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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Heart Injuries
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Accession:DOID:9007588 term browser browse the term
Definition:General or unspecified injuries to the heart.
Synonyms:exact_synonym: Heart Injury;   Traumatic Cardiac Rupture;   Traumatic Cardiac Ruptures;   Traumatic Heart Rupture;   Traumatic Heart Ruptures
 primary_id: MESH:D006335
 xref: EFO:0009506


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Heart Injuries term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member ISO CTD Direct Evidence: therapeutic CTD PMID:23500772 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Fis1 fission, mitochondrial 1 IEP mRNA, protein:increased expression:heart (rat) RGD PMID:25677476 RGD:12437078 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377 		JBrowse link
G Il1b interleukin 1 beta ameliorates IEP
ISO		 protein:increased expression:spinal cord
associated with obesity		 RGD PMID:17719662 PMID:32084395 RGD:7401227, RGD:242905211 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 ameliorates ISO associated with obesity RGD PMID:32084395 RGD:242905211 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mirlet7f2 microRNA let-7f-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31570982 NCBI chr  X:20,980,632...20,980,714
Ensembl chr  X:20,980,632...20,980,714 		JBrowse link
G Myl1 myosin, light chain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19854236 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IEP mRNA, protein:increased expression:heart (rat) RGD PMID:25677476 RGD:12437078 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ameliorates ISO associated with obesity RGD PMID:32084395 RGD:242905211 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor ameliorates ISO associated with obesity RGD PMID:32084395 RGD:242905211 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnnt2 troponin T2, cardiac type ISO CTD Direct Evidence: marker/mechanism CTD PMID:19854236 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
Acute Heart Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccn1 cellular communication network factor 1 ameliorates ISO RGD PMID:23329650 RGD:329845572 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Mfn1 mitofusin 1 IEP mRNA, protein:increased expression:heart (rat) RGD PMID:25677476 RGD:12437078 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19065
    Wounds and Injuries 988
      Thoracic Injuries 301
        Heart Injuries 12
          Acute Heart Injury 2
          Myocardial Contusions + 0
paths to the root