RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Craniocerebral Trauma
Accession: DOID:9007621
browse the term
Definition: Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.
Synonyms: exact_synonym: Craniocerebral Injuries; Craniocerebral Injury; Craniocerebral Traumas; Crushing Skull Injuries; Crushing Skull Injury; Forehead Trauma; Forehead Traumas; Frontal Region Trauma; Frontal Region Traumas; Head Injuries; Head Injury; Head Trauma; Head Traumas; Minor Head Injuries; Minor Head Injury; Multiple Head Injuries; Multiple Head Injury; Occipital Region Trauma; Occipital Region Traumas; Occipital Trauma; Occipital Traumas; Open Head Injuries; Open Head Injury; Parietal Region Trauma; Parietal Region Traumas; Superficial Head Injuries; Superficial Head Injury; Temporal Region Trauma; Temporal Region Traumas
primary_id: MESH:D006259 ; RDO:0005059
xref: EFO:0009505
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Adnp
activity-dependent neuroprotector homeobox
ISO
RGD
PMID:11123362
RGD:2312784
NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312
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Il1a
interleukin 1 alpha
ISO
protein:increased expression:microglial cell
RGD
PMID:7830934
RGD:10045949
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Postn
periostin
IEP
RGD
PMID:17878602
RGD:10041014
NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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Serpinc1
serpin family C member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8810955
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Epo
erythropoietin
treatment
ISO
RGD
PMID:23415790
RGD:10401075
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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F7
coagulation factor VII
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:12503044
NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
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Kcnn4
potassium calcium-activated channel subfamily N member 4
treatment
IMP
RGD
PMID:15379997
RGD:329969897
NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
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Cfl1
cofilin 1
treatment
ISO
RGD
PMID:25708984
RGD:12738361
NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
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Drd2
dopamine receptor D2
IEP
RGD
PMID:26448536
RGD:13506960
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Drd3
dopamine receptor D3
IEP
RGD
PMID:26448536
RGD:13506960
NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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Drd4
dopamine receptor D4
IEP
RGD
PMID:26448536
RGD:13506960
NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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Il6
interleukin 6
treatment
IDA
RGD
PMID:27113205
RGD:11062140
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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C3
complement C3
ameliorates
IMP
RGD
PMID:31654641
RGD:408418727
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Casp3
caspase 3
treatment
IEP
RGD
PMID:28140659
RGD:13782305
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
treatment
IEP
RGD
PMID:28140659
RGD:13782305
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Il1b
interleukin 1 beta
treatment
IEP
RGD
PMID:31654641
RGD:408418727
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Pycard
PYD and CARD domain containing
treatment
IMP
RGD
PMID:19401709
RGD:5491174
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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Tnf
tumor necrosis factor
treatment
IEP
RGD
PMID:31654641
RGD:408418727
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Abcc8
ATP binding cassette subfamily C member 8
treatment
IMP
RGD
PMID:21107131
RGD:12791995
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Acan
aggrecan
IEP
mRNA:increased expression:fascia dentata (rat)
RGD
PMID:18511192
RGD:2315807
NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627
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Actr2
actin related protein 2
IEP
mRNA, protein:decreased expression:hippocampus (rat)
RGD
PMID:22120305
RGD:11530046
NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524
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Adcyap1
adenylate cyclase activating polypeptide 1
IDA
RGD
PMID:16689670
RGD:2325298
NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
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Adra1a
adrenoceptor alpha 1A
IEP
mRNA:increased expression:frontal cortex
RGD
PMID:20974230
RGD:5688366
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Ager
advanced glycosylation end product-specific receptor
ISO IEP
protein:increased expression:brain (rat)
RGD
PMID:22915134 PMID:24859607 PMID:22491548
RGD:7245513 , RGD:8696001 , RGD:7245557
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Aif1
allograft inflammatory factor 1
IEP
protein:increased expression:cerebral cortex (rat)
RGD
PMID:19520144
RGD:2313020
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Aifm1
apoptosis inducing factor, mitochondria associated 1
IEP
protein:increased expression:nucleus:
RGD
PMID:12091479
RGD:10053567
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Akt1
AKT serine/threonine kinase 1
IEP
protein:increased phosphorylation:brain, neuron
RGD
PMID:16234845
RGD:5509090
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:7909931 PMID:17188501
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Ambp
alpha-1-microglobulin/bikunin precursor
ISO
protein:increased expression:urine
RGD
PMID:14592616
RGD:6904155
NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
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Ank3
ankyrin 3
IEP
RGD
PMID:20557305
RGD:6767288
NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
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Anp32a
acidic nuclear phosphoprotein 32 family member A
IEP
RGD
PMID:24385964
RGD:10401136
NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443
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Apaf1
apoptotic peptidase activating factor 1
IEP
protein:increased expression:cerebral cortex
RGD
PMID:11567033
RGD:2325751
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Apbb1
amyloid beta precursor protein binding family B member 1
IEP
mRNA:increased expression:brain
RGD
PMID:12707777
RGD:2301208
NCBI chr 1:159,896,889...159,920,505
Ensembl chr 1:159,896,880...159,920,627
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11447995
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Apod
apolipoprotein D
IEP
mRNA, protein:increased expression:cerebral cortex, glia cell, neuron
RGD
PMID:10501208
RGD:2311202
NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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Apoe
apolipoprotein E
ISO
GAD
PMID:15118671
RGD:1331525
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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App
amyloid beta precursor protein
ISO
protein:increased expression:hippocampus
RGD
PMID:16300758
RGD:10054281
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Aqp4
aquaporin 4
IEP ISO
protein:increased expression:cerebral cortex
RGD
PMID:21083433 PMID:21488209
RGD:5148014 , RGD:5148034
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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Asic1
acid sensing ion channel subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21307247
NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
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Astn1
astrotactin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14499481
NCBI chr13:70,537,423...70,855,440
Ensembl chr13:70,537,703...70,855,440
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Atg12
autophagy related 12
IEP
protein:altered localization:brain
RGD
PMID:18059433
RGD:2301217
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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Atp5pd
ATP synthase peripheral stalk subunit d
treatment
IDA
RGD
PMID:26813465
RGD:13800884
NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
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Avpr1a
arginine vasopressin receptor 1A
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:17244947
RGD:2300372
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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Bad
BCL2-associated agonist of cell death
IEP
mRNA, protein:increased expression:cerebral cortex
RGD
PMID:15941375
RGD:2292694
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
RGD
PMID:20888848
RGD:10054247
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcat1
branched chain amino acid transaminase 1
IEP
Protein:increased expression:neurons
RGD
PMID:10686349
RGD:631308
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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Bcl2
BCL2, apoptosis regulator
treatment
IMP IEP
RGD
PMID:18093155 PMID:20888848
RGD:2293059 , RGD:10054247
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bdnf
brain-derived neurotrophic factor
IEP ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:15500971 PMID:21269288 PMID:20544832
RGD:4891136
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Becn1
beclin 1
IEP ISO
protein:increased expression:neuron, astrocyte CTD Direct Evidence: therapeutic protein:increased expression:hippocampus protein:increased expression:brain
CTD RGD
PMID:34929507 PMID:18500386 PMID:24221859 PMID:16874043
RGD:6483098 , RGD:11558018 , RGD:6483314
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Birc5
