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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Otitis
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Accession:DOID:9007481 term browser browse the term
Definition:Inflammation of the ear, which may be marked by pain (EARACHE), fever, HEARING DISORDERS, and VERTIGO. Inflammation of the external ear is OTITIS EXTERNA; of the middle ear, OTITIS MEDIA; of the inner ear, LABYRINTHITIS.
Synonyms:exact_synonym: Ear Inflammation;   Ear Inflammations;   Otitides
 primary_id: MESH:D010031;   RDO:0005953
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
Acute Otitis Media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc4 actin related protein 2/3 complex, subunit 4 ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr 6:113,378,113...113,390,447
Ensembl chr 6:113,378,115...113,390,448
JBrowse link
G Bmp1 bone morphogenetic protein 1 IEP mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr14:70,474,555...70,520,716
Ensembl chr14:70,474,558...70,520,234
JBrowse link
G Bmp4 bone morphogenetic protein 4 IEP mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669
JBrowse link
G Bmp6 bone morphogenetic protein 6 IEP mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr13:38,345,716...38,500,314
Ensembl chr13:38,345,107...38,500,302
JBrowse link
G Bmp7 bone morphogenetic protein 7 IEP mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr 2:172,868,012...172,940,321
Ensembl chr 2:172,868,012...172,940,321
JBrowse link
G Bmp8a bone morphogenetic protein 8a IEP mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr 4:123,312,645...123,343,252
Ensembl chr 4:123,312,645...123,343,252
JBrowse link
G Cald1 caldesmon 1 ISO mRNA, protein:decreased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr 6:34,598,495...34,775,469
Ensembl chr 6:34,598,500...34,775,473
JBrowse link
G Col3a1 collagen, type III, alpha 1 ISO RGD PMID:10453785 RGD:11556224 NCBI chr 1:45,311,538...45,349,706
Ensembl chr 1:45,311,538...45,349,706
JBrowse link
G Dstn destrin ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr 2:143,915,331...143,943,324
Ensembl chr 2:143,915,320...143,943,324
JBrowse link
G Fgf10 fibroblast growth factor 10 IEP mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr13:118,714,699...118,792,573
Ensembl chr13:118,669,791...118,792,115
JBrowse link
G Fgf3 fibroblast growth factor 3 IEP mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr 7:144,838,612...144,843,348
Ensembl chr 7:144,838,083...144,844,436
JBrowse link
G Fgf6 fibroblast growth factor 6 IEP mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr 6:127,015,542...127,024,718
Ensembl chr 6:127,015,586...127,028,187
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 IEP mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr 8:25,518,759...25,575,718
Ensembl chr 8:25,513,654...25,575,718
JBrowse link
G Fn1 fibronectin 1 ISO RGD PMID:10453785 RGD:11556224 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Il17a interleukin 17A disease_progression ISO protein:increased expression:serum (rat) RGD PMID:27497403 RGD:40818299 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il22 interleukin 22 disease_progression ISO protein:increased expression:serum (rat) RGD PMID:27497403 RGD:40818299 NCBI chr10:118,204,584...118,210,047
Ensembl chr10:118,204,942...118,210,047
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr14:75,131,105...75,230,842
Ensembl chr14:75,131,101...75,230,842
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEP mRNA:decreased expression:middle ear (mouse) RGD PMID:21307808 RGD:150340689 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp3 matrix metallopeptidase 3 IEP mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr 9:7,445,822...7,455,975
