID:29748970 RGD:13782289 NCBI chrNW_004624899:427,064...450,931
Ensembl chrNW_004624899:424,363...451,087 		JBrowse link
G Cat catalase ISO associated with Obesity RGD PMID:19188683 RGD:5130761 NCBI chrNW_004624767:12,680,940...12,715,468
Ensembl chrNW_004624767:12,680,953...12,715,739 		JBrowse link
G Cblb Cbl proto-oncogene B ISO RGD PMID:17601987 RGD:2314038 NCBI chrNW_004624731:43,803,743...44,018,682
Ensembl chrNW_004624731:43,803,768...44,015,870 		JBrowse link
G Cd163 CD163 molecule exacerbates ISO associated with hepatitis C, human immunodeficiency virus infectious disease;protein:increased expression:blood plasma (human)
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:26554542 PMID:29035695 RGD:149735574 NCBI chrNW_004624860:3,976,746...4,000,349
Ensembl chrNW_004624860:3,975,747...4,000,349 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) ISO associated with Diabetes Mellitus, Type 2
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:11175782 PMID:12923231 PMID:14640889 PMID:15231693 PMID:25477422 RGD:11040926 RGD:11041132 RGD:2307217 RGD:68930 NCBI chrNW_004624739:29,341,620...29,441,232
Ensembl chrNW_004624739:29,407,568...29,441,333 		JBrowse link
G Cd40 CD40 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chrNW_004624790:8,475,640...8,485,927
Ensembl chrNW_004624790:8,476,158...8,485,856 		JBrowse link
G Cd68 CD68 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chrNW_004624786:10,195,337...10,197,963 JBrowse link
G Cers1 ceramide synthase 1 ameliorates ISO RGD PMID:30605666 RGD:156431060 NCBI chrNW_004624908:1,937,007...1,949,780
Ensembl chrNW_004624908:1,941,393...1,949,760 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO associated with Obesity RGD PMID:19553924 RGD:2314662 NCBI chrNW_004624799:6,100,709...6,126,530
Ensembl chrNW_004624799:6,101,728...6,126,520 		JBrowse link
G Coq2 coenzyme Q2, polyprenyltransferase ISO associated with obesity RGD PMID:26296322 RGD:10755343 NCBI chrNW_004624900:272,440...288,090
Ensembl chrNW_004624900:272,404...288,675 		JBrowse link
G Cpb2 carboxypeptidase B2 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression, increased activity:plasma RGD PMID:11836301 RGD:2313645 NCBI chrNW_004624748:8,850,128...8,927,986
Ensembl chrNW_004624748:8,849,900...8,928,853 		JBrowse link
G Cpe carboxypeptidase E ISO CTD Direct Evidence: marker/mechanism CTD PMID:15358678 NCBI chrNW_004624758:11,464,418...11,603,660
Ensembl chrNW_004624758:11,463,012...11,604,224 		JBrowse link
G Ctf1 cardiotrophin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21803294 NCBI chrNW_004624782:13,976,308...13,979,327 JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 treatment ISO RGD PMID:26394137 RGD:329955565 NCBI chrNW_004624817:1,386,876...1,418,129
Ensembl chrNW_004624817:1,386,764...1,418,300 		JBrowse link
G Dio2 iodothyronine deiodinase 2 ISO DNA:SNP: :rs225014, p.T92A (human) RGD PMID:11872697 RGD:2313698 NCBI chrNW_004624734:21,787,705...21,802,096 JBrowse link
G Drd1 dopamine receptor D1 ISO associated with Obesity;protein:increased serine phosphorylation:renal proximal tubule RGD PMID:15798088 RGD:2302119 NCBI chrNW_004624733:14,517,540...14,522,173
Ensembl chrNW_004624733:14,518,146...14,520,905 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 treatment ISO RGD PMID:31961704 RGD:21408561 NCBI chrNW_004624794:12,196,402...12,203,674
Ensembl chrNW_004624794:12,195,385...12,203,606 		JBrowse link
G Egfr epidermal growth factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22238402 NCBI chrNW_004624740:584,133...713,205
Ensembl chrNW_004624740:589,606...713,271 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO ClinVar Annotator: match by term: Insulin resistance, susceptibility to ClinVar PMID:10480624 PMID:11739459 PMID:14671192 PMID:14988267 PMID:15001634 More... NCBI chrNW_004624753:5,918,005...5,983,480
Ensembl chrNW_004624753:5,917,689...5,982,308 		JBrowse link
G F7 coagulation factor VII severity ISO associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased activity:plasma (human) RGD PMID:9187410 RGD:2312406 NCBI chrNW_004624793:780,057...788,105
Ensembl chrNW_004624793:780,059...788,095 		JBrowse link
G Fabp3 fatty acid binding protein 3 severity ISO RGD PMID:16249436 RGD:1578459 NCBI chrNW_004624764:14,698,062...14,705,379
Ensembl chrNW_004624764:14,698,062...14,705,972 		JBrowse link
G Fanca FA complementation group A ISO RGD PMID:22482891 RGD:11046266 NCBI chrNW_004624746:206,069...253,473
Ensembl chrNW_004624746:215,193...252,569 		JBrowse link
G Fancc FA complementation group C ISO RGD PMID:22482891 RGD:11046266 NCBI chrNW_004624753:16,566,864...16,811,438 JBrowse link
G Fas Fas cell surface death receptor treatment ISO associated with hypothalamic disease RGD PMID:29522769 RGD:13792596 NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848 		JBrowse link
G Fasn fatty acid synthase treatment ISO RGD PMID:26394137 RGD:329955565 NCBI chrNW_004624801:10,910,022...10,926,505
Ensembl chrNW_004624801:10,909,647...10,927,547 		JBrowse link
G Fgf19 fibroblast growth factor 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28673684 NCBI chrNW_004624767:17,434,501...17,439,351
Ensembl chrNW_004624767:17,432,358...17,438,173 		JBrowse link
G Fis1 fission, mitochondrial 1 ISO protein:increased expression:liver (rat) RGD PMID:24663492 RGD:12453042 NCBI chrNW_004624740:16,052,777...16,056,438
Ensembl chrNW_004624740:16,052,820...16,057,098 		JBrowse link
G Foxc2 forkhead box C2 ISO DNA:polymorphism:5'ut:-512C>T RGD PMID:12453913 RGD:1601219 NCBI chrNW_004624746:2,632,547...2,634,867
Ensembl chrNW_004624746:2,632,619...2,634,085 		JBrowse link
G Foxo1 forkhead box O1 ISO mRNA:increased expression:adipose tissue: RGD PMID:16041833 RGD:1599150 NCBI chrNW_004624748:1,413,754...1,529,646
Ensembl chrNW_004624748:1,413,983...1,529,992 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO associated with diabetes mellitus;DNA:SNP: :rs9939609 (human)
mRNA, protein:increased expression:liver
DNA:SNPs, haplotype: :rs1121980, rs1558902, rs9939609 (human)
associated with obesity;DNA:SNP:intron:rs17817449 (human) 		RGD PMID:20075932 PMID:21919686 PMID:30273662 PMID:35945320 RGD:329812018 RGD:329812040 RGD:329853775 RGD:329951016 NCBI chrNW_004624757:2,675,810...3,081,751
Ensembl chrNW_004624757:2,675,671...3,080,480 		JBrowse link
G Fxn frataxin ISO DNA:repeats:intron:GAA (human) RGD PMID:10969848 RGD:2307049 NCBI chrNW_004624736:4,027,054...4,047,881
Ensembl chrNW_004624736:4,027,354...4,047,854 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase ISO associated with Obesity;protein:increased expression:pancreas RGD PMID:23015612 RGD:10449129 NCBI chrNW_004624946:989,376...1,001,787
Ensembl chrNW_004624946:986,107...1,001,955 		JBrowse link
G Gck glucokinase ISO protein:increased expression:pancreatic islet RGD PMID:19039094 RGD:7488970 NCBI chrNW_004624740:7,844,496...7,885,900
Ensembl chrNW_004624740:7,852,390...7,886,758 		JBrowse link
G Gfpt1 glutamine--fructose-6-phosphate transaminase 1 ISO RGD PMID:11118009 RGD:1625423 NCBI chrNW_004624762:3,943,074...4,016,090
Ensembl chrNW_004624762:3,942,972...4,010,498 		JBrowse link
G Gnas GNAS complex locus ISO CTD Direct Evidence: marker/mechanism CTD PMID:17062894 NCBI chrNW_004624741:25,138,678...25,197,194
Ensembl chrNW_004624741:25,183,329...25,196,880 		JBrowse link
G Gnb3 G protein subunit beta 3 ISO DNA:polymorphism: :825C>T (human) RGD PMID:12624279 RGD:1580411 NCBI chrNW_004624860:3,509,185...3,515,025
Ensembl chrNW_004624860:3,509,397...3,515,352 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial treatment ISO RGD PMID:26394137 RGD:329955565 NCBI chrNW_004624737:34,198,773...34,268,815
Ensembl chrNW_004624737:34,198,518...34,265,192 		JBrowse link
G Gpr17 G protein-coupled receptor 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34144038 NCBI chrNW_004624732:14,115,267...14,129,714
Ensembl chrNW_004624732:14,115,325...14,128,169 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma 		CTD
RGD		 PMID:19270708 PMID:24361363 RGD:401827920 NCBI chrNW_004624733:40,957,895...40,963,469
Ensembl chrNW_004624733:40,957,999...40,962,993 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:15994203 RGD:1625791 NCBI chrNW_004624767:19,212,218...19,231,218
Ensembl chrNW_004624767:19,210,965...19,231,082 		JBrowse link
G Gsta4 glutathione S-transferase alpha 4 ISO mRNA:decreased expression:omental fat pad, subcutaneous adipose tissue (human) RGD PMID:20150287 RGD:5687771 NCBI chrNW_004624850:201,119...217,302
Ensembl chrNW_004624850:201,592...216,680 		JBrowse link
G Gys1 glycogen synthase 1 susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:missense mutation:exon:p.M416V (human) RGD PMID:9267990 RGD:2313176 NCBI chrNW_004624832:5,029,272...5,044,679
Ensembl chrNW_004624832:5,029,057...5,045,190 		JBrowse link
G Hamp hepcidin antimicrobial peptide ISO mRNA:decreased expression:liver RGD PMID:17350134 RGD:1601515 NCBI chrNW_004624794:8,257,760...8,259,243
Ensembl chrNW_004624794:8,257,760...8,259,264 		JBrowse link
G Hmga1 high mobility group AT-hook 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23512162 NCBI chrNW_004624754:22,888,052...22,900,685
Ensembl chrNW_004624754:22,892,226...22,898,807 		JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic
mRNA:decreased expression:muscle:defective protection against oxidative stress 		CTD
RGD		 PMID:12941774 PMID:18375438 PMID:19171794 RGD:1601621 NCBI chrNW_004624750:341,699...346,005
Ensembl chrNW_004624750:342,146...345,887 		JBrowse link