baculoviral IAP repeat-containing 5
IEP
mRNA, protein:increased expression:brain, astrocyte, neuron
RGD
PMID:15453988
RGD:2293136
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Bmp6
bone morphogenetic protein 6
IEP
protein:increased expression:brain, astrocyte, neuron
RGD
PMID:16388909
RGD:2289020
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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Bmpr2
bone morphogenetic protein receptor type 2
IEP
mRNA:increased expression:dentate gyrus, neuron
RGD
PMID:9080432
RGD:5129488
NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
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Bysl
bystin-like
IEP
mRNA, protein:increased expression:substantia nigra, striatum (rat)
RGD
PMID:15305856
RGD:2316201
NCBI chr 9:13,382,806...13,392,557
Ensembl chr 9:13,382,557...13,394,339
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C1qa
complement C1q A chain
IEP
RGD
PMID:23808389
RGD:10054313
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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C3
complement C3
IEP
RGD
PMID:23808389
RGD:10054313
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Cask
calcium/calmodulin dependent serine protein kinase
IEP
RGD
PMID:25089700
RGD:11576302
NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694
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Casp1
caspase 1
IEP
mRNA, protein:increased expression:brain
RGD
PMID:17188500
RGD:2315917
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp12
caspase 12
severity
IEP
mRNA, protein:increased expression, increased activity:cerebral cortex, hippocampus, neuron, astrocyte
RGD
PMID:14675152
RGD:2311485
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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Casp3
caspase 3
treatment
IEP
RGD
PMID:20888848
RGD:10054247
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
IEP
protein:altered localization
RGD
PMID:15590916
RGD:1624191
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Cast
calpastatin
severity
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:15307896
RGD:5509821
NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659
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Ccl2
C-C motif chemokine ligand 2
treatment
IEP ISO IMP
protein:increased expression:brain, neuron CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21549006 PMID:19210118 PMID:11113322
RGD:2306999 , RGD:9587789
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl20
C-C motif chemokine ligand 20
treatment
IEP
RGD
PMID:22040257
RGD:7483630
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ccr5
C-C motif chemokine receptor 5
IEP
mRNA:increased expression:hippocampus
RGD
PMID:24344922
RGD:8552265
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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Cd14
CD14 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd40
CD40 molecule
treatment
IDA
RGD
PMID:23924471
RGD:7248749
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Cd40lg
CD40 ligand
treatment
IEP IDA
RGD
PMID:11755016 PMID:25972624
RGD:8547803 , RGD:11344972
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
IEP
protein:increased expression:nucleus:
RGD
PMID:9914434
RGD:8662346
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
IEP
protein:decreased expression:cerebral cortex
RGD
PMID:21728064
RGD:10045359
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Cebpa
CCAAT/enhancer binding protein alpha
ISO
mRNA, protein:increased expression:cerebral cortex (mouse)
RGD
PMID:19833158
RGD:10401206
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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Cebpb
CCAAT/enhancer binding protein beta
ISO
mRNA, protein:increased expression:cerebral cortex (mouse) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21549006 PMID:19833158
RGD:10401206
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Ces1d
carboxylesterase 1D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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Cfb
complement factor B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17474994
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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Chrm2
cholinergic receptor, muscarinic 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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Ckmt1
creatine kinase, mitochondrial 1
treatment
IEP
RGD
PMID:24252176
RGD:11565089
NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758
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Clec4e
C-type lectin domain family 4, member E
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
IEP
protein:increased expression:hippocampus
RGD
PMID:20215974
RGD:6483336
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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Comt
catechol-O-methyltransferase
IEP
protein:increased expression:hippocampus
RGD
PMID:17240060
RGD:2289740
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
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Crp
C-reactive protein
disease_progression
ISO
RGD
PMID:24456846
RGD:9585646
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Csf2
colony stimulating factor 2
disease_progression
IDA
RGD
PMID:21515263
RGD:5686795
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Csf3
colony stimulating factor 3
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21549006 PMID:24239694
RGD:11039431
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Cspg4
chondroitin sulfate proteoglycan 4
IEP
protein:altered expression:cerebral cortex
RGD
PMID:19473238
RGD:5686860
NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010
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Cul5
cullin 5
IEP
mRNA, protein:decreased expression:cerebral cortex, hippocampus
RGD
PMID:17010517
RGD:2301432
NCBI chr 8:54,012,963...54,066,751
Ensembl chr 8:54,016,006...54,066,666
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Cxcl1
C-X-C motif chemokine ligand 1
IEP
mRNA:increased expression:choroid plexus, cerebral cortex
RGD
PMID:19471279
RGD:5135009
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl2
C-X-C motif chemokine ligand 2
IEP
protein:increased expression:brain, neuron
RGD
PMID:19210118
RGD:2306999
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
IEP
mRNA:increased expression:hindbrain
RGD
PMID:16329132
RGD:1599699
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp4f1
cytochrome P450, family 4, subfamily f, polypeptide 1
IEP
RGD
PMID:18847377
RGD:2301705
NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
G
Dab2
DAB adaptor protein 2
IEP
RGD
PMID:15774263
RGD:7243841
NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
G
Dnmt1
DNA methyltransferase 1
IEP
RGD
PMID:19429151
RGD:9588608
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
G
Dpysl2
dihydropyrimidinase-like 2
IEP
protein:increased degradation:cerebral cortex, hippocampus
RGD
PMID:17402852
RGD:2303056
NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
G
Drd2
dopamine receptor D2
IDA
RGD
PMID:18509630
RGD:2311580
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
G
Dusp5
dual specificity phosphatase 5
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:12503083
RGD:2317873
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
G
Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
IDA
RGD
PMID:11526986
RGD:10395358
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
G
Eif3e
eukaryotic translation initiation factor 3 subunit E
treatment
IMP
RGD
PMID:22960363
RGD:10395371
NCBI chr 7:74,339,848...74,372,483
Ensembl chr 7:74,339,828...74,373,096
G
Elk1
ETS transcription factor ELK1
IDA
RGD
PMID:15362724
RGD:7488910
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
G
Eno2
enolase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34533065
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
G
Epas1
endothelial PAS domain protein 1
treatment
IDA
RGD
PMID:22960363
RGD:10395371
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
G
Epha4
Eph receptor A4
ISO
protein:increased expression, increased activity:astrocyte
RGD
PMID:22318127
RGD:5688763
NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
G
Ephx2
epoxide hydrolase 2
ISO
RGD
PMID:21075124
RGD:5688356
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
G
Epo
erythropoietin
treatment
ISO IEP
CTD Direct Evidence: therapeutic mRNA:increased expression:brain:
CTD RGD
PMID:20833152 PMID:23063952 PMID:18093155
RGD:10401061 , RGD:2293059
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
G
Epor
erythropoietin receptor
IEP
mRNA:increased expression:brain:
RGD
PMID:18093155
RGD:2293059
NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
G
F2
coagulation factor II, thrombin
severity
ISO
RGD
PMID:21355766
RGD:5147766
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
G
Fas
Fas cell surface death receptor
IEP ISO
mRNA:increased expression:hippocampus associated with Hyperoxia
RGD
PMID:16078565 PMID:19107989
RGD:1600354 , RGD:8662854
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fgf2
fibroblast growth factor 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21269288
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Fmr1
fragile X messenger ribonucleoprotein 1
IEP
protein:altered localization:hippocampus (rat)
RGD
PMID:16510718
RGD:11667962
NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9630518
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Foxp1
forkhead box P1
treatment
IDA
RGD
PMID:26842647
RGD:11561903
NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