Ensembl chr 9:7,445,822...7,455,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr 1:152,800,153...152,836,990
Ensembl chr 1:152,800,194...152,836,991
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) ISO mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chr 3:90,692,630...90,695,721
Ensembl chr 3:90,692,632...90,695,721
JBrowse link
labyrinthitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor IEP protein:increased expression: cochleas, endolymphatic sac: RGD PMID:12943369 RGD:7394706 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
mastoiditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein, pentraxin-related disease_progression ISO RGD PMID:22578647 RGD:9491592 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tlr2 toll-like receptor 2 ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tlr4 toll-like receptor 4 ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
otitis externa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crp C-reactive protein, pentraxin-related disease_progression ISO RGD PMID:22032882 RGD:9491591 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
otitis media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin treatment ISO RGD PMID:2459981 PMID:2473673 RGD:11553864 RGD:11553918 NCBI chr 6:121,636,165...121,679,238
Ensembl chr 6:121,635,376...121,679,227
JBrowse link
G Actl6a actin-like 6A ISO ClinVar Annotator: match by term: Susceptibility to otitis media ClinVar PMID:25741868 PMID:28649782 NCBI chr 3:32,708,546...32,726,973
Ensembl chr 3:32,706,298...32,726,973
JBrowse link
G Bpifa1 BPI fold containing family A, member 1 IEA OMIM:166760 MouseDO NCBI chr 2:154,142,880...154,149,217
Ensembl chr 2:154,142,880...154,149,219
JBrowse link
G Btc betacellulin, epidermal growth factor family member ISO mRNA:decreased expression:middle ear RGD PMID:12148846 RGD:2306978 NCBI chr 5:91,357,261...91,402,994
Ensembl chr 5:91,357,261...91,402,994
JBrowse link
G C2 complement component 2 (within H-2S) IMP associated with Pneumococcal Infections RGD PMID:20065024 RGD:7411716 NCBI chr17:34,862,602...34,882,100
Ensembl chr17:34,862,604...34,898,265
JBrowse link
G C3 complement component 3 IEP associated with Pneumococcal Infections RGD PMID:21502587 RGD:7401269 NCBI chr17:57,203,967...57,228,136
Ensembl chr17:57,203,970...57,228,136
JBrowse link
G Cat catalase treatment ISO protein:decreased activity:cochlea,serum: RGD PMID:22173336 RGD:7401215 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cby1 chibby family member 1, beta catenin antagonist IEA OMIM:166760 MouseDO NCBI chr15:79,659,103...79,667,660
Ensembl chr15:79,659,199...79,667,660
JBrowse link
G Cfb complement factor B IMP associated with Pneumococcal Infections RGD PMID:20065024 RGD:7411716 NCBI chr17:34,856,374...34,862,514
Ensembl chr17:34,856,374...34,862,518
JBrowse link
G Crp C-reactive protein, pentraxin-related treatment ISO RGD PMID:7724300 RGD:9491381 NCBI chr 1:172,698,056...172,699,966
Ensembl chr 1:172,698,055...172,833,031
JBrowse link
G Ctsb cathepsin B ISO mRNA:increased expression:middle ear mucosa (rat) RGD PMID:15179208 RGD:1342442 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Ctsk cathepsin K ISO mRNA:decreased expression:middle ear RGD PMID:15179208 RGD:1342442 NCBI chr 3:95,499,210...95,509,387
Ensembl chr 3:95,499,256...95,509,362
JBrowse link
G Ctsl cathepsin L ISO mRNA:decreased expression:middle ear mucosa (rat) RGD PMID:15179208 RGD:1342442 NCBI chr13:64,361,890...64,370,772
Ensembl chr13:64,359,337...64,370,890
JBrowse link
G Cx3cr1 chemokine (C-X3-C motif) receptor 1 susceptibility ISO DNA:missense mutation:cds:p.T280M (human) RGD PMID:24718616 RGD:9491764 NCBI chr 9:120,048,683...120,068,296
Ensembl chr 9:119,901,616...120,069,879