G Hnf1a HNF1 homeobox A ISO ClinVar Annotator: match by term: SERUM HDL CHOLESTEROL LEVEL, MODIFIER OF ClinVar PMID:8945470 PMID:9112026 PMID:9287053 PMID:9604876 PMID:10333057 More... NCBI chrNW_004624747:12,717,713...12,746,040
Ensembl chrNW_004624747:12,717,707...12,746,724 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21786805 NCBI chrNW_004624807:2,260,702...2,293,962
Ensembl chrNW_004624807:2,261,006...2,293,804 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO RGD PMID:18948349 RGD:10402862 NCBI chrNW_004624889:2,736,727...2,746,333 JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO associated with Peripheral Vascular Diseases RGD PMID:17062970 RGD:1624367 NCBI chrNW_004624748:8,154,288...8,223,226
Ensembl chrNW_004624748:8,155,107...8,223,259 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Obesity;protein:increased secretion:plasma (human)
protein:increased expression:serum 		RGD PMID:11782876 PMID:19394054 RGD:1625753 RGD:2313467 NCBI chrNW_004624828:2,432,584...2,451,997
Ensembl chrNW_004624828:2,432,550...2,453,071 		JBrowse link
G Igf2bp2 insulin like growth factor 2 mRNA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chrNW_004624730:70,914,763...71,061,313
Ensembl chrNW_004624730:70,914,804...71,059,642 		JBrowse link
G Igfals insulin like growth factor binding protein acid labile subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17726072 NCBI chrNW_004624913:460,862...464,457
Ensembl chrNW_004624913:458,844...465,193 		JBrowse link
G Igfbp2 insulin like growth factor binding protein 2 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:17259371 PMID:22537059 RGD:1626479 NCBI chrNW_004624823:8,460,968...8,486,495
Ensembl chrNW_004624823:8,460,553...8,486,495 		JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO RGD PMID:17237715 RGD:2313762 NCBI chrNW_004624740:6,878,818...6,886,512
Ensembl chrNW_004624740:6,877,348...6,886,512 		JBrowse link
G Igfbp6 insulin like growth factor binding protein 6 ISO human transgene overexpressed in mouse brain RGD PMID:15889232 RGD:2301717 NCBI chrNW_004624904:1,153,890...1,159,095
Ensembl chrNW_004624904:1,154,882...1,159,209 		JBrowse link
G Igfbp7 insulin like growth factor binding protein 7 ISO protein:increased expression:serum
associated with metabolic dysfunction-associated steatotic liver disease 		RGD PMID:16873698 PMID:31397492 RGD:1626516 RGD:401960873 NCBI chrNW_004624761:12,318,571...12,387,489
Ensembl chrNW_004624761:12,318,006...12,387,582 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:11533494 PMID:19073766 PMID:29036520 RGD:10045961 RGD:7495768 NCBI chrNW_004624780:922,524...978,687
Ensembl chrNW_004624780:923,744...970,519 		JBrowse link
G Il18 interleukin 18 treatment ISO associated with Graves Disease RGD PMID:16732281 PMID:23257837 RGD:14695532 RGD:8655938 NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687 		JBrowse link
G Il1b interleukin 1 beta treatment ISO associated with Obesity;mRNA:increased expression:adipose tissue
associated with hypothalamic disease 		RGD PMID:16865359 PMID:29522769 RGD:13792596 RGD:1626632 NCBI chrNW_004624749:12,852,128...12,858,478
Ensembl chrNW_004624749:12,852,021...12,858,760 		JBrowse link
G Il6 interleukin 6 ISO mRNA:increased expression:islet of Langerhans
associated with Diabetes Mellitus, Experimental; protein:increased expression:extracellular space (rat) 		RGD PMID:19328014 PMID:21826222 RGD:10402828 RGD:2307252 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Il6r interleukin 6 receptor ISO protein:decreased expression:serum RGD PMID:14962155 RGD:1625431 NCBI chrNW_004624885:2,910,367...2,946,916
Ensembl chrNW_004624885:2,910,112...2,946,886 		JBrowse link
G Il7 interleukin 7 ISO CTD Direct Evidence: therapeutic CTD PMID:20376352 NCBI chrNW_004624744:12,562,536...12,604,037
Ensembl chrNW_004624744:12,567,661...12,604,074 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase like 1 ISO associated with Metabolic Syndrome X RGD PMID:12453826 PMID:17327370 RGD:2312440 RGD:2312442 NCBI chrNW_004624817:4,779,875...4,794,644
Ensembl chrNW_004624817:4,779,057...4,793,732 		JBrowse link
G Ins insulin ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:3322910 PMID:11522680 PMID:24648896 PMID:25796170 PMID:33651899 RGD:2311112 NCBI chrNW_004624767:14,999,088...15,000,035
Ensembl chrNW_004624767:14,999,088...15,000,035 		JBrowse link
G Insr insulin receptor disease_progression
treatment 		ISO mRNA, protein:decreased expression:liver (rat)
ClinVar Annotator: match by term: Insulin resistance | ClinVar Annotator: match by term: Insulin-resistance syndrome type A 		RGD
ClinVar		 PMID:1314826 PMID:1644241 PMID:1890161 PMID:1963473 PMID:1971035 More... RGD:10403037 RGD:11529553 NCBI chrNW_004624828:345,135...485,856
Ensembl chrNW_004624828:345,135...486,184 		JBrowse link
G Irs1 insulin receptor substrate 1 ISO ClinVar Annotator: match by term: Insulin resistance, susceptibility to ClinVar PMID:1311924 PMID:7623569 PMID:8104271 PMID:8647950 PMID:10084586 More... NCBI chrNW_004624843:1,113,075...1,178,859
Ensembl chrNW_004624843:1,120,974...1,178,859 		JBrowse link
G Irs2 insulin receptor substrate 2 ISO DNA:polymorphism:exon:G1057D
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:15811564 PMID:25808216 RGD:1625025 NCBI chrNW_004624793:2,615,092...2,636,835
Ensembl chrNW_004624793:2,614,589...2,636,947 		JBrowse link
G Itgam integrin subunit alpha M ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chrNW_004624782:14,316,505...14,367,841
Ensembl chrNW_004624782:14,318,499...14,367,922 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9032110 NCBI chrNW_004624766:9,012,166...9,015,269
Ensembl chrNW_004624766:9,013,225...9,014,397 		JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 ISO mRNA, protein:decreased expression:aorta, mesenteric artery RGD PMID:21425425 RGD:10412047 NCBI chrNW_004624733:19,582,646...19,593,581
Ensembl chrNW_004624733:19,582,489...19,597,722 		JBrowse link
G Klf11 KLF transcription factor 11 ISO RGD PMID:18505768 RGD:2311539 NCBI chrNW_004624865:5,023,074...5,031,347 JBrowse link
G Klf14 KLF transcription factor 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29632379 NCBI chrNW_004624783:5,593,860...5,595,803
Ensembl chrNW_004624783:5,593,860...5,594,855 		JBrowse link
G Klk1 kallikrein 1 ISO RGD PMID:17272402 RGD:1641794 NCBI chrNW_004624832:3,869,255...3,873,350
Ensembl chrNW_004624832:3,868,465...3,873,290 		JBrowse link
G Lep leptin ISO associated with Obesity
CTD Direct Evidence: marker/mechanism|therapeutic
protein:increased expression:plasma
DNA:nonsense mutation:cds: 		RGD
CTD		 PMID:10753628 PMID:11342529 PMID:19296906 PMID:19419916 PMID:23800849 More... RGD:2311127 RGD:5128697 RGD:8549777 NCBI chrNW_004624783:7,708,820...7,721,610
Ensembl chrNW_004624783:7,708,588...7,721,727 		JBrowse link
G Lepr leptin receptor ISO associated with Obesity;DNA:missense mutation:CDS:p.K656N (human)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:missense mutation:CDS:p.K656N (human) 		RGD
CTD		 PMID:18413223 PMID:18632178 PMID:19452630 PMID:20567778 PMID:23154293 More... RGD:13432147 RGD:2311138 RGD:2311142 NCBI chrNW_004624742:29,221,742...29,313,273
Ensembl chrNW_004624742:29,223,392...29,337,049 		JBrowse link
G Lipc lipase C, hepatic type ISO CTD Direct Evidence: marker/mechanism CTD PMID:15504970 NCBI chrNW_004624781:13,342,469...13,468,120
Ensembl chrNW_004624781:13,342,357...13,455,055 		JBrowse link
G Lmna lamin A/C ISO ClinVar Annotator: match by term: Insulin-resistance syndrome type A ClinVar PMID:15919811 PMID:16478798 PMID:20848652 PMID:23785128 PMID:24033266 More... NCBI chrNW_004624885:1,423,563...1,466,657
Ensembl chrNW_004624885:1,447,395...1,467,554 		JBrowse link
G LOC101719398 serotransferrin ISO protein:increased expression:plasma RGD PMID:17350134 RGD:1601515 NCBI chrNW_004624730:10,078,165...10,109,349 JBrowse link
G LOC101724787 vitamin D 25-hydroxylase ISO DNA:SNP:CDS: rs12794714|rs10766197 (human) RGD PMID:34906413 RGD:401900724 NCBI chrNW_004624766:6,667,662...6,678,045
Ensembl chrNW_004624766:6,667,234...6,677,992 		JBrowse link
G Lpin1 lipin 1 ISO RGD PMID:17563064 RGD:1641822 NCBI chrNW_004624865:4,220,047...4,258,014
Ensembl chrNW_004624865:4,219,081...4,258,448 		JBrowse link
G Lpl lipoprotein lipase ISO RGD PMID:18952837 RGD:2313300 NCBI chrNW_004624758:15,652,553...15,680,107
Ensembl chrNW_004624758:15,651,992...15,680,762 		JBrowse link
G Lta lymphotoxin alpha no_association ISO DNA:polymorphism RGD PMID:9245742 RGD:1625035 NCBI chrNW_004624754:24,626,930...24,628,412
Ensembl chrNW_004624754:24,627,318...24,628,182 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO associated with polycystic ovary syndrome RGD PMID:23349861 RGD:13800789 NCBI chrNW_004624782:13,150,824...13,158,327
Ensembl chrNW_004624782:13,152,039...13,159,113 		JBrowse link
G Mc4r melanocortin 4 receptor ISO CTD Direct Evidence: marker/mechanism
mRNA, protein:decreased expression:liver (rat)
DNA:nonsense mutation:cds:p.K314X (rat) 		CTD
RGD		 PMID:18454146 PMID:24400148 PMID:35945320 RGD:13825242 RGD:329951016 NCBI chrNW_004624792:5,865,902...5,867,498
Ensembl chrNW_004624792:5,866,119...5,867,120 		JBrowse link
G Metrnl meteorin like, glial cell differentiation regulator ISO CTD Direct Evidence: therapeutic CTD PMID:30213948 NCBI chrNW_004624801:11,701,821...11,715,693
Ensembl chrNW_004624801:11,701,778...11,715,383 		JBrowse link
G Mettl14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chrNW_004624867:5,508,847...5,533,395
Ensembl chrNW_004624867:5,508,886...5,533,395 		JBrowse link
