Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Otitis
go back to main search page
Accession:DOID:9007481 term browser browse the term
Definition:Inflammation of the ear, which may be marked by pain (EARACHE), fever, HEARING DISORDERS, and VERTIGO. Inflammation of the external ear is OTITIS EXTERNA; of the middle ear, OTITIS MEDIA; of the inner ear, LABYRINTHITIS.
Synonyms:exact_synonym: Ear Inflammation;   Ear Inflammations;   Otitides
 primary_id: MESH:D010031;   RDO:0005953
For additional species annotation, visit the Alliance of Genome Resources.


GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
 
Acute Otitis Media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp1 bone morphogenetic protein 1 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004936555:5,990,822...6,023,864 JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004936697:1,054,237...1,061,468 JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004936534:4,707,658...4,871,865 JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004936530:71,965...143,940 JBrowse link
G Bmp8a bone morphogenetic protein 8a ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853
G Cald1 caldesmon 1 ISO mRNA, protein:decreased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004936579:868,681...1,046,198 JBrowse link
G Col3a1 collagen type III alpha 1 chain ISO RGD PMID:10453785 RGD:11556224 NCBI chrNW_004936506:8,886,494...8,923,921 JBrowse link
G Dstn destrin, actin depolymerizing factor ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004936485:2,504,492...2,537,507 JBrowse link
G Fgf10 fibroblast growth factor 10 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004936480:18,114,231...18,195,884 JBrowse link
G Fgf3 fibroblast growth factor 3 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004936599:868,634...875,464 JBrowse link
G Fgf6 fibroblast growth factor 6 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004936606:4,613,052...4,624,587 JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004936710:1,760,365...1,815,269 JBrowse link
G Fn1 fibronectin 1 ISO RGD PMID:10453785 RGD:11556224 NCBI chrNW_004936586:1,708,803...1,773,372 JBrowse link
G Il17a interleukin 17A disease_progression ISO protein:increased expression:serum (rat) RGD PMID:27497403 RGD:40818299 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il22 interleukin 22 disease_progression ISO protein:increased expression:serum (rat) RGD PMID:27497403 RGD:40818299 NCBI chrNW_004936545:6,227,118...6,231,745 JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004936857:646,363...726,338 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21307808 RGD:150340689 NCBI chrNW_004936728:1,775,746...1,893,895 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004936481:6,300,894...6,325,878 JBrowse link
G S100a9 S100 calcium binding protein A9 ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004936580:3,228,097...3,230,652 JBrowse link
labyrinthitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor ISO protein:increased expression: cochleas, endolymphatic sac: RGD PMID:12943369 RGD:7394706 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
mastoiditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101969640 C-reactive protein disease_progression ISO RGD PMID:22578647 RGD:9491592 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004936599:3,800,142...3,810,583 JBrowse link
G Tlr2 toll like receptor 2 ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr4 toll like receptor 4 ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
otitis externa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101969640 C-reactive protein disease_progression ISO RGD PMID:22032882 RGD:9491591 NCBI chrNW_004936740:885,855...888,854 JBrowse link
otitis media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actl6a actin like 6A ISO ClinVar Annotator: match by term: Susceptibility to otitis media ClinVar PMID:25741868 PMID:28649782 NCBI chrNW_004936566:3,577,412...3,587,182 JBrowse link