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 ISO RGD PMID:10085040 RGD:11553900 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 ISO RGD PMID:20433028 RGD:11553910 NCBI chr14:73,025,672...73,049,114
Ensembl chr14:73,025,603...73,049,114
JBrowse link
G Defb1 defensin beta 1 ISO RGD PMID:22072973 RGD:11554036 NCBI chr 8:21,776,555...21,795,185
Ensembl chr 8:21,776,599...21,795,185
JBrowse link
G Dnah5 dynein, axonemal, heavy chain 5 IEA OMIM:166760 MouseDO NCBI chr15:28,154,854...28,472,045
Ensembl chr15:28,203,752...28,472,052
JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment IEP RGD PMID:22610099 RGD:7771533 NCBI chr17:26,505,591...26,508,472
Ensembl chr17:26,505,590...26,562,128
JBrowse link
G E2f4 E2F transcription factor 4 IEA OMIM:166760 MouseDO NCBI chr 8:105,297,663...105,305,370
Ensembl chr 8:105,297,663...105,305,370
JBrowse link
G Eda ectodysplasin-A IMP RGD PMID:31028034 RGD:14398763 NCBI chr  X:99,975,606...100,400,760
Ensembl chr  X:99,975,606...100,400,762
JBrowse link
G Edar ectodysplasin-A receptor treatment IMP RGD PMID:31028034 RGD:14398763 NCBI chr10:58,600,780...58,675,696
Ensembl chr10:58,600,789...58,675,654
JBrowse link
G Edaradd EDAR (ectodysplasin-A receptor)-associated death domain ISO RGD PMID:31028034 RGD:14398763 NCBI chr13:12,471,209...12,520,535
Ensembl chr13:12,472,632...12,520,438
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 IEA OMIM:166760 MouseDO NCBI chr10:24,637,914...24,712,159
Ensembl chr10:24,637,914...24,712,159
JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 IEA OMIM:166760 MouseDO NCBI chr10:23,102,962...23,350,838
Ensembl chr10:23,102,963...23,350,786
JBrowse link
G Fbxo11 F-box protein 11 IEA OMIM:166760 MouseDO NCBI chr17:87,990,859...88,066,045
Ensembl chr17:87,990,859...88,065,291
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 IEA OMIM:166760 MouseDO NCBI chr 8:25,518,759...25,575,718
Ensembl chr 8:25,513,654...25,575,718
JBrowse link
G Fut2 fucosyltransferase 2 ISO ClinVar Annotator: match by term: Familial Otitis Media ClinVar PMID:7876234 PMID:7876235 PMID:8755920 PMID:8928486 PMID:12692541 More... NCBI chr 7:45,648,591...45,666,394
Ensembl chr 7:45,648,591...45,666,394
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:20926702 RGD:8547580 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Idua iduronidase, alpha-L IEA OMIM:166760 MouseDO NCBI chr 5:108,660,331...108,685,446
Ensembl chr 5:108,660,331...108,684,557
JBrowse link
G Ifng interferon gamma ISO
IMP
associated with adenoidal hypertrophy; protein:decreased expression:T cell:
associated with Pneumococcal infections;
RGD PMID:18266836 PMID:16730398 RGD:7987910, RGD:8142343 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il10 interleukin 10 susceptibility ISO
IMP
associated with Pneumococcal Infections;protein:increased expression:middle ear, serum
associated with Pneumococcal Infections;mRNA:increased expression:middle ear
DNA:SNP:promoter:-1082G>A (human)
associated with Haemophilus Infections
associated with respiratory syncytial virus infectious disease, associated with common cold;DNA:SNPs, haplotypes:promoter:-1082G>A, -819T>C, -592A>C (human)
RGD PMID:23404508 PMID:14500471 PMID:17908769 PMID:18524391 PMID:18560870 More... RGD:7364816, RGD:7365082, RGD:7365054, RGD:4891398, RGD:7365038, RGD:7365029 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il17a interleukin 17A severity IMP RGD PMID:24664502 RGD:8698659 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il1a interleukin 1 alpha ISO associated with Haemophilus Infections; mRNA, protein:increased expression:middle ear RGD PMID:18524391 RGD:4891398 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:22173336 RGD:7401215 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il2 interleukin 2 disease_progression IEP RGD PMID:7769948 RGD:8662922 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il6 interleukin 6 susceptibility ISO
