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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Arbovirus Infections
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Accession:DOID:9007579 term browser browse the term
Definition:Infections caused by arthropod-borne viruses, general or unspecified.
Synonyms:exact_synonym: Arbovirus Infection
 primary_id: MESH:D001102
 xref: EFO:1001269



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babesiosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pecam1 platelet/endothelial cell adhesion molecule 1 ISO protein:decreased expression:serum (human) RGD PMID:25539588 RGD:11541121 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454
JBrowse link
boutonneuse fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement component 3 ISO protein:increased expression:serum RGD PMID:3361150 RGD:11041575 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
JBrowse link
G Cfb complement factor B ISO protein:increased expression:serum RGD PMID:3361150 RGD:11041575 NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEP RGD PMID:14507644 RGD:5135450 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 IEP RGD PMID:14507644 RGD:5135450 NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
JBrowse link
Crimean-Congo hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifna1 interferon alpha 1 susceptibility ISO DNA:SNP:promoter: -1823G>A (rs1332190)(human) RGD PMID:26694082 RGD:36174029 NCBI chr 4:88,768,324...88,768,893
Ensembl chr 4:88,768,324...88,768,893
JBrowse link
dengue disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd209d CD209d antigen severity ISO DNA:SNP:promoter: -336G>A (human) RGD PMID:16274635 RGD:39939064 NCBI chr 8:3,921,824...3,928,548
Ensembl chr 8:3,921,824...3,928,555
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 treatment IMP RGD PMID:30098206 RGD:39938828 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405
JBrowse link
G F2 coagulation factor II ISO RGD PMID:22138554 RGD:40818430 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III severity ISO DNA:polymorphism:cds:p.H131R(human) RGD PMID:26240159 RGD:13463456 NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504
JBrowse link
G Gc vitamin D binding protein ISO protein:increased expression:plasma RGD PMID:19845402 RGD:5509870 NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:31821895 RGD:39939074 NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 treatment IMP RGD PMID:30098206 RGD:39938828 NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575
JBrowse link
G Il33 interleukin 33 severity IDA RGD PMID:30098206 RGD:39938828 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEP protein:increased phosphorylation:liver (mouse) RGD PMID:28188818 RGD:150340680 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
JBrowse link
G Mir146 microRNA 146 ISO RNA:decreased expression:serum: RGD PMID:26941580 RGD:41404658 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
JBrowse link
G Mir21a microRNA 21a ISO RNA:increased expression:serum: RGD PMID:26941580 RGD:41404658 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984
JBrowse link
G Stat2 signal transducer and activator of transcription 2 susceptibility IMP RGD PMID:21075352 PMID:21379341 RGD:41789625, RGD:41789629 NCBI chr10:128,106,367...128,128,722
Ensembl chr10:128,106,428...128,128,718
JBrowse link
dengue hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 antigen disease_progression ISO protein:increased expression:cd14-positive monocyte (human) RGD PMID:24945350 RGD:127345113 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748
JBrowse link
G Clec5a C-type lectin domain family 5, member a ISO CTD Direct Evidence: therapeutic CTD PMID:18496526 NCBI chr 6:40,551,832...40,562,739
Ensembl chr 6:40,551,828...40,562,755
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III susceptibility ISO DNA:polymorphism:cds:p.H131R(human) RGD PMID:22817980 RGD:11040906 NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504
JBrowse link
G Il21 interleukin 21 severity ISO protein:increased expression:blood serum (human) RGD PMID:24858204 RGD:127285368 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785
JBrowse link
G Mill2 MHC I like leukocyte 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22001756 NCBI chr 7:18,573,878...18,603,621
Ensembl chr 7:18,573,891...18,599,327
JBrowse link
G Osbp oxysterol binding protein ISO mRNA:increased expression:peripheral blood mononuclear cell RGD PMID:28241052 RGD:41404654 NCBI chr19:11,943,208...11,971,478
Ensembl chr19:11,943,305...11,971,476
JBrowse link
G Plce1 phospholipase C, epsilon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22001756 NCBI chr19:38,469,438...38,773,549
Ensembl chr19:38,469,557...38,773,474
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 severity ISO DNA;polymorphism:5'utr: (rs25531) (human) RGD PMID:30452889 RGD:38676265 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
JBrowse link
G Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) susceptibility ISO DNA:SNPs: : RGD PMID:18071882 RGD:6482261 NCBI chr17:34,423,453...34,435,295
Ensembl chr17:34,422,501...34,435,295
JBrowse link
Japanese encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 IEP RGD PMID:17010311 RGD:18337278 NCBI chr 4:138,182,459...138,187,437
Ensembl chr 4:138,181,625...138,187,434
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 ameliorates IMP RGD PMID:32265853 RGD:127229907 NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322
JBrowse link