G Mfn2 mitofusin 2 treatment ISO RGD PMID:24715199 RGD:13204838 NCBI chrNW_004624818:1,041,371...1,065,061
Ensembl chrNW_004624818:1,041,369...1,065,023 		JBrowse link
G Mif macrophage migration inhibitory factor ISO protein:increased expression:plasma RGD PMID:12552367 RGD:1641955 NCBI chrNW_004624747:10,307,826...10,308,649
Ensembl chrNW_004624747:10,303,919...10,308,821 		JBrowse link
G Mlxipl MLX interacting protein like treatment ISO RGD PMID:26394137 RGD:329955565 NCBI chrNW_004624740:14,150,425...14,187,687
Ensembl chrNW_004624740:14,168,238...14,187,264 		JBrowse link
G Mlycd malonyl-CoA decarboxylase treatment ISO RGD PMID:26394137 RGD:329955565 NCBI chrNW_004624746:3,604,773...3,619,790
Ensembl chrNW_004624746:3,604,773...3,619,775 		JBrowse link
G Mrc1 mannose receptor C-type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29035695 NCBI chrNW_004624796:10,041,483...10,184,458
Ensembl chrNW_004624796:10,145,610...10,180,671
Ensembl chrNW_004624796:10,145,610...10,180,671 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO associated with Polycystic Ovary Syndrome;protein:increased expression:serum RGD PMID:17582143 RGD:1642341 NCBI chrNW_004624739:23,411,478...23,444,590
Ensembl chrNW_004624739:23,411,488...23,442,359 		JBrowse link
G Neil1 nei like DNA glycosylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21285402 NCBI chrNW_004624894:282,799...287,265
Ensembl chrNW_004624894:282,695...288,058 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO associated with obesity; protein:decreased expression:hepatocyte:
CTD Direct Evidence: therapeutic 		RGD
CTD		 PMID:32102936 PMID:33933676 RGD:21201281 NCBI chrNW_004624787:14,355,330...14,381,353
Ensembl chrNW_004624787:14,355,791...14,381,251 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35226250 NCBI chrNW_004624937:564,191...584,470 JBrowse link
G Nos2 nitric oxide synthase 2 ISO mRNA, protein:increased expression:retroperitoneum, adipose tissue (rat) RGD PMID:21846719 PMID:22023455 RGD:5509041 RGD:5509075 NCBI chrNW_004624786:491,944...530,427
Ensembl chrNW_004624786:489,311...528,271 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO CTD Direct Evidence: marker/mechanism|therapeutic
protein:decreased expression:serum 		RGD
CTD		 PMID:11457755 PMID:12716763 PMID:12947532 PMID:18298918 PMID:19008412 More... RGD:13450950 RGD:2292098 NCBI chrNW_004624800:5,600,215...5,619,020
Ensembl chrNW_004624800:5,600,212...5,619,004 		JBrowse link
G Nppb natriuretic peptide B ISO associated with Obesity and Hypertension;protein:decreased expression:serum RGD PMID:17392814 RGD:1642192 NCBI chrNW_004624818:1,139,776...1,141,010 JBrowse link
G Nr1h4 nuclear receptor subfamily 1 group H member 4 susceptibility ISO RGD PMID:16557297 RGD:1625076 NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4 group A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17785466 NCBI chrNW_004624816:271,345...288,265
Ensembl chrNW_004624816:267,303...293,227 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4 group A member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17785466 NCBI chrNW_004624825:1,098,915...1,141,373
Ensembl chrNW_004624825:1,097,432...1,141,446 		JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit ISO CTD Direct Evidence: therapeutic CTD PMID:33812996 NCBI chrNW_004624798:12,132,570...12,154,252
Ensembl chrNW_004624798:12,130,569...12,154,314 		JBrowse link
G Parl presenilin associated rhomboid like ISO mRNA:decreased expression:gastrocnemius (rat) RGD PMID:19859837 RGD:12880442 NCBI chrNW_004624730:72,642,828...72,683,820
Ensembl chrNW_004624730:72,642,925...72,683,820 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 ISO protein:increased expression:pancreatic duct (rat)
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:decreased expression:pancreatic islet (mouse) 		RGD PMID:16046294 PMID:18288891 RGD:2311222 RGD:2311223 NCBI chrNW_004624776:10,591,855...10,596,738
Ensembl chrNW_004624776:10,591,855...10,596,676 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO CTD Direct Evidence: marker/mechanism
associated with Pre-Eclampsia;protein:increased tyrosine phosphorylation:placenta 		CTD
RGD		 PMID:10426374 PMID:14714311 PMID:16332940 PMID:17283057 RGD:1625211 RGD:1625212 RGD:1625262 NCBI chrNW_004624815:1,290,106...1,376,961
Ensembl chrNW_004624815:1,289,997...1,369,610 		JBrowse link
G Pklr pyruvate kinase L/R treatment ISO mRNA, protein:decreased expression:liver RGD PMID:12958186 PMID:26394137 RGD:1625583 RGD:329955565 NCBI chrNW_004624885:2,261,850...2,272,175
Ensembl chrNW_004624885:2,264,928...2,272,171 		JBrowse link
G Pla2g1b phospholipase A2 group IB susceptibility ISO RGD PMID:12376327 RGD:1302550 NCBI chrNW_004624747:13,322,095...13,329,928
Ensembl chrNW_004624747:13,322,675...13,329,926 		JBrowse link
G Plac8 placenta associated 8 ISO associated with obesity RGD PMID:26296322 RGD:10755343 NCBI chrNW_004624900:134,075...157,982
Ensembl chrNW_004624900:133,889...158,050 		JBrowse link
G Plekhs1 pleckstrin homology domain containing S1 ISO associated with obesity; RGD PMID:27523322 RGD:11532750 NCBI chrNW_004624737:32,810,663...32,835,211
Ensembl chrNW_004624737:32,810,212...32,835,258 		JBrowse link
G Plin2 perilipin 2 ISO associated with Obesity RGD PMID:17484887 RGD:1625752 NCBI chrNW_004624736:23,114,149...23,122,634
Ensembl chrNW_004624736:23,111,265...23,122,193 		JBrowse link
G Pltp phospholipid transfer protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:12754275 NCBI chrNW_004624790:8,673,212...8,686,094
Ensembl chrNW_004624790:8,673,089...8,685,942 		JBrowse link
G Pmch pro-melanin concentrating hormone ISO RGD PMID:16002548 RGD:1642484 NCBI chrNW_004624750:6,109,542...6,110,834
Ensembl chrNW_004624750:6,109,284...6,111,547 		JBrowse link
G Pon1 paraoxonase 1 ISO DNA:SNP:CDS:p.L55M (human), LL genotype (P < 0.001) RGD PMID:11788650 RGD:1642617 NCBI chrNW_004624813:1,953,796...1,979,846
Ensembl chrNW_004624813:1,949,614...1,979,882 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:16168052 PMID:19322024 PMID:21324916 RGD:5683642 NCBI chrNW_004624752:3,646,499...3,702,553
Ensembl chrNW_004624752:3,650,922...3,701,672 		JBrowse link
G Ppard peroxisome proliferator activated receptor delta ISO associated with Diabetes Mellitus, Non-Insulin-Dependent
associated with Obesity 		RGD PMID:14676330 PMID:19818749 RGD:2313780 RGD:2324897 NCBI chrNW_004624754:22,021,465...22,084,320 JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO CTD Direct Evidence: therapeutic
DNA:nonsense mutation 		CTD
RGD		 PMID:12118251 PMID:16168052 PMID:21354099 PMID:21484566 RGD:1601446 NCBI chrNW_004624956:84,673...207,176
Ensembl chrNW_004624956:83,842...149,481 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha treatment ISO DNA:missense mutation:cds:p.G482S rs8192678 (human)
mRNA:decreased expression:liver (rat) 		RGD PMID:22658649 PMID:23449621 PMID:26394137 RGD:329955565 RGD:7241821 RGD:7242170 NCBI chrNW_004624755:7,826,219...8,460,746
Ensembl chrNW_004624755:8,375,596...8,465,297 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta treatment ISO RGD PMID:16896940 PMID:26394137 RGD:1642499 RGD:329955565 NCBI chrNW_004624774:9,056,138...9,178,645
Ensembl chrNW_004624774:9,056,322...9,174,388 		JBrowse link
G Ppp1r3a protein phosphatase 1 regulatory subunit 3A ISO ClinVar Annotator: match by term: Insulin resistance, susceptibility to ClinVar PMID:7581368 PMID:25741868 NCBI chrNW_004624827:5,543,497...5,581,779
Ensembl chrNW_004624827:5,543,420...5,581,847 		JBrowse link
G Prdx3 peroxiredoxin 3 ISO associated with obesity; RGD PMID:27523322 RGD:11532750 NCBI chrNW_004624737:27,625,120...27,635,221 JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism
associated with Obesity 		CTD
RGD		 PMID:19934007 PMID:22231922 RGD:6484545 NCBI chrNW_004624759:14,143,439...14,174,971
Ensembl chrNW_004624759:14,142,956...14,171,718 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 susceptibility ISO DNA:SNPs
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:16567511 PMID:19934007 RGD:1625266 NCBI chrNW_004624862:3,443,720...3,496,078
Ensembl chrNW_004624862:3,450,078...3,496,142 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:29367455 NCBI chrNW_004624870:3,552,608...3,575,461
Ensembl chrNW_004624870:3,552,745...3,574,880 		JBrowse link
G Prkcb protein kinase C beta ISO RGD PMID:12665248 RGD:1625515 NCBI chrNW_004624782:8,974,995...9,287,609
Ensembl chrNW_004624782:8,974,765...9,287,702 		JBrowse link
G Prkcd protein kinase C delta ISO associated with Obesity;protein:increased activity:adipocyte
protein:altered localization:nucleus 		RGD PMID:12217885 PMID:15507533 RGD:1642527 RGD:729667 NCBI chrNW_004624822:4,035,819...4,062,907
Ensembl chrNW_004624822:4,033,130...4,059,555 		JBrowse link
G Prkcq protein kinase C theta ISO associated with Obesity;protein:decreased expression:skeletal muscle
protein:altered localization:skeletal muscle 		RGD PMID:9000691 PMID:10923637 RGD:1625603 RGD:1625604 NCBI chrNW_004624775:1,419,596...1,543,805
Ensembl chrNW_004624775:1,419,509...1,502,064 		JBrowse link
G Prkcz protein kinase C zeta ISO protein::skeletal muscle:reduced response to insulin in obese and diabetic subjects RGD PMID:12882908 RGD:1642650 NCBI chrNW_004624818:7,758,192...7,846,950
Ensembl chrNW_004624818:7,759,770...7,847,208 		JBrowse link
G Prkd1 protein kinase D1 susceptibility ISO human gene in a mouse model RGD PMID:25173922 RGD:307436943 NCBI chrNW_004624820:2,408,562...2,726,199
Ensembl chrNW_004624820:2,408,360...2,726,606 		JBrowse link