G
G6pd
glucose-6-phosphate dehydrogenase
IEP
protein:decreased expression:hippocampus
RGD
PMID:18501200
RGD:2307353
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
G
Gabrg3
gamma-aminobutyric acid type A receptor subunit gamma 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 1:107,627,450...108,247,483
Ensembl chr 1:107,627,390...108,246,763
G
Gdnf
glial cell derived neurotrophic factor
IEP
mRNA:increased expression:brain
RGD
PMID:18501516
RGD:2324932
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
G
Gja1
gap junction protein, alpha 1
treatment
IEP
RGD
PMID:23485053
RGD:8662424
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
G
Gja5
gap junction protein, alpha 5
IEP
protein:increased expression:cerebral artery
RGD
PMID:21895483
RGD:7207391
NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
G
Gpx1
glutathione peroxidase 1
IEP
mRNA:decreased expression:hippocampus, neuron
RGD
PMID:15791111
RGD:2306624
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Grm8
glutamate metabotropic receptor 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 4:55,805,762...56,731,690
Ensembl chr 4:55,805,955...56,730,831
G
Gsk3b
glycogen synthase kinase 3 beta
IEP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:24675465 PMID:22643085
RGD:10045646
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Gsn
gelsolin
IEP
RGD
PMID:14588109
RGD:1599864
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
G
Hcn1
hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
IEP
mRNA,protein:decreased expression:hippocampus:
RGD
PMID:11726545
RGD:9686434
NCBI chr 2:49,495,771...49,899,983
Ensembl chr 2:49,495,771...49,899,774
G
Hmgb1
high mobility group box 1
treatment
IMP
RGD
PMID:22915134
RGD:7245513
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
IMP
RGD
PMID:18562561
RGD:5508455
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmox1
heme oxygenase 1
IEP
RGD
PMID:23470432
RGD:10755702
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hp
haptoglobin
IEP
mRNA:increased expression:liver
RGD
PMID:23172820
RGD:11041806
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
ISO
mRNA:increased expression:brain CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21549006 PMID:21549006
RGD:5147593
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa4
heat shock protein family A (Hsp70) member 4
IEP
protein:increased expression:cerebral white matter (rat)
RGD
PMID:22067617
RGD:5688785
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
G
Hspb1
heat shock protein family B (small) member 1
IEP
RGD
PMID:11746764
RGD:6480530
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
G
Htr7
5-hydroxytryptamine receptor 7
IMP
RGD
PMID:22465320
RGD:6482178
NCBI chr 1:233,636,442...233,761,063
Ensembl chr 1:233,636,452...233,760,626
G
Icam1
intercellular adhesion molecule 1
IEP
protein:increased expression:brain:
RGD
PMID:16230799
RGD:11522716
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Ifnl3
interferon, lambda 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 1:83,814,456...83,816,096
Ensembl chr 1:83,814,564...83,816,096
G
Igf1
insulin-like growth factor 1
treatment
ISO
human protein in a rat model
RGD
PMID:9344566
RGD:12904928
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Igf2
insulin-like growth factor 2
IEP
mRNA:decreased expression:brain
RGD
PMID:11123717
RGD:5509972
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
G
Il10
interleukin 10
severity treatment
ISO IDA
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21549006 PMID:23075771 PMID:23971414
RGD:7364822 , RGD:7364983
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il12rb2
interleukin 12 receptor subunit beta 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 4:96,426,396...96,515,251
Ensembl chr 4:96,426,842...96,515,289
G
Il13ra2
interleukin 13 receptor subunit alpha 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
G
Il16
interleukin 16
IEP
RGD
PMID:17983426
RGD:5024939
NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
G
Il17rd
interleukin 17 receptor D
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr16:2,228,438...2,295,122
Ensembl chr16:2,228,287...2,292,556
G
Il18
interleukin 18
severity
IMP ISO
mRNA, protein:increased expression:brain
RGD
PMID:17188500 PMID:17188500
RGD:2315917 , RGD:2315917
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il18r1
interleukin 18 receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 9:42,727,416...42,760,971
Ensembl chr 9:42,727,869...42,760,715
G
Il1a
interleukin 1 alpha
IEP ISO
mRNA, protein:increased expression:cerebral cortex CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21549006 PMID:16024175
RGD:2311098
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
IEP ISO
mRNA, protein:increased expression:cerebral cortex CTD Direct Evidence: marker/mechanism protein:increased expression:brain, cerebrospinal fluid mRNA, protein:increased expression:brain
CTD RGD
PMID:19800810 PMID:21549006 PMID:16024175 PMID:22503903 PMID:17612572
RGD:2311098 , RGD:6482651 , RGD:1626652
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1r1
interleukin 1 receptor type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
G
Il1rn
interleukin 1 receptor antagonist
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:25665855
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
G
Il2
interleukin 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il3
interleukin 3
disease_progression
IDA ISO
protein: increased expression: brain: microdialysis perfusate
RGD
PMID:21515263 PMID:20717122
RGD:5686795 , RGD:5686886
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
G
Il31ra
interleukin 31 receptor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 2:44,118,748...44,189,943
Ensembl chr 2:44,122,624...44,183,767
G
Il4
interleukin 4
IEP
protein:decreased expression:plasma
RGD
PMID:24519543
RGD:10402802
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il5
interleukin 5
treatment
IEP
RGD
PMID:24602693 PMID:24530657
RGD:11522766 , RGD:11522770
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Il6
interleukin 6
IEP ISO
protein:increased expression:cerebrospinal fluid (rat) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19800810 PMID:21549006 PMID:23159883 PMID:10027774
RGD:11049549
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Il7
interleukin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
G
Il9r
interleukin 9 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:15,431,706...15,444,144
Ensembl chr10:15,431,706...15,441,990
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Irf1
interferon regulatory factor 1
IEP ISO
mRNA:increased expression:cerebral cortex CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21549006 PMID:12503083
RGD:2317873
NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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Jak2
Janus kinase 2
IMP
RGD
PMID:21596098
RGD:6483023
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
IEP
RGD
PMID:20861444
RGD:8662901
NCBI chr13:84,802,026...84,835,383
Ensembl chr13:84,802,009...84,835,461
G
Kdr
kinase insert domain receptor
IEP IMP
protein:increased expression:cerebral cortex
RGD
PMID:21307798 PMID:19733172
RGD:5684382 , RGD:5684402
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Lep
leptin
IEP
RGD
PMID:21276361
RGD:5128517
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lsg1
large 60S subunit nuclear export GTPase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:14499481
NCBI chr11:70,132,919...70,168,526
Ensembl chr11:70,143,847...70,168,518
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Ly86
lymphocyte antigen 86
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr17:27,415,807...27,499,695
Ensembl chr17:27,415,830...27,487,260
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Mag
myelin-associated glycoprotein
susceptibility
IMP
RGD
PMID:17156367
RGD:9685230
NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
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Map1b
microtubule-associated protein 1B
IEP
protein:increased expression, increased phosphorylation:brain
RGD
PMID:10906717
RGD:2304029
NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317
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Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
IEP
RGD
PMID:24221859
RGD:11558018
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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Map2
microtubule-associated protein 2
IEP IDA
protein:decreased expression:cerebral cortex, neuron
RGD
PMID:21401443 PMID:20568963
RGD:6483087 , RGD:6483089
NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
G
Map3k7
mitogen activated protein kinase kinase kinase 7
treatment
IEP ISO IMP
associated with Subarachnoid Hemorrhage
RGD
PMID:27000704 PMID:33414375 PMID:26100626
RGD:155791672 , RGD:155882440 , RGD:155804286
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
G
Mbl2
mannose binding lectin 2
disease_progression
ISO
RGD
PMID:18183030
RGD:12910935
NCBI chr 1:228,016,439...228,024,736
G
Mbp
myelin basic protein
IDA
RGD
PMID:18583256
RGD:7349333
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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Mdm2
MDM2 proto-oncogene
IEP
protein:increased expression:brain cortex (rat)
RGD
PMID:15165363
RGD:2317397
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
G
Mif
macrophage migration inhibitory factor
IEP
RGD
PMID:15922484
RGD:1641989
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 Ensembl chr 4:12,790,902...12,799,504
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Mir132
