RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Arbovirus Infections
Accession: DOID:9007579
browse the term
Definition: Infections caused by arthropod-borne viruses, general or unspecified.
Synonyms: exact_synonym: Arbovirus Infection
primary_id: MESH:D001102
xref: EFO:1001269
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Pecam1
platelet/endothelial cell adhesion molecule 1
ISO
protein:decreased expression:serum (human)
RGD
PMID:25539588
RGD:11541121
NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454
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C3
complement component 3
ISO
protein:increased expression:serum
RGD
PMID:3361150
RGD:11041575
NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136
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Cfb
complement factor B
ISO
protein:increased expression:serum
RGD
PMID:3361150
RGD:11041575
NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494
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Cxcl10
C-X-C motif chemokine ligand 10
IEP
RGD
PMID:14507644
RGD:5135450
NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748
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Cxcl9
C-X-C motif chemokine ligand 9
IEP
RGD
PMID:14507644
RGD:5135450
NCBI chr 5:92,469,190...92,475,938
Ensembl chr 5:92,469,206...92,475,938
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Ifna1
interferon alpha 1
susceptibility
ISO
DNA:SNP:promoter: -1823G>A (rs1332190)(human)
RGD
PMID:26694082
RGD:36174029
NCBI chr 4:88,768,324...88,768,893
Ensembl chr 4:88,768,324...88,768,893
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Cd209d
CD209d antigen
severity
ISO
DNA:SNP:promoter: -336G>A (human)
RGD
PMID:16274635
RGD:39939064
NCBI chr 8:3,921,824...3,928,548
Ensembl chr 8:3,921,824...3,928,555
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Cxcr2
C-X-C motif chemokine receptor 2
treatment
IMP
RGD
PMID:30098206
RGD:39938828
NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405
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F2
coagulation factor II
ISO
RGD
PMID:22138554
RGD:40818430
NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759
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Fcgr3
Fc receptor, IgG, low affinity III
severity
ISO
DNA:polymorphism:cds:p.H131R(human)
RGD
PMID:26240159
RGD:13463456
NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504
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Gc
vitamin D binding protein
ISO
protein:increased expression:plasma
RGD
PMID:19845402
RGD:5509870
NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757
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Ido1
indoleamine 2,3-dioxygenase 1
treatment
ISO
RGD
PMID:31821895
RGD:39939074
NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025
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Il1rl1
interleukin 1 receptor-like 1
treatment
IMP
RGD
PMID:30098206
RGD:39938828
NCBI chr 1:40,444,105...40,504,575
Ensembl chr 1:40,468,730...40,504,575
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Il33
interleukin 33
severity
IDA
RGD
PMID:30098206
RGD:39938828
NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118
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Mapk8
mitogen-activated protein kinase 8
IEP
protein:increased phosphorylation:liver (mouse)
RGD
PMID:28188818
RGD:150340680
NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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Mir146
microRNA 146
ISO
RNA:decreased expression:serum:
RGD
PMID:26941580
RGD:41404658
NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
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Mir21a
microRNA 21a
ISO
RNA:increased expression:serum:
RGD
PMID:26941580
RGD:41404658
NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984
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Stat2
signal transducer and activator of transcription 2
susceptibility
IMP
RGD
PMID:21075352 PMID:21379341
RGD:41789625 , RGD:41789629
NCBI chr10:128,106,367...128,128,722
Ensembl chr10:128,106,428...128,128,718
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Cd1d1
CD1d1 antigen
disease_progression
ISO
protein:increased expression:cd14-positive monocyte (human)
RGD
PMID:24945350
RGD:127345113
NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748
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Clec5a
C-type lectin domain family 5, member a
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:18496526
NCBI chr 6:40,551,832...40,562,739
Ensembl chr 6:40,551,828...40,562,755
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Fcgr3
Fc receptor, IgG, low affinity III
susceptibility
ISO
DNA:polymorphism:cds:p.H131R(human)
RGD
PMID:22817980
RGD:11040906
NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504
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Il21
interleukin 21
severity
ISO