G Prl prolactin ISO associated with Hyperprolactinemia RGD PMID:3888755 RGD:1642560 NCBI chrNW_004624756:4,585,542...4,593,285 JBrowse link
G Prmt7 protein arginine methyltransferase 7 ISO ClinVar Annotator: match by term: Insulin resistance ClinVar PMID:25741868 PMID:26437029 PMID:27718516 PMID:28492532 PMID:28902392 NCBI chrNW_004624746:17,949,443...18,017,344
Ensembl chrNW_004624746:17,948,085...18,001,259 		JBrowse link
G Pten phosphatase and tensin homolog ISO CTD Direct Evidence: marker/mechanism
protein:increased activity:liver (human)
protein:increased expression, decreased acetylation:liver 		CTD
RGD		 PMID:18303120 PMID:18385463 PMID:24367090 RGD:127285595 RGD:2292521 NCBI chrNW_004624791:13,975,235...14,056,900 JBrowse link
G Ptgds prostaglandin D2 synthase susceptibility ISO RGD PMID:15970590 RGD:1642581 NCBI chrNW_004624760:920,292...923,174
Ensembl chrNW_004624760:920,877...923,283 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO protein:decreased activity:aorta (rat) RGD PMID:16528409 RGD:401960098 NCBI chrNW_004624790:5,850,647...5,885,754
Ensembl chrNW_004624790:5,850,810...5,886,014 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO associated with Obesity RGD PMID:16039993 RGD:1642605 NCBI chrNW_004624758:22,065,448...22,182,604
Ensembl chrNW_004624758:22,124,836...22,182,605 		JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 ISO ClinVar Annotator: match by term: Insulin resistance, susceptibility to ClinVar PMID:11833006 NCBI chrNW_004624790:5,070,537...5,135,243
Ensembl chrNW_004624790:5,073,476...5,135,181 		JBrowse link
G Ptprf protein tyrosine phosphatase receptor type F ISO protein:increased activity, increased expression:skeletal muscle:activity increased to 140-170% of control in insulin-resistant obese (BMI>30) nondiabetic subjects (p<0.05); activity decreased to 39% in obese NIDDM subjects (p<0.05)
protein:increased expression::mouse model overexpressing human transgene, fasting plasma insulin increased 2.5-fold, glucose disposal and uptake into muscle reduced 		RGD PMID:9218523 PMID:11309481 RGD:1642733 RGD:1642735 NCBI chrNW_004624892:2,825,771...2,932,854 JBrowse link
G Pyy peptide YY ISO protein:decreased expression RGD PMID:17045646 RGD:1625281 NCBI chrNW_004624795:887,963...903,315
Ensembl chrNW_004624795:902,260...903,409 		JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO mRNA:decreased expression:adipose tissue RGD PMID:23315497 RGD:8547988 NCBI chrNW_004624748:6,358,588...6,533,217
Ensembl chrNW_004624748:6,358,180...6,533,249 		JBrowse link
G Rbp4 retinol binding protein 4 disease_progression
ameliorates 		ISO protein:decreased expression:blood serum (human) RGD PMID:21365528 PMID:29747616 RGD:329849113 RGD:329853304 NCBI chrNW_004624737:4,795,054...4,800,830
Ensembl chrNW_004624737:4,791,628...4,800,989 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:altered localization:soleus RGD PMID:18073321 PMID:18198644 RGD:2298857 RGD:2298860 NCBI chrNW_004624767:20,732,813...20,742,016
Ensembl chrNW_004624767:20,732,938...20,741,272 		JBrowse link
G Retn resistin ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:16493877 PMID:18789551 RGD:2313499 NCBI chrNW_004624828:735,562...737,166
Ensembl chrNW_004624828:735,503...737,166 		JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator ISO RGD PMID:16537411 RGD:2311703 NCBI chrNW_004624746:19,584,061...19,587,476
Ensembl chrNW_004624746:19,583,541...19,587,598 		JBrowse link
G Selenop selenoprotein P ISO CTD Direct Evidence: marker/mechanism CTD PMID:14714311 NCBI chrNW_004624759:12,207,251...12,218,857 JBrowse link
G Serpine1 serpin family E member 1 treatment ISO mRNA:increased expression:white adipose tissue (rat) RGD PMID:19776253 PMID:26188590 RGD:11073726 RGD:8547949 NCBI chrNW_004624740:16,128,145...16,136,696
Ensembl chrNW_004624740:16,128,059...16,137,337 		JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO associated with Hypertension
human protein in a rat model 		RGD PMID:19073347 PMID:22714715 PMID:24288442 RGD:2312339 RGD:8642993 RGD:8655563 NCBI chrNW_004624786:4,487,005...4,497,706
Ensembl chrNW_004624786:4,486,978...4,497,585 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO mRNA:increased expression:adipose tissue RGD PMID:17986714 RGD:1643171 NCBI chrNW_004624885:2,511,039...2,520,883
Ensembl chrNW_004624885:2,511,240...2,521,155 		JBrowse link
G Si sucrase-isomaltase ISO associated with Diabetes Mellitus, Type 2;mRNA:increased expression:small intestine RGD PMID:9878708 RGD:1625544 NCBI chrNW_004624730:42,984,277...43,112,819
Ensembl chrNW_004624730:42,984,431...43,112,819 		JBrowse link
G Sirt1 sirtuin 1 treatment ISO associated with Obesity
CTD Direct Evidence: marker/mechanism|therapeutic 		RGD
CTD		 PMID:19996381 PMID:20068143 PMID:21321189 PMID:24442997 PMID:25849131 More... RGD:9585759 NCBI chrNW_004624754:2,304,476...2,332,705
Ensembl chrNW_004624754:2,304,634...2,330,946 		JBrowse link
G Sirt4 sirtuin 4 ISO RGD PMID:20651844 RGD:9586052 NCBI chrNW_004624747:13,329,662...13,352,151
Ensembl chrNW_004624747:13,335,442...13,352,201 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 ISO protein::heart:basal level increased but unresponsive to insulin on a high cholesterol, high fructose diet RGD PMID:17400720 RGD:1642795 NCBI chrNW_004624908:531,313...549,570
Ensembl chrNW_004624908:531,308...549,990 		JBrowse link
G Slc27a4 solute carrier family 27 member 4 ISO mRNA:increased expression:subcutaneous adipose tissue RGD PMID:15168018 RGD:1625638 NCBI chrNW_004624760:6,529,028...6,542,067
Ensembl chrNW_004624760:6,529,027...6,542,149 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 ISO mRNA,protein:decreased expression:muscle RGD PMID:11436180 RGD:1642802 NCBI chrNW_004624860:5,069,246...5,153,435 JBrowse link
G Slc2a4 solute carrier family 2 member 4 ISO associated with Heart Failure, Congestive;protein:decreased expression:skeletal muscle
CTD Direct Evidence: therapeutic 		RGD
CTD		 PMID:11947963 PMID:18778861 RGD:2313624 NCBI chrNW_004624786:9,903,176...9,908,953
Ensembl chrNW_004624786:9,902,509...9,909,684 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO associated with Diabetes Mellitus RGD PMID:15240880 RGD:1625677 NCBI chrNW_004624824:8,444,877...8,446,628 JBrowse link
G Socs3 suppressor of cytokine signaling 3 susceptibility ISO associated with Obesity
associated with Diabetes Mellitus 		RGD PMID:15240880 PMID:17295835 RGD:1625677 RGD:2313789 NCBI chrNW_004624801:7,841,230...7,843,912
Ensembl chrNW_004624801:7,840,889...7,843,860 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:22829583 NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367 		JBrowse link
G Sod3 superoxide dismutase 3 ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:plasma RGD PMID:15171689 RGD:1625698 NCBI chrNW_004624755:7,535,044...7,541,298
Ensembl chrNW_004624755:7,535,044...7,541,221 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 susceptibility ISO RGD PMID:17351624 RGD:1642731 NCBI chrNW_004624737:6,646,837...6,875,408
Ensembl chrNW_004624737:6,647,651...6,786,335 		JBrowse link
G Sox6 SRY-box transcription factor 6 ISO RGD PMID:16148004 RGD:1581307 NCBI chrNW_004624766:7,683,492...8,301,823
Ensembl chrNW_004624766:7,689,775...8,084,764 		JBrowse link
G Sqstm1 sequestosome 1 ISO CTD Direct Evidence: therapeutic CTD PMID:33933676 NCBI chrNW_004624733:42,689,454...42,700,916
Ensembl chrNW_004624733:42,691,841...42,700,916 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 treatment
susceptibility 		ISO associated with Fatty Liver;mRNA:increased expression:liver
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:17241878 PMID:18692268 PMID:22658938 PMID:26394137 RGD:2308807 RGD:2308809 RGD:329955565 NCBI chrNW_004624849:3,602,103...3,623,922
Ensembl chrNW_004624849:3,602,261...3,623,465 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20699619 NCBI chrNW_004624752:6,815,075...6,871,674
Ensembl chrNW_004624752:6,816,468...6,871,567 		JBrowse link
G Stk11 serine/threonine kinase 11 ISO associated with obesity;protein:decreased expression:gastrocnemius RGD PMID:16352671 RGD:1601389 NCBI chrNW_004624828:7,444,339...7,466,926
Ensembl chrNW_004624828:7,445,069...7,467,298 		JBrowse link
G Sts steroid sulfatase ISO CTD Direct Evidence: therapeutic CTD PMID:24497646 NCBI chrNW_004624834:4,805,556...4,975,264
Ensembl chrNW_004624834:4,853,045...4,978,111 		JBrowse link
G Syn1 synapsin I ISO RGD PMID:29566703 RGD:13542091 NCBI chrNW_004624978:110,640...179,910
Ensembl chrNW_004624978:110,506...180,568 		JBrowse link
G Tbc1d4 TBC1 domain family member 4 ISO ClinVar Annotator: match by term: Insulin resistance ClinVar NCBI chrNW_004624751:24,999,301...25,183,905
Ensembl chrNW_004624751:24,999,386...25,181,702 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO DNA:SNP (human) RGD PMID:19509102 RGD:2312433 NCBI chrNW_004624737:33,341,574...33,526,814
Ensembl chrNW_004624737:33,341,029...33,526,928 		JBrowse link
G Tfap2b transcription factor AP-2 beta ISO RGD PMID:16373417 RGD:1601544 NCBI chrNW_004624855:5,353,347...5,381,454
Ensembl chrNW_004624855:5,355,239...5,381,477 		JBrowse link
G Thbd thrombomodulin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:11453033 RGD:2312460 NCBI chrNW_004624741:22,880,481...22,883,962 JBrowse link
G Tlr4 toll like receptor 4 severity ISO associated with Obesity
protein:increased expression:skeletal muscle 		RGD PMID:17426960 PMID:18633101 PMID:19675137 RGD:1620681 RGD:2312483 RGD:2312489 NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120 		JBrowse link