microRNA 132
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
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Mir144
microRNA 144
IEP
RGD
PMID:25089700
RGD:11576302
NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430
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Mir153
microRNA 153
IEP
RGD
PMID:25089700
RGD:11576302
NCBI chr 6:138,163,595...138,163,681
Ensembl chr 6:138,163,595...138,163,681
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Mir183
microRNA 183
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723
G
Mmp9
matrix metallopeptidase 9
treatment
IDA IMP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19631748 PMID:16671440 PMID:24661104
RGD:1582656 , RGD:13207312
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mpo
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Mt-co2
mitochondrially encoded cytochrome c oxidase II
IEP
mRNA, protein:increased expression:hippocampus
RGD
PMID:11686499
RGD:2302298
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
G
Mt2A
metallothionein 2A
ISO IEP
mRNA:increased expression:liver (mouse) mRNA:increased expression:dentate gyrus (rat)
RGD
PMID:22363575 PMID:15650329
RGD:6483812 , RGD:6483847
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
G
Mt3
metallothionein 3
treatment
IDA IEP
RGD
PMID:16314047 PMID:10595827 PMID:10218634
RGD:6480628 , RGD:9685805 , RGD:9685803
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Myoc
myocilin
IEP
mRNA:increased expression:cerebral cortex (rat)
RGD
PMID:12799138
RGD:7401267
NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
G
Nfe2l2
NFE2 like bZIP transcription factor 2
IEP
protein:increased expression:lung:
RGD
PMID:18787991 PMID:25089700
RGD:5134971 , RGD:11576302
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Ngb
neuroglobin
severity
IEP
RGD
PMID:21915648
RGD:9743963
NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830
G
Ngfr
nerve growth factor receptor
treatment
IDA
RGD
PMID:23940017
RGD:10414074
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Nos2
nitric oxide synthase 2
IEP
RGD
PMID:11526986
RGD:10395358
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nox4
NADPH oxidase 4
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:36762617
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Nppb
natriuretic peptide B
ISO
associated with lung diseases;protein:increased expression:serum: CTD Direct Evidence: therapeutic
CTD RGD
PMID:19803787 PMID:23837838
RGD:7247620
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Npy
neuropeptide Y
IEP
protein:increased expression:adrenal medulla
RGD
PMID:23570732
RGD:10448961
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
IEP
mRNA:increased expression:lung associated with Subarachnoid Hemorrhage
RGD
PMID:18787991 PMID:20864352
RGD:5134971 , RGD:11035222
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nt5e
5' nucleotidase, ecto
IEP
protein:altered expression:cerebral cortex (rat)
RGD
PMID:21337375
RGD:5134348
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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P2ry1
purinergic receptor P2Y1
IEP
protein:increased expression:brain, astrocyte
RGD
PMID:19115395
RGD:2315811
NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457
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Palld
palladin, cytoskeletal associated protein
IEP
protein:increased expression:brain, astrocyte
RGD
PMID:12932445
RGD:2325786
NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337
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Parp1
poly (ADP-ribose) polymerase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17640816
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pawr
pro-apoptotic WT1 regulator
IEP
mRNA,protein:increased expression:brain:
RGD
PMID:11421591
RGD:9835358
NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
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Pde4d
phosphodiesterase 4D
IEP
mRNA, protein:alternative form, decreased phosphorylation:brain
RGD
PMID:23057870
RGD:7327147
NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
G
Pdgfa
platelet derived growth factor subunit A
IEP
mRNA:increased expression:cerebral cortex, hippocampus
RGD
PMID:9645955
RGD:11084932
NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
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Pdgfb
platelet derived growth factor subunit B
IEP
mRNA:increased expression:cerebral cortex, hippocampus
RGD
PMID:9645955
RGD:11084932
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pdgfra
platelet derived growth factor receptor alpha
IEP
mRNA:increased expression:cerebral cortex, hippocampus
RGD
PMID:9645955
RGD:11084932
NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
G
Pdgfrb
platelet derived growth factor receptor beta
IEP
mRNA:increased expression:cerebral cortex, hippocampus
RGD
PMID:9645955
RGD:11084932
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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Pecam1
platelet and endothelial cell adhesion molecule 1
IDA
RGD
PMID:22658532
RGD:6484732
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Pglyrp1
peptidoglycan recognition protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr 1:78,531,815...78,537,001
Ensembl chr 1:78,531,815...78,537,001
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Pgr
progesterone receptor
IEP
RGD
PMID:23211561
RGD:7248711
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Phb1
prohibitin 1
IEP
protein:increased oxidation:cerebral cortex
RGD
PMID:17518533
RGD:2292409
NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
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Phb2
prohibitin 2
IEP
RGD
PMID:24566151
RGD:12903261
NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272
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Pias1
protein inhibitor of activated STAT, 1
IEP
protein:decreased expression:brain, nucleus
RGD
PMID:21545521
RGD:8693413
NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
G
Ppara
peroxisome proliferator activated receptor alpha
IDA
agonist more effective in combination with simvastatin
RGD
PMID:18562561
RGD:5508455
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Ppargc1a
PPARG coactivator 1 alpha
treatment
ISO IEP
protein:decreased expression:frontal cortex (rat)
RGD
PMID:22642418 PMID:24345766
RGD:6484257 , RGD:10059630
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Ppp3ca
protein phosphatase 3 catalytic subunit alpha
IEP ISO
protein: :hippocampus CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:14499481 PMID:19751097
RGD:6483311
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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Prf1
perforin 1
ISO
RGD
PMID:20537642
RGD:6482807
NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
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Ptger3
prostaglandin E receptor 3
IEP
protein:increased expression:striatum, microglia (rat)
RGD
PMID:15234107
RGD:9850280
NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
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Ptgs1
prostaglandin-endoperoxide synthase 1
ISO IEP
protein:increased expression:microglia, macrophage protein:increased expression:microglial cells, macrophage, endothelial cell
RGD
PMID:19719848 PMID:11565600 PMID:12005397
RGD:5688162 , RGD:5688242 , RGD:5688239
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
IMP ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12410334 PMID:20810888 PMID:21549006 PMID:21866634 PMID:19719848
RGD:5508191 , RGD:5688162
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptprz1
protein tyrosine phosphatase, receptor type Z1
IEP
RGD
PMID:12088737
RGD:727637
NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218
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Rchy1
ring finger and CHY zinc finger domain containing 1
IEP
protein:increased expression:cerebral cortex
RGD
PMID:21728064
RGD:10045359
NCBI chr14:16,113,263...16,129,017
Ensembl chr14:16,113,224...16,129,167
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Reg3b
regenerating family member 3 beta
IEP
mRNA:increased expression:cerebral cortex (rat)
RGD
PMID:19351265
RGD:9831399
NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
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Rela
RELA proto-oncogene, NF-kB subunit
IEP
protein:increased expression:ileum
RGD
PMID:18288455
RGD:2298787
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Ret
ret proto-oncogene
IEP
mRNA:increased expression:brain
RGD
PMID:18501516
RGD:2324932
NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
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Rhoa
ras homolog family member A
IEP
protein:increased expression:microglial cell, brain
RGD
PMID:17929039
RGD:2298888
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Robo1
roundabout guidance receptor 1
IEP
mRNA:increased expression:brain protein:increased expression:brain, immune cell
RGD
PMID:16262652 PMID:26550694
RGD:2316136 , RGD:243048437
NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203
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Robo2
roundabout guidance receptor 2
IEP
mRNA:increased expression:brain
RGD
PMID:16262652
RGD:2316136
NCBI chr11:12,528,949...14,096,726
Ensembl chr11:12,528,951...13,041,536
G
Robo3
roundabout guidance receptor 3
IEP
mRNA:increased expression:brain
RGD
PMID:16262652
RGD:2316136
NCBI chr 8:37,133,542...37,151,674
Ensembl chr 8:37,133,916...37,151,315
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Rps27a
ribosomal protein S27a
IEP
mRNA:decreased expression:cerebral cortex, hippocampus