protein:increased expression:blood serum (human)
RGD
PMID:24858204
RGD:127285368
NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785
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Mill2
MHC I like leukocyte 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22001756
NCBI chr 7:18,573,878...18,603,621
Ensembl chr 7:18,573,891...18,599,327
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Osbp
oxysterol binding protein
ISO
mRNA:increased expression:peripheral blood mononuclear cell
RGD
PMID:28241052
RGD:41404654
NCBI chr19:11,943,208...11,971,478
Ensembl chr19:11,943,305...11,971,476
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Plce1
phospholipase C, epsilon 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22001756
NCBI chr19:38,469,438...38,773,549
Ensembl chr19:38,469,557...38,773,474
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Slc6a4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
severity
ISO
DNA;polymorphism:5'utr: (rs25531) (human)
RGD
PMID:30452889
RGD:38676265
NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
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Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
susceptibility
ISO
DNA:SNPs: :
RGD
PMID:18071882
RGD:6482261
NCBI chr17:34,423,453...34,435,295
Ensembl chr17:34,422,501...34,435,295
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Camk2n1
calcium/calmodulin-dependent protein kinase II inhibitor 1
IEP
RGD
PMID:17010311
RGD:18337278
NCBI chr 4:138,182,459...138,187,437
Ensembl chr 4:138,181,625...138,187,434
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Ripk3
receptor-interacting serine-threonine kinase 3
ameliorates
IMP
RGD
PMID:32265853
RGD:127229907
NCBI chr14:56,022,452...56,026,314
Ensembl chr14:56,022,452...56,026,322
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Ccl20
C-C motif chemokine ligand 20
ISO
protein:increased expression:synovial fluid
RGD
PMID:23371320
RGD:7488895
NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
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Cxcr2
C-X-C motif chemokine receptor 2
severity
IMP
RGD
PMID:12847259
RGD:7257681
NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405
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Mir146
microRNA 146
exacerbates
IMP
RGD
PMID:24967703
RGD:126925141
NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288
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Nod2
nucleotide-binding oligomerization domain containing 2
IMP
RGD
PMID:21387014
RGD:5508754
NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102
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Plaur
plasminogen activator, urokinase receptor
IMP ISO
mRNA:increased expression:skin
RGD
PMID:19461880 PMID:19461880
RGD:6483813 , RGD:6483813
NCBI chr 7:24,161,857...24,175,393
Ensembl chr 7:24,161,909...24,175,393
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Ccl2
C-C motif chemokine ligand 2
ISO
protein:increased expression:serum (human)
RGD
PMID:16358960
RGD:11528571
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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Cd40
CD40 antigen
ISO
protein:increased expression:cerebrospinal fluid (human)
RGD
PMID:16463218
RGD:11352252
NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
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Cd40lg
CD40 ligand
ISO
protein:increased expression:cerebrospinal fluid (human)
RGD
PMID:16463218
RGD:11352252
NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402
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Cxcl15
C-X-C motif chemokine ligand 15
treatment
ISO
RGD
PMID:24239846
RGD:39939054
NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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Il1b
interleukin 1 beta
ISO
RGD
PMID:23134838
RGD:7193053
NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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Rapgef3
Rap guanine nucleotide exchange factor (GEF) 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24218580
NCBI chr15:97,637,886...97,666,300
Ensembl chr15:97,642,651...97,665,853
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Cd40
CD40 antigen
ISO
protein:increased expression:cerebrospinal fluid (human)
RGD
PMID:16463218
RGD:11352252
NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868
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Cd40lg
CD40 ligand
ISO
protein:increased expression:cerebrospinal fluid (human)
RGD
PMID:16463218
RGD:11352252
NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402
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Ifih1
interferon induced with helicase C domain 1
IEP
mRNA:increased expression:brain
RGD
PMID:24173226
RGD:126781836
NCBI chr 2:62,426,137...62,476,599
Ensembl chr 2:62,426,142...62,476,599
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Lcn2
lipocalin 2
IEP