G Tnf tumor necrosis factor treatment ISO associated with Obesity
CTD Direct Evidence: marker/mechanism
associated with obesity 		RGD
CTD		 PMID:9832430 PMID:14764603 PMID:16202847 PMID:16493877 PMID:20943792 More... RGD:10450578 RGD:14995428 RGD:1580214 RGD:1580312 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11b ISO associated with obesity;protein:increased expression:serum RGD PMID:15936463 RGD:1620889 NCBI chrNW_004624763:17,139,109...17,166,398
Ensembl chrNW_004624763:17,138,847...17,166,453 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression RGD PMID:11882518 RGD:1624180 NCBI chrNW_004624860:3,111,244...3,123,041
Ensembl chrNW_004624860:3,111,630...3,122,711 		JBrowse link
G Trib3 tribbles pseudokinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20461355 NCBI chrNW_004624741:1,486,223...1,494,005
Ensembl chrNW_004624741:1,484,863...1,494,829 		JBrowse link
G Tsc1 TSC complex subunit 1 ISO RGD PMID:15380067 RGD:1624197 NCBI chrNW_004624760:3,479,028...3,536,612
Ensembl chrNW_004624760:3,498,692...3,532,011 		JBrowse link
G Ucp1 uncoupling protein 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP:5' utr:-112A>C (rs10011540) (human) RGD PMID:16338218 RGD:1624979 NCBI chrNW_004625006:155,179...162,544
Ensembl chrNW_004625006:155,100...162,551 		JBrowse link
G Ucp2 uncoupling protein 2 ISO DNA:polymorphism, insertion:promoter:-866G>A (rs659366)(human) RGD PMID:17870627 RGD:2313512 NCBI chrNW_004624817:3,067,358...3,075,045
Ensembl chrNW_004624817:3,067,320...3,075,043 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO RGD PMID:11882338 RGD:1580351 NCBI chrNW_004624857:3,606,573...3,625,991
Ensembl chrNW_004624857:3,606,431...3,627,063 		JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:25801026 RGD:14402022 NCBI chrNW_004624816:4,314,146...4,423,946
Ensembl chrNW_004624816:4,365,961...4,424,514 		JBrowse link
G Vwf von Willebrand factor ISO protein:increased expression:plasma RGD PMID:16631442 RGD:1625711 NCBI chrNW_004624860:2,843,268...2,973,888
Ensembl chrNW_004624860:2,858,088...2,973,052 		JBrowse link
G Xbp1 X-box binding protein 1 treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:15486293 PMID:26394137 PMID:27325692 RGD:2326004 RGD:329955565 NCBI chrNW_004624747:5,123,085...5,128,465 JBrowse link
G Zc3h10 zinc finger CCCH-type containing 10 ISO CTD Direct Evidence: therapeutic CTD PMID:31775033 NCBI chrNW_004624802:11,886,029...11,891,640
Ensembl chrNW_004624802:11,886,878...11,891,491 		JBrowse link
abdominal obesity-metabolic syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctf1 cardiotrophin 1 ISO MouseDO NCBI chrNW_004624782:13,976,308...13,979,327 JBrowse link
G Gucy2c guanylate cyclase 2C ISO MouseDO NCBI chrNW_004624752:23,285,987...23,357,662
Ensembl chrNW_004624752:23,286,093...23,357,662 		JBrowse link
G Lep leptin ISO MouseDO NCBI chrNW_004624783:7,708,820...7,721,610
Ensembl chrNW_004624783:7,708,588...7,721,727 		JBrowse link
G Neil1 nei like DNA glycosylase 1 ISO MouseDO NCBI chrNW_004624894:282,799...287,265
Ensembl chrNW_004624894:282,695...288,058 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15309680 NCBI chrNW_004624752:3,646,499...3,702,553
Ensembl chrNW_004624752:3,650,922...3,701,672 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO MouseDO NCBI chrNW_004624956:84,673...207,176
Ensembl chrNW_004624956:83,842...149,481 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO mRNA:increased expression:gastrocnemius muscle (rat) RGD PMID:23320128 RGD:7241841 NCBI chrNW_004624755:7,826,219...8,460,746
Ensembl chrNW_004624755:8,375,596...8,465,297 		JBrowse link
G Prkci protein kinase C iota ISO MouseDO NCBI chrNW_004624730:48,258,524...48,340,217 JBrowse link
G Sirt3 sirtuin 3 ISO MouseDO NCBI chrNW_004624766:22,199,741...22,233,933
Ensembl chrNW_004624766:22,199,601...22,233,933 		JBrowse link
G Slc2a9 solute carrier family 2 member 9 ISO MouseDO NCBI chrNW_004624755:21,165,374...21,328,843
Ensembl chrNW_004624755:21,171,274...21,322,543 		JBrowse link
abdominal obesity-metabolic syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO protein:increased oxidation:cardiac muscle cell RGD PMID:23997093 RGD:13782087 NCBI chrNW_004624747:21,509,360...21,567,424
Ensembl chrNW_004624747:21,509,366...21,568,098 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chrNW_004624832:5,050,222...5,068,565
Ensembl chrNW_004624832:5,050,222...5,055,506 		JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chrNW_004624792:8,854,345...9,032,727
Ensembl chrNW_004624792:8,859,522...9,031,344 		JBrowse link
G Fadd Fas associated via death domain treatment ISO RGD PMID:27131981 RGD:13792503 NCBI chrNW_004624767:17,050,929...17,059,648
Ensembl chrNW_004624767:17,055,509...17,059,705 		JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:30172001 RGD:13792561 NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848 		JBrowse link
G Lep leptin ISO OMIM:605552 MouseDO NCBI chrNW_004624783:7,708,820...7,721,610
Ensembl chrNW_004624783:7,708,588...7,721,727 		JBrowse link
G Lpl lipoprotein lipase treatment ISO RGD PMID:26996629 RGD:13794382 NCBI chrNW_004624758:15,652,553...15,680,107
Ensembl chrNW_004624758:15,651,992...15,680,762 		JBrowse link
G Mttp microsomal triglyceride transfer protein ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 1 ClinVar PMID:8533758 PMID:9671739 PMID:16721486 PMID:25741868 PMID:28492532 NCBI chrNW_004624830:7,463,671...7,505,607
Ensembl chrNW_004624830:7,464,686...7,506,129 		JBrowse link
G Tlr2 toll like receptor 2 susceptibility ISO RGD PMID:19841034 RGD:15090861 NCBI chrNW_004624858:4,931,820...4,984,175
Ensembl chrNW_004624858:4,979,485...4,981,833 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 ISO OMIM:605552 MouseDO NCBI chrNW_004624763:2,278,751...2,297,149
Ensembl chrNW_004624763:2,277,794...2,296,423 		JBrowse link
abdominal obesity-metabolic syndrome 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahdc1 AT-hook DNA binding motif containing 1 ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3 ClinVar PMID:25741868 PMID:29696776 PMID:33644933 NCBI chrNW_004624764:11,416,674...11,482,622
Ensembl chrNW_004624764:11,416,674...11,482,601 		JBrowse link
G Dyrk1b dual specificity tyrosine phosphorylation regulated kinase 1B ISO ClinVar Annotator: match by term: Abdominal obesity-metabolic syndrome 3 | ClinVar Annotator: match by term: CENTRAL OBESITY, TYPE 2 DIABETES, HYPERTENSION, AND EARLY-ONSET CORONARY ARTERY DISEASE | ClinVar Annotator: match by term: DYRK1B-related condition OMIM
ClinVar		 PMID:9536098 PMID:17576681 PMID:24827035 PMID:25741868 PMID:28492532 More... NCBI chrNW_004624925:40,175...56,177
Ensembl chrNW_004624925:46,748...55,481 		JBrowse link
Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor ISO ClinVar Annotator: match by term: DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS, TYPE A | ClinVar Annotator: match by term: IRAN, TYPE A OMIM
ClinVar		 PMID:1644241 PMID:1963473 PMID:1971035 PMID:2002058 PMID:2040394 More... NCBI chrNW_004624828:345,135...485,856
Ensembl chrNW_004624828:345,135...486,184 		JBrowse link
G Lmna lamin A/C ISO ClinVar Annotator: match by term: IRAN, TYPE A ClinVar PMID:15919811 PMID:16478798 PMID:20848652 PMID:23785128 PMID:24033266 More... NCBI chrNW_004624885:1,423,563...1,466,657
Ensembl chrNW_004624885:1,447,395...1,467,554 		JBrowse link
Metabolic Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 susceptibility ISO DNA:SNP:exon:p.R230C (rs9282541) (human) RGD PMID:17287470 RGD:1601092 NCBI chrNW_004624758:6,449,583...6,590,244
Ensembl chrNW_004624758:6,449,629...6,588,664 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha ameliorates ISO mRNA:increased expression:liver (mouse) RGD PMID:27821167 PMID:29684438 RGD:329333017 RGD:401799622 NCBI chrNW_004624871:4,103,014...4,364,690
Ensembl chrNW_004624871:4,105,067...4,412,325 		JBrowse link
G Acacb acetyl-CoA carboxylase beta ISO mRNA:increased expression:liver (mouse) RGD PMID:29684438 RGD:329333017 NCBI chrNW_004624747:12,287,817...12,426,340
Ensembl chrNW_004624747:12,307,541...12,424,897 		JBrowse link
G Acadvl acyl-CoA dehydrogenase very long chain treatment ISO RGD PMID:25191539 RGD:10047118 NCBI chrNW_004624786:9,838,102...9,843,506
Ensembl chrNW_004624786:9,838,227...9,843,332 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 susceptibility ISO DNA:polymorphism RGD PMID:14557872 RGD:1581921 NCBI chrNW_004624855:3,177,402...3,199,634
Ensembl chrNW_004624855:3,176,171...3,199,705 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNP: :276G>T (human)
CTD Direct Evidence: marker/mechanism
protein:decreased expression:serum
associated with vascular diseases; protein:decreased expression:plasma 		RGD
CTD		 PMID:16793964 PMID:17618945 PMID:17893004 PMID:18162013 PMID:19690575 More... RGD:2313234 RGD:5686407 RGD:5686428 RGD:5686800 NCBI chrNW_004624730:69,941,963...69,959,266
Ensembl chrNW_004624730:69,941,001...69,957,012 		JBrowse link
G Adrb2 adrenoceptor beta 2 susceptibility ISO DNA:polymorphisms: :p.R16G, p.Q27E RGD PMID:14557466 RGD:1601127 NCBI chrNW_004624774:8,211,723...8,215,962
Ensembl chrNW_004624774:8,211,984...8,213,240 		JBrowse link
G Agt angiotensinogen ISO mRNA, protein:increased expression:adipose tissue RGD PMID:17260464 RGD:1601134 NCBI chrNW_004624775:18,846,222...18,856,093
Ensembl chrNW_004624775:18,849,118...18,855,577 		JBrowse link
G Agtr1 angiotensin II receptor type 1 susceptibility ISO DNA:snp:3' utr:c.5186A>C RGD PMID:17211857 RGD:1601146 NCBI chrNW_004624730:25,964,848...26,006,468