IEP
DNA:polymorphism:promoter:-174G>C(human)
mRNA,protein:increased expression:middle ear,inner ear:
mRNA,protein:increased expression:middle ear:
RGD PMID:17908769 PMID:21271590 PMID:11165648 RGD:7365054, RGD:8547980, RGD:7829801 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Lmna lamin A IEA OMIM:166760 MouseDO NCBI chr 3:88,481,148...88,509,932
Ensembl chr 3:88,480,147...88,509,956
JBrowse link
G Lta4h leukotriene A4 hydrolase ISO RGD PMID:20433028 RGD:11553910 NCBI chr10:93,453,396...93,484,896
Ensembl chr10:93,453,411...93,484,875
JBrowse link
G Ltb4r1 leukotriene B4 receptor 1 ISO RGD PMID:20433028 RGD:11553910 NCBI chr14:55,765,962...55,768,492
Ensembl chr14:55,765,962...55,768,494
JBrowse link
G Ltc4s leukotriene C4 synthase ISO RGD PMID:20433028 RGD:11553910 NCBI chr11:50,236,461...50,238,532
Ensembl chr11:50,236,461...50,238,616
JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 ISO DNA:haplotype,SNP:promoter,exons: RGD PMID:16750996 RGD:8693692 NCBI chr19:30,232,906...30,239,687
Ensembl chr19:30,232,942...30,239,687
JBrowse link
G Mecom MDS1 and EVI1 complex locus IMP
IEA
OMIM:166760 MouseDO
RGD
PMID:26611891 RGD:11054805 NCBI chr 3:29,951,296...30,509,759
Ensembl chr 3:29,951,296...30,548,008
JBrowse link
G Muc1 mucin 1, transmembrane ISO associated with Pneumococcal Infections;mRNA:increased expression:middle ear RGD PMID:11576628 RGD:2303743 NCBI chr 3:89,229,056...89,233,381
Ensembl chr 3:89,229,057...89,233,381
JBrowse link
G Muc3 mucin 3, intestinal ISO associated with Pneumococcal Infections RGD PMID:11576628 RGD:2303743 NCBI chr 5:137,134,924...137,166,048
Ensembl chr 5:137,134,922...137,149,322
JBrowse link
G Muc4 mucin 4 ISO associated with Pneumococcal Infections;mRNA:increased expression:middle ear RGD PMID:11576628 PMID:14690056 RGD:2303743, RGD:7349395 NCBI chr16:32,735,886...32,782,391
Ensembl chr16:32,735,886...32,782,391
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric ISO
IGI
mRNA:increased expression:ear
associated with CHARGE Syndrome
RGD PMID:11425202 PMID:22539951 RGD:2324973, RGD:7349405 NCBI chr 7:141,788,958...141,819,227
Ensembl chr 7:141,788,972...141,819,231
JBrowse link
G Muc5b mucin 5, subtype B, tracheobronchial ISO
IGI
mRNA:increased expression:middle ear
associated with CHARGE Syndrome
RGD PMID:14690056 PMID:22539951 RGD:7349395, RGD:7349405 NCBI chr 7:141,839,059...141,873,089
Ensembl chr 7:141,839,070...141,873,084
JBrowse link
G Naglu alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB) IEA OMIM:166760 MouseDO NCBI chr11:101,070,090...101,077,672
Ensembl chr11:101,070,012...101,077,672
JBrowse link
G Nf2 neurofibromin 2 IEA OMIM:166760 MouseDO NCBI chr11:4,757,639...4,849,544
Ensembl chr11:4,765,845...4,849,536
JBrowse link
G Nisch nischarin IEA OMIM:166760 MouseDO NCBI chr14:31,170,928...31,206,826
Ensembl chr14:31,170,930...31,216,946
JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO associated with Haemophilus Infections; mRNA, protein:increased expression:middle ear RGD PMID:18524391 RGD:4891398 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked IEA OMIM:166760 MouseDO NCBI chr  X:157,162,075...157,415,286
Ensembl chr  X:157,162,075...157,415,312
JBrowse link
G Plau plasminogen activator, urokinase treatment ISO RGD PMID:2473673 RGD:11553864 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Plg plasminogen ISO ClinVar Annotator: match by term: Otitis media, susceptibility to ClinVar PMID:10233898 PMID:12850227 PMID:16849641 PMID:25741868 PMID:28492532 More... NCBI chr17:12,378,609...12,419,384
Ensembl chr17:12,378,608...12,419,385
JBrowse link