mRNA,protein:increased expression:brain
RGD
PMID:24173226
RGD:126781836
NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264
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Rigi
RNA sensor RIG-I
IEP
mRNA:increased expression:brain
RGD
PMID:24173226
RGD:126781836
NCBI chr 4:40,203,775...40,239,843
Ensembl chr 4:40,203,773...40,239,828
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Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
disease_progression
IMP
RGD
PMID:16809306
RGD:40902815
NCBI chr 1:153,625,089...153,644,441
Ensembl chr 1:153,625,172...153,639,967
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Sting1
stimulator of interferon response cGAMP interactor 1
severity
IMP
RGD
PMID:31415679
RGD:39128224
NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607
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Tlr3
toll-like receptor 3
IEP
mRNA:increased expression:brain
RGD
PMID:24173226
RGD:126781836
NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117
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Ccr5
C-C motif chemokine receptor 5
susceptibility
ISO
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: West Nile virus, susceptibility to
CTD OMIM ClinVar
PMID:8639485 PMID:8751444 PMID:8756719 PMID:9055842 PMID:9132277 PMID:9140404 PMID:9207783 PMID:9466996 PMID:9511755 PMID:9585595 PMID:9600249 PMID:9768627 PMID:10520641 PMID:10615909 PMID:10803840 PMID:11081537 PMID:11403804 PMID:11403814 PMID:11517319 PMID:11781692 PMID:12874407 PMID:15744032 PMID:15863470 PMID:16216086 PMID:16248677 PMID:16418398 PMID:19017985 PMID:19073967 PMID:28492532 More...
NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736
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Irf5
interferon regulatory factor 5
disease_progression
IMP
RGD
PMID:25031348
RGD:40924561
NCBI chr 6:29,526,129...29,541,874
Ensembl chr 6:29,526,624...29,541,870
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Mavs
mitochondrial antiviral signaling protein
severity
IMP
RGD
PMID:28094802
RGD:40903045
NCBI chr 2:131,075,445...131,089,945
Ensembl chr 2:131,075,983...131,089,945
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Rfc1
replication factor C (activator 1) 1
susceptibility
ISO
DNA:silent mutation:CDS:p.P847P (rs2066786) (human)
RGD
PMID:21881118
RGD:41410434
NCBI chr 5:65,419,195...65,492,988
Ensembl chr 5:65,419,193...65,493,013
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S100b
S100 protein, beta polypeptide, neural
ISO
RGD
PMID:19790244
RGD:5508797
NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993
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Stat2
signal transducer and activator of transcription 2
susceptibility
IMP
RGD
PMID:31043530
RGD:41789622
NCBI chr10:128,106,367...128,128,722
Ensembl chr10:128,106,428...128,128,718
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Atf4
activating transcription factor 4
IEP
mRNA:increased expression:brain
RGD
PMID:30241539
RGD:32733625
NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742
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Atg16l1
autophagy related 16 like 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:28694387
NCBI chr 1:87,683,730...87,720,150
Ensembl chr 1:87,683,592...87,720,150
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Ddit3
DNA-damage inducible transcript 3
IEP
mRNA:increased expression:brain
RGD
PMID:30241539
RGD:32733625
NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157 Ensembl chr10:127,126,643...127,132,157
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Edem1
ER degradation enhancer, mannosidase alpha-like 1
IEP
mRNA:increased expression:brain
RGD
PMID:30241539
RGD:32733625
NCBI chr 6:108,800,984...108,836,317
Ensembl chr 6:108,805,602...108,836,317
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Ern1
endoplasmic reticulum to nucleus signalling 1
IEP
RGD
PMID:30241539
RGD:32733625
NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678
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Hspa5
heat shock protein 5
IEP
mRNA,protein:increased expression:brain
RGD
PMID:30241539
RGD:32733625
NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
IEP
mRNA:increased expression:brain
RGD
PMID:30241539
RGD:32733625
NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692
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Stat2
signal transducer and activator of transcription 2
susceptibility
ISO IMP
human gene in a mouse model
RGD
PMID:29746837 PMID:28278235
RGD:41789627 , RGD:41789631
NCBI chr10:128,106,367...128,128,722
Ensembl chr10:128,106,428...128,128,718
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Xbp1
X-box binding protein 1
IEP
protein:increased expression:cerebellum, mesocephalon
RGD
PMID:30241539
RGD:32733625
NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
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