Ensembl chrNW_004624730:25,964,811...26,006,463 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated susceptibility ISO protein:increased expression:serum RGD PMID:16249437 RGD:1601174 NCBI chrNW_004624764:6,393,741...6,447,739
Ensembl chrNW_004624764:6,393,765...6,447,829 		JBrowse link
G Apoa1 apolipoprotein A1 ISO protein:decreased expression:serum (human)
DNA: polymorphism: :G2, G3 and G5 		RGD PMID:17217166 PMID:21410987 RGD:1601183 RGD:5508220 NCBI chrNW_004624784:12,249,283...12,251,215
Ensembl chrNW_004624784:12,249,283...12,251,136 		JBrowse link
G Apoa2 apolipoprotein A2 ISO protein:decreased expression:serum RGD PMID:19817643 RGD:2313955 NCBI chrNW_004624794:164,351...165,676
Ensembl chrNW_004624794:164,370...166,248 		JBrowse link
G Apoa5 apolipoprotein A5 susceptibility ISO DNA:polymorphism: :p.S19W (human) RGD PMID:18789138 RGD:2313315 NCBI chrNW_004624784:12,213,205...12,216,039
Ensembl chrNW_004624784:12,213,744...12,216,026 		JBrowse link
G Apob apolipoprotein B ISO protein:increased expression:plasma RGD PMID:16828905 RGD:1601198 NCBI chrNW_004624738:3,579,747...3,622,508
Ensembl chrNW_004624738:3,580,033...3,620,192 		JBrowse link
G Apoc3 apolipoprotein C3 susceptibility ISO protein:increased expression:serum (human)
DNA:polymorphism:promoter:-482C>T, -455T>C 		RGD PMID:16298371 PMID:17416293 RGD:1601223 RGD:2306766 NCBI chrNW_004624784:12,244,565...12,246,790
Ensembl chrNW_004624784:12,244,646...12,246,790 		JBrowse link
G Apom apolipoprotein M ISO protein:decreased expression:plasma RGD PMID:19539616 RGD:2314236 NCBI chrNW_004624754:24,554,705...24,558,093
Ensembl chrNW_004624754:24,554,705...24,557,098 		JBrowse link
G Atm ATM serine/threonine kinase ISO RGD PMID:17084711 RGD:1601248 NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216 		JBrowse link
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit ISO RGD PMID:23320804 RGD:13838660 NCBI chrNW_004624776:18,466,952...18,495,693
Ensembl chrNW_004624776:18,467,967...18,495,651 		JBrowse link
G Bche butyrylcholinesterase ISO protein:increased expression:serum RGD PMID:15907830 RGD:1601317 NCBI chrNW_004624730:43,793,550...43,849,169
Ensembl chrNW_004624730:43,793,040...43,843,519 		JBrowse link
G Bdnf brain derived neurotrophic factor ISO RGD PMID:11935372 RGD:1580935 NCBI chrNW_004624766:17,281,882...17,330,601
Ensembl chrNW_004624766:17,279,630...17,330,490 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO protein:decreased expression:serum RGD PMID:21760737 RGD:6483594 NCBI chrNW_004624885:1,526,625...1,528,235
Ensembl chrNW_004624885:1,527,538...1,528,109 		JBrowse link
G C3 complement C3 ISO RGD PMID:16488421 RGD:2314030 NCBI chrNW_004624828:3,773,816...3,798,077
Ensembl chrNW_004624828:3,770,221...3,797,946 		JBrowse link
G Capn10 calpain 10 ISO DNA:polymorphism RGD PMID:16546286 RGD:1625050 NCBI chrNW_004624847:4,911,052...4,922,549
Ensembl chrNW_004624847:4,911,737...4,922,192 		JBrowse link
G Cck cholecystokinin ISO protein:decreased expression:plasma:associated with Obesity, Morbid (MeSH:D009767) RGD PMID:17443025 RGD:1625798 NCBI chrNW_004624730:77,310,080...77,314,258
Ensembl chrNW_004624730:77,309,633...77,314,384 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:plasma (rat) RGD PMID:19905967 RGD:4889977 NCBI chrNW_004624875:3,334,136...3,342,085
Ensembl chrNW_004624875:3,334,078...3,341,614 		JBrowse link
G Cd163 CD163 molecule susceptibility ISO protein:increased expression:blood serum (human) RGD PMID:31027316 RGD:127345132 NCBI chrNW_004624860:3,976,746...4,000,349
Ensembl chrNW_004624860:3,975,747...4,000,349 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) ISO DNA:SNPs: :multiple (human) RGD PMID:9916795 PMID:18305138 RGD:2307208 RGD:619666 NCBI chrNW_004624739:29,341,620...29,441,232
Ensembl chrNW_004624739:29,407,568...29,441,333 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:serum RGD PMID:16423632 PMID:20006362 RGD:2314214 RGD:5490591 NCBI chrNW_004624808:10,472,028...10,484,407
Ensembl chrNW_004624808:10,472,572...10,484,338 		JBrowse link
G Chek2 checkpoint kinase 2 ISO mRNA:increased expression:heart left ventricle (rat) RGD PMID:25129990 RGD:10400905 NCBI chrNW_004624747:5,035,045...5,072,555
Ensembl chrNW_004624747:5,035,200...5,070,332 		JBrowse link
G Ciita class II major histocompatibility complex transactivator ISO DNA:polymorphism:promoter:-168A>G RGD PMID:17183695 RGD:5491201 NCBI chrNW_004624824:8,099,877...8,156,661
Ensembl chrNW_004624824:8,116,537...8,153,482 		JBrowse link
G Crp C-reactive protein ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16644639 PMID:21357282 RGD:6482318 NCBI chrNW_004624794:1,531,555...1,533,804
Ensembl chrNW_004624794:1,531,571...1,533,804 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 ISO RGD PMID:32360427 RGD:151347874 NCBI chrNW_004624754:24,881,439...24,905,633
Ensembl chrNW_004624754:24,880,496...24,896,995 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 treatment ISO RGD PMID:21990351 RGD:10401057 NCBI chrNW_004624735:12,525,120...12,535,436
Ensembl chrNW_004624735:12,525,284...12,535,193 		JBrowse link
G Dio2 iodothyronine deiodinase 2 ISO DNA:polymorphism: :p.T92A (human) RGD PMID:18198294 RGD:2313696 NCBI chrNW_004624734:21,787,705...21,802,096 JBrowse link
G Ephx2 epoxide hydrolase 2 ISO RGD PMID:22007192 RGD:5688391 NCBI chrNW_004624758:22,216,462...22,252,467
Ensembl chrNW_004624758:22,221,314...22,254,813 		JBrowse link
G F3 coagulation factor III, tissue factor ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:12417540 RGD:2313865 NCBI chrNW_004624742:3,112,827...3,123,424
Ensembl chrNW_004624742:3,112,801...3,124,301 		JBrowse link
G Fadd Fas associated via death domain ISO protein:increased expression:heart left ventricle RGD PMID:23657904 RGD:11344884 NCBI chrNW_004624767:17,050,929...17,059,648
Ensembl chrNW_004624767:17,055,509...17,059,705 		JBrowse link
G Fas Fas cell surface death receptor ISO mRNA:increased expression:liver (rat) RGD PMID:11934685 RGD:628329 NCBI chrNW_004624791:15,290,022...15,315,848
Ensembl chrNW_004624791:15,289,348...15,315,848 		JBrowse link
G Fasn fatty acid synthase ameliorates ISO mRNA:increased expression:liver (mouse) RGD PMID:27821167 PMID:29684438 PMID:31353547 RGD:329333017 RGD:401799622 RGD:401850595 NCBI chrNW_004624801:10,910,022...10,926,505
Ensembl chrNW_004624801:10,909,647...10,927,547 		JBrowse link
G Fgf19 fibroblast growth factor 19 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28673684 NCBI chrNW_004624767:17,434,501...17,439,351
Ensembl chrNW_004624767:17,432,358...17,438,173 		JBrowse link
G Fgf21 fibroblast growth factor 21 treatment ISO RGD PMID:25306889 RGD:10401890 NCBI chrNW_004624832:5,165,195...5,166,865
Ensembl chrNW_004624832:5,164,856...5,167,370 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO DNA:SNPs: :rs1421085, rs1558902, rs8050136, rs9939609 (human)
DNA:SNP: :rs9939973 (human) 		RGD PMID:21796137 PMID:32061761 RGD:329853776 RGD:329901771 NCBI chrNW_004624757:2,675,810...3,081,751
Ensembl chrNW_004624757:2,675,671...3,080,480 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chrNW_004624795:1,331,592...1,339,575
Ensembl chrNW_004624795:1,331,601...1,339,580 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment ISO RGD PMID:19374165 PMID:24868532 RGD:10449117 RGD:2307350 NCBI chrNW_004624946:989,376...1,001,787
Ensembl chrNW_004624946:986,107...1,001,955 		JBrowse link
G Gcg glucagon ameliorates ISO RGD PMID:31353547 RGD:401850595 NCBI chrNW_004624732:3,361,897...3,370,020
Ensembl chrNW_004624732:3,362,234...3,370,536 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment ISO RGD PMID:34200262 RGD:329970293 NCBI chrNW_004624731:14,459,164...14,502,485
Ensembl chrNW_004624731:14,459,303...14,500,429 		JBrowse link
G Gck glucokinase ameliorates ISO RGD PMID:31353547 RGD:401850595 NCBI chrNW_004624740:7,844,496...7,885,900
Ensembl chrNW_004624740:7,852,390...7,886,758 		JBrowse link
G Gckr glucokinase regulator ISO RGD PMID:19861489 RGD:7242423 NCBI chrNW_004624738:9,552,260...9,574,082
Ensembl chrNW_004624738:9,552,386...9,574,082 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 susceptibility ISO RGD PMID:17095717 PMID:24847614 RGD:14747015 RGD:1601300 NCBI chrNW_004624747:10,030,034...10,048,554 JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO ClinVar Annotator: match by term: Metabolic syndrome, susceptibility to ClinVar PMID:11502844 PMID:12050239 PMID:12161552 PMID:16204371 PMID:25741868 NCBI chrNW_004624731:5,257,813...5,262,878
Ensembl chrNW_004624731:5,257,830...5,262,473 		JBrowse link
G Gpr17 G protein-coupled receptor 17 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34144038 NCBI chrNW_004624732:14,115,267...14,129,714
Ensembl chrNW_004624732:14,115,325...14,128,169 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO protein:increased expression:serum RGD PMID:24819036 RGD:401827122 NCBI chrNW_004624733:40,957,895...40,963,469
Ensembl chrNW_004624733:40,957,999...40,962,993 		JBrowse link
G Gsn gelsolin severity ISO RGD PMID:29684438 RGD:329333017 NCBI chrNW_004624760:13,943,680...14,004,660
Ensembl chrNW_004624760:13,943,888...13,969,905 		JBrowse link
G Hdac3 histone deacetylase 3 ISO RGD PMID:21763752 RGD:9590183 NCBI chrNW_004624774:845,970...864,080
Ensembl chrNW_004624774:845,358...863,809 		JBrowse link
G Hgf hepatocyte growth factor ISO study in the Japanese population RGD PMID:15713721 RGD:1642702 NCBI chrNW_004624739:30,233,589...30,307,508
Ensembl chrNW_004624739:30,236,146...30,307,356 		JBrowse link