G Btc betacellulin ISO mRNA:decreased expression:middle ear RGD PMID:12148846 RGD:2306978 NCBI chrNW_004936598:971,253...1,019,043 JBrowse link
G C2 complement C2 ISO associated with Pneumococcal Infections RGD PMID:20065024 RGD:7411716 NCBI chrNW_004936727:1,602,400...1,615,974 JBrowse link
G C3 complement C3 ISO associated with Pneumococcal Infections RGD PMID:19139190 PMID:21502587 RGD:11554035 RGD:7401269 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cat catalase treatment ISO protein:decreased activity:cochlea,serum: RGD PMID:22173336 RGD:7401215 NCBI chrNW_004936533:3,601,270...3,637,128 JBrowse link
G Cfb complement factor B ISO associated with Pneumococcal Infections RGD PMID:20065024 RGD:7411716 NCBI chrNW_004936727:1,595,872...1,602,274 JBrowse link
G Ctsk cathepsin K ISO mRNA:decreased expression:middle ear RGD PMID:15179208 RGD:1342442 NCBI chrNW_004936580:1,022,762...1,038,020 JBrowse link
G Ctsl cathepsin L ISO mRNA:decreased expression:middle ear mucosa (rat) RGD PMID:15179208 RGD:1342442 NCBI chrNW_004936680:3,047,355...3,050,640 JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 susceptibility ISO DNA:missense mutation:cds:p.T280M (human) RGD PMID:24718616 RGD:9491764 NCBI chrNW_004936473:28,508,726...28,535,640 JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 ISO RGD PMID:20433028 RGD:11553910 NCBI chrNW_004936565:1,917,970...1,919,027 JBrowse link
G Defb1 defensin beta 1 ISO RGD PMID:22072973 RGD:11554036 NCBI chrNW_004936615:4,780,229...4,790,516 JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment ISO RGD PMID:22610099 RGD:7771533 NCBI chrNW_004936609:2,688,170...2,691,057 JBrowse link
G Eda ectodysplasin A ISO RGD PMID:31028034 RGD:14398763 NCBI chrNW_004936777:1,545,293...1,561,109 JBrowse link
G Edar ectodysplasin A receptor treatment ISO RGD PMID:31028034 RGD:14398763 NCBI chrNW_004936829:429,667...458,943 JBrowse link
G Edaradd EDAR associated death domain ISO RGD PMID:31028034 RGD:14398763 NCBI chrNW_004936484:16,394,753...16,446,102 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:20926702 RGD:8547580 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Ifng interferon gamma ISO associated with adenoidal hypertrophy; protein:decreased expression:T cell:
associated with Pneumococcal infections;
RGD PMID:16730398 PMID:18266836 RGD:7987910 RGD:8142343 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il10 interleukin 10 susceptibility ISO associated with respiratory syncytial virus infectious disease, associated with common cold;DNA:SNPs, haplotypes:promoter:-1082G>A, -819T>C, -592A>C (human)
associated with Pneumococcal Infections;mRNA:increased expression:middle ear
DNA:SNP:promoter:-1082G>A (human)
associated with Pneumococcal Infections;protein:increased expression:middle ear, serum
associated with Haemophilus Infections
RGD PMID:14500471 PMID:17908769 PMID:18524391 PMID:18560870 PMID:18771082 More... RGD:4891398 RGD:7364816 RGD:7365029 RGD:7365038 RGD:7365054 RGD:7365082 NCBI chrNW_004936557:5,834,874...5,838,502 JBrowse link
G Il17a interleukin 17A severity ISO RGD PMID:24664502 RGD:8698659 NCBI chrNW_004936476:8,621,860...8,625,008 JBrowse link
G Il1a interleukin 1 alpha ISO associated with Haemophilus Infections;mRNA, protein:increased expression:middle ear RGD PMID:18524391 RGD:4891398 NCBI chrNW_004936783:1,210,715...1,218,315 JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:10085040 PMID:22173336 RGD:11553900 RGD:7401215 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il2 interleukin 2 disease_progression ISO RGD PMID:7769948 RGD:8662922 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
G Il6 interleukin 6 susceptibility ISO mRNA,protein:increased expression:middle ear,inner ear:
mRNA,protein:increased expression:middle ear:
DNA:polymorphism:promoter:-174G>C(human)
RGD PMID:10085040 PMID:11165648 PMID:17908769 PMID:21271590 RGD:11553900 RGD:7365054 RGD:7829801 RGD:8547980 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G LOC101959212 alpha-2-macroglobulin treatment ISO RGD PMID:2459981 PMID:2473673 RGD:11553864 RGD:11553918 NCBI chrNW_004936870:424,832...468,303 JBrowse link