Lyme disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 ISO protein:increased expression:synovial fluid RGD PMID:23371320 RGD:7488895 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 severity IMP RGD PMID:12847259 RGD:7257681 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405
JBrowse link
G Mir146 microRNA 146 exacerbates IMP RGD PMID:24967703 RGD:126925141 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 IMP RGD PMID:21387014 RGD:5508754 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102
JBrowse link
G Plaur plasminogen activator, urokinase receptor IMP
ISO
mRNA:increased expression:skin RGD PMID:19461880 PMID:19461880 RGD:6483813, RGD:6483813 NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393
JBrowse link
Lyme Neuroborreliosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 ISO protein:increased expression:serum (human) RGD PMID:16358960 RGD:11528571 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Cd40 CD40 antigen ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 treatment ISO RGD PMID:24239846 RGD:39939054 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:23134838 RGD:7193053 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
Tick-Borne Diseases term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24218580 NCBI chr15:97,637,886...97,666,300
Ensembl chr15:97,642,651...97,665,853
JBrowse link
tick-borne encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 antigen ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402
JBrowse link
West Nile encephalitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifih1 interferon induced with helicase C domain 1 IEP mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 2:62,426,137...62,476,599
Ensembl chr 2:62,426,142...62,476,599
JBrowse link
G Lcn2 lipocalin 2 IEP mRNA,protein:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
JBrowse link
G Rigi RNA sensor RIG-I IEP mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 4:40,203,775...40,239,843
Ensembl chr 4:40,203,773...40,239,828
JBrowse link
G Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) disease_progression IMP RGD PMID:16809306 RGD:40902815 NCBI chr 1:153,625,089...153,644,441
Ensembl chr 1:153,625,172...153,639,967
JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 severity IMP RGD PMID:31415679 RGD:39128224 NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607
JBrowse link
G Tlr3 toll-like receptor 3 IEP mRNA:increased expression:brain RGD PMID:24173226 RGD:126781836 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117
JBrowse link
West Nile fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr5 C-C motif chemokine receptor 5 susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: West Nile virus, susceptibility to
CTD
OMIM
ClinVar
PMID:8639485 PMID:8751444 PMID:8756719 PMID:9055842 PMID:9132277 More... NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736
JBrowse link
G Irf5 interferon regulatory factor 5 disease_progression IMP RGD PMID:25031348 RGD:40924561 NCBI chr 6:29,526,129...29,541,874
Ensembl chr 6:29,526,624...29,541,870
JBrowse link
G Mavs mitochondrial antiviral signaling protein severity IMP RGD PMID:28094802 RGD:40903045 NCBI chr 2:131,075,445...131,089,945
Ensembl chr 2:131,075,983...131,089,945
JBrowse link
G Rfc1 replication factor C (activator 1) 1 susceptibility ISO DNA:silent mutation:CDS:p.P847P (rs2066786) (human) RGD PMID:21881118 RGD:41410434 NCBI chr 5:65,419,195...65,492,988
Ensembl chr 5:65,419,193...65,493,013
JBrowse link
G S100b S100 protein, beta polypeptide, neural ISO RGD PMID:19790244 RGD:5508797 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993
JBrowse link
yellow fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stat2 signal transducer and activator of transcription 2 susceptibility IMP RGD PMID:31043530 RGD:41789622 NCBI chr10:128,106,367...128,128,722
Ensembl chr10:128,106,428...128,128,718
JBrowse link
Zika fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 IEP mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742
JBrowse link
G Atg16l1 autophagy related 16 like 1 ISO CTD Direct Evidence: therapeutic CTD PMID:28694387 NCBI chr 1:87,683,730...87,720,150
Ensembl chr 1:87,683,592...87,720,150
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IEP mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157
JBrowse link
G Edem1 ER degradation enhancer, mannosidase alpha-like 1 IEP mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chr 6:108,800,984...108,836,317
Ensembl chr 6:108,805,602...108,836,317
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 IEP RGD PMID:30241539 RGD:32733625 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678
JBrowse link
G Hspa5 heat shock protein 5 IEP mRNA,protein:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A IEP mRNA:increased expression:brain RGD PMID:30241539 RGD:32733625 NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692
JBrowse link
G Stat2 signal transducer and activator of transcription 2 susceptibility ISO
IMP
human gene in a mouse model RGD PMID:29746837 PMID:28278235 RGD:41789627, RGD:41789631 NCBI chr10:128,106,367...128,128,722
Ensembl chr10:128,106,428...128,128,718
JBrowse link
G Xbp1 X-box binding protein 1 IEP protein:increased expression:cerebellum, mesocephalon RGD PMID:30241539 RGD:32733625 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16225
    disease by infectious agent 2238
      viral infectious disease 1727
        Arbovirus Infections 56
          African Horse Sickness 0
          Arbovirus Encephalitis + 15
          Bluetongue 0
          Equine Encephalomyelitis + 0
          Phlebotomus fever 0
          Rift Valley fever 0
          Tick-Borne Diseases + 17
          Zika fever + 9
          dengue disease + 20
          yellow fever 1
paths to the root