G Hmga1 high mobility group AT-hook 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23512162 NCBI chrNW_004624754:22,888,052...22,900,685
Ensembl chrNW_004624754:22,892,226...22,898,807 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ameliorates ISO RGD PMID:19461650 PMID:27821167 PMID:31353547 RGD:401799622 RGD:401850595 RGD:5508692 NCBI chrNW_004624951:681,559...711,476
Ensembl chrNW_004624951:682,178...711,474 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:22193921 RGD:10763276 NCBI chrNW_004624750:341,699...346,005
Ensembl chrNW_004624750:342,146...345,887 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha ISO Finnish population; DNA:haplotype:CDS:SNPs rs6031558-rs745975-rs3212198, haplotype H1A (1-1-2) RGD PMID:16804065 RGD:1601642 NCBI chrNW_004624790:10,039,344...10,065,167
Ensembl chrNW_004624790:10,038,999...10,100,649 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 susceptibility
disease_progression 		ISO DNA:SNPs:5'utr,enhancer: (rs846910,rs12086634) (human)
DNA:SNP:: (rs846910) (human)
DNA:SNP: (rs12086634)T>G (human)
mRNA:increased expression:ascending aorta,epicardial fat (human) 		RGD PMID:14697232 PMID:21622477 PMID:23007990 PMID:23869418 PMID:28750217 RGD:1625074 RGD:329901909 RGD:329901919 RGD:329901929 RGD:329901930 NCBI chrNW_004624807:2,260,702...2,293,962
Ensembl chrNW_004624807:2,261,006...2,293,804 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:17632216 PMID:18515891 PMID:19142101 NCBI chrNW_004624940:1,040,744...1,299,266
Ensembl chrNW_004624940:1,040,911...1,157,057 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:19394054 RGD:2313467 NCBI chrNW_004624828:2,432,584...2,451,997
Ensembl chrNW_004624828:2,432,550...2,453,071 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 susceptibility ISO RGD PMID:31064654 RGD:14985252 NCBI chrNW_004624768:17,094,649...17,111,333
Ensembl chrNW_004624768:17,094,655...17,111,397 		JBrowse link
G Igf2 insulin like growth factor 2 ISO DNA:insertion RGD PMID:18418699 RGD:2311520 NCBI chrNW_004624767:14,969,977...14,997,577
Ensembl chrNW_004624767:14,969,866...14,979,026 		JBrowse link
G Igfbp2 insulin like growth factor binding protein 2 ISO RGD PMID:16915540 RGD:1626481 NCBI chrNW_004624823:8,460,968...8,486,495
Ensembl chrNW_004624823:8,460,553...8,486,495 		JBrowse link
G Il18 interleukin 18 treatment ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:serum 		RGD
CTD		 PMID:16644639 PMID:19717152 PMID:24456735 RGD:4889401 RGD:8655985 NCBI chrNW_004624784:7,294,286...7,312,959
Ensembl chrNW_004624784:7,294,183...7,304,687 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16644639 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Il6r interleukin 6 receptor susceptibility ISO DNA:polymorphism: :p.D358A RGD PMID:16817825 RGD:1625430 NCBI chrNW_004624885:2,910,367...2,946,916
Ensembl chrNW_004624885:2,910,112...2,946,886 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase like 1 ISO DNA:SNPs: :rs2276047,snp8(human)
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:15220217 RGD:1626127 NCBI chrNW_004624817:4,779,875...4,794,644
Ensembl chrNW_004624817:4,779,057...4,793,732 		JBrowse link
G Ins insulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:11274935 PMID:16259526 NCBI chrNW_004624767:14,999,088...15,000,035
Ensembl chrNW_004624767:14,999,088...15,000,035 		JBrowse link
G Insr insulin receptor ameliorates ISO RGD PMID:31353547 RGD:401850595 NCBI chrNW_004624828:345,135...485,856
Ensembl chrNW_004624828:345,135...486,184 		JBrowse link
G Irs1 insulin receptor substrate 1 ameliorates ISO protein:decreased expression:skeletal muscle RGD PMID:10842668 PMID:31353547 RGD:401850595 RGD:6482864 NCBI chrNW_004624843:1,113,075...1,178,859
Ensembl chrNW_004624843:1,120,974...1,178,859 		JBrowse link
G Irs2 insulin receptor substrate 2 ameliorates ISO RGD PMID:31353547 RGD:401850595 NCBI chrNW_004624793:2,615,092...2,636,835
Ensembl chrNW_004624793:2,614,589...2,636,947 		JBrowse link
G Itgav integrin subunit alpha V ISO RGD PMID:16784924 RGD:1627640 NCBI chrNW_004624899:3,235,434...3,292,584
Ensembl chrNW_004624899:3,239,112...3,291,586 		JBrowse link
G Kl klotho ISO mRNA:decreased expression:kidney: RGD PMID:11027545 RGD:10403056 NCBI chrNW_004624915:95,155...110,834 JBrowse link
G Lbp lipopolysaccharide binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:23349936 NCBI chrNW_004624842:1,306,299...1,332,269
Ensembl chrNW_004624842:1,301,831...1,332,346 		JBrowse link
G Ldlr low density lipoprotein receptor ameliorates ISO RGD PMID:31353547 RGD:401850595 NCBI chrNW_004624828:2,999,122...3,021,893
Ensembl chrNW_004624828:2,999,169...3,021,987 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma (rat) 		CTD
RGD		 PMID:16793964 PMID:18515891 PMID:19462476 PMID:25380250 RGD:10053625 RGD:2311125 NCBI chrNW_004624783:7,708,820...7,721,610
Ensembl chrNW_004624783:7,708,588...7,721,727 		JBrowse link
G Lepr leptin receptor ISO DNA:mutations::cds: : (rat)
DNA:mutations:cds: : (rat) 		RGD PMID:10901178 PMID:28746409 PMID:32710530 RGD:401960103 RGD:401965413 RGD:401965414 NCBI chrNW_004624742:29,221,742...29,313,273
Ensembl chrNW_004624742:29,223,392...29,337,049 		JBrowse link
G Lipe lipase E, hormone sensitive type ISO mRNA:increased expression:liver (mouse) RGD PMID:29684438 RGD:329333017 NCBI chrNW_004624907:360,462...379,266
Ensembl chrNW_004624907:363,572...379,194 		JBrowse link
G Lipg lipase G, endothelial type ISO RGD PMID:16354105 RGD:1580865 NCBI chrNW_004624778:13,107,037...13,133,162
Ensembl chrNW_004624778:13,107,283...13,133,270 		JBrowse link
G Lmna lamin A/C ISO DNA:SNP: :c.138747C>T (human) RGD PMID:15205219 RGD:2306121 NCBI chrNW_004624885:1,423,563...1,466,657
Ensembl chrNW_004624885:1,447,395...1,467,554 		JBrowse link
G LOC101700701 cytochrome P450 11B1, mitochondrial susceptibility ISO DNA:polymorphism:promoter:-344C>T (human) RGD PMID:17261471 RGD:2307294 NCBI chrNW_004624735:13,701,382...13,708,750 JBrowse link
G LOC101701685 cholesterol 7-alpha-monooxygenase ameliorates ISO RGD PMID:31353547 RGD:401850595 NCBI chrNW_004624744:33,563,564...33,619,851
Ensembl chrNW_004624744:33,612,901...33,619,869 		JBrowse link
G LOC101717043 cytochrome b-245 light chain ISO RGD PMID:16741160 RGD:2317864 NCBI chrNW_004624746:911,852...919,361
Ensembl chrNW_004624746:911,842...919,362 		JBrowse link
G LOC101719398 serotransferrin susceptibility ISO protein:increased expression:serum RGD PMID:17416791 RGD:1601514 NCBI chrNW_004624730:10,078,165...10,109,349 JBrowse link
G Lrp6 LDL receptor related protein 6 ISO DNA:missense mutation:cds RGD PMID:17332414 RGD:2298725 NCBI chrNW_004624752:25,605,444...25,756,573
Ensembl chrNW_004624752:25,605,302...25,751,893 		JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 susceptibility ISO associated with Coronary Disease;DNA:SNP:exon RGD PMID:14557872 RGD:1581921 NCBI chrNW_004624755:24,436,128...24,447,923
Ensembl chrNW_004624755:24,436,208...24,449,147 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 ISO mRNA:decreased expression:blood, leukocyte (human) RGD PMID:26956845 RGD:155791561 NCBI chrNW_004624828:5,489,085...5,511,166
Ensembl chrNW_004624828:5,488,814...5,511,445 		JBrowse link
G Mlxipl MLX interacting protein like ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chrNW_004624740:14,150,425...14,187,687
Ensembl chrNW_004624740:14,168,238...14,187,264 		JBrowse link
G Mtmr9 myotubularin related protein 9 ISO DNA:SNP: :rs2293855 (human) RGD PMID:21796137 RGD:329853776 NCBI chrNW_004624758:24,993,783...25,033,130
Ensembl chrNW_004624758:24,994,164...25,027,682 		JBrowse link
G Mttp microsomal triglyceride transfer protein ISO ClinVar Annotator: match by term: Metabolic syndrome X ClinVar PMID:8533758 PMID:9671739 PMID:16721486 PMID:25741868 PMID:28492532 NCBI chrNW_004624830:7,463,671...7,505,607
Ensembl chrNW_004624830:7,464,686...7,506,129 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO protein:increased expression:plasma
DNA:repeats:intron 		RGD PMID:15922301 PMID:17556870 RGD:1642337 RGD:1642345 NCBI chrNW_004624739:23,411,478...23,444,590
Ensembl chrNW_004624739:23,411,488...23,442,359 		JBrowse link
G Neil1 nei like DNA glycosylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16446448 PMID:17389588 NCBI chrNW_004624894:282,799...287,265
Ensembl chrNW_004624894:282,695...288,058 		JBrowse link
G Ngf nerve growth factor ISO RGD PMID:11935372 RGD:1580935 NCBI chrNW_004624772:11,009,765...11,070,050
Ensembl chrNW_004624772:11,010,845...11,070,017 		JBrowse link
G Nnmt nicotinamide N-methyltransferase ISO mRNA,protein:increased expression,increased activity:adipose tissue (rat) RGD PMID:25719492 RGD:401793724 NCBI chrNW_004624784:9,765,582...9,783,004
Ensembl chrNW_004624784:9,765,582...9,783,004 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO ClinVar Annotator: match by term: Metabolic syndrome, susceptibility to RGD
ClinVar		 PMID:28361419 PMID:28967023 RGD:13461762 NCBI chrNW_004624800:5,600,215...5,619,020
Ensembl chrNW_004624800:5,600,212...5,619,004 		JBrowse link
G Nox1 NADPH oxidase 1 ISO protein:increased expression, increased activity:peripheral blood mononuclear cell (human) RGD PMID:16380495 RGD:1580973 NCBI chrNW_004624902:1,741,921...1,754,932
Ensembl chrNW_004624902:1,736,704...1,755,504 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1 group H member 3 ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chrNW_004624767:1,459,601...1,473,224