G Pth parathyroid hormone ISO protein:increased expression:serum (human) RGD PMID:23543299 RGD:7242409 NCBI chr 7:113,385,576...113,388,672
Ensembl chr 7:113,385,580...113,388,570
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Rpl38 ribosomal protein L38 IEA OMIM:166760 MouseDO NCBI chr11:114,667,818...114,672,333
Ensembl chr11:114,668,524...114,672,331
JBrowse link
G Sall4 spalt like transcription factor 4 IEA OMIM:166760 MouseDO NCBI chr 2:168,748,332...168,767,201
Ensembl chr 2:168,748,332...168,767,943
JBrowse link
G Scgb1a1 secretoglobin, family 1A, member 1 (uteroglobin) ISO mRNA,protein:increased expression:epithelial cell RGD PMID:15799573 RGD:5144051 NCBI chr19:9,083,642...9,087,956
Ensembl chr19:9,083,636...9,087,958
JBrowse link
G Scn2b sodium channel, voltage-gated, type II, beta ISO RGD PMID:12206256 RGD:6484586 NCBI chr 9:45,117,876...45,130,070
Ensembl chr 9:45,117,782...45,130,070
JBrowse link
G Sh3pxd2b SH3 and PX domains 2B IEA OMIM:166760 MouseDO NCBI chr11:32,347,773...32,428,189
Ensembl chr11:32,347,820...32,428,173
JBrowse link
G Spink5 serine peptidase inhibitor, Kazal type 5 ISO ClinVar Annotator: match by term: OTITIS MEDIA, CHRONIC/RECURRENT ClinVar PMID:28492532 PMID:32709676 NCBI chr18:43,959,545...44,022,487
Ensembl chr18:43,963,235...44,022,501
JBrowse link
G Tbx1 T-box 1 IEA OMIM:166760 MouseDO NCBI chr16:18,580,979...18,590,671
Ensembl chr16:18,580,979...18,590,671
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 IEA OMIM:166760 MouseDO NCBI chr17:70,844,205...70,853,532
Ensembl chr17:70,844,205...70,853,546
JBrowse link
G Tlr2 toll-like receptor 2 ISO
IMP
protein:increased expression:middle ear:
protein:increased expression:mucosa of middle ear,skin of ear canal:
associated with Pneumococcal Infections;
associated with Haemophilus Infections;
RGD PMID:23380629 PMID:24690988 PMID:19414550 PMID:19586996 RGD:7800666, RGD:8552995, RGD:8552783, RGD:7777086 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tlr4 toll-like receptor 4 IMP
ISO
associated with Haemophilus Infections;
protein:increased expression:mucosa of middle ear,skin of ear canal:
protein:increased expression:middle ear:
RGD PMID:19586996 PMID:24690988 PMID:23380629 RGD:7777086, RGD:8552995, RGD:7800666 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor ISO
IEP
associated with Haemophilus Infections; mRNA, protein:increased expression:middle ear
protein:increased expression:ear:
RGD PMID:18524391 PMID:22173336 PMID:21818352 RGD:4891398, RGD:7401215, RGD:7394703 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Trp73 transformation related protein 73 IEA OMIM:166760 MouseDO NCBI chr 4:154,056,249...154,139,875
Ensembl chr 4:154,056,253...154,140,208
Ensembl chr 4:154,056,253...154,140,208
JBrowse link
G Vegfa vascular endothelial growth factor A IEP mRNA:increased expression:middle ear:
mRNA,protein:increased expression:middle ear,inner ear:
RGD PMID:22104377 PMID:21271590 RGD:8547975, RGD:8547980 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
Otitis Media with Effusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO RGD PMID:2454602 RGD:11560528 NCBI chr 6:121,636,165...121,679,238
Ensembl chr 6:121,635,376...121,679,227
JBrowse link
G C3 complement component 3 disease_progression ISO RGD PMID:11037838 RGD:7401253 NCBI chr17:57,203,967...57,228,136
Ensembl chr17:57,203,970...57,228,136
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 ISO mRNA:increased expression:mucosa of the middle ear; RGD PMID:12875575 RGD:8547977 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Glb1 galactosidase, beta 1 ISO RGD PMID:2837976 RGD:11557999 NCBI chr 9:114,401,078...114,474,379
Ensembl chr 9:114,401,076...114,474,898
JBrowse link
G Gusb glucuronidase, beta ISO RGD PMID:2837976 RGD:11557999 NCBI chr 5:129,989,011...130,003,049