RGD
PMID:17936732
RGD:11041870
NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011
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S100b
S100 calcium binding protein B
severity
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD RGD
PMID:11520488 PMID:21783483 PMID:21976236
RGD:5508761
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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Sele
selectin E
IEP
protein:increased expression:brain
RGD
PMID:19107536
RGD:2313599
NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
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Serpinc1
serpin family C member 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:21534203
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Serpinf1
serpin family F member 1
treatment
ISO IEP
human gene in a rat model protein:altered expression:cerebellum (rat)
RGD
PMID:20142768 PMID:17709187
RGD:8612994 , RGD:8622925
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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Sirt1
sirtuin 1
treatment
IEP
RGD
PMID:17970622
RGD:9497541
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Skp2
S-phase kinase associated protein 2
IEP
protein:increased expression:brain
RGD
PMID:19852587
RGD:2315049
NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
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Slc18a3
solute carrier family 18 member A3
IEP
protein:decreased expression:brain
RGD
PMID:18848922
RGD:5686682
NCBI chr16:7,713,630...7,716,491
G
Slit1
slit guidance ligand 1
IEP
mRNA:increased expression:brain
RGD
PMID:16262652
RGD:2316136
NCBI chr 1:240,409,559...240,558,127
Ensembl chr 1:240,409,561...240,558,127
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Slit2
slit guidance ligand 2
exacerbates
IMP
RGD
PMID:26550694
RGD:243048437
NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948
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Slit3
slit guidance ligand 3
IEP
mRNA:increased expression:brain
RGD
PMID:16262652
RGD:2316136
NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634
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Snca
synuclein alpha
ISO IEP
RGD
PMID:14637093 PMID:25089700
RGD:6480195 , RGD:11576302
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Sncb
synuclein, beta
ISO
RGD
PMID:14637093
RGD:6480195
NCBI chr17:9,846,802...9,855,013
Ensembl chr17:9,846,802...9,855,012
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Sncg
synuclein, gamma
ISO
RGD
PMID:14637093
RGD:6480195
NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368
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Snw1
SNW domain containing 1
IEP
mRNA, protein:increased expression:cerebral cortex (rat)
RGD
PMID:22965216
RGD:11035237
NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
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Sod1
superoxide dismutase 1
ISO
RGD
PMID:16248885
RGD:1581214
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:24462953 PMID:16248885
RGD:1581214
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sparc
secreted protein acidic and cysteine rich
IEP
mRNA:increased expression:brain, blood vessel
RGD
PMID:9704602
RGD:2300066
NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
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Sstr2
somatostatin receptor 2
IEP
RGD
PMID:11879809
RGD:2325002
NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
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Sstr3
somatostatin receptor 3
IEP
RGD
PMID:11879809
RGD:2325002
NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769
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Sstr4
somatostatin receptor 4
IEP
RGD
PMID:11879809
RGD:2325002
NCBI chr 3:135,854,826...135,856,689
Ensembl chr 3:135,854,826...135,856,689
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Stat1
signal transducer and activator of transcription 1
IMP
RGD
PMID:21596098
RGD:6483023
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
IMP IDA
protein:increased phosphorylation:brain
RGD
PMID:21596098 PMID:22145815 PMID:22827467
RGD:6483023 , RGD:8694312 , RGD:6892706
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Strn
striatin
IEP
RGD
PMID:16351572
RGD:2311293
NCBI chr 6:16,335,265...16,422,159
Ensembl chr 6:16,335,358...16,417,083
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Tardbp
TAR DNA binding protein
ISO
RGD
PMID:22101322
RGD:5687195
NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
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Tf
transferrin
IEP
RGD
PMID:22538758
RGD:7244386
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Th
tyrosine hydroxylase
IEP
protein:decreased activity:striatum (rat)
RGD
PMID:21047500
RGD:5128822
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Thbd
thrombomodulin
onset
ISO
RGD
PMID:17895610
RGD:5685007
NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
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Ticam2
TIR domain containing adaptor molecule 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462
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Timp1
TIMP metallopeptidase inhibitor 1
IEP
mRNA:increased expression:brain, astrocytes
RGD
PMID:10719361
RGD:2290468
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Timp2
TIMP metallopeptidase inhibitor 2
IEP
mRNA:increased expression:brain, neuron, microglial cell
RGD
PMID:10719361
RGD:2290468
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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Tjp1
tight junction protein 1
IEP
RGD
PMID:19889224
RGD:2325128
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tlr1
toll-like receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
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Tlr2
toll-like receptor 2
IEP ISO
mRNA:increased expression:brain CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21549006 PMID:18316784
RGD:2312713
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
IEP ISO
mRNA:increased expression:brain CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21549006 PMID:18316784
RGD:2312713
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr9
toll-like receptor 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21549006
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
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Tnf
tumor necrosis factor
ISO IMP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19800810 PMID:21549006 PMID:10674461
RGD:13825262
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf13b
TNF receptor superfamily member 13B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:45,801,860...45,824,932
Ensembl chr10:45,801,860...45,822,987
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Tnfrsf13c
TNF receptor superfamily member 13C
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 7:113,736,046...113,738,523
Ensembl chr 7:113,736,055...113,738,517
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Tnfrsf14
TNF receptor superfamily member 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703
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Tnfrsf1a
TNF receptor superfamily member 1A
IEP ISO
protein:increased expression:brain CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:21549006 PMID:17074049
RGD:1624183
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Tnfsf10
TNF superfamily member 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tnfsf12
TNF superfamily member 12
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
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Traf4
Tnf receptor associated factor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23159883
NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284
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Trpm2
transient receptor potential cation channel, subfamily M, member 2
IEP
mRNA, protein:increased expression:cerebral cortex, hippocampus
RGD
PMID:20309649
RGD:9999437
NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181
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Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
IEP
mRNA:decreased expression:cerebral cortex, hippocampus (rat)
RGD
PMID:17936732
RGD:11041870
NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
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Ucp2
uncoupling protein 2
ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:12858170 PMID:12858170
RGD:7204436
NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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Vegfa
vascular endothelial growth factor A
IEP ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:18065154 PMID:12230324
RGD:1580574
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vegfb
vascular endothelial growth factor B
IEP
mRNA, protein:increased expression:brain
RGD
PMID:12230324
RGD:1580574
NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
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Vim
vimentin
ISO IEP
protein:increased expression:brain
RGD
PMID:19728994 PMID:15527750
RGD:6480519 , RGD:6480527
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Xdh
xanthine dehydrogenase
treatment
IEP
RGD
PMID:26528358
RGD:13208950
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Apoe
apolipoprotein E
susceptibility
ISO
DNA:polymorphism:exon:
RGD
PMID:9214529
RGD:7495763
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
G
Tardbp
TAR DNA binding protein
ISO
protein:increased expression:brain
RGD
PMID:20720505
RGD:5687179
NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
G
Becn1
beclin 1
ISO
protein:increased expression:neuron