G LOC101964013 mucin-17 ISO associated with Pneumococcal Infections RGD PMID:11576628 RGD:2303743 NCBI chrNW_004936543:976,794...987,062 JBrowse link
G LOC101964975 interleukin-8 ISO RGD PMID:10085040 RGD:11553900 NCBI chrNW_004936598:1,779,471...1,781,353 JBrowse link
G LOC101969640 C-reactive protein treatment ISO RGD PMID:7724300 RGD:9491381 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Lta4h leukotriene A4 hydrolase ISO RGD PMID:20433028 RGD:11553910 NCBI chrNW_004936507:12,082,373...12,120,078 JBrowse link
G Ltb4r leukotriene B4 receptor ISO RGD PMID:20433028 RGD:11553910 NCBI chrNW_004936722:232,320...233,802 JBrowse link
G Ltc4s leukotriene C4 synthase ISO RGD PMID:20433028 RGD:11553910 NCBI chrNW_004936739:975,494...978,426 JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO RGD PMID:26611891 RGD:11054805 NCBI chrNW_004936593:2,742,236...3,282,596 JBrowse link
G Muc1 mucin 1, cell surface associated ISO associated with Pneumococcal Infections;mRNA:increased expression:middle ear RGD PMID:11576628 RGD:2303743 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
G Muc4 mucin 4, cell surface associated ISO mRNA:increased expression:middle ear
associated with Pneumococcal Infections;mRNA:increased expression:middle ear
RGD PMID:11576628 PMID:14690056 RGD:2303743 RGD:7349395 NCBI chrNW_004936784:515,608...539,915 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:increased expression:ear
associated with CHARGE Syndrome
RGD PMID:11425202 PMID:22539951 RGD:2324973 RGD:7349405 NCBI chrNW_004936816:129,926...159,396 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:middle ear
associated with CHARGE Syndrome
RGD PMID:14690056 PMID:22539951 RGD:7349395 RGD:7349405 NCBI chrNW_004936816:174,943...209,241 JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with Haemophilus Infections; mRNA, protein:increased expression:middle ear RGD PMID:18524391 RGD:4891398 NCBI chrNW_004936538:4,052,277...4,097,051 JBrowse link
G Plau plasminogen activator, urokinase treatment ISO RGD PMID:2473673 RGD:11553864 NCBI chrNW_004936521:5,238,128...5,243,829 JBrowse link
G Plg plasminogen ISO ClinVar Annotator: match by term: Otitis media, susceptibility to ClinVar PMID:10233898 PMID:12850227 PMID:16849641 PMID:25741868 PMID:28492532 More... NCBI chrNW_004936489:11,775,243...11,808,482 JBrowse link
G Pth parathyroid hormone ISO protein:increased expression:serum (human) RGD PMID:23543299 RGD:7242409 NCBI chrNW_004936528:5,081,569...5,084,030 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004936599:3,800,142...3,810,583 JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO mRNA,protein:increased expression:epithelial cell RGD PMID:15799573 RGD:5144051 NCBI chrNW_004936581:798,738...801,614 JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 ISO RGD PMID:12206256 RGD:6484586 NCBI chrNW_004936542:3,262,161...3,274,545 JBrowse link
G Spink5 serine peptidase inhibitor Kazal type 5 ISO ClinVar Annotator: match by term: OTITIS MEDIA, CHRONIC/RECURRENT ClinVar PMID:28492532 PMID:32709676 NCBI chrNW_004936504:6,653,703...6,750,110 JBrowse link
G Tlr2 toll like receptor 2 ISO associated with Haemophilus Infections;
protein:increased expression:middle ear:
protein:increased expression:mucosa of middle ear,skin of ear canal:
associated with Pneumococcal Infections;
RGD PMID:19414550 PMID:19586996 PMID:23380629 PMID:24690988 RGD:7777086 RGD:7800666 RGD:8552783 RGD:8552995 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr4 toll like receptor 4 ISO associated with Haemophilus Infections;
protein:increased expression:middle ear:
protein:increased expression:mucosa of middle ear,skin of ear canal:
RGD PMID:19586996 PMID:23380629 PMID:24690988 RGD:7777086 RGD:7800666 RGD:8552995 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
G Tnf tumor necrosis factor ISO associated with Haemophilus Infections; mRNA, protein:increased expression:middle ear
protein:increased expression:ear:
RGD PMID:10085040 PMID:18524391 PMID:21818352 PMID:22173336 RGD:11553900 RGD:4891398 RGD:7394703 RGD:7401215 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA:increased expression:middle ear:
mRNA,protein:increased expression:middle ear,inner ear:
RGD PMID:21271590 PMID:22104377 RGD:8547975 RGD:8547980 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
Otitis Media with Effusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 disease_progression ISO RGD PMID:11037838 RGD:7401253 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO mRNA:increased expression:mucosa of the middle ear; RGD PMID:12875575 RGD:8547977 NCBI chrNW_004936472:23,442,946...23,617,523 JBrowse link
G Glb1 galactosidase beta 1 ISO RGD PMID:2837976 RGD:11557999 NCBI chrNW_004936473:23,348,431...23,440,271 JBrowse link
G Gusb glucuronidase beta ISO RGD PMID:2837976 RGD:11557999 NCBI chrNW_004936543:7,721,273...7,732,468 JBrowse link
G Ifng interferon gamma ISO protein:decreased expression:serum:
protein:decreased expression:middle ear:
RGD PMID:15938212 PMID:16055981 RGD:7987911 RGD:8142354 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:8302123 PMID:18568516 RGD:11554174 RGD:7394746 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il4r interleukin 4 receptor treatment ISO RGD PMID:12297806 RGD:11530017 NCBI chrNW_004936501:11,025,590...11,058,807 JBrowse link
G Kdr kinase insert domain receptor ISO mRNA:increased expression:mucosa of the middle ear; RGD PMID:12875575 RGD:8547977 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G LOC101959212 alpha-2-macroglobulin ISO RGD PMID:2454602 RGD:11560528 NCBI chrNW_004936870:424,832...468,303 JBrowse link
G Ltf lactotransferrin treatment ISO RGD PMID:21079169 RGD:11554025 NCBI chrNW_004936596:344,287...373,788 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:increased expression:middle ear
mRNA:decreased expression:ear
RGD PMID:20713760 PMID:22336013 RGD:7364731 RGD:7364764 NCBI chrNW_004936816:129,926...159,396 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:middle ear
mRNA:decreased expression:ear
RGD PMID:16540890 PMID:22336013 RGD:7364744 RGD:7364764 NCBI chrNW_004936816:174,943...209,241 JBrowse link
G Oxgr1 oxoglutarate receptor 1 ISO RGD PMID:23200873 RGD:7775025 NCBI chrNW_004936472:13,047,918...13,049,041 JBrowse link
G Ptafr platelet activating factor receptor treatment ISO RGD PMID:14759570 RGD:11554333 NCBI chrNW_004936474:12,333,905...12,337,140 JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:22336013 RGD:7364764 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:22336013 RGD:7364764 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:middle ear effusion: RGD PMID:18568516 RGD:7394746 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:mucosa of middle ear: RGD PMID:22907120 RGD:8547964 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
suppurative otitis media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma disease_progression ISO RGD PMID:19640314 RGD:8142346 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G LOC101959212 alpha-2-macroglobulin ISO RGD PMID:1696441 RGD:11556250 NCBI chrNW_004936870:424,832...468,303 JBrowse link
G Tlr2 toll like receptor 2 ISO mRNA,protein:increased expression:mucosa: RGD PMID:22883581 RGD:7800662 NCBI chrNW_004936576:522,234...531,660 JBrowse link
G Tlr4 toll like receptor 4 ISO mRNA,protein:increased expression:mucosa: RGD PMID:22883581 RGD:7800662 NCBI chrNW_004936487:6,519,140...6,532,018 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13024
    sensory system disease 5014
      auditory system disease 764
        Otitis 75
          labyrinthitis + 1
          otitis externa + 1
          otitis media + 75
Path 2
Term Annotations click to browse term
  disease 13024
    disease of anatomical entity 12705
      nervous system disease 10560
        sensory system disease 5014
          Otorhinolaryngologic Diseases 1171
            auditory system disease 764
              Otitis 75
                labyrinthitis + 1
                otitis externa + 1
                otitis media + 75
paths to the root