Ensembl chr 5:129,989,011...130,003,049
JBrowse link
G Ifng interferon gamma ISO
IEP
protein:decreased expression:serum:
protein:decreased expression:middle ear:
RGD PMID:16055981 PMID:15938212 RGD:7987911, RGD:8142354 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:18568516 RGD:7394746 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 ISO protein:increased expression:middle ear RGD PMID:18975780 RGD:2317282 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il4ra interleukin 4 receptor, alpha treatment IDA
ISO
RGD PMID:12297806 PMID:12297806 RGD:11530017, RGD:11530017 NCBI chr 7:125,552,271...125,579,474
Ensembl chr 7:125,552,120...125,579,474
JBrowse link
G Kdr kinase insert domain protein receptor ISO mRNA:increased expression:mucosa of the middle ear; RGD PMID:12875575 RGD:8547977 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Ltf lactotransferrin treatment ISO RGD PMID:21079169 RGD:11554025 NCBI chr 9:111,019,292...111,042,766
Ensembl chr 9:111,019,271...111,042,767
JBrowse link
G Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric ISO
IGI
mRNA:increased expression:middle ear
mRNA:decreased expression:ear
RGD PMID:20713760 PMID:22336013 RGD:7364731, RGD:7364764 NCBI chr 7:141,788,958...141,819,227
Ensembl chr 7:141,788,972...141,819,231
JBrowse link
G Muc5b mucin 5, subtype B, tracheobronchial ISO
IGI
mRNA:increased expression:middle ear
mRNA:decreased expression:ear
RGD PMID:16540890 PMID:22336013 RGD:7364744, RGD:7364764 NCBI chr 7:141,839,059...141,873,089
Ensembl chr 7:141,839,070...141,873,084
JBrowse link
G Oxgr1 oxoglutarate (alpha-ketoglutarate) receptor 1 IMP RGD PMID:23200873 RGD:7775025 NCBI chr14:120,019,585...120,042,435
Ensembl chr14:120,019,585...120,042,435
JBrowse link
G Ptafr platelet-activating factor receptor treatment ISO RGD PMID:14759570 RGD:11554333 NCBI chr 4:132,564,067...132,582,683
Ensembl chr 4:132,564,067...132,582,683
JBrowse link
G Tlr2 toll-like receptor 2 IMP RGD PMID:22336013 RGD:7364764 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tlr4 toll-like receptor 4 IMP RGD PMID:22336013 RGD:7364764 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor IEP protein:increased expression:middle ear effusion: RGD PMID:18568516 RGD:7394746 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:mucosa of middle ear: RGD PMID:22907120 RGD:8547964 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
suppurative otitis media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO RGD PMID:1696441 RGD:11556250 NCBI chr 6:121,636,165...121,679,238
Ensembl chr 6:121,635,376...121,679,227
JBrowse link
G Alb albumin ISO RGD PMID:1696441 RGD:11556250 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Ifng interferon gamma disease_progression ISO RGD PMID:19640314 RGD:8142346 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Tlr2 toll-like receptor 2 ISO mRNA,protein:increased expression:mucosa: RGD PMID:22883581 RGD:7800662 NCBI chr 3:83,836,272...83,841,824
Ensembl chr 3:83,836,272...83,841,767
JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA,protein:increased expression:mucosa: RGD PMID:22883581 RGD:7800662 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14541
    sensory system disease 5479
      auditory system disease 906
        Otitis 101
          labyrinthitis + 1
          otitis externa + 1
          otitis media + 101
Path 2
Term Annotations click to browse term
  disease 14541
    disease of anatomical entity 14141
      nervous system disease 11644
        sensory system disease 5479
          Otorhinolaryngologic Diseases 1345
            auditory system disease 906
              Otitis 101
                labyrinthitis + 1
                otitis externa + 1
                otitis media + 101
paths to the root