RGD
PMID:16004578
RGD:6483315
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Gfap
glial fibrillary acidic protein
IEP
RGD
PMID:8833197
RGD:6480531
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Got1
glutamic-oxaloacetic transaminase 1
ISO
human protein in a rat model
RGD
PMID:17014847
RGD:13504858
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Igf1
insulin-like growth factor 1
ISO
protein:decreased expression:serum:
RGD
PMID:12002507
RGD:8548865
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Igfbp3
insulin-like growth factor binding protein 3
ISO
protein:decreased expression:serum:
RGD
PMID:12002507
RGD:8548865
NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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Vim
vimentin
IEP
RGD
PMID:8833197
RGD:6480531
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Aldh3a1
aldehyde dehydrogenase 3 family, member A1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28038895
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
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Tp63
tumor protein p63
ISO
RGD
PMID:12167247
RGD:11568649
NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
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Ifng
interferon gamma
ISO
mRNA,protein:increased expression:corneal
RGD
PMID:15832292
RGD:8157597
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Bmp4
bone morphogenetic protein 4
IEP
mRNA:increased expression:superior cervical ganglion
RGD
PMID:16420416
RGD:2289006
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
G
Cx3cl1
C-X3-C motif chemokine ligand 1
IEP
RGD
PMID:15153618
RGD:4891994
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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S100b
S100 calcium binding protein B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30076900
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
G
Il10
interleukin 10
treatment
IDA
RGD
PMID:22553604
RGD:7364851
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il1b
interleukin 1 beta
ISO
protein:increased expression:retina
RGD
PMID:9618720
RGD:7794723
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Pparg
peroxisome proliferator-activated receptor gamma
IEP
protein:increased expression:cornea, neutrophil, macrophage (rat)
RGD
PMID:24194635
RGD:8552904
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Fgf2
fibroblast growth factor 2
ISO IEP
protein:increased expression:lens
RGD
PMID:15273655 PMID:15273655
RGD:8655664 , RGD:8655664
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Mir182
microRNA 182
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27208084
NCBI chr 4:58,784,818...58,784,879
Ensembl chr 4:58,784,818...58,784,879
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Mir183
microRNA 183
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27208084
NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723
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Mir96
microRNA 96
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27208084
NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
G
Pparg
peroxisome proliferator-activated receptor gamma
treatment
ISO
RGD
PMID:18658087
RGD:8552893
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Adcyap1
adenylate cyclase activating polypeptide 1
IEP
mRNA:increased expression:facial VII nucleus
RGD
PMID:19427307
RGD:2325258
NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
G
Atf2
activating transcription factor 2
IEP
RGD
PMID:9813301
RGD:10047413
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
G
Ccr3
C-C motif chemokine receptor 3
ISO
RGD
PMID:19922414
RGD:6892922
NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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Cd59b
CD59b molecule
IEP
mRNA, protein:increased expression:facial VII nucleus
RGD
PMID:9846834
RGD:1600495
NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
G
Clu
clusterin
IEP
protein:increased expression:neuron,astrocyte
RGD
PMID:10800205
RGD:408418725
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
G
Csf1
colony stimulating factor 1
IEP
protein:increased expression:facial VII nerve, microglial cell
RGD
PMID:20831658
RGD:5131509
NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
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Ctss
cathepsin S
ISO
RGD
PMID:17539023
RGD:5686912
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
G
Gfra1
GDNF family receptor alpha 1
IEP
mRNA:increased expression:facial VII nucleus
RGD
PMID:9582449
RGD:6218984
NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
G
Hgf
hepatocyte growth factor
treatment
IDA
RGD
PMID:21562589
RGD:8548634
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Mt3
metallothionein 3
treatment
IDA
RGD
PMID:14625437
RGD:9685806
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Ndufa5
NADH:ubiquinone oxidoreductase subunit A5
IEP
mRNA:increased expression:skeletal muscle
RGD
PMID:8875451
RGD:2302319
NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598 Ensembl chr 5:52,995,546...53,005,598
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Ret
ret proto-oncogene
IEP
mRNA:increased expression:facial VII nucleus
RGD
PMID:9582449
RGD:6218984
NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
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Acvr1b
activin A receptor type 1B
IEP
RGD
PMID:9013782
RGD:151665480
NCBI chr 7:132,286,266...132,329,679
Ensembl chr 7:132,286,275...132,329,673
G
Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
IEP
mRNA:increased expression:hypoglossal nerve
RGD
PMID:11311987
RGD:5037239
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
G
Aif1
allograft inflammatory factor 1
IEP
RGD
PMID:9698327
RGD:704401
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Csnk2b
casein kinase 2 beta
IEP
RGD
PMID:11068334
RGD:11565824
NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133
G
Fgf2
fibroblast growth factor 2
IEP
RGD
PMID:9183688
RGD:8655640
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Fgfr1
Fibroblast growth factor receptor 1
IEP
RGD
PMID:9183688
RGD:8655640
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
G
Gfra1
GDNF family receptor alpha 1
IEP
mRNA:increased expression:hypoglossal XII nerve
RGD
PMID:10407179
RGD:6218979
NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
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Il1r1
interleukin 1 receptor type 1
IEP
mRNA:increased expression:hypoglossal nerve
RGD
PMID:11311987
RGD:5037239
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
G
Mcam
melanoma cell adhesion molecule
IEP
RGD
PMID:10076889
RGD:7364787
NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571
G
Mme
membrane metallo-endopeptidase
IEP
RGD
PMID:8201016
RGD:13801045
NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
IEP
RGD
PMID:7769990
RGD:7327191
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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Prkacb
protein kinase cAMP-activated catalytic subunit beta
IEP
RGD
PMID:7769990
RGD:7327191
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
G
Ret
ret proto-oncogene
IEP
mRNA:increased expression:hypoglossal XII nerve
RGD
PMID:10407179
RGD:6218979
NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
G
Smad1
SMAD family member 1
IEP
mRNA:increased expression:hypoglossal nucleus
RGD
PMID:17166487
RGD:1643227
NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
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Smad2
SMAD family member 2
IEP
mRNA:increased expression:hypoglossal nucleus
RGD
PMID:17166487
RGD:1643227
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
G
Smad3
SMAD family member 3
IEP
mRNA:increased expression:hypoglossal nucleus
RGD
PMID:17166487
RGD:1643227
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
G
Smad4
SMAD family member 4
IEP
mRNA:increased expression:hypoglossal nucleus
RGD
PMID:17166487
RGD:1643227
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
G
Smad7
SMAD family member 7
IEP
mRNA:increased expression:hypoglossal nucleus
RGD
PMID:17166487
RGD:1643227
NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
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Smad9
SMAD family member 9
IEP
mRNA:decreased expression:hypoglossal nucleus
RGD
PMID:17166487
RGD:1643227
NCBI chr 2:138,956,326...139,006,315
Ensembl chr 2:138,986,471...139,006,307
G
Txnrd1
thioredoxin reductase 1
IEP
mRNA, protein:increased expression:neuron
RGD
PMID:19833109
RGD:5133729
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Gp6
glycoprotein VI
exacerbates
ISO
RGD
PMID:21258336
RGD:401824683
NCBI chr 1:69,429,232...69,492,709
Ensembl chr 1:69,465,789...69,491,326
G
Mdm2
MDM2 proto-oncogene
treatment
IMP
RGD
PMID:34334113
RGD:155882538
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
G
Zeb2
zinc finger E-box binding homeobox 2
treatment
IMP IEP
protein:increased expression:brain (rat)
RGD
PMID:34334113 PMID:34334113
RGD:155882538 , RGD:155882538
NCBI chr 3:29,214,581...29,344,890
Ensembl chr 3:29,218,301...29,345,157
G
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
IEP
mRNA:decreased expression:bone
RGD
PMID:19607804
RGD:5147852
NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897
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Ihh
Indian hedgehog signaling molecule
IEP
RGD
PMID:23992905
RGD:12911207
NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
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Ntrk2
neurotrophic receptor tyrosine kinase 2
IEP
mRNA:increased expression:motor neuron
RGD
PMID:21456016
RGD:5684341
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