Ensembl chrNW_004624767:1,459,601...1,467,795 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1 group I member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20869355 NCBI chrNW_004624731:28,371,707...28,405,327
Ensembl chrNW_004624731:28,371,707...28,381,357 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1 group I member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20869355 NCBI chrNW_004624794:141,316...158,059 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 ameliorates ISO RGD PMID:27821167 RGD:401799622 NCBI chrNW_004624741:23,985,257...23,990,354
Ensembl chrNW_004624741:23,985,675...23,989,790 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 ameliorates ISO RGD PMID:31353547 RGD:401850595 NCBI chrNW_004624862:4,873,457...4,895,836
Ensembl chrNW_004624862:4,879,561...4,895,776 		JBrowse link
G Pde9a phosphodiesterase 9A treatment ISO RGD PMID:34618683 RGD:242170038 NCBI chrNW_004624745:27,834,814...27,919,264
Ensembl chrNW_004624745:27,839,682...27,919,299 		JBrowse link
G Pla2g4a phospholipase A2 group IVA ISO mRNA:decreased expression:liver RGD PMID:21172452 RGD:6482748 NCBI chrNW_004624814:6,597,248...6,744,294
Ensembl chrNW_004624814:6,597,005...6,744,286 		JBrowse link
G Pla2g6 phospholipase A2 group VI ISO mRNA:decreased expression:liver RGD PMID:21172452 RGD:6482748 NCBI chrNW_004624752:9,792,778...9,841,817
Ensembl chrNW_004624752:9,792,807...9,843,457 		JBrowse link
G Pla2g7 phospholipase A2 group VII ISO mRNA:increased expression:liver RGD PMID:21172452 RGD:6482748 NCBI chrNW_004624754:13,905,084...13,932,366
Ensembl chrNW_004624754:13,904,797...13,931,670 		JBrowse link
G Plat plasminogen activator, tissue type ISO protein:increased expression:serum RGD PMID:18249307 RGD:2311664 NCBI chrNW_004624780:1,014,429...1,063,636
Ensembl chrNW_004624780:1,028,085...1,063,649 		JBrowse link
G Pon1 paraoxonase 1 ISO protein:decreased activity:serum
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:14602783 PMID:21573798 RGD:1642618 NCBI chrNW_004624813:1,953,796...1,979,846
Ensembl chrNW_004624813:1,949,614...1,979,882 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ameliorates ISO mRNA:decreased expression:liver (rat) RGD PMID:11934685 PMID:31353547 RGD:401850595 RGD:628329 NCBI chrNW_004624752:3,646,499...3,702,553
Ensembl chrNW_004624752:3,650,922...3,701,672 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ameliorates
no_association 		ISO DNA:SNP: :p.P12A (human) RGD PMID:16183630 PMID:16186413 PMID:18959602 PMID:31353547 RGD:1580683 RGD:1580686 RGD:2301843 RGD:401850595 NCBI chrNW_004624956:84,673...207,176
Ensembl chrNW_004624956:83,842...149,481 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO mRNA:decreased expression:gastrocnemius muscle (rat) RGD PMID:20383225 RGD:10059661 NCBI chrNW_004624755:7,826,219...8,460,746
Ensembl chrNW_004624755:8,375,596...8,465,297 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ameliorates ISO RGD PMID:31353547 RGD:401850595 NCBI chrNW_004624862:3,443,720...3,496,078
Ensembl chrNW_004624862:3,450,078...3,496,142 		JBrowse link
G Prl prolactin ISO RGD PMID:16303834 RGD:1642558 NCBI chrNW_004624756:4,585,542...4,593,285 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:liver RGD PMID:17883899 RGD:1642586 NCBI chrNW_004624814:6,897,818...6,904,890
Ensembl chrNW_004624814:6,897,857...6,903,728 		JBrowse link
G Rbp4 retinol binding protein 4 disease_progression ISO protein:increased expression:blood serum (human)
associated with obstructive sleep apnea;protein:increased expression:blood plasma (human) 		RGD PMID:19003725 PMID:19339013 RGD:329845591 RGD:329853307 NCBI chrNW_004624737:4,795,054...4,800,830
Ensembl chrNW_004624737:4,791,628...4,800,989 		JBrowse link
G Reg1a regenerating family member 1 alpha treatment ISO RGD PMID:21685239 RGD:10044029 NCBI chrNW_004624749:23,993,755...23,995,923 JBrowse link
G Retn resistin ISO DNA:SNP:promoter:-420C>G (human)
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:17598818 PMID:18328350 RGD:7207155 NCBI chrNW_004624828:735,562...737,166
Ensembl chrNW_004624828:735,503...737,166 		JBrowse link
G Scg3 secretogranin III ISO DNA:SNP: :rs3764220 (human) RGD PMID:21796137 RGD:329853776 NCBI chrNW_004624731:8,652,648...8,681,905
Ensembl chrNW_004624731:8,650,631...8,681,923 		JBrowse link
G Selp selectin P ISO RGD PMID:19061719 RGD:2312292 NCBI chrNW_004624826:7,510,039...7,544,332
Ensembl chrNW_004624826:7,511,646...7,537,924 		JBrowse link
G Serpina12 serpin family A member 12 treatment ISO human protein in a mouse model RGD PMID:16030142 RGD:1547845 NCBI chrNW_004624734:7,191,049...7,204,386
Ensembl chrNW_004624734:7,191,010...7,206,020 		JBrowse link
G Serpine1 serpin family E member 1 treatment ISO RGD PMID:26084260 RGD:11073736 NCBI chrNW_004624740:16,128,145...16,136,696
Ensembl chrNW_004624740:16,128,059...16,137,337 		JBrowse link
G Shbg sex hormone binding globulin ISO protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:16968811 PMID:17884445 PMID:17992261 RGD:2313785 NCBI chrNW_004624786:10,234,484...10,239,034 JBrowse link
G Sim1 SIM bHLH transcription factor 1 ISO ClinVar Annotator: match by term: SIM1-associated metabolic syndrome ClinVar NCBI chrNW_004624810:4,479,589...4,558,735
Ensembl chrNW_004624810:4,479,589...4,558,434 		JBrowse link
G Sirt1 sirtuin 1 treatment ISO protein:decreased expression:hippocampus (rat)
CTD Direct Evidence: marker/mechanism 		RGD
CTD		 PMID:20068143 PMID:21514307 PMID:25356430 RGD:10053569 RGD:9585758 NCBI chrNW_004624754:2,304,476...2,332,705
Ensembl chrNW_004624754:2,304,634...2,330,946 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 susceptibility ISO DNA:gene knockout::Slc27a1-/- mice resistant to diet-induced obesity and metabolic syndrome RGD PMID:16611988 RGD:1642790 NCBI chrNW_004624908:531,313...549,570
Ensembl chrNW_004624908:531,308...549,990 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 ameliorates ISO RGD PMID:31353547 RGD:401850595 NCBI chrNW_004624892:2,110,310...2,148,023
Ensembl chrNW_004624892:2,117,561...2,148,037 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 ameliorates ISO RGD PMID:31353547 RGD:401850595 NCBI chrNW_004624786:9,903,176...9,908,953
Ensembl chrNW_004624786:9,902,509...9,909,684 		JBrowse link
G Soat2 sterol O-acyltransferase 2 susceptibility ISO DNA:SNPs RGD PMID:14557872 RGD:1581921 NCBI chrNW_004624904:1,160,275...1,170,249
Ensembl chrNW_004624904:1,160,203...1,170,935 		JBrowse link
G Sod2 superoxide dismutase 2 treatment ISO RGD PMID:28875871 RGD:26923956 NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 disease_progression
ameliorates 		ISO protein:increased expression:liver (mouse)
mRNA:increased expression:liver (rat) 		RGD PMID:11934685 PMID:29173234 PMID:31353547 RGD:401827867 RGD:401850595 RGD:628329 NCBI chrNW_004624849:3,602,103...3,623,922
Ensembl chrNW_004624849:3,602,261...3,623,465 		JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO mRNA:increased expression:left heart ventricle RGD PMID:18692559 RGD:2306739 NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605 		JBrowse link
G Thbd thrombomodulin ISO associated with Diabetic Nephropathies;protein:increased expression:plasma RGD PMID:16567841 RGD:1601641 NCBI chrNW_004624741:22,880,481...22,883,962 JBrowse link
G Tlr2 toll like receptor 2 ameliorates ISO RGD PMID:32151955 RGD:597538509 NCBI chrNW_004624858:4,931,820...4,984,175
Ensembl chrNW_004624858:4,979,485...4,981,833 		JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:24441717 RGD:10450604 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO associated with obesity;protein:increased expression:plasma RGD PMID:17200772 RGD:1624178 NCBI chrNW_004624860:3,111,244...3,123,041
Ensembl chrNW_004624860:3,111,630...3,122,711 		JBrowse link
G Trib3 tribbles pseudokinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18497449 NCBI chrNW_004624741:1,486,223...1,494,005
Ensembl chrNW_004624741:1,484,863...1,494,829 		JBrowse link
G Ucp2 uncoupling protein 2 ISO mRNA:decreased expression:liver (rat) RGD PMID:11934685 RGD:628329 NCBI chrNW_004624817:3,067,358...3,075,045
Ensembl chrNW_004624817:3,067,320...3,075,043 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO RGD PMID:18718174 RGD:2313109 NCBI chrNW_004624857:3,606,573...3,625,991
Ensembl chrNW_004624857:3,606,431...3,627,063 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:plasma: RGD PMID:22206010 RGD:7483588 NCBI chrNW_004624754:15,929,414...15,943,637 JBrowse link
G Vwf von Willebrand factor ISO protein:increased expression:plasma RGD PMID:16764036 RGD:1625709 NCBI chrNW_004624860:2,843,268...2,973,888
Ensembl chrNW_004624860:2,858,088...2,973,052 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14234
    syndrome 9756
      hyperinsulinism 362
        Insulin Resistance 301
          HAIR-AN syndrome 0
          Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans 2
          Metabolic Syndrome + 153
          Pseudoacromegaly with Severe Insulin Resistance 0
Path 2
Term Annotations click to browse term
  disease 14234
    Developmental Disease 12524
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 11800
        genetic disease 11525
          inherited metabolic disorder 5504
            carbohydrate metabolic disorder 2658
              glucose metabolism disease 1476
                hyperinsulinism 362
                  Insulin Resistance 301
                    HAIR-AN syndrome 0
                    Insulin-Resistant Diabetes Mellitus, with Acanthosis Nigricans 2
                    Metabolic Syndrome + 153
                    Pseudoacromegaly with Severe Insulin Resistance 0
paths to the root