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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chronic Lung Allograft Dysfunction
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Accession:DOID:9007461 term browser browse the term
Definition:Chronic and progressive loss of function in a transplanted lung. It involves a persistent decline in FEV1 (Forced expiratory volume in 1 second) of more than 20%, independent of the type of pulmonary function defect.
Synonyms:exact_synonym: CLAD
 xref: EFO:0008497


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Chronic Lung Allograft Dysfunction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPAS1 endothelial PAS domain protein 1 ISO mRNA:increased expression:lung RGD PMID:22305384 RGD:10395369 NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17996
    Wounds and Injuries 934
      Thoracic Injuries 284
        Lung Injury 279
          Lung Reperfusion Injury 27
            Chronic Lung Allograft Dysfunction 1
Path 2
Term Annotations click to browse term
  disease 17996
    disease of anatomical entity 15260
      respiratory system disease 3351
        lower respiratory tract disease 2146
          lung disease 2108
            Lung Injury 279
              Lung Reperfusion Injury 27
                Chronic Lung Allograft Dysfunction 1
paths to the root