G
Adcy10
adenylate cyclase 10
IEP
protein:decreased expression:retina
RGD
PMID:22649251
RGD:329347828
NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951
G
Adnp
activity-dependent neuroprotector homeobox
IDA
RGD
PMID:18414890
RGD:2312783
NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312
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Amigo3
adhesion molecule with Ig like domain 3
treatment
IEP
RGD
PMID:23613963
RGD:14390159
NCBI chr 8:108,741,899...108,743,425
Ensembl chr 8:108,693,060...108,744,555
G
Aqp4
aquaporin 4
IEP
RGD
PMID:20216911
RGD:2326035
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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Aqp9
aquaporin 9
IEP
RGD
PMID:20216911
RGD:2326035
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Arg2
arginase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30618589
NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
G
Atf2
activating transcription factor 2
IEP
RGD
PMID:10366744
RGD:10047417
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
G
Bax
BCL2 associated X, apoptosis regulator
IEP
mRNA:increased expression:optic nerve, retina
RGD
PMID:24357921
RGD:10054098
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
IEP
mRNA:decreased expression:optic nerve, retina
RGD
PMID:24357921
RGD:10054098
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bdnf
brain-derived neurotrophic factor
treatment
ISO IEP
RGD
PMID:15140649 PMID:11050383 PMID:9520478
RGD:8655584 , RGD:8655586 , RGD:8655637
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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C3
complement C3
IEP
mRNA:increased expression:optic nerve
RGD
PMID:14577867
RGD:5129542
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Cdk2
cyclin dependent kinase 2
IEP
mRNA:increased expression:retina
RGD
PMID:16723461
RGD:2293567
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cfl1
cofilin 1
treatment
IDA
RGD
PMID:27443501
RGD:11568693
NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
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Clu
clusterin
IEP
RGD
PMID:14577867
RGD:5129542
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
G
Csf1r
colony stimulating factor 1 receptor
IEP
mRNA:increased expression:retina (rat)
RGD
PMID:20187850
RGD:151665810
NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
G
Csf3
colony stimulating factor 3
treatment
ISO
RGD
PMID:20144610
RGD:11039471
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Ctsb
cathepsin B
IEP
protein:increased expression:retina (rat)
RGD
PMID:18775855
RGD:2315508
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Edn1
endothelin 1
IEP
protein:increased expression:retina
RGD
PMID:18600494
RGD:4892579
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Ednra
endothelin receptor type A
IEP
mRNA:increased expression:retina
RGD
PMID:18600494
RGD:4892579
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
G
Ednrb
endothelin receptor type B
IEP
mRNA:increased expression:retina
RGD
PMID:18600494
RGD:4892579
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
G
Ep300
E1A binding protein p300
IEP ISO
protein:decreased expression:retinal ganglion cell layer (rat) human gene in rat model
RGD
PMID:21705428 PMID:21705428
RGD:7349392 , RGD:7349392
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
G
Fgf2
fibroblast growth factor 2
treatment
ISO
RGD
PMID:14664816
RGD:8554854
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Fto
FTO, alpha-ketoglutarate dependent dioxygenase
IEP
mRNA:increased expression:retina
RGD
PMID:33664770
RGD:329951020
NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083
G
Gdnf
glial cell derived neurotrophic factor
IEP
RGD
PMID:15144875
RGD:6218970
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
G
Gfra1
GDNF family receptor alpha 1
IEP
RGD
PMID:15144875
RGD:6218970
NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
G
Gfra2
GDNF family receptor alpha 2
IEP
RGD
PMID:15144875
RGD:6218970
NCBI chr15:45,941,841...46,033,715
Ensembl chr15:45,941,828...46,033,714
G
Hgf
hepatocyte growth factor
treatment
ISO
RGD
PMID:21443522
RGD:8548549
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Igf1r
insulin-like growth factor 1 receptor
IMP IEP
protein: altered activity: eye protein:increased expression:retina:
RGD
PMID:19484445 PMID:23648097
RGD:5686431 , RGD:10046025
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
IEP
RGD
PMID:10366744
RGD:10047417
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
G
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
IEP
RGD
PMID:20216911
RGD:2326035
NCBI chr13:84,802,026...84,835,383
Ensembl chr13:84,802,009...84,835,461
G
Mt-co1
mitochondrially encoded cytochrome c oxidase I
ISO
mRNA:increased expression:retina
RGD
PMID:12076086
RGD:8662362
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Myrf
myelin regulatory factor
IEP
mRNA:decreased expression: oligodendrocyte
RGD
PMID:29915135
RGD:213230153
NCBI chr 1:206,854,175...206,886,276
Ensembl chr 1:206,854,175...206,886,157
G
Nampt
nicotinamide phosphoribosyltransferase
treatment
IMP
RGD
PMID:28032230
RGD:13781885
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
G
Ncam1
neural cell adhesion molecule 1
ISO
RGD
PMID:18757519
RGD:2326023
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
G
Nefm
neurofilament medium chain
IEP
RGD
PMID:8501527
RGD:9743936
NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
G
Neo1
neogenin 1
IEP
protein:increased expression:retina
RGD
PMID:21887516
RGD:9850142
NCBI chr 8:59,273,860...59,426,486
Ensembl chr 8:59,275,569...59,430,348
G
Ngf
nerve growth factor
IEP
protein:increased expression:retina
RGD
PMID:28067793
RGD:402463954
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
G
Ngfr
nerve growth factor receptor
IDA
RGD
PMID:20943663
RGD:5508695
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
G
Ntrk1
neurotrophic receptor tyrosine kinase 1
IDA
RGD
PMID:20943663
RGD:5508695
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
G
Ntrk2
neurotrophic receptor tyrosine kinase 2
treatment
IDA
RGD
PMID:20357199 PMID:34245756
RGD:5684908 , RGD:597015764
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
G
Pawr
pro-apoptotic WT1 regulator
IEP
mRNA:increased expression:retina:
RGD
PMID:12836167
RGD:1299297
NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
G
Pax6
paired box 6
IEP
protein:increased expression:retina (rat)
RGD
PMID:23297010
RGD:8552379
NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
G
Pdgfb
platelet derived growth factor subunit B
IEP
protein:decreased expression:nerve fiber:
RGD
PMID:9893812
RGD:10449496
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
G
Pecam1
platelet and endothelial cell adhesion molecule 1
IEP
protein:increased expression:optic nerve (rat)
RGD
PMID:22336118
RGD:6767293
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
G
Plau
plasminogen activator, urokinase
IEP
mRNA:increased expression:optic nerve (rat)
RGD
PMID:20798533
RGD:6483802
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
G
Ptpn5
protein tyrosine phosphatase, non-receptor type 5
IEP
protein:increased expression:retina (rat)
RGD
PMID:15555919
RGD:9835027
NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882
G
Rhoa
ras homolog family member A
IEP
protein:increased expression, altered localization:retina
RGD
PMID:17534117
RGD:1642826
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
G
Snw1
SNW domain containing 1
IEP
protein:increased expression:retina (rat)
RGD
PMID:25074585
RGD:11035254
NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536
G
Tlr4
toll-like receptor 4
ISO
protein:increased expression:optic nerve
RGD
PMID:23103505
RGD:7794777
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tnfrsf1a
TNF receptor superfamily member 1A
IEP ISO
RGD
PMID:18552980 PMID:14697498
RGD:7794683 , RGD:8661743
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
G
Tradd
TNFRSF1A-associated via death domain
IEP
protein:increased expression: retina
RGD
PMID:18552980
RGD:7794683
NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
G
Ybx3
Y box binding protein 3
IEP
mRNA:increased expression:retinal ganglion cell
RGD
PMID:11750989
RGD:2311250
NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161
G
Fgf2
fibroblast growth factor 2
ISO
mRNA:increased expression:retina
RGD
PMID:9268592
RGD:8655567
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
G
Neo1
neogenin 1
IEP
protein:increased expression:retina
RGD
PMID:21887516
RGD:9850142
NCBI chr 8:59,273,860...59,426,486
Ensembl chr 8:59,275,569...59,430,348
G
Rgma
repulsive guidance molecule BMP co-receptor a
IEP
protein:increased expression:retina
RGD
PMID:21887516
RGD:9850142
NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918
G
Entpd1
ectonucleoside triphosphate diphosphohydrolase 1
IEP
protein:increased expression,increased activity:cerebral cortex:
RGD
PMID:16672190
RGD:9685448
NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317
G
Fgfr1
Fibroblast growth factor receptor 1
IEP
mRNA,protein:increased expression:astrocyte,macrophage,neutrophil:
RGD
PMID:11168551
RGD:10402049
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
G
Gfap
glial fibrillary acidic protein
ISO
RGD
PMID:10225952
RGD:6480471
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Pdgfb
platelet derived growth factor subunit B
IEP
protein:increased expression:neuron:
RGD
PMID:7526956
RGD:10449485
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
G
Vim
vimentin
ISO
RGD
PMID:10225952
RGD:6480471
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
G
Trh
thyrotropin releasing hormone
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:8690305
NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
G
Bmp4
bone morphogenetic protein 4
treatment
ISO
RGD
PMID:16332232
RGD:8699514
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
G
Igf1
insulin-like growth factor 1
ISO
protein:decreased expression:serum:
RGD
PMID:12002507
RGD:8548865
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Plat
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:1899364
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
G
Adam10
ADAM metallopeptidase domain 10
IEP
RGD
PMID:22489706
RGD:13703033
NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
G
Ahr
aryl hydrocarbon receptor
IEP
protein:increased expression:T cell, neuron, brain cortex, hippocampus
RGD
PMID:27506546
RGD:405878081
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
App
amyloid beta precursor protein
treatment
ISO
RGD
PMID:29320530
RGD:13782048
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
G
Bad
BCL2-associated agonist of cell death
treatment
IEP
RGD
PMID:24582457
RGD:13782254
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
G
Bdnf
brain-derived neurotrophic factor
IEP
mRNA:increased expression:CA3 field of hippocampus, dentate gyrus
RGD
PMID:10925157
RGD:596936229
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Bid
BH3 interacting domain death agonist
disease_progression severity
IEP
RGD
PMID:12172380 PMID:15307896
RGD:632018 , RGD:5509821
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
G
Capn1
calpain 1
severity
IEP
protein:increased expression:cytosol, plasma membrane
RGD
PMID:9469158 PMID:15307896
RGD:13792664 , RGD:5509821
NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
G
Capn2
calpain 2
severity
IEP
RGD
PMID:9469158 PMID:15307896
RGD:13792664 , RGD:5509821
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
G
Casp3
caspase 3
severity
IEP
protein:increased expression:cerebral cortex
RGD
PMID:27614125 PMID:15307896
RGD:329961568 , RGD:5509821
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
disease_progression severity
IEP
RGD
PMID:12172380 PMID:15307896
RGD:632018 , RGD:5509821
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
disease_progression severity
IEP
RGD
PMID:12172380 PMID:15307896
RGD:632018 , RGD:5509821
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccng1
cyclin G1
treatment
IEP
RGD
PMID:24398934 PMID:18612315
RGD:151356934 , RGD:151356935
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
G
Cd163
CD163 molecule
IEP
protein:increased expression:brain, macrophage (rat)
RGD
PMID:22583855
RGD:127285798
NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
G
Cd8a
CD8 subunit alpha
ISO
mRNA:increased expression:brain (mouse)
RGD
PMID:31383034
RGD:124715446
NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
G
Cit
citron rho-interacting serine/threonine kinase
IEP
mRNA:decreased expression:cerebral cortex��(rat)
RGD
PMID:12503083
RGD:2317873
NCBI chr12:40,603,073...40,764,846
Ensembl chr12:40,605,563...40,763,860
G
Cxcl10
C-X-C motif chemokine ligand 10
treatment
ISO
RGD
PMID:26435412
RGD:27095897
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
G
Cxcl12
C-X-C motif chemokine ligand 12
IEP
protein:increased expression:cerebral cortex
RGD
PMID:27614125
RGD:329961568
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
treatment
IEP
RGD
PMID:26068867
RGD:401901590
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Drd1
dopamine receptor D1
treatment
IEP
RGD
PMID:24047867
RGD:13506948
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
G
Drd2
dopamine receptor D2
treatment
IEP
RGD
PMID:24047867
RGD:13506948
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
G
Fto
FTO, alpha-ketoglutarate dependent dioxygenase
IEP
mRNA:decreased expression:cerebral cortex
RGD
PMID:31992337
RGD:329901857
NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083
G
Fubp1
far upstream element binding protein 1
IEP
RGD
PMID:23797733
RGD:13673879
NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602
G
Gnal
G protein subunit alpha L
IEP
RGD
PMID:29215295
RGD:13513923
NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599
G
Gria1
glutamate ionotropic receptor AMPA type subunit 1
IEP
protein:increased phosphorylation:central amygdaloid nucleus (rat)
RGD
PMID:30638118
RGD:405101698
NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283
G
Icam1
intercellular adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28642177
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28642177
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Itgb1
integrin subunit beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Lama1
laminin subunit alpha 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593
NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
G
Lamp2
lysosomal-associated membrane protein 2
IEP
protein:increased expression:hippocampus:
RGD
PMID:28365875
RGD:13703062
NCBI chr X:117,173,097...117,222,090
Ensembl chr X:117,057,606...117,260,522
G
Lcn2
lipocalin 2
IEP
RGD
PMID:31539545
RGD:126781751
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
G
Mapt
microtubule-associated protein tau
treatment
IDA IEP
RGD
PMID:28412141 PMID:25771151 PMID:26484783 PMID:26729399
RGD:13800902 , RGD:13800917 , RGD:13800912 , RGD:13800909
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
G
Mettl14
methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
IEP
mRNA:decreased expression:cerebral cortex
RGD
PMID:31992337
RGD:329901857
NCBI chr 2:211,530,598...211,546,845
Ensembl chr 2:211,530,602...211,546,821
G
Mir155
microRNA 155
ISO
RGD
PMID:28804446
RGD:25314324
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
G
Mmp2
matrix metallopeptidase 2
IEP
protein:increased expression:cerebral cortex
RGD
PMID:27614125
RGD:329961568
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Mmp9
matrix metallopeptidase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mpo
myeloperoxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Ncstn
nicastrin
ISO
RGD
PMID:18240300
RGD:13801189
NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454
G
Nfe2l2
NFE2 like bZIP transcription factor 2
IEP
protein:increased expression:brain:
RGD
PMID:30855558
RGD:26884463
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Ngf
nerve growth factor
treatment
IMP
RGD
PMID:26285082
RGD:402463964
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
G
Nmnat1
nicotinamide nucleotide adenylyltransferase 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27822499
NCBI chr 5:159,910,242...159,928,201
Ensembl chr 5:159,910,242...159,928,180
G
Nos2
nitric oxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28642177
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nox1
NADPH oxidase 1
IEP
protein:increased expression:cerebral cortex
RGD
PMID:27614125
RGD:329961568
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
IEP
protein:increased phosphorylation:amygdala mRNA:decreased expression:hippocampus, hypothalamus
RGD
PMID:30638118 PMID:36637480
RGD:405101698 , RGD:408364984
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Ntrk2
neurotrophic receptor tyrosine kinase 2
IEP
mRNA:increased expression:dentate gyrus
RGD
PMID:10925157
RGD:596936229
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
G
Ocln
occludin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
G
Parp1
poly (ADP-ribose) polymerase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15829224 PMID:28642177
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pde10a
phosphodiesterase 10A
IEP
RGD
PMID:29215295
RGD:13513923
NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
G
Pdyn
prodynorphin
IEP
mRNA:increased expression:hippocampus
RGD
PMID:12626770
RGD:633616
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
G
Phactr1
phosphatase and actin regulator 1
treatment
ISO
RGD
PMID:36571365
RGD:401901253
NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831
G
Ppp3r1
protein phosphatase 3, regulatory subunit B, alpha
IEP
RGD
PMID:20713027
RGD:13830881
NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907
G
Ppp3r2
protein phosphatase 3, regulatory subunit B, beta
IEP
RGD
PMID:20713027
RGD:13830881
NCBI chr 5:64,026,903...64,027,898
Ensembl chr 5:64,026,903...64,032,548
G
Psen1
presenilin 1
ISO
RGD
PMID:18240300
RGD:13801189
NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650
G
Ptgs2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28642177
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25668593 PMID:28642177
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Tgfb1
transforming growth factor, beta 1
treatment
IEP
RGD
PMID:28433746
RGD:14995478
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28642177
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
treatment
IMP
RGD
PMID:27553877
RGD:14995939
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Ube4b
ubiquitination factor E4B
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:27822499
NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509
G
F7
coagulation factor VII
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:20370756
NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
G
Abcc8
ATP binding cassette subfamily C member 8
treatment
IMP
RGD
PMID:18854840
RGD:2325137
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
G
Tp53
tumor protein p53
IEP
RGD
PMID:22977862
RGD:8547771
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Adrb2
adrenoceptor beta 2
IEP
mRNA:increased expression:Vestibulocochlear nerve:
RGD
PMID:22178544
RGD:8548530
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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